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controlling blood sugar levels

Milad Daneshi-Maskooni, Seyed Ali Keshavarz, Mostafa Qorbani, Siavash Mansouri, Seyed Moayed Alavian, Mahtab Badri-Fariman, Seyed Ali Jazayeri-Tehrani, Gity Sotoudeh
BACKGROUND: Despite the reported health effects of cardamom on dyslipidemia, hepatomegaly, and fasting hyperglycemia, no human research has studied its potency in non-alcoholic fatty liver disease (NAFLD) as the hepatic part of metabolic syndrome. Our aim was determining the effects of green cardamom (GC) on serum glucose indices, lipids, and irisin level among overweight or obese NAFLD patients. METHODS: The place of participant recruitment was the polyclinic of the National Iranian Oil Company (NIOC) central hospital in Tehran...
March 12, 2019: BMC Complementary and Alternative Medicine
J William Allwood, Yun Xu, Pilar Martinez-Martin, Raphaёlle Palau, Alexander Cowan, Royston Goodacre, Athole Marshall, Derek Stewart, Catherine Howarth
INTRODUCTION: Oats (Avena sativa L.) are a whole grain cereal recognised for their health benefits and which are cultivated largely in temperate regions providing both a source of food for humans and animals, as well as being used in cosmetics and as a potential treatment for a number of diseases. Oats are known as being a cereal source high in dietary fibre (e.g. β-glucans), as well as being high in antioxidants, minerals and vitamins. Recently, oats have been gaining increased global attention due to their large number of beneficial health effects...
March 12, 2019: Metabolomics: Official Journal of the Metabolomic Society
Kristina Simacek, Christopher Curran, Peter Fenici, Ricardo Garcia-Sanchez
Purpose: This study aimed to assess awareness of glycated hemoglobin (A1C) testing and targets, perceived level of glycemic control and risk of complications, attitudes toward medications and self-management, and regimen-related distress in an international sample of patients with type 2 diabetes (T2D). Methods: The descriptive study used a single time-point survey of adults in online health communities in the USA, Canada, the UK, Germany, Spain, and Mexico, who self-reported T2D diagnosed by a physician...
2019: Patient Preference and Adherence
Kaustubh Bora, Alice Abraham Ruram
BACKGROUND: Although inadequate vitamin D and altered parathyroid hormone (PTH) are implicated in deranged glucose metabolism and risk of future diabetes, their role in regulating glucose homeostasis in established cases of diabetes is unclear. We aimed to (i) evaluate vitamin D status, and (ii) determine if vitamin D and PTH were associated with parameters of glucose homeostasis in type 2 diabetes (T2D) patients from Meghalaya, India. METHODS: We determined 25-hydroxyvitamin D (25-OH-D) and PTH concentrations in 251 T2D patients (not on insulin), and examined their associations with the following parameters of glucose homeostasis: fasting blood sugar (FBS), post-prandial blood sugar (PPBS), glycated hemoglobin (HbA1c), fasting insulin (FI), homeostasis model assessments of insulin resistance (HOMA-IR) and β-cell function (HOMA-β)...
March 11, 2019: International Journal for Vitamin and Nutrition Research. Journal International de Vitaminologie et de Nutrition
Saima Nazish, Azra Zafar, Rizwana Shahid, Abdullah Al Sulaiman, Majed Alabdali, Danah Aljaafari, Fahad A Alkhamis, Fahad A Alkhamis, Zakia M Yasawy, Noman Ishaque, Nehad M Soltan, Ejaz A Vohra
OBJECTIVE: To study the frequency of multiple vascular risk factors and electrophysiological severity of carpal tunnel syndrome (CTS) in Saudi diabetic patients. METHODS: This retrospective cross-sectional study was conducted in Neurology Department, King Fahd Hospital of University, Al-Khobar, Kingdom of Saudi Arabia from April 2017 to March 2018 and included 200 patients with CTS. Body parameters, such as blood pressure (BP), weight, height, and body mass index (BMI), along with laboratory and median nerve electrophysiological parameters, of diabetic and non-diabetic patients were compared, and a p-value<0...
January 2019: Neurosciences: the Official Journal of the Pan Arab Union of Neurological Sciences
Suman Bhattacharya, Uttam Maji, Gausal A Khan, Rahul Das, Asru K Sinha, Chandradipa Ghosh, Smarajit Maiti
INTRODUCTION: Garlic has been reported to stimulate nitric-oxide (NO) synthesis in various cells. The role of aqueous-extract of garlic (AEG) and a purified NO-generating protein from garlic (NGPG) was investigated to control hyperglycemia by hepatic insulin synthesis through NGPG induced synthesis of NO via glucose-activated NO-synthase and glucose transporter-4 (Glut-4) in the hepatocytes. METHODS: Type-1-diabetic mellitus mice were prepared by alloxan treatment, NO was determined by methemoglobin method, insulin synthesis was quantitated by ELISA...
March 2019: Biomedicine & Pharmacotherapy
Ali Rastegari, Fatemeh Mottaghitalab, Rassoul Dinarvand, Mohsen Amini, Ehsan Arefian, Mahdi Gholami, Fatemeh Atyabi
Diabetes mellitus is a chronic metabolic disorder characterized by insulin deficiency and impaired glucose metabolism. Overexpression of cAMP response element binding protein (CREB)-regulated transcriptional coactivator 2 (CRTC2) plays an important role in high gluconeogenesis in patients with diabetes type II. Using RNA interference technology for silencing CRTC2 gene expression could be helpful in controlling the level of blood glucose and gluconeogenesis. In this study, we designed a siRNA delivery platform comprising blended chitosan lactate (CT) and polyethylene glycol (PEG) conjugated with glycyrrhetinic acid (GA) for controlling gluconeogenesis...
March 1, 2019: Drug Delivery and Translational Research
Muhammad Farooq
OBJECTIVE: To assess the level of zinc in type 2 diabetes mellitus and its relation to glycemic control. STUDY DESIGN: Descriptive cross-sectional study. PLACE AND DURATION OF STUDY: Department of Medicine, Dallah Hospital, Riyadh, KSA, from May 2014 to June 2015. METHODOLOGY: This study employed 200 diabetic and 192 control subjects. The demographic data was taken from all 392 subjects; and laboratory investigations like, fasting blood sugar (FBS), glycosylated hemoglobin (HbA1C), and serum zinc level were done...
March 2019: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Archana Shrestha, Dipesh Tamrakar, Biraj Man Karmacharya, Abha Shrestha, Rajeev Shrestha, Rajendra Dev Bhatta, Prajjwal Pyakurel, Polyna Khudyakov, Vasanti Malik, Josiemer Mattei, Donna Spiegelman
BACKGROUND: To increase cardiovascular disease prevention efforts, worksite interventions can promote healthy food choices, facilitate health education, increase physical activity and provide social support. This pioneer study will measure the effectiveness of a cafeteria and a behavioral intervention on cardio-metabolic risk in a worksite in Nepal. METHODS: The Nepal Pioneer Worksite Intervention Study is a two-step intervention study conducted in Dhulikhel Hospital in eastern Nepal...
February 28, 2019: BMC Cardiovascular Disorders
Laila M Aboul-Mahasen, Rasha Abdulrahman Alshali
BACKGROUND: Hyperlipidemia is a risk factor for the development and progression of atherosclerosis and is linked to various diseases. This study was done to evaluate the possible protective effects of virgin olive oil and Nigella sativa seeds on the biochemical and histopathological changes which occurred in the pancreas of the rats. The study lasts 8 weeks and included 24 albino rats that were divided into four groups (6 rats each); group I, control group, fed with normal standard diet, group II fed with high fat diet (HFD), group III fed with HFD and virgin Olive oil, group IV fed with HFD and Nigella sativa seeds powder...
February 28, 2019: Folia Morphologica (Warsz)
Mohammed Alkharaiji, Uchenna Anyanwagu, Richard Donnelly, Iskandar Idris
Background: NHS England has recommended a multidisciplinary weight management services (MWMS-Tier 3 services) for patients requiring specialized management of obesity, including bariatric surgery, but clinical and measurable health-related outcomes from these services remains fragmented. We therefore undertook a systematic review to explore the evidence base of effect on body weight loss and comorbidities outcomes of Tier 3 or UK pre-bariatric MWMPs. Methods: AMED, CINAHL, EMBASE, HMIC, MEDLINE, PsycINFO, PubMed, HDAS search and Google Scholar were searched from January 2000 to September 2017 in a free-text fashion and crossed-references of included studies to identify potential illegibility...
January 2019: Endocrinology, Diabetes & Metabolism
Raissa Silva Bacelar de Andrade, Luiz Felipe de Carvalho França, Larissa Dos Santos Pessoa, Bruno de Almeida Arrais Landim, Ayane Araújo Rodrigues, Even Herlany Pereira Alves, David Di Lenardo, Hélio Mateus Silva Nascimento, Francisca Beatriz de Melo Sousa, André Luiz Dos Reis Barbosa, Jand-Venes Rolim Medeiros, Any Carolina Cardoso Guimarães Vasconcelos, Daniel Fernando Pereira Vasconcelos
BACKGROUND: Periodontitis is an inflammatory disease that causes periodontium and hepatic alterations. Liver disease is related to the intake of foods rich in fat and sugars (high-fat). The objective of this study was to evaluate whether a high-fat diet can aggravate the liver disease caused by ligature-induced periodontitis in rats. METHODS: Twenty-one female rats were divided into three groups (n = 7 in each group): control; periodontitis (periodontitis induced with ligature) and high-fat + periodontitis (received hypercaloric diet and induction of periodontitis)...
February 23, 2019: Journal of Periodontology
Taotao Dai, Jun Chen, David Julian McClements, Ti Li, Chengmei Liu
Procyanidins are reported to inhibit α-glucosidase, which may be a useful attribute for developing functional foods that control post-prandial blood sugar levels. At present, the nature of the molecular interaction between procyanidins and α-glucosidase is poorly understood. In this study, spectroscopic analyses and computer simulations were used to investigate the interactions between α-glucosidase and B-type procyanidin dimer (BPD). Our results suggest that BPD binds to α-glucosidase through a combination of hydrophobic and hydrophilic interactions...
February 19, 2019: International Journal of Biological Macromolecules
Ya-Bing Zhu, Gai-Li Jia, Jia-Hui Lu, Mao-Biao Zhang, Jun Li, Hong Cao
OBJECTIVE: To investigate the relationship between autophagy function in spinal cord and type 2 diabetic neuropathic pain in rats. METHODS: Forty-two male Sprague-Dawley rats were fed with a high-sugar, high-fat diet for 8 weeks to induce the insulin resistance, and then received a single intraperitoneal streptozocin (STZ) injection to establish type 2 diabetes rat model. Two weeks after STZ injection, mechanical withdrawal threshold (MWT) and thermal withdrawal latency (TWL) of rats were detected, the rats with MWT and TWL decreasing to below 80% compared to baseline were chosen as type 2 diabetic neuropathic pain rats (group DNP, n =24), the rest of the rats were chosen as type 2 diabetic non-neuropathic pain rats (group DA, n =18)...
April 8, 2018: Chinese Journal of Applied Physiology
Shailendra Dandge, Panniyammakal Jeemon, P S Reddy
OBJECTIVES: We aimed to determine the feasibility and effectiveness of an intervention anchored on mHealth and task sharing strategy of involving non-physician health workers (NPHW) on population level detection, treatment and control of hypertension and diabetes in India. METHODS: Non-physician health workers (NPHWs) equipped with tablet computers that were linked with point-of-care devices for blood pressure (BP) and blood sugar measurements visited households, screened adult individuals for hypertension and diabetes from two randomly selected villages in the Medchal district, Telangana, India...
2019: PloS One
Hanan H Ahmed, Fatma M Taha, Heba S Omar, Heba M Elwi, Marwa Abdelnasser
DN is recognized as not only a leading cause of end stage renal disease (ESRD) but also an independent risk factor for cardiovascular disease (CVD). Novel therapeutic approaches to diabetic nephropathy (DN) are needed, or else, healthcare resources will be overwhelmed by the expected worldwide increase in associated cases of ESRD and CVD. Reactive oxygen species (ROS) and advanced glycation end product (AGE) are implicated in the development of DN. Hydrogen sulfide (H2 S) is known for its antioxidant and antiapoptotic characteristics...
February 18, 2019: Molecular and Cellular Biochemistry
Nashwa Othman, Osama Gheith, Torki Al-Otaibi, Tarek Mahmoud, Faisal Al-Refaei, Fatma Mahmoud, Heba Abduo, Narayanan Nampoory, Medhat A Halim, Ayman Najeb
OBJECTIVES: Diabetes knowledge among kidney transplant recipients with posttransplant diabetes has not been exhaustively assessed. We evaluated levels of diabetes knowledge among our kidney transplant patients using a 35-item diabetes self-care management questionnaire. MATERIALS AND METHODS: The study comprised renal transplant patients with posttransplant diabetes mellitus who were referred from Hamed Al-Essa Organ Transplant Center of Kuwait to the Dasman Diabetes Institute...
January 2019: Experimental and Clinical Transplantation
Nashwa Othman, Osama Gheith, Torki Al-Otaibi, Heba Abdou, Medhat A Halim, Tarek Mahmoud, Prasad Nair, Jude Yagan, Ayman Maher, Mohamed Dahab, Ahmed Yahya
Posttransplant diabetes is a common complication of solid-organ transplantation. We present the possible role of diabetes education in improvement of posttransplant diabetes in a 36-year-old bodybuilder who was a kidney transplant recipient. The patient had been abusing some medications to help in bodybuilding. He underwent living unrelated-donor renal transplant with thymoglobulin induction and was maintained on steroids, tacrolimus, and mycophenolate mofetil. Posttransplant diabetes was confirmed by blood tests...
January 2019: Experimental and Clinical Transplantation
Hui-Jie Wei, Li Liu, Fang-Lian Chen, Dong Wang, Liang Wang, Zeng-Guang Wang, Rong-Cai Jiang, Jing-Fei Dong, Jie-Li Chen, Jian-Ning Zhang
Hyperglycemia reduces the number of circulating endothelial progenitor cells, accelerates their senescence and impairs their function. However, the relationship between blood glucose levels and endothelial progenitor cells in peripheral blood of patients with traumatic brain injury is unclear. In this study, 101 traumatic brain injury patients admitted to the Department of Neurosurgery, Tianjin Medical University General Hospital or the Department of Neurosurgery, Tianjin Huanhu Hospital, China, were enrolled from April 2005 to March 2007...
June 2019: Neural Regeneration Research
Sahar Ahmed, Rasha Sobh
BACKGROUND: Osteoprotegerin (OPG) is a tumor necrosis factor receptor super-family member. It specifically acts on bone by increasing bone mineral density and bone volume. Recent studies have evidenced its close relation to the development of atherosclerosis and plaque destabilization. Elevated OPG level has also been associated with the degree of coronary calcification in the general population and it has been considered to be a marker of coronary atherosclerosis. OBJECTIVE: The aim of this study was to determine the relation between OPG levels and coronary artery calcification score (CACs) in Type 2 diabetic patients in comparison to healthy controls...
February 11, 2019: Endocrine, Metabolic & Immune Disorders Drug Targets
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