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Wenxian Li, Di Wei, Xiaomei Xie, Jianye Liang, Kangping Song, Li'an Huang
Previous findings have demonstrated, in a rat model, that chronic cerebral hypoperfusion (CCH) decreases cortical cerebral blood flow (CBF) while Dl-3-n-Butylphthalide (DNB) accelerates the timely recovery of CBF. However, potential biomarkers, therapeutic targets, and underlying mechanisms for these processes are unclear. In this study, a solid-phase antibody microarray for simultaneously detecting multiple proteins was used to search cortex biotargets in CCH compared to a sham control group, and these results were further examined by biological functional analysis...
March 18, 2019: Biomedicine & Pharmacotherapy
Xue-Ling Hu, Xiao-Xue Wang, Yan-Meng Zhu, Li-Na Xuan, Li-Wei Peng, Yun-Qi Liu, Hua Yang, Chao Yang, Lei Jiao, Peng-Zhou Hang, Li-Hua Sun
Nav1.1 and Nav1.2 are the voltage-gated sodium channel alpha subunit1 and 2, encoded by the genes of SCN1 A and SCN2 A. Previous studies have shown that chronic cerebral hypoperfusion (CCH) could induce neuropathological and cognitive impairment and increased total Nav1.1 and Nav1.2protein levels, yet the detailed mechanisms are not fully understood. MicroRNAs (miRNAs) are a class of small, non-coding RNAs that are involved in the regulation of dementia. miR-132 is known to play a key role in neurodegenerative disease...
March 15, 2019: Behavioural Brain Research
Cecilia Rosso, Giovanni Felisati, Antonio Bulfamante, Carlotta Pipolo
Among cephalgias, cluster headache (CH) is the rarest and the most disabling, explaining the appellation of "suicide headache." Up to 20% of chronic CH reveals to be resistant to pharmacological treatments, in which case interventional procedures should be considered. Many reports evaluated invasive approaches and a wide strand of research is dedicated to the sphenopalatine ganglion. Our paper will now be focused on providing an overview on modern applications on the sphenopalatine ganglion (SPG), their outcomes, and their feasibility in terms of risks and benefits...
March 16, 2019: Neurological Sciences
Heui-Soo Moon, Soo-Jin Cho, Byung-Kun Kim, Mi Ji Lee, Pil-Wook Chung, Jong-Hee Sohn, Soo-Kyoung Kim, Yun-Ju Choi, Tae-Jin Song, Jae-Moon Kim, Jeong Wook Park, Kwang-Yeol Park, Jae-Myun Chung, Jin-Young Ahn, Byung-Su Kim, Kyungmi Oh, Kwang-Soo Lee, Chin-Sang Chung, Min Kyung Chu
BACKGROUND: *These authors are shared first authors. The recently published third edition of the International Classification of Headache Disorders (ICHD-3) revised the criteria for accompanying symptoms of cluster headache (CH) and the remission period of chronic cluster headache (CCH). This study aimed at testing the validity of the ICHD-3 criteria for CH by using data from the Korean Cluster Headache Registry. METHODS: Consecutive patients with CH and probable cluster headache (PCH) were prospectively recruited from 15 hospitals...
March 11, 2019: Cephalalgia: An International Journal of Headache
Juan José Mora Román, Miguel Del Campo, Javiera Villar, Francesca Paolini, Gianfranca Curzio, Aldo Venuti, Lilian Jara, Jorge Ferreira, Paola Murgas, Alvaro Lladser, Augusto Manubens, María Inés Becker
Mollusk hemocyanins have been used for decades in immunological and clinical applications as natural, nontoxic, nonpathogenic, and nonspecific immunostimulants for the treatment of superficial bladder cancer, as carriers/adjuvants of tumor-associated antigens in cancer vaccine development and as adjuvants to dendritic cell-based immunotherapy, because these glycoproteins induce a bias towards Th1 immunity. Here, we analyzed the preclinical therapeutic potential of the traditional keyhole limpet hemocyanin (KLH) and two new hemocyanins from Concholepas concholepas (CCH) and Fissurella latimarginata (FLH) in mouse models of oral squamous cell carcinoma...
2019: Journal of Immunology Research
Maximilian Neuwirth, Lukas Kalt, Wolfgang Pipam, Matthias Rab
INTRODUCTION: CCH (Collagenase Clostridium Histolyticum; Xiapex® ) has become established as a simple and reliable alternative to traditional treatments for Dupuytren's contracture. This study aims to analyse our results and discuss our modifications of this therapy. PATIENTS AND METHODS: The study included 312 fingers treated with CCH between 2011 and 2018 (256 patients; 225 men and 31 women). There were 157 fingers (50.3 %) with an isolated joint contracture, while multiple joints were affected in 155 fingers (49...
February 2019: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
Yue Hei, Rong Chen, Xingang Mao, Jiancai Wang, Qianfa Long, Weiping Liu
Neuregulin1 (NRG1) is an effective neuroprotectant. Previously we demonstrated that the expression of hippocampal NRG1/ErbB4 gradually decreased and correlates with neuronal apoptosis during chronic cerebral hypoperfusion (CCH). Here we aimed to further investigate the protective role of NRG1 in CCH. AG1478, an ErbB4 inhibitor, was used to explore the involvement of ErbB4 receptors in NRG1's action. Permanent bilateral common carotid artery occlusion (2VO) or sham operation was performed in Sprague-Dawley rats...
February 28, 2019: Behavioural Brain Research
Wenjing Zong, Xiangchang Zeng, Siyu Chen, Lulu Chen, Luping Zhou, Xintong Wang, Qing Gao, Guirong Zeng, Kai Hu, Dongsheng Ouyang
Ginsenoside compound K (CK) is the main metabolite of protopanaxadiol-type ginsenosides and has been demonstrated to exert neuroprotective and cognition-enhancing effects. The effects of CK on cognitive function in vascular dementia (VD) has not been elucidated. Therefore, the present study aims to elucidate the effects of CK on memory function as well as its potential mechanism in VD rats. Sprague-Dawley rats were subjected to Chronic Cerebral Hypoperfusion (CCH) by permanent bilateral common carotid artery occlusion (2VO)...
February 13, 2019: Journal of Pharmacological Sciences
Yogeshkanna Sathyamoorthy, Kathiravan Kaliappan, Pradeepkumar Nambi, Rameshkumar Radhakrishnan
BACKGROUND: Chronic cerebral hypoperfusion (CCH), a concern for neurocognitive health, is linked to various vascular ailments and other comorbidities. This study primarily aims to explain the mitigating effects of glycyrrhizic acid (GA) on cognitive health challenged by chronic cerebral hypoperfusion. METHODS: Adult male Sprague Dawley rats were allocated into four groups: (i) Sham, (ii) Lesion (2VO), (iii) GA treated (20 mg/kg), and (iv) lithium chloride (Li) treated (40 mg/kg)...
February 22, 2019: Nutritional Neuroscience
Sihua Ren, Chunyan Ma, Songbai Li
Criss-cross heart (CCH) is an extremely rare complex congenital heart malformation. It accounts for less than 0.1% of congenital heart diseases. Here, we describe a unique case of CCH with double-outlet right ventricle, huge subpulmonary ventricular septal defect, bicuspid pulmonary valve, and right-hand aortic arch. The anatomic features were observed with echocardiography, and the diagnosis was confirmed at surgery. Many variations of CCH have been described. The present case expands the spectrum of this entity and may provide new insight into this complex anatomy...
February 15, 2019: Journal of Clinical Ultrasound: JCU
Jesus H Gonzalez-Cortes, Abraham Olvera-Barrios, Jose R Perez-Salas, Hugo A Trevino-Rodríguez, Ezequiel E Trevino-Cavazos, Jesus E Gonzalez-Cantu, Jesus Mohamed-Hamsho
Circumscribed choroidal hemangiomas (CCHs) are relatively rare. We report the response of a symptomatic CCH to photodynamic therapy (PDT). A 70-year-old male presented with blurred vision of the left eye (OS). Best-corrected visual acuity (BCVA) was 20/60 right eye and 20/160 OS. Biomicroscopy revealed bilateral cataracts. Diagnosis of CCH was made fundoscopically for OS and confirmed with optical coherence tomography (OCT). One session of PDT with individualized parameters was administered. After 2 months, anatomical improvement was evidenced with OCT and BCVA was 20/60...
2019: Cirugia y Cirujanos
T A Masterson, A Galante, M Butaney, A Pastuszak, H Sadeghi-Nejad, R Ramasamy
Collagenase clostridium histolyticum (CCH, Xiaflex, Xiapex) is the only FDA-approved medication for treatment of Peyronie's disease. It is unclear how practitioners actually use CCH in their own practices. The objectives of the study were: (1) to identify variability in practice patterns for CCH among practitioners, (2) to assess adherence to the package insert instructions, and (3) to evaluate whether provider satisfaction was associated with adherence to instructions. A 30-question online survey was distributed to 1270 members of the International Society for Sexual Medicine (ISSM) from the EU, USA, Canada and Australia...
February 12, 2019: International Journal of Impotence Research
A O Vasilyev, A V Govorov, A A Shiryaev, P I Bykov, A Kim Yu, N A Kalinina, M G Schneiderman, D Yu Pushkar
INTRODUCTION: The experience of comparative evaluation of the effectiveness of various types of urethral catheters in prevention of catheter-associated infection is described in this article. MATERIALS AND METHODS: The study included 69 patients treated at the CCH n.a. S.I. Spasokukotsky in the period from December 2017 to March 2018. The average age of patients was 67.5 years. In all patients, the bladder was drained by a two-way Foley catheter No. 16-18 Ch (100% silicone)...
December 2018: Urologii︠a︡
Takayoshi Masuoka, Junsuke Uwada, Makiko Kudo, Hatsumi Yoshiki, Yuka Yamashita, Takanobu Taniguchi, Matomo Nishio, Takaharu Ishibashi, Ikunobu Muramatsu
Hippocampal cholinergic activity enhances long-term potentiation (LTP) of synaptic transmission in intrahippocampal circuits and regulates cognitive function. We recently demonstrated intracellular distribution of functional M1-muscarinic acetylcholine receptors (mAChRs) and neuronal uptake of acetylcholine (ACh) in the central nervous system. Here we examined whether endogenous ACh acts on intracellular M1-mAChRs following its uptake and causes cholinergic facilitation of hippocampal LTP. ACh esterase (AChE) activities and [3 H]ACh uptake was measured in rat hippocampal segments...
January 29, 2019: Neuroscience
Yuki Kai, Momoko Motegi, Yuta Suzuki, Hiroto Takeuchi, Yui Harada, Fumiaki Sato, Yoshihiko Chiba, Junzo Kamei, Hiroyasu Sakai
There has been considerable research on the involvement of RhoA/Rho kinase signalling in smooth muscle contractions. However, only a few reports have addressed the specific role of Rac1, which is a member of the Rho GTPase superfamily. Therefore, this study investigated the role of Rac1-related pathways in bronchial smooth muscle (BSM) contractions. Bronchial rings isolated from mice were suspended in an organ bath, and the isometric contractions of circular smooth muscles were monitored. The phosphorylation of myosin light chains (MLCs) was analysed by immunoblotting...
January 29, 2019: Basic & Clinical Pharmacology & Toxicology
Giorgio Ivan Russo, Giovanni Cacciamani, Andrea Cocci, Thomas M Kessler, Giuseppe Morgia, Ege Can Serefoglu, Maarten Albersen, Paolo Verze
INTRODUCTION: Medical treatment of Peyronie's disease (PD) in terms of intralesional therapy is still a matter of debate. AIM: To compare the efficacy of different classes of intralesional therapy with a network meta-analysis (NMA) method. METHODS: The search was conducted using documents published in PubMed, Scopus, and Web of Science databases until September 30, 2017. We included randomized controlled trials comparing at least 1 intralesional therapy with a placebo therapy or with another drug for the treatment of PD...
February 2019: Journal of Sexual Medicine
Yusuke Kataoka, Raiki Fukumoto, Natsumi Yano, Daiki Atarashi, Hidekazu Tanaka, Tatsuya Kawamoto, Makoto Handa
The reactions of [Rh₂(O₂CCH₃)₄(OH₂)₂] with n -naphthalenecarboxylic acids ( n = 1: 1-HNC, n = 2: 2-HNC) afford the dirhodium tetra-μ-( n -naphthoate) complexes [Rh₂(1-NC)₄] ( 1 ) and [Rh₂(2-NC)₄] ( 2 ), respectively. Single crystal X-ray diffraction analyses of [1(OCMe₂)₂] and [2(OCMe₂)₂], which were obtained by recrystallization from acetone (OCMe₂) solutions of 1 and 2 , reveal that the dirhodium cores are coordinated by four equatorially bridging naphthoate ligands and two axial OCMe₂ ligands...
January 27, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Jason Fletcher, Ezekiel S L Tan, Michael Thomas, Fraser Taylor, Devlin Elliott, Randy Bindra
BACKGROUND: Dupuytren's disease causes a flexion contracture of the hand that limits hand function and reduces quality of life. Traditional management is surgical excision which is associated with potentially serious complications. A viable alternative is collagenase Clostridium histolyticum (CCH) (Xiaflex®; Pfizer Australia) which is an effective, safe, outpatient treatment that to date has no published data in the Australian public health setting. METHODS: A prospective cohort, single centre study, enrolling 54 patients to treat 81 joints with CCH...
January 26, 2019: ANZ Journal of Surgery
Wen Chen, Yong He, Chuansheng Chen, Ming Zhu, Suyu Bi, Jin Liu, Mingrui Xia, Qixiang Lin, Yiwen Wang, Wenjing Wang
As a visual art form, Chinese calligraphic handwriting (CCH) has been found to correlate with certain brain activity and to induce functional connectivity reorganization of the brain. This study investigated the effect of long-term CCH training on brain functional plasticity as assessed with network measures. With the resting-state fMRI data from 31 participants with at least five years of CCH training and 40 controls, we constructed brain functional networks, examined group differences at both the whole brain and modular levels, and correlated the topological characteristics with calligraphy skills...
2019: PloS One
Burcu Karagoz, Aaron Reinicker, Andrew J Gellman
The mechanism and kinetics of aspartic acid (Asp, HO2 CCH(NH2 )CH2 CO2 H) decomposition on Cu(100) have been studied using X-ray photoemission spectroscopy and temperature-programmed reaction spectroscopy. We investigate the Asp decomposition mechanism in detail using unlabeled d-Asp and isotopically labeled l-Asp-4-13 C (HO2 CCH(NH2 )CH2 13 CO2 H), l-Asp- d7 (DO2 CCD(ND2 )CD2 CO2 D), l-Asp-2,3,3- d3 (HO2 CCD(NH2 )CD2 CO2 H), and l-Asp-15 N-2,3,3- d3 (HO2 CCD(15 NH2 )CD2 CO2 H). The monolayer of Asp adsorbed on the Cu(100) surface is in a doubly deprotonated bi-aspartate form (-O2 CCH(NH2 )CH2 CO2 -)...
February 11, 2019: Langmuir: the ACS Journal of Surfaces and Colloids
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