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maternal factors

Anthony M Kendle, Jason L Salemi, Jean Paul Tanner, Judette M Louis
BACKGROUND: Sepsis is a leading cause of pregnancy-related mortality. Previous studies have reported an increased prevalence of sepsis during pregnancy. Despite national campaigns to increase sepsis awareness, there is a lack of pregnancy-specific guidelines. OBJECTIVE: We aimed to provide updated national estimates of the prevalence and trends of sepsis, sepsis-related in-hospital mortality, and factors associated with in-hospital mortality among women with sepsis at delivery...
February 13, 2019: American Journal of Obstetrics and Gynecology
Mark A Clapp, Kaitlyn E James, Sara V Bates, Anjali J Kaimal
BACKGROUND: Unexpected admissions of term neonates to the neonatal intensive care unit (NICU) and unexpected postnatal complications have been proposed as neonatal-focused quality metrics for intrapartum care. Previous studies have noted significant variation in overall hospital NICU admission rates; however, little is known about the influence of obstetric practices on these rates or whether variation among unanticipated admissions in low risk, term neonates can be attributed to systemic hospital practices...
February 13, 2019: American Journal of Obstetrics and Gynecology
Aleha Aziz, Cynthia Gyamfi-Bannerman, Zainab Siddiq, Jason D Wright, Dena Goffman, Jean-Ju Sheen, Mary E D'Alton, Alexander M Friedman
BACKGROUND: Maternal race may be an important risk factor for postpartum readmissions and associated adverse outcomes. OBJECTIVE: To determine the association of race with serious complications during postpartum readmissions. STUDY DESIGN: This repeated cross sectional analysis utilized the National (Nationwide) Inpatient Sample from the Healthcare Cost and Utilization Project from 2012 to 2014. Women ages 15 to 54 readmitted postpartum after a delivery hospitalization were identified by Centers for Disease Control and Prevention criteria...
February 13, 2019: American Journal of Obstetrics and Gynecology
Cathrine Fowler, Janet Green, Doug Elliott, Julia Petty, Lisa Whiting
AIMS: To explore the experiences of mothers of extremely premature babies during their Neonatal Intensive Care Unit stay and transition home. BACKGROUND: Mothers of extremely preterm infants (28-weeks-or-less gestation) experience a continuum of regular and repeated stressful and traumatic events; during the perinatal period, while the Neonatal Intensive Care Unit, and during transition home. METHOD: An interpretive description method guided this study...
February 20, 2019: Journal of Clinical Nursing
Claudia Fecher-Trost, Femke Lux, Kai-Markus Busch, Ahsan Raza, Manuel Winter, Franziska Hielscher, Thabet Belkacemi, Bram van der Eerden, Ulrich Boehm, Marc Freichel, Petra Weissgerber
Embryonic growth and bone development depend on placental Ca2+ transport across the feto-maternal barrier to supply minerals to the fetus. The individual factors and cellular mechanisms that regulate placental Ca2+ transfer, however, are only beginning to emerge. We find that the Ca2+ -selective transient receptor potential vanilloid 6 (TRPV6) channel is expressed in trophoblasts of the fetal labyrinth, in the yolk sac, and in the maternal part of the placenta. Lack of functional TRPV6 channels in the mother leads to a reduced Ca2+ content in both placenta and embryo...
February 20, 2019: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
Elizabeth M Westrupp, Fabrizio D'Esposito, Jane Freemantle, Fiona K Mensah, Jan M Nicholson
OBJECTIVE: To examine health outcomes in Australian Aboriginal and Torres Strait Islander children experiencing perinatal risk and identify protective factors in the antenatal period. METHODS: Baby/Child cohorts of the Longitudinal Study of Indigenous Children, born 2001-2008, across four annual surveys (aged 0-8 years, N = 1483). Children with 'mild' and 'moderate-to-high' perinatal risk were compared to children born normal weight at term for maternal-rated global health and disability, and body-mass-index measured by the interviewer...
2019: PloS One
Mahnaz Bahri Khomami, Anju E Joham, Jacqueline A Boyle, Terhi Piltonen, Chavy Arora, Michael Silagy, Marie L Misso, Helena J Teede, Lisa J Moran
Polycystic ovary syndrome (PCOS) is associated with worsened pregnancy and infant outcomes, higher body mass index (BMI), and longitudinal weight gain. Despite most of the clinical features of PCOS being risk factors for worsened infant outcomes in the general population, their impact on infant outcomes in PCOS is unknown. We aimed to investigate the association of PCOS with infant outcomes considering maternal adiposity, other known risk factors, and potential confounders. The meta-analyses included 42 studies in 7041 women with PCOS and 63 722 women without PCOS...
February 20, 2019: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
João Alexandre Mendes Teixeira, Waleska Regina Machado Araujo, Ana Goretti Kalume Maranhão, Juan José Cortez-Escalante, Leandro Fórnias Machado de Rezende, Alicia Matijasevich
OBJECTIVE: to calculate mortality rates on the first day of life from 2010 to 2015 in eight Brazilian Federative Units providing better quality information, to assess associated factors and to classify deaths by underlying causes and avoidability. METHODS: this was a descriptive study; mortality rates were compared according to maternal and child characteristics; avoidability analysis used the 'Brazilian list of avoidable causes of death'. RESULTS: 21...
February 18, 2019: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
Natália Peixoto Lima, Diego G Bassani, Bruna G C da Silva, Janaína V S Motta, Elma Izze S Magalhães, Fernando C Barros, Bernardo L Horta
This study aimed at assessing the association of breastfeeding with maternal body mass index (BMI), waist circumference, fat mass index, fat free mass index, android/gynoid fat ratio and bone mineral density. In 1982, the maternity hospitals in Pelotas, Rio Grande do Sul State, Brazil, were daily visited and all live births were identified and examined. These subjects underwent follow-up for several times. At 30 years of age, the participants were interviewed and examined. Parous women provided information on parity and duration of breastfeeding...
February 18, 2019: Cadernos de Saúde Pública
Naomi Carlisle, Paul T Seed, Lindsay Gillman
BACKGROUND: Complications due to influenza are contributory factors for maternal deaths in the United Kingdom (UK). Less than half of all pregnant women in the UK receive the influenza vaccination. Increasing immunisation rates for seasonal influenza in pregnant women must remain a public health priority. METHOD: A retrospective cohort study was undertaken, utilising the electronic health record of 4817 women who had given birth at a South London NHS Hospital from 1st January-31st December 2015...
February 10, 2019: Midwifery
Tricia Aung, Debora Niyeha, Shagihilu Shagihilu, Rose Mpembeni, Joyceline Kaganda, Ashley Sheffel, Rebecca Heidkamp
Background: Reproductive, maternal, newborn, child health, and nutrition (RMNCH&N) data is an indispensable tool for program and policy decisions in low- and middle-income countries. However, being equipped with evidence doesn't necessarily translate to program and policy changes. This study aimed to characterize data visualization interpretation capacity and preferences among RMNCH&N Tanzanian program implementers and policymakers ("decision-makers") to design more effective approaches towards promoting evidence-based RMNCH&N decisions in Tanzania...
2019: Global Health Research and Policy
Xin Lu, Jun Qian
Maternally expressed gene 3 (MEG3) in rheumatoid arthritis (RA) and its underlying mechanism were explored. Synovial tissues from 10 RA patients and 10 controls were collected to detect MEG3 expression in fibroblast-like synoviocytes (FLS). The relationship between MEG3 expression and TNF-α was analyzed. After MEG3 knockdown by lentivirus transfection, cell cycle, proliferation, apoptosis, invasion and secretion of inflammatory factors were detected. Furthermore, the effect of MEG3 on STAT3 and PI3K/AKT pathways was explored...
March 2019: Experimental and Therapeutic Medicine
Xianjin Zhou, Jiang Li, Shengqiong Deng, Zhendong Xu, Zhiqiang Liu
Effects of ropivacaine at different concentrations on intrapartum fever, interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in parturient with epidural labor analgesia were compared to provide reference for the rational selection of anesthetics in clinic. Medical records of 198 cases of primi-paras admitted to the Obstetrics and Gynecology Department, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, from January 2017 to January 2018 were analyzed retrospectively and divided into 2 groups...
March 2019: Experimental and Therapeutic Medicine
Junichi Sugawara, Daisuke Ochi, Riu Yamashita, Takafumi Yamauchi, Daisuke Saigusa, Maiko Wagata, Taku Obara, Mami Ishikuro, Yoshiki Tsunemoto, Yuki Harada, Tomoko Shibata, Takahiro Mimori, Junko Kawashima, Fumiki Katsuoka, Takako Igarashi-Takai, Soichi Ogishima, Hirohito Metoki, Hiroaki Hashizume, Nobuo Fuse, Naoko Minegishi, Seizo Koshiba, Osamu Tanabe, Shinichi Kuriyama, Kengo Kinoshita, Shigeo Kure, Nobuo Yaegashi, Masayuki Yamamoto, Satoshi Hiyama, Masao Nagasaki
PURPOSE: A prospective cohort study for pregnant women, the Maternity Log study, was designed to construct a time-course high-resolution reference catalogue of bioinformatic data in pregnancy and explore the associations between genomic and environmental factors and the onset of pregnancy complications, such as hypertensive disorders of pregnancy, gestational diabetes mellitus and preterm labour, using continuous lifestyle monitoring combined with multiomics data on the genome, transcriptome, proteome, metabolome and microbiome...
February 19, 2019: BMJ Open
Sarka Lisonkova, Justin Tan, Qi Wen, Lobna Abdellatif, Lindsay L Richter, Sukainah Alfaraj, Paul J Yong, Mohamed A Bedaiwy
OBJECTIVE: To examine temporal trend in maternal mortality/severe morbidity associated with hospitalisation due to ectopic pregnancy. DESIGN: A population-based observational study. SETTING AND PARTICIPANTS: All women hospitalised for ectopic pregnancy in Washington State, USA, 1987-2014 (n=20 418). The main composite outcome of severe morbidity/mortality included death, sepsis, need for transfusion, hysterectomy and systemic or organ failure, identified by diagnostic and procedure codes from hospitalisation files...
February 19, 2019: BMJ Open
Prestige Tatenda Makanga, Charfudin Sacoor, Nadine Schuurman, Tang Lee, Faustino Carlos Vilanculo, Khatia Munguambe, Helena Boene, Ugochinyere Vivian Ukah, Marianne Vidler, Laura A Magee, Esperanca Sevene, Peter von Dadelszen, Tabassum Firoz
OBJECTIVES: To identify and measure the place-specific determinants that are associated with adverse maternal and perinatal outcomes in the southern region of Mozambique. DESIGN: Retrospective cohort study. Choice of variables informed by literature and Delphi consensus. SETTING: Study conducted during the baseline phase of a community level intervention for pre-eclampsia that was led by community health workers. PARTICIPANTS: A household census identified 50 493 households that were home to 80 483 women of reproductive age (age 12-49 years)...
February 19, 2019: BMJ Open
Deogratius Bintabara, Alex Ernest, Bonaventura Mpondo
OBJECTIVE: This study used a nationally representative sample from Tanzania as an example of low-resource setting with a high burden of maternal and newborn deaths, to assess the availability and readiness of health facilities to provide basic emergency obstetric and newborn care (BEmONC) and its associated factors. DESIGN: Health facility-based cross-sectional survey. SETTING: We analysed data for obstetric and newborn care services obtained from the 2014-2015 Tanzania Service Provision Assessment survey, using WHO-Service Availability and Readiness Assessment tool...
February 19, 2019: BMJ Open
Zahra Roustaei, Sari Räisänen, Mika Gissler, Seppo Heinonen
OBJECTIVES: We described the trend of fertility rates, age-specific fertility rates and associated factors in Finland over a 30-year period. DESIGN: A descriptive population-based register study. SETTING: Fertility data, including age at first birth, childlessness and educational levels were gathered from the Finnish Medical Birth Register and Statistics Finland. PARTICIPANTS: All 1 792 792 live births from 1987 to 2016 in Finland...
January 15, 2019: BMJ Open
Junying Ye, Huan Wang, Hao Wu, Liaosha Ye, Qi Li, Xiang-Yu Ma, Xiaodong Yu, Hua Zhang, Xu Luo
OBJECTIVES: Hospitals devoted to maternal and child health represent unique healthcare institutions in China. Healthcare professionals in these hospitals attend to health services for women and children, and also provide technical services and support for district maternal and children's healthcare as well as family planning. However, few studies have examined occupational burnout among doctors employed in these hospitals. This research addresses the gap in the literature. METHODS: A cross-sectional survey of obstetricians and paediatricians from 11 maternal and child health hospitals across China was conducted May through June 2017...
January 25, 2019: BMJ Open
Jian Zhang, Guang-Hui Liu, Yu-Wei Zhao, Hui-Qin Wang, Shuang-Gen Mao, Guo-Shun Mao, Kang-Ming Xi, Li-Li Wang, Chuan-Long Zhang, Cheng-Ju Gao, Dao-Dan Huang
OBJECTIVE: To investigate the risk factors for brain injury in preterm infants by a multicenter epidemiological investigation of brain injury in hospitalized preterm infants in Anhui, China. METHODS: Preterm infants who were hospitalized in the department of neonatology in 9 hospitals of Anhui Neonatal Collaboration Network between January 2016 and January 2017 were enrolled as subjects. The data of maternal pregnancy and clinical data of preterm infants were collected, and the logistic regression model was used to analyze the risk factors for brain injury in preterm infants...
February 2019: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
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