Weiping Su, Yanan Li, Alan Kueichieh Chang, Tongling Sheng, Ying Pei, Jianxin Li, Haoran Li, Kai Liu, Liuping Xu, Wenbao Liu, Jiao Ai, Zhicheng Zhang, Yimeng Wang, Zhen Jiang, Xiao Liang
Six new alkaloids (compounds 1 - 6 ) were isolated from Portulaca oleracea L. The compounds were triple pair ( 1 and 2 , 3 and 4 , and 5 and 6 ) enantiomers, with 1 , 3 , and 5 in the R -configuration and 2 , 4 , and 6 in the S -configuration, and all could bind to SUR1 according to molecular docking analysis. Treatment of STC-1 cells with each compound led to an influx of intracellular Ca2+ , eventually leading to the secretion of glucagon-like peptide-1 (GLP-1), with compound 3 giving the highest secretion, resulting in 24...
December 1, 2023: Journal of Agricultural and Food Chemistry