Isaiah Odeyemi, Teri A Douglas, Nosakhare F Igie, James A Hargrove, Grace Hamilton, Brianna B Bradley, Cathy Thai, Brendan Le, Maitri Unjia, Dylan Wicherts, Zackery Ferneyhough, Anjali Pillai, Shailendra Koirala, Laurel M Hagge, Himanshu Polara, Raymond C Trievel, Robert J Fick, Allison L Stelling
S-adenosyl-L-methionine (SAM) is an abundant biomolecule used by methyltransferases to regulate a wide range of essential cellular processes such as gene expression, cell signaling, protein functions, and metabolism. Despite considerable effort, there remain many specificity challenges associated with designing small molecule inhibitors for methyltransferases, most of which exhibit off-target effects. Interestingly, NMR evidence suggests that SAM undergoes conformeric exchange between several states when free in solution...
January 2, 2024: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy