Sebastián M Muñoz, Gabriel Vallejos-Baccelliere, Augusto Manubens, Michelle L Salazar, Andrey F Z Nascimento, Patricio Tapia-Reyes, Claudio Meneses, Andre L B Ambrosio, María Inés Becker, Victoria Guixé, Victor Castro-Fernandez
Mollusk hemocyanins, among the largest known proteins, are used as immunostimulants in biomedical and clinical applications. The hemocyanin of the Chilean gastropod Concholepas concholepas (CCH) exhibits unique properties, which makes it safe and effective for human immunotherapy, as observed in animal models of bladder cancer and melanoma, and dendritical cell vaccine trials. Despite its potential, the structure and amino acid sequence of CCH remain unknown. This study reports two sequence fragments of CCH, representing three complete functional units (FUs)...
March 14, 2024: Structure