keyword
https://read.qxmd.com/read/37559645/sealing-effectiveness-of-a-novel-nhs-pox-based-patch-experiments-in-a-dynamic-ex-vivo-porcine-lung
#1
JOURNAL ARTICLE
Bob P Hermans, Wilson W L Li, Edwin A Roozen, Daniël I M van Dort, Jort Evers, Erik H F M van der Heijden, Stefan M van der Heide, Harry van Goor, Ad F T M Verhagen
BACKGROUND: Sealants are used to prevent prolonged pulmonary air leakage (PAL) after lung resections (incidence 5.6-30%). However, clinical evidence to support sealant use is insufficient, with an unmet need for a more effective product. We compared a novel gelatin patch impregnated with functionalized polyoxazolines (NHS-POx) (GATT-Patch) to commercially available sealant products. METHODS: GATT-Patch Single/Double layers were compared to Progel® , Coseal® , Hemopatch® and TachoSil® in an ex vivo porcine lung model (first experiment)...
July 31, 2023: Journal of Thoracic Disease
https://read.qxmd.com/read/36584062/robotic-assisted-thoracoscopic-repair-of-iatrogenic-tracheal-rupture
#2
JOURNAL ARTICLE
Alexandru Melinte, Alexandru Steriade, Georgiana Pavel, Catalina Ceausescu, Felix Dobritoiu, Catalin Copaescu
Introduction: Tracheal rupture is a rare condition, and its most common cause is head and neck trauma. Iatrogenic rupture is extremely rare and has multiple causes of which orotracheal intubation is the most common (1). Its importance derives from the associated high morbidity and mortality. The specific therapy is either conservatory or surgical, either through a posterolateral thoracotomy or minimally invasive (VATS). Robotic assisted surgery to repair the postintubation iatrogenic tracheal rupture after elective surgery has not been described so far in the literature...
December 2022: Chirurgia
https://read.qxmd.com/read/35748414/composition-host-responses-and-clinical-applications-of-bioadhesives
#3
REVIEW
Vignesh Dhandapani, Vickie Ringuette, Monika Desrochers, Marco Sirois, Patrick Vermette
Bioadhesives are medical devices used to join or seal tissues that have been injured or incised. They have been classified into tissue adhesives, sealants, and hemostatic agents. Bioadhesives such as FloSeal®, CoSeal®, BioGlue®, Evicel®, Tisseel®, Progel™ PALS, and TissuGlu® have been commercialized and used in clinical setting. They can be formulated with natural or synthetic components or a combination of both including albumin, glutaraldehyde, chitosan, cyanoacrylate, fibrin and thrombin, gelatin, polyethylene glycol (PEG), along with urethanes...
December 2022: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://read.qxmd.com/read/35108064/an-off-the-shelf-bioadhesive-patch-for-sutureless-repair-of-gastrointestinal-defects
#4
JOURNAL ARTICLE
Jingjing Wu, Hyunwoo Yuk, Tiffany L Sarrafian, Chuan Fei Guo, Leigh G Griffiths, Christoph S Nabzdyk, Xuanhe Zhao
Surgical sealing and repair of injured and resected gastrointestinal (GI) organs are critical requirements for successful treatment and tissue healing. Despite being the standard of care, hand-sewn closure of GI defects using sutures faces limitations and challenges. In this work, we introduce an off-the-shelf bioadhesive GI patch capable of atraumatic, rapid, robust, and sutureless repair of GI defects. The GI patch integrates a nonadhesive top layer and a dry, bioadhesive bottom layer, resulting in a thin, flexible, transparent, and ready-to-use patch with tissue-matching mechanical properties...
February 2, 2022: Science Translational Medicine
https://read.qxmd.com/read/33717526/application-of-prosthesis-eversion-method-for-ascending-aorta-replacement-guarantees-better-clinical-outcomes-of-type-a-acute-aortic-dissection-surgery
#5
JOURNAL ARTICLE
Zhipeng Hu, Zhiwei Wang, Jinxing Chang, Min Zhang, Xiaoping Hu, Zongli Ren, Bowen Li, Rui Hu
BACKGROUND: The advantages of prosthesis eversion method in patients diagnosed with Stanford type A acute aortic dissection (AAD) undergoing ascending aorta replacement (AAR) is unknown. This research is designed to explore it. METHODS: We retrospectively analyzed the data of a total of 283 patients diagnosed with type A aortic dissection that underwent surgery in Renmin Hospital of Wuhan University from March, 2006 to April, 2020. Eighty-eight patients underwent surgical repair with traditional continuous suture technique, and 195 patients received prosthesis eversion...
February 2021: Journal of Thoracic Disease
https://read.qxmd.com/read/33453711/the-histopathological-effects-of-reabsorbable-polyethylene-glycol-hydrogel-coseal-on-epidural-fibrosis-in-an-experimental-postlaminectomy-model-in-rats
#6
JOURNAL ARTICLE
Emrah Keskin, Hasan Ali Aydın, Murat Kalaycı, Emre Işık, Utku Özgen, Kenan Şimşek, Deniz Baklacı, Mertol Gökçe
Background/aim: To investigate the histopathological effects of reabsorbable polyethylene glycol hydrogel (RPGH, Coseal) on epidural fibrosis (EF) following laminectomy in rats. Materials and methods: A total of 24 rats were equally divided into three groups. In the first group, no treatment was applied after laminectomy (control group, Group 1). In the second group, hemostasis was achieved after laminectomy, and 2 mm absorbable gelatin sponge soaked in saline was placed over the epidural space and the wound was closed (Group 2)...
June 28, 2021: Turkish Journal of Medical Sciences
https://read.qxmd.com/read/32464953/intra-operative-amiodarone-releasing-hydrogel-to-prevent-post-lung-transplant-atrial-fibrillation-a-pilot-clinical-trial
#7
JOURNAL ARTICLE
W M Whited, S A Smith, J Rice, J R Trivedi, M P Fox, V H van Berkel
PURPOSE: The purpose of this study was to evaluate the effectiveness of topical amiodarone applied to the atria and pulmonary veins at the time of lung transplantation (LTx) in decreasing postoperative atrial fibrillation (POAF). METHODS: Twenty patients undergoing LTx at a single institution were enrolled in this prospective pilot study and compared to 40 historical controls. An Amiodarone-containing hydrogel was created using CoSeal Surgical Sealant (Baxter Healthcare) and Amiodarone, which was applied to the pulmonary vein anastomoses and atria at time of LTx in the study group...
April 2020: Journal of Heart and Lung Transplantation
https://read.qxmd.com/read/31931934/efficacy-of-surgical-tissue-glues-and-supporters-for-treatment-of-prolonged-air-leaks-in-bullous-emphysema
#8
JOURNAL ARTICLE
Erkan Akar, Miktat Arif Haberal, Ozlem Sengören Dikis
OBJECTIVE: To investigate the effect of collagen matrix tissue supporter made of bovine pericardium and polyethylene glycol (PEG) tissue glue on prolonged air leak and postoperative complications in patients with bullous emphysema. STUDY DESIGN: A retrospective study. PLACE AND DURATION OF STUDY: Department of Thoracic Surgery, Health Sciences University, Bursa Yuksek Ihtisas Training and Research Hospital, Bursa, Turkey, from January 2010 to December 2018...
January 2020: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://read.qxmd.com/read/31859475/fast-and-high-strength-soft-tissue-bioadhesives-based-on-a-peptide-dendrimer-with-antimicrobial-properties-and-hemostatic-ability
#9
JOURNAL ARTICLE
Haofang Zhu, Xingheng Mei, Yiyan He, Hongli Mao, Wenbo Tang, Rong Liu, Jun Yang, Kui Luo, Zhongwei Gu, Lian Zhou
Due to the inconvenience of application, risk of extra damage to fragile soft tissues, and the high incidence of late-stage complications, significant research endeavors have been focused on developing safe and effective bioadhesives to replace or assist the traditional suture techniques for wound closure. Here, we describe a fast and high strength bioadhesive based on polysaccharides and peptide dendrimers (OCMC/G3KP) with inherent hemostatic ability and antibacterial properties. Compared with the commercial bioadhesive Coseal, the OCMC/G3KP hydrogel shows a remarkable 5-fold increase in adhesion strength...
January 29, 2020: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/30600147/mechanical-strength-of-biliary-defect-closure-after-topical-sealing-comparison-of-four-sealants-in-a-porcine-model
#10
COMPARATIVE STUDY
Mohammad Al-Saeedi, Hamidreza Fonouni, Arash Kashfi, Omid Ghamarnejad, Ali Majlesara, Negin Gharabaghi, Oliver Stahlheber, Thomas W Kraus, Arianeb Mehrabi, Yakup Kulu
BACKGROUND/OBJECTIVE: Biliary leakage is a potential complication of liver resection and is still a concern. The aim of the present study was to evaluate the effectiveness of four routinely used sealants in preventing bile leakage under pressure from an induced perforation of the gallbladder in a porcine model. METHODS: Forty Landrace pigs were randomly assigned to one of five groups. These included a control group (n = 8) and one group each for the sealants TachoSil®, TissuCol Duo®, Coseal®, and FloSeal® (n = 8 per group)...
July 2019: Asian Journal of Surgery
https://read.qxmd.com/read/30274840/cytocompatibility-and-mechanical-properties-of-surgical-sealants-for-cardiovascular-applications
#11
JOURNAL ARTICLE
Mark H Murdock, Jordan T Chang, Samuel K Luketich, Drake Pedersen, George S Hussey, Antonio D'Amore, Stephen F Badylak
OBJECTIVES: The present study compared physical, mechanical, and biologic characteristics of 4 clinically available surgical sealants for cardiovascular repair. METHODS: BioGlue (Cryolife Inc, Kennesaw, Ga), PreveLeak (Mallinckrodt Pharmaceuticals, St Louis, Mo), Tridyne VS (BD, Franklin Lakes, NJ), and Coseal (Baxter Healthcare Corporation, Westlake Village, Calif) were compared for the following properties: hydrated swelling, cytocompatibility, burst strength, biaxial stretching (elasticity), and in vitro degradation...
January 2019: Journal of Thoracic and Cardiovascular Surgery
https://read.qxmd.com/read/28755096/analysis-of-the-hemostatic-potential-of-modern-topical-sealants-on-arterial-and-venous-anastomoses-an-experimental-porcine-study
#12
JOURNAL ARTICLE
Hamidreza Fonouni, Arash Kashfi, Ali Majlesara, Oliver Stahlheber, Lukas Konstantinidis, Thomas W Kraus, Arianeb Mehrabi, Hani Oweira
One of the widely accepted adjunctive agents in the variety of surgical modalities are sealants. Our study aim was to compare four commonly used modern sealants in a standardized experimental setting to assess their feasibility, and hemostatic efficacy in vascular anastomosis. Forty landrace pigs (weight: 24.7 ± 3.8 kg) were randomized into the control (n = 8) and four sealant groups; TachoSil® (n = 8), Tissucol Duo® (n = 8), Coseal® (n = 8), and FloSeal® (n = 8). After doing a portal vein end-to-end anastomosis as well as stitches of aortic incision, the sealants were applied on anastomotic site...
September 2017: Journal of Materials Science. Materials in Medicine
https://read.qxmd.com/read/28644516/hemostatic-efficiency-of-modern-topical-sealants-comparative-evaluation-after-liver-resection-and-splenic-laceration-in-a-swine-model
#13
COMPARATIVE STUDY
Hamidreza Fonouni, Arash Kashfi, Ali Majlesara, Oliver Stahlheber, Lukas Konstantinidis, Negin Gharabaghi, Thomas W Kraus, Arianeb Mehrabi, Hani Oweira
Parenchymal transection during hepatobiliary surgery can disrupt small vasculature or bile ducts, which could be managed difficultly. Sealants are helpful tools to achieve better hemostasis. The aim of this study is to analyze the hemostatic efficiency of four modern sealants in a porcine model. In this study, 40 landrace pigs were assigned equally to the control (without sealant) and four sealant groups. Standardized liver resection and splenic lesions were performed and left without using sealant (control) or treated with one of the following sealants: TachoSil® , Tissucol Duo® , Coseal® , and FloSeal® ...
April 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://read.qxmd.com/read/27800586/liquid-antiadhesive-agents-for-intraperitoneal-hernia-repair-procedures-artiss-%C3%A2-compared-to-coseal-%C3%A2-and-adept-%C3%A2-in-an-ipom-rat-model
#14
COMPARATIVE STUDY
Simone Gruber-Blum, R H Fortelny, C Keibl, J Brand, M Lechner, H Redl, A H Petter-Puchner
BACKGROUND: Adhesion formation remains an important issue in hernia surgery. Liquid agents were developed for easy and versatile application, especially in laparoscopy. The aim of this study was to compare the antiadhesive effect of fibrin sealant (FS, Artiss® ), Icodextrin (ID, Adept® ) and Polyethylene glycol (PEG, CoSeal® ) alone and in combination and to evaluate the resulting effect on tissue integration of the mesh. METHODS: A total of 56 Sprague-Dawley rats were operated in open IPOM technique...
December 2017: Surgical Endoscopy
https://read.qxmd.com/read/25499774/prevention-of-lymphoceles-using-floseal-and-coseal-after-laparoscopic-lymphadenectomy-in-patients-with-gynecologic-malignancies
#15
JOURNAL ARTICLE
Christhardt Köhler, Sarah Kyeyamwa, Simone Marnitz, Audrey Tsunoda, Filiberto Vercelino, Achim Schneider, Giovanni Favero
INTRODUCTION: Pelvic ± para-aortic lymphadenectomy (LAE) is an essential element of staging and treatment of different gynecologic malignancies. However, LAE can induce asymptomatic and symptomatic pelvic lymphoceles (LCs) in a considerable percentage of patients. Therapy of symptomatic LCs may cause additional morbidity. The best strategy to reduce the rate of LCs has not established yet. MATERIALS AND METHODS: Between January 2011 and May 2012, transperitoneal laparoscopic pelvic ± para-aortic LAE was performed at the Department of Gynecology at Charité University Hospital Berlin in 238 patients with cervical, endometrial, ovarian, or groin-positive vulvar cancer...
2015: Journal of Minimally Invasive Gynecology
https://read.qxmd.com/read/25120403/intraoperative-surgical-sealant-application-during-cardiac-defect-repair
#16
JOURNAL ARTICLE
Luis J Garcia-Morales, Mahesh Ramchandani, Matthias Loebe, Michael J Reardon, Brian A Bruckner, Basel Ramlawi
Bleeding can occur as a sequela to cardiac surgery. Surgical products-such as conventional sutures and clips, and somewhat less conventional sealants-have been developed to prevent this event. Among these, CoSeal is a sealant used at our institution; here we report the cases of 2 patients in whom CoSeal was used successfully as either a supplement or an alternative to suture repair. This sealant was found to be useful in attaining hemostasis both in high-pressure ventricular repair and in the rupture of a friable coronary sinus adjacent to vital structures (in this instance, a left circumflex coronary artery)...
August 2014: Texas Heart Institute Journal
https://read.qxmd.com/read/24316852/adhesion-prevention-in-reabsorbable-polyethylene-glycol-hydrogel-coseal%C3%A2-coated-polypropylene-mesh-in-rabbits
#17
JOURNAL ARTICLE
Reynaldo Martins e Quinino, Irami Araújo-Filho, Francisco Piganataro Lima, André Luís Costa Barbosa, Tatiana de Carvalho Maia, Alberto Goldenberg
PURPOSE: To evaluate of postoperative adhesion prevention and inflammatory response to polypropylene mesh, coated with reabsorbable hydrogel of polyethylene glycol (Coseal®) in contact with small bowel in an experimental model in rabbits. METHODS: Twenty female rabbits underwent laparotomy to implant two polypropylene meshes, 2 x 1 cm, in the right and left flanks. The right mesh was protected with Coseal® spray (Group 1) and the left mesh received no treatment after implantation (Group 2)...
December 2013: Acta Cirúrgica Brasileira
https://read.qxmd.com/read/23860428/comparison-of-synthetic-glues-and-10-0-nylon-in-rabbit-lamellar-keratoplasty
#18
COMPARATIVE STUDY
Soon Young Cho, Man Soo Kim, Su Ja Oh, Sung Kun Chung
PURPOSES: To evaluate changes in mean keratometry and to compare wound repair with corneal lamellar grafts in rabbit eyes using human synthetic tissue adhesives and 10-0 nylon. METHODS: Corneal grafts were made using a 6.0-mm-diameter trephine and blades in the eyes of 15 New Zealand white rabbits. Human fibrin tissue adhesive (Tisseel) was used in group 1, human fibrin tissue adhesive (Beriplast P) was used in group 2, polyethylene glycol adhesive (Coseal) was used in group 3, and 8 bite sutures with 10-0 nylon were used in group 4 (control) for lamellar keratoplasty...
September 2013: Cornea
https://read.qxmd.com/read/23416754/histological-findings-following-use-of-coseal-in-a-patient-with-a-left-ventricular-assist-device
#19
JOURNAL ARTICLE
Aldo Cannata, Duccio Petrella, Marcello Gambacorta, Claudio F Russo, Giuseppe Bruschi, Luigi Martinelli
Adhesions are a formidable challenge in patients undergoing reoperative cardiac surgery, particularly in those supported by an intracorporeal left ventricular assist device (LVAD) and undergoing heart transplantation. This report describes the pathological findings following the clinical use of a surgical sealant (CoSeal, Baxter Healthcare, Fremont, CA), in a patient who underwent LVAD implantation. On the treated surfaces, a minimal amount of adhesions were observed, whereas in untreated surfaces adhesions were present...
December 2013: Surgical Innovation
https://read.qxmd.com/read/23043755/use-of-a-sealant-to-prevent-prolonged-air-leaks-after-lung-resection-a-prospective-randomized-study
#20
RANDOMIZED CONTROLLED TRIAL
Cosimo Lequaglie, Gabriella Giudice, Rita Marasco, Aniello Della Morte, Massimiliano Gallo
BACKGROUND: Pulmonary air leaks are common complications of lung resection and result in prolonged hospital stays and increased costs. The purpose of this study was to investigate whether, compared with standard care, the use of a synthetic polyethylene glycol matrix (CoSeal®) could reduce air leaks detected by means of a digital chest drain system (DigiVent™), in patients undergoing lung resection (sutures and/or staples alone). METHODS: Patients who intraoperatively showed moderate or severe air leaks (evaluated by water submersion tests) were intraoperatively randomized to receive just sutures/staples (control group) or sutures/staples plus CoSeal® (sealant group)...
October 8, 2012: Journal of Cardiothoracic Surgery
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