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hepatic failure children

Claire Geurten, Marie Geurten, Claire Hoyoux, Marie-Christine Lebrethon
Background Neuroblastoma (NBL) is a child neoplasia affecting extracranial tissue of neuroectodermal origin. It accounts for 10% of solid malignancies in children and is characterized by a survival rate approaching 70%, confronting physicians with the emergence of an adult survivor population who have been previously exposed to surgery, cytotoxic drugs, radiation therapy or metaiodobenzylguanidine (MIBG) therapy. All these treatments potentially affect the endocrine system. Our study consists in a retrospective review of late endocrine effects arising in survivors treated for NBL during childhood...
March 15, 2019: Journal of Pediatric Endocrinology & Metabolism: JPEM
Tri Wangrangsimakul, Rachel C Greer, Chulapong Chanta, Supalert Nedsuwan, Stuart D Blacksell, Nicholas P J Day, Daniel H Paris
BACKGROUND: Scrub typhus, caused by Orientia tsutsugamushi, is a major cause of acute febrile illness in children in the rural tropics. METHODS: We recruited 60 febrile pediatric patients with a positive scrub typhus rapid diagnostic test result and 40 healthy controls from Chiang Rai Province in northern Thailand. Diagnosis was confirmed by the detection of (1) O. tsutsugamushi-specific DNA in blood or eschar samples with a polymerase chain reaction assay, (2) a fourfold rise in immunoglobulin M (IgM) titer to ≥1:3200 in paired plasma samples with an indirect immunofluorescence assay (IFA), or (3) a single IgM titer of ≥1:3200 in an acute plasma sample with an IFA...
March 13, 2019: Journal of the Pediatric Infectious Diseases Society
Seyed Mohsen Dehghani, Iraj Shahramian, Ali Bazi, Maryam Mohammadi Mofrad, Samira Mardani
OBJECTIVES: Liver transplant has been used as a curative approach for children with end-stage liver diseases. Here, we describe the underlying causes for pediatric liver transplant performed at the Shiraz Organ Transplantation Center, Nemazee Hospital, Shiraz, Iran. MATERIALS AND METHODS: In this cross-sectional des-criptive study, children < 18 years old who were candidates for liver transplant from 2007 to 2010 at the Shiraz Organ Transplantation Center were included...
March 5, 2019: Experimental and Clinical Transplantation
L F Dai, F Fang, Z M Liu, D M Shen, C H Ding, J W Li, X T Ren, H S Wu
Objective: To explore the phenotype and genotype of mitochondrial DNA depletion syndromes (MDS) in Chinese children. Methods: The clinical and genetic data of 12 MDS patients (8 were boys and 4 were girls) diagnosed in the Department of Neurology in Beijing Children's Hospital, Capital Medical University from October 2010 to April 2018 were retrospectively collected and analyzed. Results: The developmental milestones were normal or mildly retardated before disease onset. The age of onset ranged from 0 to 2...
March 2, 2019: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
Ana Carolina Kogawa, Leena Peltonen, Selma Gutierrez Antonio, Hérida Regina Nunes Salgado
Rifaximin, an oral antimicrobial drug, is marketed as 200-mg tablets. The daily dose ranges from 600 mg (1 tablet 3 times a day) to 800 mg (2 tablets twice a day). It is used for a wide range of ages, from adults to children, since it is indicated for the treatment of hepatic encephalopathy, travelers' diarrhea, irritable bowel syndrome, Clostridium difficile, ulcerative colitis, and acute diarrhea. The success of pharmacotherapy will depend on correct fulfillment of drug administration; however, it becomes difficult when the tablets are large and the doses are frequent...
February 25, 2019: AAPS PharmSciTech
Tadayuki Kumagai, Hiroshi Terashima, Hajime Uchida, Akinari Fukuda, Mureo Kasahara, Motomichi Kosuga, Torayuki Okuyama, Tomoyuki Tsunoda, Ayano Inui, Tomoo Fujisawa, Aya Narita, Yoshikatsu Eto, Masaya Kubota
BACKGROUND: Niemann-Pick type C (NPC) is a lysosomal lipid storage disease with mutation of NPC1/NPC2 genes, which transport lipids in the endosome and lysosome, and various neurological symptoms. NPC patients also develop hepatosplenomegaly or liver disorder in the neonatal period, and 10% suffer severe liver failure. Neonatal hemochromatosis (NH) is a liver disorder characterized by hepatic and extrahepatic siderosis. Although the etiology of NH is unclear, recent reports suggest that the gestational alloimmune mechanism is the cause of NH...
February 5, 2019: Brain & Development
P-M Dugourd, A Dupont, T Hubiche, C Chiaverini, A Alkhalifa, L Roudiere, A Tristan, C-A Gustave, P Del Giudice
BACKGROUND: Toxic shock syndrome (TSS) was first described by Todd in 1978. The relevant Lancet publication reported 7 cases of children with fever, exanthema, hypotension and diarrhoea associated with multiple organ failure. An association between TSS and use of hyper-absorbent tampons in menstruating women was discovered in the 1980s. Following the market withdrawal of such tampons, TSS virtually disappeared. Herein we report a new case of TSS in a 15-year-old girl. PATIENTS AND METHODS: A 15-year-old patient was admitted to intensive care for severe sepsis and impaired consciousness associated with diffuse abdominal pain...
January 25, 2019: Annales de Dermatologie et de Vénéréologie
Mohammad Abd Alkhalik Basha, Rania Refaat, Ayman F Ahmed, Hala Y Yousef, Ahmed Mohamed Alsowey, Maha Ibrahim Metwally, Sameh Abdelaziz Aly, Hatem M Hussien, Hosam F El-Saadany, Asghan A AlGhobashy, Mohamed A Talat, Mona M Amer, Ashraf Mahrous Eid
PURPOSE: Although brain magnetic resonance spectroscopy (MRS) imaging findings in adult Wilson disease (WD) have been explained in extensive details, a paucity of information currently exists regarding brain MRS imaging findings in pediatric WD. The purpose of this study was to clarify the role of brain MRS in detecting early metabolite abnormalities in children with WD. PATIENT AND METHODS: A case-controlled prospective study included 26 children with WD and 26 healthy controls...
February 2019: European Journal of Radiology
Sarah Israel, Hila Fruchtman, David Hakimian, Zvi Ackerman
BACKGROUND: Since the implementation of a hepatitis A virus (HAV) immunization program for children, which began in 1999 in Israel, HAV infections in the country have occurred mostly in adults. HAV infection in adults is usually symptomatic and may present with hepatic, as well as extrahepatic, abdominal complications. OBJECTIVES: To estimate the prevalence of extrahepatic abdominal complications in patients diagnosed with HAV. METHODS: Most extrahepatic abdominal complications corresponding to HAV infection have ultrasonographic manifestations; therefore, we retrospectively collected findings from ultrasound examinations in addition to laboratory data from adult patients with HAV infection who were admitted to our medical center between 2004 and 2016...
January 2019: Israel Medical Association Journal: IMAJ
Kriti Puri, Hardeep Singh, Susan W Denfield, Antonio G Cabrera, William J Dreyer, Hari P Tunuguntla, Jack F Price
OBJECTIVE: To determine frequency of missed heart failure diagnosis at first presentation among children with no known heart disease admitted with new-onset heart failure. STUDY DESIGN: Using a retrospective design, we reviewed electronic medical records of all patients aged <21 years with no known heart disease, hospitalized with new-onset heart failure during 2003-2015 at a tertiary-quaternary care institution. We assessed records for missed diagnosis of heart failure (primary outcome), associated process breakdowns, and clinical outcomes using a structured data collection instrument...
January 21, 2019: Journal of Pediatrics
Xiao-Yan Chen, Min Ruan, Bei-Bei Zhao, Shu-Chun Wang, Xiao-Juan Chen, Li Zhang, Ye Guo, Wen-Yu Yang, Yao Zou, Yu-Mei Chen, Xiao-Fan Zhu
OBJECTIVE: To investigate the complications and clinical outcome of children with acute myeloid leukemia (AML) undergoing mitoxantrone-cytarabine-etoposide (MAE) induction therapy. METHODS: A total of 170 children with AML were given MAE induction therapy, and the complications and remission rate were analyzed after treatment. RESULTS: The male/female ratio was 1.33:1 and the mean age was 7.4 years (range 1-15 years). Leukocyte count at diagnosis was 29...
January 2019: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
Athena F Zuppa, Daniela J Conrado, Nicole R Zane, Martha A Q Curley, Jonathan Bradfield, Hakon Hakonarson, Madeleine S Gastonguay, Ganesh Moorthy, Janice Prodell, Marc R Gastonguay
OBJECTIVES: To develop a pharmacokinetic-pharmacogenomic population model of midazolam in critically ill children with primary respiratory failure. DESIGN: Prospective pharmacokinetic-pharmacogenomic observational study. SETTING: Thirteen PICUs across the United States. PATIENTS: Pediatric subjects mechanically ventilated for acute respiratory failure, weight greater than or equal to 7 kg, receiving morphine and/or midazolam continuous infusions...
January 21, 2019: Critical Care Medicine
Iwona Popiołek, Katarzyna Piotrowicz-Wójcik, Grzegorz Porebski
Paracetamol is a popular and easily available drug which is used world-wide as analgesic, antipyretic agent. Hypersensitivity reactions to this drug involve a wide range of symptoms of various importance for patient management. The EudraVigilance (EV) database serves as a system for monitoring adverse events (AE) due to drug intake. We retrospectively recorded AE reports for "paracetamol" reported from 1 January 2007 to 1 October 2018 which fulfilled the category of "serious" in EV. For further analysis the retrieved AE reports were selected according to the keywords corresponding to hypersensitivity symptoms...
January 17, 2019: Pharmacy (Basel, Switzerland)
Mohamad Hanouneh, Michael M Ritchie, Mona Ascha, Mustafa S Ascha, Alice Chedid, Anawin Sanguankeo, Nizar N Zein, Ibrahim A Hanouneh
BACKGROUND: There is paucity of data on alternative drug therapies for patients with autoimmune hepatitis (AIH). Tacrolimus (TAC) is a promising salvage agent. We present a review of TAC therapy in AIH patients. METHODS: A search for studies with keywords 'autoimmune hepatitis' and 'tacrolimus' was performed. Reviews, studies of AIH post-transplant and AIH in children were excluded. Diagnosis of AIH was based on criteria established by the International Autoimmune Hepatitis Group...
January 16, 2019: Scandinavian Journal of Gastroenterology
L L Cao, M Zhang, S S Zhu, Y Dong, Z Q Xu, D W Chen, L M Wang, F C Wang, Y Gan, J G Yan, P Wang, A Q Li
Objective: To review and analyze the clinical and pathological data of children with autoimmune hepatitis (AIH). Methods: Medical records of 46 patients hospitalized in Pediatric Liver Diseases Treatment and Research Center, Fifth Medical Center, General Hospital of People's Liberation Army(PLA) from April 2012 to April 2018 were extracted. Medical data included type of AIH, clinical manifestations, biochemical parameters, liver biopsy results, and outcomes of treatment were analyzed retrospectively. Among 46 children, 19 were males and 27 were females...
January 2, 2019: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
Andreia Ribeiro, Maria-Jose Igual-Perez, Ermelinda Santos Silva, Etienne M Sokal
Nonalcoholic fatty liver disease (NAFLD) is an emerging entity, becoming the most prevalent pediatric chronic liver disease. Its broad spectrum of histological findings, comorbidities, and complications, including cirrhosis and liver failure, can occur in childhood, emphasizing the severity of pediatric NAFLD. Current lifestyle and diet modifications have been linked to the increasing prevalence of NAFLD, including the rise of fructose consumption, a monosaccharide present in foods that contain added sugar, such as sugar-sweetened beverages...
January 2019: Hepatology Communications
Mandar Ramachandra Sane, Kamal Malukani, Rashmi Kulkarni, Abhishek Varun
Acute iron toxicity is usually seen in children with accidental ingestion of iron-containing syrups. However, the literature on acute iron toxicity with suicidal intent in adults is scant. We report an instance wherein an adult committed suicide by ingestion of multiple iron tablets. Delay in treatment was there due to misdiagnosis of the intoxicating agent. She developed fulminant hepatic failure with rapid clinical deterioration. Despite aggressive supportive management, the patient succumbed to the toxic doses of iron...
November 2018: Indian Journal of Critical Care Medicine
Rashmi D'Souza, Tassos Grammatikopoulos, Akhilesh Pradhan, Harry Sutton, Abdel Douiri, Mark Davenport, Anita Verma, Anil Dhawan
OBJECTIVES: Acute-on-chronic liver failure (ACLF) is an acute decompensation of cirrhosis complicated by other organ failure and is associated with increased mortality and morbidity. ACLF has not been studied in children with biliary atresia (BA), which is the commonest indication for pediatric liver transplantation (LT) worldwide. This study aims to evaluate ACLF and outcomes in children with BA while awaiting deceased donor LT. METHODS: This was a subanalysis of the dataset from a prospective cohort study of patients aged 0-18 years who underwent portoenterostomy for BA and were listed for LT at King's College Hospital, London, between 1999 and 2003...
December 30, 2018: Pediatric Transplantation
Seyed Hamdollah Mosavat, Mojtaba Heydari, Mohammad Hashem Hashempur, Seyed Mohsen Dehghani
Background: The use of complementary and alternative medicine (CAM) is becoming increasingly popular in Middle Eastern countries; it is often used for paediatric medical conditions such as chronic gastrointestinal complaints and failure to thrive. It is also commonly used in patients with chronic hepatic conditions such as cirrhosis and in hepatic transplant patients. Aims: This study aimed to evaluate the prevalence, types and associated factors of CAM use in children with hepatogastrointestinal disease in Shiraz, Islamic Republic of Iran...
December 18, 2018: Eastern Mediterranean Health Journal
Rui-Hai Liu, Jing Li, Ni-Yan Qu, Zi-Pu Li
A retrospective analysis was performed for the clinical data of four children with Epstein-Barr virus (EBV)-related acute liver failure. There were two boys and two girls with a median age of 10 months (range 8.5-44 months). Of the four children, three were diagnosed with infectious mononucleosis (IM), among whom two met the diagnostic criteria of hemophagocytic lymphohistiocytosis (HLH), and one was diagnosed with past EBV infection. All the children had positive EBV DNA in blood and all had pyrexia, hepatomegaly, and jaundice on admission...
December 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
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