Gerard Anmella, Silvia Amoretti, Gemma Safont, Ana Meseguer, Eduard Vieta, Maria Teresa Pons-Cabrera, Miqueu Alfonso, Carla Hernández, Monica Sanchez-Autet, Ferran Pérez-Baldellou, Leticia González-Blanco, Maria Paz García-Portilla, Miquel Bernardo, Belén Arranz
BACKGROUND: Altered intestinal permeability and low-grade chronic inflammation disrupt the integrity of the blood-brain barrier (microbiota-gut-brain axis), probably playing a role in the pathophysiology of schizophrenia-spectrum disorders. However, studies assessing the microbiota-gut-brain axis are inconsistent. This article describes the rationale, objectives, protocol, and presents descriptive results for a new project. METHODS: The sample of this study came from an observational, cross-sectional and multisite study including four centers in Spain (PI17/00246) recruiting adult patients with DSM-5 schizophrenia-spectrum disorders at any stage of the disease...
October 12, 2023: Span J Psychiatry Ment Health