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REVIEW
Eun Byul Cho, Seul Ki Lee, Jee-Young Kim, Yuri Kim
Synovial sarcomas are rare and highly aggressive soft-tissue sarcomas, primarily affecting adolescents and young adults aged 15-40 years. These tumors typically arise in the deep soft tissues, often near the large joints of the extremities. While the radiological features of these tumors are not definitely indicative, the presence of calcification in a soft-tissue mass (occurring in 30% of cases), adjacent to a joint, strongly suggests the diagnosis. Cross-sectional imaging characteristics play a crucial role in diagnosing synovial sarcomas...
October 5, 2023: Cancers
#2
JOURNAL ARTICLE
Liping Li, Oksana A Bailiff, Brielle Blanchard, Jerad M Gardner
Epithelioid sarcoma (ES) is a distinctive malignant mesenchymal neoplasm with atypical epithelioid cells palisading around a central zone of necrosis. ES is a rare entity even in soft tissue pathology. Immunohistochemically, tumors usually show diffuse epithelial membrane antigen and cytokeratin expression and loss of nuclear INI1 (SMARCB1) expression. Here, we report a case of a 64-year-old man with ES arising in the left conchal bowl. Given the clinical presentation including patient's age, sun-exposed area of skin, and slow-growing, asymptomatic, small pink pearly papule, this patient was initially misdiagnosed with basal cell carcinoma clinically and treated with topical imiquimod at an outside facility...
June 1, 2023: American Journal of Dermatopathology
#3
JOURNAL ARTICLE
Qing Luo, Junhan Liu, Qian Ma, Suying Xu, Leyu Wang
Gadolinium (Gd)-based complexes are extensively utilized as contrast agents (CAs) in magnetic resonance imaging (MRI), yet, suffer from potential safety concerns and poor tumor targeting. Herein, as a mimic of Gd complex, single-atom Gd nanoprobes with r1 and r2 values of 34.2 and 80.1 mM-1 s-1 (far higher than that of commercial Gd CAs) at 3 T are constructed, which possessed T1 /T2 dual-mode MRI with excellent stability and good tumor targeting ability. Specifically, single-atom Gd is anchored on nitrogen-doped carbon matrix (Gd-Nx C) through spatial-confinement method, which is further subjected to controllable chemical etching to afford fully etched bowl-shape Gd-Nx C (feGd-Nx C) with hydrophilic properties and defined coordination structure, similar to commercial Gd complex...
March 14, 2023: Small
#4
JOURNAL ARTICLE
Shanshan Zhang, Shujun Xia, Liang Chen, Yu Chen, Jianqiao Zhou
Covalent organic frameworks (COFs) have attracted increasing attention for biomedical applications. COFs-based nanosensitizers with uniform nanoscale morphology and tumor-specific curative effects are in high demand; however, their synthesis is yet challenging. In this study, distinct COF nanobowls are synthesized in a controlled manner and engineered as activatable nanosensitizers with tumor-specific sonodynamic activity. High crystallinity ensures an ordered porous structure of COF nanobowls for the efficient loading of the small-molecule sonosensitizer rose bengal (RB)...
January 3, 2023: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
#5
JOURNAL ARTICLE
Vivek Subbiah, Philippe A Cassier, Salvatore Siena, Elena Garralda, Luis Paz-Ares, Pilar Garrido, Ernest Nadal, Jacqueline Vuky, Gilberto Lopes, Gregory P Kalemkerian, Daniel W Bowles, Mahesh Seetharam, Jianhua Chang, Hui Zhang, Jennifer Green, Alena Zalutskaya, Martin Schuler, Yun Fan, Giuseppe Curigliano
Oncogenic RET fusions occur in diverse cancers. Pralsetinib is a potent, selective inhibitor of RET receptor tyrosine kinase. ARROW ( NCT03037385 , ongoing) was designed to evaluate pralsetinib efficacy and safety in patients with advanced RET-altered solid tumors. Twenty-nine patients with 12 different RET fusion-positive solid tumor types, excluding non-small-cell lung cancer and thyroid cancer, who had previously received or were not candidates for standard therapies, were enrolled. The most common RET fusion partners in 23 efficacy-evaluable patients were CCDC6 (26%), KIF5B (26%) and NCOA4 (13%)...
August 12, 2022: Nature Medicine
#6
JOURNAL ARTICLE
Mustapha Abubakar, Maeve Mullooly, Sarah Nyante, Ruth M Pfeiffer, Erin J Aiello Bowles, Renata Cora, Clara Bodelon, Eboneé Butler, Donna Butcher, Lawrence Sternberg, Melissa A Troester, Sheila Weinmann, Mark Sherman, Andrew G Glass, Amy Berrington de Gonzalez, Gretchen L Gierach
BACKGROUND: Mammographic breast density (MBD) decline post-tamoxifen initiation is a favorable prognostic factor in estrogen receptor (ER)-positive breast cancer (BC) and has potential utility as a biomarker of tamoxifen response. However, the prognostic value of MBD decline may vary by molecular characteristics among ER-positive patients. METHODS: We investigated associations between MBD decline (≥10% vs <10%) and breast cancer-specific mortality (BCSM) among ER-positive breast cancer patients aged 36-87 years at diagnosis treated with tamoxifen at Kaiser Permanente Northwest (1990-2008)...
May 2, 2022: JNCI Cancer Spectrum
#7
Mohammed H Basendowah, Mohammed A Ashour, Ammar Y Hassan, Shahad Alshaynawi, Lujain K Alyazidi
Carcinoid tumors are one of the most common types of small intestinal neuroendocrine tumors (SI-NETs). However, SI-NETs that manifest as subacute intestinal obstruction are extremely rare. The annual occurrence rate of jejuno-ileal NETs is 0.28-0.8 per 100,000 people. In this report, we describe a case of subacute intestinal obstruction due to a mid-ileal stricture. The patient underwent laparotomy after evaluation and investigation. Mid-ileal growth was noted, and small bowel resection was performed with primary end-to-end anastomosis...
September 2021: Curēus
#8
REVIEW
Andrea Piccioni, Laura Franza, Vanessa Vaccaro, Angela Saviano, Christian Zanza, Marcello Candelli, Marcello Covino, Francesco Franceschi, Veronica Ojetti
The microbiota is the set of commensal microorganisms, residing in the organism, helping proper functioning of organs and systems. The role that the microbiota plays in maintaining the health of vertebrates is widely accepted, particularly in the gastrointestinal system, where it is fundamental for immunity, development, and conversion of nutrients. Dysbiosis is an alteration of the microbiota which refers to a disturbed balance, which can cause a number of pathologies. Probiotics have proven to be effective in modulating the microbiota of the gastrointestinal system and, therefore, in promoting the health of the individual...
August 5, 2021: Medicina
#9
Taoufik El Abbassi, Wafaa Hliwa, Yassine El Berni, Salahedine Elmassi, Wafaa Badre, M Rachid Lefriyekh
The Video Capsule Diagnostic Imaging is a technique for exploring the digestive tract, particularly the small bowel. It is indicated for any unexplained digestive bleeding or as a means of monitoring intestinal polyposis or inflammatory diseases. This videocapsule is not digestible, and the risk of its retention, symptomatic or not, is not negligible following an inflammatory, anastomatous or tumoral stenosis. This retention or blockage is defined by the presence of the Video Capsule in the digestive tract at least two weeks after ingestion...
May 2021: Annals of Medicine and Surgery
#10
REVIEW
Aleksandr Filippov, Kimberley-Jane C Bonjoc, Junie Chea, Nicole Bowles, Erasmus Poku, Ammar Chaudhry
Theranostics is a re-emerging field of medicine that aims to create targeted agents that can be used for diagnostic and/or therapeutic indications. In the past, theranostics has been used to treat neoplasms, such as thyroid cancer and neuroblastomas. More recently, theranostics has seen a resurgence with advent of new therapeutic antibodies and small molecules which can be transformed into Theranostic agents through radioconjugating with a radioactive isotope. Positron emitting radioisotopes can be used for diagnostic purposes while alpha- and beta-emitting radioisotopes can be used for therapy...
September 2020: Journal of Thoracic Disease
#11
REVIEW
Douglas Grossman, Nwanneka Okwundu, Edmund K Bartlett, Michael A Marchetti, Megan Othus, Daniel G Coit, Rebecca I Hartman, Sancy A Leachman, Elizabeth G Berry, Larissa Korde, Sandra J Lee, Menashe Bar-Eli, Marianne Berwick, Tawnya Bowles, Elizabeth I Buchbinder, Elizabeth M Burton, Emily Y Chu, Clara Curiel-Lewandrowski, Julia A Curtis, Adil Daud, Dekker C Deacon, Laura K Ferris, Jeffrey E Gershenwald, Kenneth F Grossmann, Siwen Hu-Lieskovan, John Hyngstrom, Joanne M Jeter, Robert L Judson-Torres, Kari L Kendra, Caroline C Kim, John M Kirkwood, David H Lawson, Philip D Leming, Georgina V Long, Ashfaq A Marghoob, Janice M Mehnert, Michael E Ming, Kelly C Nelson, David Polsky, Richard A Scolyer, Eric A Smith, Vernon K Sondak, Mitchell S Stark, Jennifer A Stein, John A Thompson, John F Thompson, Suraj S Venna, Maria L Wei, Susan M Swetter
Importance: Use of prognostic gene expression profile (GEP) testing in cutaneous melanoma (CM) is rising despite a lack of endorsement as standard of care. Objective: To develop guidelines within the national Melanoma Prevention Working Group (MPWG) on integration of GEP testing into the management of patients with CM, including (1) review of published data using GEP tests, (2) definition of acceptable performance criteria, (3) current recommendations for use of GEP testing in clinical practice, and (4) considerations for future studies...
September 1, 2020: JAMA Dermatology
#12
JOURNAL ARTICLE
Maciej Kujawski, Lin Li, Supriyo Bhattacharya, Patty Wong, Wen-Hui Lee, Lindsay Williams, Harry Li, Junie Chea, Kofi Poku, Nicole Bowles, Nagarajan Vaidehi, Paul Yazaki, John E Shively
BACKGROUND: Bispecific T-cell engaging antibodies (BiTES), comprising dual anti-CD3 and anti-tumor antigen scFv fragments, are important therapeutic agents for the treatment of cancer. The dual scFv construct for BiTES requires proper protein folding while their small molecular size leads to rapid kidney clearance. METHODS: An intact (150 kDa) anti-tumor antigen antibody to CEA was joined in high yield (ca. 30%) to intact (150 kDa) anti-murine and anti-human CD3 antibodies using hinge region specific Click chemistry to form dual-specific, bivalent BiTES (dbBiTES, 300 kDa)...
September 5, 2019: BMC Cancer
#13
JOURNAL ARTICLE
Bihui Liu, Jing Zhang, Peng Sun, Ruokun Yi, Xiaoyan Han, Xin Zhao
A high-fat diet-induced C57BL/6N mouse model of non-alcoholic fatty liver disease (NAFLD) was established. The effect and mechanism of Raw Bowl Tea polyphenols (RBTP) on preventing NAFLD via regulating intestinal function were observed. The serum, liver, epididymis, small intestine tissues, and feces of mice were examined by biochemical and molecular biological methods, and the composition of RBTP was analyzed by HPLC assay. The results showed that RBTP could effectively reduce the body weight, liver weight, and liver index of NAFLD mice...
September 1, 2019: Biomolecules
#14
JOURNAL ARTICLE
Lisa A McPherson, Clara I Troccoli, Debin Ji, Annie E Bowles, Makelle L Gardiner, Michael G Mohsen, Nagaraj S Nagathihalli, Dao M Nguyen, David J Robbins, Nipun B Merchant, Eric T Kool, Priyamvada Rai, James M Ford
Cellular homeostasis is dependent on a balance between DNA damage and DNA repair mechanisms. Cells are constantly assaulted by both exogenous and endogenous stimuli leading to high levels of reactive oxygen species (ROS) that cause oxidation of the nucleotide dGTP to 8-oxodGTP. If this base is incorporated into DNA and goes unrepaired, it can result in G > T transversions, leading to genomic DNA damage. MutT Homolog 1 (MTH1) is a nucleoside diphosphate X (Nudix) pyrophosphatase that can remove 8-oxodGTP from the nucleotide pool before it is incorporated into DNA by hydrolyzing it into 8-oxodGMP...
July 5, 2019: DNA Repair
#15
JOURNAL ARTICLE
Hayley Stowe, Stella Ogake, Sunil Sharma, Suzanne Kelly, Morgan McDonald, Kayla Stanley, Paul Walker, Hyder Arastu, Carlos Anciano Granadillo, Mark Bowling, Andrew Ju
BACKGROUND: Stereotactic ablative radiotherapy (SABR) is a treatment option for patients with early stage non-small cell lung cancer (NSCLC) and recurrent or oligometastatic disease who are not surgical candidates. Due to the continuous motion of tumors within the lungs, implementing a strategy to track the target lesion is crucial. One method is to place fiducial markers which the robotic SABR system is able to track during treatment. However, placing these markers in a manner that maximizes tracking efficacy can be challenging...
July 11, 2019: Radiation Oncology
#16
JOURNAL ARTICLE
Amanda Truong, John R Hyngstrom, Robert H I Andtbacka, R Dirk Noyes, Melissa Wright, John Snyder, Alyssa Winters, William T Sause, Kenneth F Grossmann, Hung T Khong, Glen M Bowen, Ying J Hitchcock, Douglas Grossman, Tawnya L Bowles
Surgical management of external ear melanoma presents unique technical challenges based on the unique anatomy and reconstruction concerns. Surgical technique, including preservation of cartilage, is variable and impact on recurrence is unclear. Our goal was to investigate surgical approach, including extent of surgical resection and sentinel lymph node biopsy (SLNB), and the impact on recurrence. In this retrospective review of primary clinical stage 1/2 external ear melanoma, demographics, tumor characteristics, surgical resection technique (including cartilage-sparing vs...
April 2020: Melanoma Research
#17
MULTICENTER STUDY
John F Thompson, Lauren E Haydu, Roger F Uren, Robert H Andtbacka, Jonathan S Zager, Peter D Beitsch, Doreen M Agnese, Nicola Mozzillo, Alessandro Testori, Tawnya L Bowles, Harald J Hoekstra, Mark C Kelley, Jeffrey Sussman, Schlomo Schneebaum, B Mark Smithers, Gregory McKinnon, Eddy Hsueh, Lisa Jacobs, Erwin Schultz, Douglas Reintgen, John M Kane, Erica B Friedman, Hejing Wang, Lisa Van Kreuningen, Vicki Schiller, David A Elashoff, Robert Elashoff, Alistair J Cochran, Stacey Stern, Mark B Faries
OBJECTIVE: To assess whether preoperative ultrasound (US) assessment of regional lymph nodes in patients who present with primary cutaneous melanoma provides accurate staging. BACKGROUND: It has been suggested that preoperative US could avoid the need for sentinel node (SN) biopsy, but in most single-institution reports, the sensitivity of preoperative US has been low. METHODS: Preoperative US data and SNB results were analyzed for patients enrolled at 20 centers participating in the screening phase of the second Multicenter Selective Lymphadenectomy Trial...
April 1, 2021: Annals of Surgery
#18
Endoscopic Findings of Esophageal Adenosquamous Carcinoma Diagnosed by Endoscopic Mucosal Resection.
Hiroyuki Endo, Tomoyuki Koike, Waku Hatta, Kiyotaka Asanuma, Kaname Uno, Naoki Asano, Akira Imatani, Mika Watanabe, Katsuaki Kato, Atsushi Masamune
Adenosquamous carcinoma (ASC) is a rare histological type of esophageal carcinoma. Esophagogastroduodenoscopy for the health checkup of a 71-year-old male revealed the presence of a slightly elevated lesion like a submucosal tumor at the lower part of the esophagus. The center of it was slightly depressed, and the depressed area was not stained by iodine. Magnifying endoscopy with narrow-band imaging revealed reticular pattern vessels in the depressed area, whereas no irregularity of the microvascular pattern of the surrounding area was evident...
January 2019: Case Reports in Gastroenterology
#19
JOURNAL ARTICLE
Nidal Issa, Yaniv Fenig, Rachel Gingold-Belfer, Muhammad Khatib, Wisam Khoury, Lea Wolfson, Hemda Schmilovitz-Weiss
BACKGROUND: Patients' selection for transanal endoscopic microsurgery (TEM) depends on diagnostic modalities; however, there are still some limitations in the preoperative diagnosis of rectal lesions, and in some reports, up to third of the adenomas resected by TEM were found to be adenocarcinoma; therefore, salvage radical resection (RR) remains necessary for achieving oncological resection. Salvage RR may encounter some technical problems as the violation of the mesorectum and the scar formation...
August 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
#20
JOURNAL ARTICLE
Nikita Pozdeyev, Laurie M Gay, Ethan S Sokol, Ryan Hartmaier, Kelsi E Deaver, Stephanie Davis, Jena D French, Pierre Vanden Borre, Daniel V LaBarbera, Aik-Choon Tan, Rebecca E Schweppe, Lauren Fishbein, Jeffrey S Ross, Bryan R Haugen, Daniel W Bowles
Purpose: To define the genetic landscape of advanced differentiated and anaplastic thyroid cancer (ATC) and identify genetic alterations of potential diagnostic, prognostic, and therapeutic significance. Experimental Design: The genetic profiles of 583 advanced differentiated and 196 ATCs generated with targeted next-generation sequencing cancer-associated gene panels MSK-IMPACT and FoundationOne were analyzed. Results: ATC had more genetic alterations per tumor, and pediatric papillary thyroid cancer had fewer genetic alterations per tumor when compared with other thyroid cancer types...
July 1, 2018: Clinical Cancer Research
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