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Sanz-Cuesta BE

Pedro Urquiza, Ana Laín, Arantza Sanz-Parra, Jorge Moreno, Ganeko Bernardo-Seisdedos, Pierre Dubus, Esperanza González, Virginia Gutiérrez-de-Juan, Sandra García, Hasier Eraña, Itxaso San Juan, Iratxe Macías, Fredj Ben Bdira, Paula Pluta, Gabriel Ortega, Julen Oyarzábal, Rosario González-Muñiz, Juan Rodríguez-Cuesta, Juan Anguita, Emilio Díez, Jean-Marc Blouin, Hubert de Verneuil, José M Mato, Emmanuel Richard, Juan M Falcón-Pérez, Joaquín Castilla, Oscar Millet
Congenital erythropoietic porphyria is a rare autosomal recessive disease produced by deficient activity of uroporphyrinogen III synthase, the fourth enzyme in the heme biosynthetic pathway. The disease affects many organs, can be life-threatening, and currently lacks curative treatments. Inherited mutations most commonly reduce the enzyme's stability, altering its homeostasis and ultimately blunting intracellular heme production. This results in uroporphyrin by-product accumulation in the body, aggravating associated pathological symptoms such as skin photosensitivity and disfiguring phototoxic cutaneous lesions...
September 19, 2018: Science Translational Medicine
Luis Gallego, Alberto Sicilia, Pelayo Sicilia, Carmen Mallo, Susana Cuesta, Mariano Sanz
OBJECTIVE: To analyze retrospectively interproximal crestal bone loss (CBL) on external-hex "non-identical" (NI) dental implants with different surface topography, when placed in the same intra-oral location in patients with a history of chronic periodontitis following maintenance care. MATERIAL AND METHODS: The patient population consisted of 206 consecutive patients with a history of chronic periodontitis who underwent implant surgery between 2007 and 2010; 755 NI implants with different implant surfaces were placed at posterior mandibular sites: 72 machined, 145 acid-etched/machined (hybrid), and 538 anodized...
June 2018: Clinical Oral Implants Research
Susana Martín-Iglesias, M Jesús Santamaría-Martín, Ahinoa Alonso-Álvarez, Milagros Rico-Blázquez, Isabel Del Cura-González, Ricardo Rodríguez-Barrientosn, Aurora Barberá-Martín, Teresa Sanz-Cuesta, M Isabel Coghen-Vigueras, Isabel de Antonio-Ramírez, Isabel Durand-Rincón, Felisa Garrido-Rodriguez, María Jesús Geijo-Rincón, Rebeca Mielgo-Salvador, M Soledad Morales-Montalvá, M Asunción Reviriego-Gutiérrez, Carmen Rivero-Garrido, Micaela Ruiz-Calabria, M Pilar Santamaría-Mechano, Roberto Santiago-Fernández, M Isabel Sillero-Quintana, Beatriz Soto-Almendro, María Terol-Claramonte, María Villa-Arranz
BACKGROUND: The World Health Organization leads a global strategy to promote the initiation and maintenance of breast-feeding. Existing literature shows that education and supportive interventions, both for breast-feeding mothers as well as for healthcare professionals, can increase the proportion of women that use exclusive breast-feeding, however, more evidence is needed on the effectiveness of group interventions. METHODS: This study involves a community-based cluster randomised trial conducted at Primary Healthcare Centres in the Community of Madrid (Spain)...
February 26, 2018: BMC Pregnancy and Childbirth
Federico Miguel Cuesta Triana, Francisco Villazón González, Alejandro Sanz Paris, Juan Ignacio Ramos-Clemente Romero, José Enrique Palacio Abizanda, Rebeca Sanz Barriuso
BACKGROUND: Enteral nutrition (EN) is an effective nutritional intervention for patients at risk of malnutrition or malnourished. However, complications such as gastrointestinal intolerance, hyperglycemia or refeeding syndrome can be triggered by EN. AIM: To investigate the effects of a tube feeding formula (TFF) on patients' nutritional status, biochemical status, bowel habits and safety. METHODOLOGY: Observational, prospective and multicenter study...
October 27, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Jorge Rodríguez-Pardo, Manuel Lara-Lara, Borja E Sanz-Cuesta, Blanca Fuentes, Exuperio Díez-Tejedor
OBJECTIVE: To perform a literature review of the epidemiology, clinical presentation, diagnostic evaluation, and clinical course of occipital condyle syndrome, including a new case report. BACKGROUND: Occipital condyle syndrome (OCS) is a rare clinical syndrome, consisting of unilateral occipital headache accompanied by ipsilateral hypoglossal palsy. This headache typically radiates to the temporal region, and is triggered by contralateral head rotation. It is usually associated with skull base metastasis, often unrevealed in basic neuroimaging studies...
May 2017: Headache
María Alonso de Leciñana, Patricia Martínez-Sánchez, Andrés García-Pastor, Michal M Kawiorski, Patricia Calleja, Borja E Sanz-Cuesta, Fernando Díaz-Otero, Remedios Frutos, Fernando Sierra-Hidalgo, Gerardo Ruiz-Ares, Eduardo Fandiño, Exuperio Díez-Tejedor, Antonio Gil-Nuñez, Blanca Fuentes
BACKGROUND AND PURPOSE: The present study was conducted with the objective of evaluating the safety of primary mechanical thrombectomy (MT) in patients with large vessel occlusion (LVO) stroke and comorbidities that preclude treatment with IV thrombolysis (IVT), compared with patients who received standard IVT treatment followed by MT. Secondary objectives were to analyse the recanalization rate and outcomes. METHODS: A prospective observational multicenter study (FUN-TPA) that recruited patients treated within 4...
November 2017: Journal of Neurointerventional Surgery
Isabel Del Cura-González, Juan A López-Rodríguez, Teresa Sanz-Cuesta, Ricardo Rodríguez-Barrientos, Jesús Martín-Fernández, Gloria Ariza-Cardiel, Elena Polentinos-Castro, Begoña Román-Crespo, Esperanza Escortell-Mayor, Milagros Rico-Blázquez, Virginia Hernández-Santiago, Amaya Azcoaga-Lorenzo, Elena Ojeda-Ruiz, Ana I González-González, José F Ávila-Tomas, Jaime Barrio-Cortés, José M Molero-García, Raul Ferrer-Peña, María Eugenia Tello-Bernabé, Mar Trujillo-Martín
BACKGROUND: Clinical practice guidelines (CPGs) have been developed with the aim of helping health professionals, patients, and caregivers make decisions about their health care, using the best available evidence. In many cases, incorporation of these recommendations into clinical practice also implies a need for changes in routine clinical practice. Using educational games as a strategy for implementing recommendations among health professionals has been demonstrated to be effective in some studies; however, evidence is still scarce...
May 17, 2016: Implementation Science: IS
María Eugenia López, Agustín Turrero, Pablo Cuesta, David López-Sanz, Ricardo Bruña, Alberto Marcos, Pedro Gil, Miguel Yus, Ana Barabash, José Antonio Cabranes, Fernando Maestú, Alberto Fernández
Recent proposals of diagnostic criteria within the healthy aging-Alzheimer's disease (AD) continuum stressed the role of biomarker information. More importantly, such information might be critical to predict those mild cognitive impairment (MCI) patients at a higher risk of conversion to AD. Usually, follow-up studies utilize a reduced number of potential markers although the conversion phenomenon may be deemed as multifactorial in essence. In addition, not only biological but also cognitive markers may play an important role...
March 5, 2016: Journal of Alzheimer's Disease: JAD
Michal M Kawiorski, Patricia Martínez-Sánchez, Andrés García-Pastor, Patricia Calleja, Blanca Fuentes, Borja E Sanz-Cuesta, Daniel Lourido, Begoña Marín, Fernando Díaz-Otero, Agustina Vicente, Fernando Sierra-Hidalgo, Gerardo Ruiz-Ares, Exuperio Díez-Tejedor, Eduardo Fandiño, María Alonso de Leciñana
INTRODUCTION: Reliable predictors of poor clinical outcome despite successful revascularization might help select patients with acute ischemic stroke for thrombectomy. We sought to determine whether baseline Alberta Stroke Program Early CT Score (ASPECTS) applied to CT angiography source images (CTA-SI) is useful in predicting futile recanalization. METHODS: Data are from the FUN-TPA study registry (; NCT02164357) including patients with acute ischemic stroke due to proximal arterial occlusion in anterior circulation, undergoing reperfusion therapies...
May 2016: Neuroradiology
César Calvo-Lobo, Soraya Pacheco-da-Costa, Jorge Martínez-Martínez, David Rodríguez-Sanz, Pedro Cuesta-Álvaro, Daniel López-López
BACKGROUND AND PURPOSE: Shoulder pain is a prevalent condition in older adults. Some authors associate nonspecific shoulder pain with myofascial trigger points (MTrPs) in the infraspinatus muscle. Dry needling is recommended to relieve the MTrP pain of shoulders in the short term (<9 days). Active MTrPs dry needling improves shoulder pain and the irritability of the satellite MTrPs in the referred pain area. Nociceptive activity at a latent MTrP may influence motor activity and the sensitivity of MTrPs in distant muscles at a similar segmental level...
January 2018: Journal of Geriatric Physical Therapy
Lorena Sanz, Silvia Murillo-Cuesta, Pedro Cobo, Rafael Cediel-Algovia, Julio Contreras, Teresa Rivera, Isabel Varela-Nieto, Carlos Avendaño
Mouse models are key tools for studying cochlear alterations in noise-induced hearing loss (NIHL) and for evaluating new therapies. Stimuli used to induce deafness in mice are usually white and octave band noises that include very low frequencies, considering the large mouse auditory range. We designed different sound stimuli, enriched in frequencies up to 20 kHz ("violet" noises) to examine their impact on hearing thresholds and cochlear cytoarchitecture after short exposure. In addition, we developed a cytocochleogram to quantitatively assess the ensuing structural degeneration and its functional correlation...
2015: Frontiers in Aging Neuroscience
María Gutiérrez-Fernández, Berta Rodríguez-Frutos, Jaime Ramos-Cejudo, Laura Otero-Ortega, Blanca Fuentes, María Teresa Vallejo-Cremades, Borja Enrique Sanz-Cuesta, Exuperio Díez-Tejedor
BACKGROUND: Rat adipose tissue-derived-mesenchymal stem cells (rAD-MSCs) have proven to be safe in experimental animal models of stroke. However, in order to use human AD-MSCs (hAD-MSCs) as a treatment for stroke patients, a proof of concept is needed. We analyzed whether the xenogeneic hAD-MSCs were as safe and effective as allogeneic rAD-MSCs in permanent Middle Cerebral Artery Occlusion (pMCAO) in rats. METHODS: Sprague-Dawley rats were randomly divided into three groups, which were intravenously injected with xenogeneic hAD-MSCs (2 × 10(6)), allogeneic rAD-MSCs (2 × 10(6)) or saline (control) at 30 min after pMCAO...
February 1, 2015: Journal of Translational Medicine
Blanca Fuentes, Andrés Cruz-Herranz, Patricia Martínez-Sánchez, Ana Rodríguez-Sanz, Gerardo Ruiz Ares, Daniel Prefasi, Borja E Sanz-Cuesta, Manuel Lara-Lara, Exuperio Díez-Tejedor
The benefit of intravenous thrombolysis (IVT) has been questioned for patients with diabetes mellitus (DM) in cases of acute ischemic stroke (IS). Our objective was to analyze the differences in outcome according to prior diagnosis of DM and the use or not of IVT. Observational study with inclusion of consecutive IS patients admitted to an stroke unit. Demographic data, vascular risk factors, comorbidity, stroke severity and 3-month follow-up outcome (modified Rankin Scale) were compared according to prior diagnosis of DM and the use or not of IVT...
November 2014: Journal of Thrombosis and Thrombolysis
Christelle Ferrà, Jaime Sanz, Miguel-Angel Díaz-Pérez, Mireia Morgades, Jorge Gayoso, José-Rafael Cabrera, Teresa Villaescusa, María-Antonia Sampol, Francesc Fernández-Avilés, Carlos Solano, Miguel Ortín, Rafael Duarte, Marian Cuesta, Inmaculada Heras, Javier de la Serna, José-María Moraleda, Cristina Barrenetxea, Marta González-Vicent, Guillermo Sanz, Josep-Maria Ribera
Strategies for reversing graft failure (GF) after allogeneic stem cell transplant (SCT) depend on the options available in each situation. GF was reported in 16 Spanish institutions from January 2006 to July 2011. Primary GF was defined as an absolute neutrophil count (ANC) > 0.5 × 10(9)/L not reached by day + 28 after SCT from peripheral blood (PB) or bone marrow (BM) progenitors and by day + 42 after SCT from unrelated cord blood (UCB) progenitors. Secondary GF was defined as a recurrent ANC < 0.5 × 10(9)/L...
March 2015: Leukemia & Lymphoma
M Gandolfo-Cano, J Bartra, E González-Mancebo, F Feo-Brito, E Gómez, B Bartolomé, E Muñoz-García, A Sanz Maroto, F Vivanco, J Cuesta-Herranz, C Pastor-Vargas
BACKGROUND: The relevance of contact allergy to plant-related food has recently emerged. Oral allergy syndrome is one of the most characteristic symptoms of fruit allergy, although it also causes systemic reactions. Plant-food allergy is increasing at the same time as pollen allergy, and fruit-induced allergic contact urticaria could be rising as well. OBJECTIVES: The present study was carried out in order to investigate whether one particular primary melon-peel allergen is responsible for contact urticaria...
March 2014: British Journal of Dermatology
Milagros Rico-Blázquez, Esperanza Escortell-Mayor, Isabel Del-Cura-González, Teresa Sanz-Cuesta, Pilar Gallego-Berciano, Gonzalo de Las Casas-Cámara, Sonia Soto-Díaz, Petra García-Sanz, Natalie Harris-de-la-Vega, María Martín-Martín, Lorena Domínguez-Pérez, Araceli Rivera-Álvarez, Juan Antonio Sarrión-Bravo, Concepción Pérez-de-Hita, Marisol de-Frías-Redondo, Carmen Ferrer-Arnedo, Montserrat Hernández-Pascual, Antonio Valdivia-Pérez, Yolanda Ramallo Fariña
BACKGROUND: In Spain, family is the main source of care for dependent people. Numerous studies suggest that providing informal (unpaid) care during a prolonged period of time results in a morbidity-generating burden. Caregivers constitute a high-risk group that experiences elevated stress levels, which reduce their quality of life.Different strategies have been proposed to improve management of this phenomenon in order to minimize its impact, but definitive conclusions regarding their effectiveness are lacking...
January 27, 2014: BMC Nursing
Irene Zubiri, Maria Posada-Ayala, Aroa Sanz-Maroto, Enrique Calvo, Marta Martin-Lorenzo, Laura Gonzalez-Calero, Fernando de la Cuesta, Juan A Lopez, Beatriz Fernandez-Fernandez, Alberto Ortiz, Fernando Vivanco, Gloria Alvarez-Llamas
UNLABELLED: Diabetic nephropathy (DN) is a major complication of diabetes mellitus (DM), the most frequent cause of end-stage renal disease (ESRD). Exosomes isolated from urine are considered a rich non-invasive source of markers for renal events. Proteinuria associated with DN patients at advanced stages may result in "contamination" of exosomal fraction by co-precipitation of high abundance urine proteins, making it enormously difficult to obtain a reliable comparison of healthy individuals and DN patients and to detect minor proteins...
January 16, 2014: Journal of Proteomics
D Risco, P Fernández-Llario, W L García-Jiménez, P Gonçalves, J M Cuesta, R Martínez, C Sanz, M Sequeda, L Gómez, J Carranza, J Hermoso de Mendoza
The wild boar is an important reservoir of bovine tuberculosis (bTB) in south-western Spain. Some risk factors such as wild boar density or age have been associated with the presence of high prevalences of bTB in wild boar. However, the influence of other risk factors such as co-infections with other pathogens has not yet been studied. This work aims to assess the influence of porcine circovirus type 2 (PCV-2) infection on bTB prevalence and bTB lesional patterns observed in wild boar. The presence of bTB-like lesions was evaluated in 551 hunted wild boar from 11 different game estates in south-western Spain, with a known history of bTB...
November 2013: Transboundary and Emerging Diseases
Maria Posada-Ayala, Irene Zubiri, Marta Martin-Lorenzo, Aroa Sanz-Maroto, Dolores Molero, Laura Gonzalez-Calero, Beatriz Fernandez-Fernandez, Fernando de la Cuesta, Carlos M Laborde, Maria G Barderas, Alberto Ortiz, Fernando Vivanco, Gloria Alvarez-Llamas
The prevalence of chronic kidney disease (CKD) is increasing and frequently progresses to end-stage renal disease. There is an urgent demand to discover novel markers of disease that allow monitoring disease progression and, eventually, response to treatment. To identify such markers, and as a proof of principle, we determined if a metabolite signature corresponding to CKD can be found in urine. In the discovery stage, we analyzed the urine metabolome by NMR of 15 patients with CKD and compared that with the metabolome of 15 healthy individuals and found a classification pattern clearly indicative of CKD...
January 2014: Kidney International
Esther Muñoz-García, Olga Luengo-Sánchez, Elisa Haroun-Díaz, Aroa Sanz Maroto, Arancha Palacín, Araceli Díaz-Perales, Manuel de las Heras Gozalo, Moisés Labrador-Horrillo, Fernando Vivanco, Javier Cuesta-Herranz, Carlos Pastor-Vargas
SCOPE: Today, about 2-8% of the population of Western countries exhibits some type of food allergy whose impact ranges from localized symptoms confined to the oral mucosa to severe anaphylactic reactions. Consumed worldwide, lettuce is a Compositae family vegetable that can elicit allergic reactions. To date, however, only one lipid transfer protein has been described in allergic reaction to lettuce. The aim of this study was to identify potential new allergens involved in lettuce allergy...
December 2013: Molecular Nutrition & Food Research
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