keyword
https://read.qxmd.com/read/38423410/effective-substances-and-molecular-mechanisms-guided-by-network-pharmacology-an-example-study-of-scrophulariae-radix-treatment-of-hyperthyroidism-and-thyroid-hormone-induced-liver-and-kidney-injuries
#1
JOURNAL ARTICLE
Meng-Yuan Sheng, De-Wei Peng, Hui-Ming Peng, Ya-Li Zhang, Ling Xiao, Meng-Ru Zhang, Si-Yu Wang, Chuan-Peng Zhao, Si-Ying Zhu, Jian-Kang Lu, Li Lin, Rong Huang, Jing Nie, Jin-Bo Fang
ETHNOPHARMACOLOGICAL RELEVANCE: Scrophulariae Radix (Xuanshen [XS]) has been used for several years to treat hyperthyroidism. However, its effective substances and pharmacological mechanisms in the treatment of hyperthyroidism and thyroid hormone-induced liver and kidney injuries have not yet been elucidated. AIM OF THE STUDY: This study aimed to explore the pharmacological material basis and potential mechanism of XS therapy for hyperthyroidism and thyroid hormone-induced liver and kidney injuries based on network pharmacology prediction and experimental validation...
February 28, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38387682/anti-papillary-thyroid-carcinoma-effects-of-dioscorea-bulbifera-l-through-ferroptosis-and-the-pi3k-akt-pathway-based-on-network-pharmacology-and-experimental-validation
#2
JOURNAL ARTICLE
Yuzhi Gao, Zhendong Yang, Tuo Ji, Ping Zhou, Lei Geng, Xuzhu Gao
ETHNOPHARMACOLOGICAL RELEVANCE: Papillary thyroid carcinoma (PTC) is the predominant form of thyroid cancer with a rising global incidence. Despite favorable prognoses, a significant recurrence rate persists. Dioscorea bulbifera L. (DBL), a traditional Chinese medicine, has been historically used for thyroid-related disorders. However, its therapeutic effects and mechanisms of action on PTC remain unclear. AIM OF THE STUDY: To explore the potential therapeutic effects, principal active components, and molecular mechanisms of DBL in the treatment of PTC through network pharmacology and molecular docking, with experimental validation conducted to corroborate these findings...
February 20, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38367931/quemeiteng-granule-relieves-goiter-by-suppressing-thyroid-microvascular-endothelial-cell-proliferation-and-angiogenesis-via-mir-217-5p-mediated-targeting-of-fgf2-induced-regulation-of-the-erk-pathway
#3
JOURNAL ARTICLE
Yang Li, Wen Yang, Xuewei Yang, Aijia Ma, Xuepeng Zhang, Hongxia Li, Hui Wu
ETHNOPHARMACOLOGICAL RELEVANCE: Goiters are enlargements of the thyroid gland and are a global public issue. Quemeiteng granule (QMTG) is a traditional Chinese medicine (TCM) formula used to treat goiter in Yunnan Province. However, the effectiveness and underlying mechanism of these treatments have not been fully elucidated. AIM OF THE STUDY: This study aimed to investigate the therapeutic effects of QMTG on goiter and the downstream regulatory mechanisms. MATERIALS AND METHODS: In this study, we first evaluated the antigoiter efficacy of QMTG through biochemical indices [body weight, thyroid coefficient, triiodothyronine (T3), thyroxine (T4), free triiodothyronine (FT3), free thyroxine (FT4), and thyroid stimulating hormone (TSH)] and hematoxylin-eosin (HE) staining in a Propylthiouracil (PTU)-induced model...
February 15, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38303002/melissa-officinalis-extract-palliates-redox-imbalance-and-inflammation-associated-with-hyperthyroidism-induced-liver-damage-by-regulating-nrf-2-keap-1-gene-expression-in-%C3%AE-irradiated-rats
#4
JOURNAL ARTICLE
Ragaa Sm Kawara, Fatma Sm Moawed, Yakout Elsenosi, Hussein Abd Elmaksoud, Esraa S A Ahmed, Omayma Ar Abo-Zaid
BACKGROUND: Melissa officinalis (MO) is a well-known medicinal plant species used in the treatment of several diseases; it is widely used as a vegetable, adding flavour to dishes. This study was designed to evaluate the therapeutic effect of MO Extract against hyperthyroidism induced by Eltroxin and γ-radiation. METHODS: Hyperthyroidism was induced by injecting rats with Eltroxin (100 µg/kg/ day) for 14 days and exposure to γ-radiation (IR) (5 Gy single dose)...
February 1, 2024: BMC complementary medicine and therapies
https://read.qxmd.com/read/38253277/metabolomic-insights-into-the-therapeutic-mechanisms-of-costus-saussurea-costus-falc-lipsch-root-extract-in-propylthiouracil-induced-hypothyroidism-rat-model
#5
JOURNAL ARTICLE
Hend M Dawood, Neveen M Barghouth, Nesrine S El-Mezayen, Reham S Ibrahim, Eman Shawky
ETHNOPHARMACOLOGICAL RELEVANCE: Saussurea costus (Falc.) Lipschitz. is one of the most reputed medicinal plants as a traditional medicine in the Arab and Middle East regions in the treatment of thyroid disorders, however, more investigations are needed to fully understand its effectiveness and mechanism of action. AIM OF THE STUDY: The primary objective of the study was to assess the impact of Saussurea costus (COST) on the metabolic profiles of propylthiouracil (PTU)-induced hypothyroidism in rats...
January 20, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38218501/antipyretic-effect-of-inhaled-tetrastigma-hemsleyanum-polysaccharide-on-substance-and-energy-metabolism-in-yeast-induced-pyrexia-mice-via-tlr4-nf-%C3%AE%C2%BAb-signaling-pathway
#6
JOURNAL ARTICLE
Siyu Fu, Xiaodan Bao, Zhejiong Wang, Youying Tang, Qian Wu, Bingqi Zhu, Fangmei Zhou, Zhishan Ding
ETHNOPHARMACOLOGICAL RELEVANCE: Tetrastigma hemsleyanum Diels et Gilg, is one of the perennial evergreen plants with grass vine, which has obvious curative effect on severe infectious diseases. Although Tetrastigma hemleyanum has long been recognized for its capacity of antipyretic and antitoxic, its specific mechanism is unknown. AIM OF THE STUDY: To evaluate the antipyretic effect of Tetrastigma hemleyanum polysaccharide (THP) on mice with dry yeast-induced fever, and to explore its specific antipyretic mechanism...
January 11, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38218499/investigating-the-mechanism-and-efficacy-material-basis-of-xiehuo-xiaoying-decoction-for-treating-graves-disease-via-thyroid-cell-apoptosis-based-on-proteomics-and-molecular-docking-techniques
#7
JOURNAL ARTICLE
Pingping Xiang, Qinning Li, Guoqian Cui, Nan Xu, Qi Xiao, Xiaoyang Qu, Yunnan Zhang, Yu Chen, Xiao Wei, Qifeng Wang, Ronglin Zhong, Kemian Liu, Chao Liu, Fenxia Zhu
ETHNOPHARMACOLOGICAL RELEVANCE: For numerous years, the Xiehuo Xiaoying decoction (XHXY), a traditional Chinese medicine formula, has demonstrated substantial promise in treating Graves' disease (GD) in clinical settings, showcasing significant potential. However, the therapeutic mechanism and efficacy material basis of XHXY remains obscure. AIM OF THE STUDY: This work aims to investigate the underlying mechanisms and to study the efficacy material basis of XHXY in anti-GD effect using a combination of TMT quantitative proteomics and molecular docking method...
January 11, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38181936/herbal-medicine-for-hashimoto-s-thyroiditis-a-systematic-review-and-network-meta-analysis
#8
REVIEW
Jinli Luo, Ling Zhou, Aru Sun, Haoyu Yang, Pei Zhang, Ke Liu, Xiaotong Yu, Yiqun Lin, Yishan Huang, Lin Han
ETHNOPHARMACOLOGICAL RELEVANCE: Conventional treatments for Hashimoto's thyroiditis (HT) are limited. Herbal medicines (HM) are considered a potential intervention for the treatment of HT. AIM OF THE STUDY: This study aimed to investigate the efficacy and safety of HM for HT. MATERIALS AND METHODS: A Bayesian network meta-analysis was conducted for patients with HT in randomized controlled trials identified in PubMed, Cochrane Library, Web of Science, EMBASE, Chinese Clinical Trial Registry (Chi CTR), China National Knowledge Infrastructure (CNKI), China Science and Technology Journal Database (the VIP), China Chinese Biomedical Database (CBM), and Wanfang Database were searched from their inception to Oct 1, 2022...
January 3, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38164884/an-inducible-crispr-dcas9-based-transcriptional-repression-system-for-cancer-therapy
#9
JOURNAL ARTICLE
Pengfei Gu, Jie Zhao, Wei Zhang, Xianhui Ruan, Linfei Hu, Yu Zeng, Xiukun Hou, Xiangqian Zheng, Ming Gao, Jiadong Chi
Gene therapy has been adapted for improving malignant tumor treatment. However, pharmacotherapies targeting cancer remain limited and are generally inapplicable for rare disease patients. Oleanolic acid (OA) is a plant-derived triterpenoid that is frequently used in Chinese medicine as a safe but slow-acting treatment for many disorders. Here, the congruent pharmacological activities of OA and CRISPR-dCas9 in targeting AURKA or KDM1A and improving disease-specific prognosis and used a synthetic-biology-inspired design principle to engineer a therapeutic gene circuit that enables a concerted action of both drugs are utilized...
January 2, 2024: Small Methods
https://read.qxmd.com/read/38160869/clinical-efficacy-and-molecular-mechanism-of-chinese-medicine-in-the-treatment-of-autoimmune-thyroiditis
#10
REVIEW
Ling Zhou, Jin-Li Luo, Aru Sun, Hao-Yu Yang, Yi-Qun Lin, Lin Han
ETHNOPHARMACOLOGICAL RELEVANCE: Autoimmune Thyroiditis (AIT) is a common refractory autoimmune disease of the endocrine system that may eventually lead to complete loss of thyroid function, with subsequent severe effects on the metabolism. Because of the deficiency in current clinical management of AIT, the need for alternative therapies is highlighted. With its multi-component and multi-target characteristics, Chinese medicine has good potential as an alternative therapy for AIT. AIM OF THE STUDY: The aim of this study was to systematically summarize the clinical efficacy and safety evaluation of TCM and its active ingredients in the treatment and regulation of AIT...
December 29, 2023: Journal of Ethnopharmacology
https://read.qxmd.com/read/37967879/increased-screening-rates-for-thyroid-cancer-among-residents-living-near-nuclear-power-plants
#11
JOURNAL ARTICLE
Ga Bin Lee, Soojin Park, Won Il Jang, Sunhoo Park, Jae Kwan Jun, Songwon Seo
Frequent screening for thyroid cancer has been suggested as a probable explanation for the observed high risk of thyroid cancer in nuclear power plant (NPP) areas. We aimed to compare thyroid cancer screening rates of residents living near NPPs to those of the general population. This study utilized data from two national survey-based studies in 2016 and in 2014, respectively, for residents (n = 1,200) living in administrative districts within 5 km of NPP sites as the interest group, and the general population (n = 228,712) including distant-living residents (n = 19,100) in administrative districts within 30 km of NPP sites as reference groups...
November 13, 2023: Journal of Korean Medical Science
https://read.qxmd.com/read/37967452/the-short-term-effect-of-olive-oil-extract-enriched-with-hydroxytyrosol-on-cardiovascular-function
#12
JOURNAL ARTICLE
Nikolaos Iakovis, Ignatios Ikonomidis, Ioanna Andreadou, Αndrew Xanthopoulos, Aikaterini Chamaidi, Nikolaos Chrysakis, Grigorios Giamouzis, John Skoularigis, Ioulia Tseti, Filippos Triposkiadis
Olive is rich in polyphenols such as hydroxytyrosol (HT) that have antioxidative and anti-inflammatory effects. In this study, we examined the short-term effects of olive oil extract (OE) enriched with HT on left atrial function, left ventricular (LV) function, and arterial elastic properties in patients with chronic coronary artery disease (CAD). Sixty-one patients with chronic CAD were enrolled. This randomized study had a two-period, two-sequence crossover (AB/BA) design. Group AB ( n  = 32) initially received OE capsules (500 mg) enriched with HT (5 mg) (two capsules/day) for 30 days, and after a wash out of 48 h, placebo for another 30 days...
November 15, 2023: Journal of Medicinal Food
https://read.qxmd.com/read/37952731/gracilaria-chorda-subcritical-water-ameliorates-hepatic-lipid-accumulation-and-regulates-glucose-homeostasis-in-a-hepatic-steatosis-cell-model-and-obese-c57bl-6j-mice
#13
JOURNAL ARTICLE
Laxmi Sen Thakuri, Chul Min Park, Hyeon-A Kim, Hyung Jung Kim, Jin Woo Park, Jong Cheol Park, Dong Young Rhyu
ETHNOPHARMACOLOGICAL RELEVANCE: Red seaweed, known as Rhodophyta, has a long history of use in traditional Asian medicine, including Traditional Chinese Medicine and Ayurveda. It is believed to have cooling and detoxification properties. Red seaweed species, such as Gracilaria, have been used in traditional remedies to address various conditions, such as inflammation, thyroid disorders, and digestive issues. AIM OF THE STUDY: Obesity is a risk factor of hepatic steatosis, a hallmark of non-alcoholic fatty liver disease (NAFLD) that affects nearly 25% of the worldwide population...
February 10, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/37830875/a-descriptive-survey-study-in-endocrinology-clinic-evaluation-of-the-use-of-natural-products
#14
JOURNAL ARTICLE
İçim Gökkaya, Gülin Renda, Hülya Coşkun, Mustafa Koçak, Ufuk Özgen
OBJECTIVE: The use of herbal products/dietary supplements (HP/DS) in endocrinal chronic diseases is growing. However, no studies have evaluated their use in patients who present to endocrinology and metabolic diseases clinics. This descriptive study aims to investigate the rate of HP/DS use and the factors affecting this in patients who presented to Karadeniz Technical University (KTU) Farabi Hospital Endocrinology and Metabolic Diseases Clinic, Türkiye between 01.11.2021 and 01...
October 13, 2023: Current Medical Research and Opinion
https://read.qxmd.com/read/37742875/mechanism-difference-of-ginseng-medicines-with-different-natures-on-hyperthyroidism
#15
JOURNAL ARTICLE
Linlin Liu, Xueying Han, Guoshun Shan, Li Fu, Deqiang Dou
ETHNOPHARMACOLOGICAL RELEVANCE: Medicinal nature is a unique index in traditional Chinese medicine (TCM) to measure the efficacy of Chinese medicines. Hyperthyroidism, qi-Yin deficiency syndrome in TCM was regarded as the classic heat syndrome category in Chinese medicine. Moreover, it is extensively employed to evaluate the medicinal nature of herbs within the framework of the 'hot/cold' nature theory. Ginseng, red and black ginseng (GS, RG, and BG, respectively), and ginseng leaves (GL) are qi-tonifying herbs with different medicinal natures and were just right used to examine the underlying mechanisms between the nature of ginseng medicines and their tonifying effect...
September 22, 2023: Journal of Ethnopharmacology
https://read.qxmd.com/read/37686882/interactions-between-polygenetic-variants-and-lifestyle-factors-in-hypothyroidism-a-hospital-based-cohort-study
#16
JOURNAL ARTICLE
Da Sol Kim, Sunmin Park
Hypothyroidism is a prevalent endocrine disorder and is associated with a variety of metabolic disturbances. This study aimed to investigate the polygenic variants associated with hypothyroidism risk and the interaction of polygenic risk scores (PRS) with dietary patterns in influencing disease risk in 56,664 participants aged >40 in a hospital-based cohort. The participants were classified as having hypothyroidism (n = 870) diagnosed by a physician and no hypothyroidism (n = 55,794). Genetic variants associated with hypothyroidism were identified using a genome-wide association study (GWAS)...
September 3, 2023: Nutrients
https://read.qxmd.com/read/37685750/role-of-absorbable-polysaccharide-hemostatic-powder-in-the-prevention-of-bleeding-and-wound-events-after-thyroid-surgery
#17
JOURNAL ARTICLE
Giovanni Docimo, Marcello Filograna Pignatelli, Sonia Ferrandes, Alessandro Monaco, Francesco Calisti, Roberto Ruggiero, Salvatore Tolone, Francesco Saverio Lucido, Luigi Brusciano, Simona Parisi, Giovanni Conzo, Ludovico Docimo, Claudio Gambardella
BACKGROUND: Bleeding is one of the most fearsome and life-threatening complications after thyroid surgery. Several medical devices and haemostatic agents have been proposed to improve haemostasis during total and hemi-thyroidectomy. Resorbable polysaccharide powder (HaemoCer™) is a plant-based polymer that is helpful in terms of the coagulation cascade becoming a gel and forming a barrier to prevent further bleeding, having tested for haemostasis in different districts. The aim of the current study was the evaluation of drain output, the presence of significant postoperative blood loss and complications in patients treated with or without resorbable polysaccharide powder during thyroid surgery...
August 31, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/37655000/-ferula-assa-foetida-l-or-foeniculum-vulgare-which-one-is-more-effective-in-the-management-of-polycystic-ovarian-syndrome-a-randomized-placebo-controlled-triple-blinded
#18
JOURNAL ARTICLE
Fatemeh Ghavi, Fatemeh Shakeri, Somayeh Abdolahian
OBJECTIVE: There are few evaluation about the effects of Fennel and Ferula on human polycystic ovary syndrome (PCOS). The goals of this study were to evaluate and compare the effectiveness of two medicinal plants of the Apiaceae family (Fennel and Ferula) in management of PCOS. MATERIALS AND METHODS: The sample size was 47 participants with PCOS who were randomly divided into 3 groups. The Ferula assa-foetida L group received 100 mg of Ferula (n=14), the Foeniculum vulgare group received 46 mg of Fennel (n=15), and the placebo group received placebo twice daily for 3 months (n=14)...
2023: Avicenna Journal of Phytomedicine
https://read.qxmd.com/read/37605988/association-between-radiation-education-and-knowledge-on-thyroid-examination-among-medical-students-in-fukushima-japan
#19
JOURNAL ARTICLE
Takuma Tsuchihashi, Tatsuya Kanno, Hiromu Nemoto, Akio Takahashi, Nobuaki Moriyama, Seiji Yasumura
No abstract text is available yet for this article.
August 22, 2023: Disaster Medicine and Public Health Preparedness
https://read.qxmd.com/read/37479066/study-on-the-substance-basis-of-the-efficacy-of-eucommiae-cortex-before-and-after-salt-processing-for-the-treatment-of-kidney-yang-deficiency-syndrome-based-on-the-spectrum-effect-relationship
#20
JOURNAL ARTICLE
Hangsha Wu, Yue Lv, Mingfang Zhao, Rui Tang, Yafei Li, Keer Fang, Feiyang Wei, Weihong Ge, Weifeng Du, Changyu Li, Yefeng Zhang
ETHNOPHARMACOLOGICAL RELEVANCE: Kidney-Yang deficiency syndrome (KYDS) is one of the common diseases of the elderly and closely related to the ageing of the body, it has a major impact on the quality of life of the patient. Eucommiae Cortex (EC) is the dried bark of Eucommia ulmoides Oliv. Which has the effect of tonifying the liver and kidneys, strengthening the muscles and bones. In Traditional Chinese Medicine clinics, EC is commonly used in the treatment of KYDS, but the material basis for the improvement of its efficacy in treating KYDS after salt processing remains unclear...
July 20, 2023: Journal of Ethnopharmacology
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