keyword
https://read.qxmd.com/read/38525134/protective-effect-of-cilostazol-on-vascular-injury-in-rats-with-acute-ischemic-stroke-complicated-with-chronic-renal-failure
#1
JOURNAL ARTICLE
Ru Sun, Qun Gu, Xufeng Zhang, Ruiqi Zeng, Dan Chen, Jingjing Yao, Jingjing Min
UNLABELLED: Chronic renal failure (CRF) resulting in vascular calcification, which does damage to blood vessels and endothelium, is an independent risk factor for stroke. It has been reported that cilostazol has a protective effect on the focal cerebral ischemic infarct. However, its impact on vascular injury in CRF combined stroke and its molecular protection mechanism have not been investigated. In this study, we carried out the effect of cilostazol on CRF combined stroke rats, and the results confirmed that it improved the neurobehavior, renal function as well as pathologic changes in both the kidney and brain...
April 2024: Toxicological Research
https://read.qxmd.com/read/38521959/inflammation-induced-trpv4-channels-exacerbate-blood-brain-barrier-dysfunction-in-multiple-sclerosis
#2
JOURNAL ARTICLE
Cathrin E Hansen, Alwin Kamermans, Kevin Mol, Kristina Berve, Carla Rodriguez-Mogeda, Wing Ka Fung, Bert van Het Hof, Ruud D Fontijn, Susanne M A van der Pol, Laura Michalick, Wolfgang M Kuebler, Boyd Kenkhuis, Willeke van Roon-Mom, Wolfgang Liedtke, Britta Engelhardt, Gijs Kooij, Maarten E Witte, Helga E de Vries
BACKGROUND: Blood-brain barrier (BBB) dysfunction and immune cell migration into the central nervous system (CNS) are pathogenic drivers of multiple sclerosis (MS). Ways to reinstate BBB function and subsequently limit neuroinflammation present promising strategies to restrict disease progression. However, to date, the molecular players directing BBB impairment in MS remain poorly understood. One suggested candidate to impact BBB function is the transient receptor potential vanilloid-type 4 ion channel (TRPV4), but its specific role in MS pathogenesis remains unclear...
March 23, 2024: Journal of Neuroinflammation
https://read.qxmd.com/read/38519806/proteomics-of-mouse-brain-endothelium-uncovers-dysregulation-of-vesicular-transport-pathways-during-aging
#3
JOURNAL ARTICLE
Katalin Todorov-Völgyi, Judit González-Gallego, Stephan A Müller, Nathalie Beaufort, Rainer Malik, Martina Schifferer, Mihail Ivilinov Todorov, Dennis Crusius, Sophie Robinson, Andree Schmidt, Jakob Körbelin, Florence Bareyre, Ali Ertürk, Christian Haass, Mikael Simons, Dominik Paquet, Stefan F Lichtenthaler, Martin Dichgans
Age-related decline in brain endothelial cell (BEC) function contributes critically to neurological disease. Comprehensive atlases of the BEC transcriptome have become available, but results from proteomic profiling are lacking. To gain insights into endothelial pathways affected by aging, we developed a magnetic-activated cell sorting-based mouse BEC enrichment protocol compatible with proteomics and resolved the profiles of protein abundance changes during aging. Unsupervised cluster analysis revealed a segregation of age-related protein dynamics with biological functions, including a downregulation of vesicle-mediated transport...
March 22, 2024: Nature aging
https://read.qxmd.com/read/38518283/a-comprehensive-review-on-the-development-of-sporadic-cerebral-arteriovenous-malformations-from-padget-to-next-generation-sequencing
#4
JOURNAL ARTICLE
Stephanie A Coffman, Keyan Peterson, Nicholas Contillo, Kyle M Fargen, Stacey Q Wolfe
Cerebral arteriovenous malformations (AVMs) are a leading cause of intracerebral hemorrhage in both children and young adults. With the continued advancement of science and technology, the understanding of the pathophysiology behind the development of these lesions has evolved. From early theory published by Harvey Cushing and Percival Bailey in 1928, Tumors Arising from the Blood-vessels of the Brain: Angiomatous Malformations and Hemangioblastoma, which regarded AVMs as tumors arising from blood vessels, to the meticulous artistry of Dorcas Padget's embryological cataloguing of the cerebral vasculature in 1948, to the proliferative capillaropathy theory of Yaşargil in 1987, to Ramey's 2014 hierarchical model of vascular development, there have been multiple hypotheses of congenital, developmental, and genetic two-hit theories in the pathogenesis of AVMs...
March 22, 2024: Journal of Neurosurgery
https://read.qxmd.com/read/38515789/glitches-in-the-brain-the-dangerous-relationship-between-radiotherapy-and-brain-fog
#5
REVIEW
Noemi Marino, Martina Bedeschi, Melania Elettra Vaccari, Marco Cambiaghi, Anna Tesei
Up to approximately 70% of cancer survivors report persistent deficits in memory, attention, speed of information processing, multi-tasking, and mental health functioning, a series of symptoms known as "brain fog." The severity and duration of such effects can vary depending on age, cancer type, and treatment regimens. In particular, every year, hundreds of thousands of patients worldwide undergo radiotherapy (RT) for primary brain tumors and brain metastases originating from extracranial tumors. Besides its potential benefits in the control of tumor progression, recent studies indicate that RT reprograms the brain tumor microenvironment inducing increased activation of microglia and astrocytes and a consequent general condition of neuroinflammation that in case it becomes chronic could lead to a cognitive decline...
2024: Frontiers in Cellular Neuroscience
https://read.qxmd.com/read/38504535/efficacy-of-sailuotong-on-neurovascular-unit-in-amyloid-precursor-protein-presenilin-1-transgenic-mice-with-alzheimer-s-disease
#6
JOURNAL ARTICLE
Sun Linjuan, L I Chengfu, Liu Jiangang, L I Nannan, Han Fuhua, Qiao Dandan, Tao Zhuang, Zhan Min, Chen Wenjie, Zhang Xiaohui, Tong Chenguang, Chen Dong, Qi Jiangxia, Liu Yang, Liang Xiao, Zheng Xiaoying, Zhang Yunling
OBJECTIVE: To discuss the influence of Sailuotong (, SLT) on the Neurovascular Unit (NVUs) of amyloid precursor protein (APP)/presenilin-1(PS1) mice and evaluate the role of gas supplementation in activating blood circulation during the progression of Alzheimer's disease (AD). METHODS: The mice were allocated into the following nine groups: (a) the C57 Black (C57BL) sham-operated group (control group), (b) ischaemic treatment in C57BL mice (the C57 ischaemic group), (c) the APP/PS1 sham surgery group (APP/PS1 model group), (d) ischaemic treatment in APP/PS1 mice (APP/PS1 ischaemic group), (e) C57BL mice treated with aspirin following ischaemic treatment (C57BL ischaemic + aspirin group), (f) C57BL mice treated with SLT following ischaemic treatment (C57BL ischaemic + SLT group), (g) APP/PS1 mice treated with SLT (APP/PS1 + SLT group), (h) APP/PS1 mice treated with donepezil hydrochloride following ischaemic treatment (APP/PS1 ischaemic + donepezil hydrochloride group) and (i) APP/PS1 mice treated with SLT following ischaemic treatment (APP/PS1 ischaemic + SLT group)...
April 2024: Journal of Traditional Chinese Medicine
https://read.qxmd.com/read/38499610/brain-derived-endothelial-cells-are-neuroprotective-in-a-chronic-cerebral-hypoperfusion-mouse-model
#7
JOURNAL ARTICLE
Yuichi Matsui, Fumitaka Muramatsu, Hajime Nakamura, Yoshimi Noda, Kinnosuke Matsumoto, Haruhiko Kishima, Nobuyuki Takakura
Whether organ-specific regeneration is induced by organ-specific endothelial cells (ECs) remains unelucidated. The formation of white matter lesions due to chronic cerebral hypoperfusion causes cognitive decline, depression, motor dysfunction, and even acute ischemic stroke. Vascular ECs are an important target for treating chronic cerebral hypoperfusion. Brain-derived ECs transplanted into a mouse chronic cerebral hypoperfusion model showed excellent angiogenic potential. They were also associated with reducing both white matter lesions and brain dysfunction possibly due to the high expression of neuroprotective humoral factors...
March 18, 2024: Communications Biology
https://read.qxmd.com/read/38498080/rgd-coated-polymeric-microbubbles-promote-ultrasound-mediated-drug-delivery-in-an-inflamed-endothelium-pericyte-co-culture-model-of-the-blood-brain-barrier
#8
JOURNAL ARTICLE
Christopher Hark, Junlin Chen, Julia Blöck, Eva Miriam Buhl, Harald Radermacher, Robert Pola, Michal Pechar, Tomáš Etrych, Quim Peña, Anne Rix, Natascha I Drude, Fabian Kiessling, Twan Lammers, Jan-Niklas May
Drug delivery to central nervous pathologies is compromised by the blood-brain barrier (BBB). A clinically explored strategy to promote drug delivery across the BBB is sonopermeation, which relies on the combined use of ultrasound (US) and microbubbles (MB) to induce temporally and spatially controlled opening of the BBB. We developed an advanced in vitro BBB model to study the impact of sonopermeation on the delivery of the prototypic polymeric drug carrier pHPMA as a larger molecule and the small molecule antiviral drug ribavirin...
March 18, 2024: Drug Delivery and Translational Research
https://read.qxmd.com/read/38496442/a-transient-brain-endothelial-translatome-response-to-endotoxin-is-associated-with-mild-cognitive-changes-post-shock-in-young-mice
#9
Shuhan Lu, Iria Di John Portela, Nina Martino, Ramon Bossardi Ramos, Abigail E Salinero, Rachel M Smith, Kristen L Zuloaga, Alejandro P Adam
Sepsis-associated encephalopathy (SAE) is a common manifestation in septic patients that is associated with increased risk of long-term cognitive impairment. SAE is driven, at least in part, by brain endothelial dysfunction in response to systemic cytokine signaling. However, the mechanisms driving SAE and its consequences remain largely unknown. Here, we performed translating ribosome affinity purification (TRAP) and RNA-sequencing (TRAP-seq) from the brain endothelium to determine the transcriptional changes after an acute endotoxemic (LPS) challenge...
March 6, 2024: bioRxiv
https://read.qxmd.com/read/38495306/neurovascular-coupling-impairment-as-a-mechanism-for-cognitive-deficits-in-covid-19
#10
REVIEW
Cameron D Owens, Camila Bonin Pinto, Sam Detwiler, Lauren Olay, Ana Clara da C Pinaffi-Langley, Peter Mukli, Anna Peterfi, Zsofia Szarvas, Judith A James, Veronica Galvan, Stefano Tarantini, Anna Csiszar, Zoltan Ungvari, Angelia C Kirkpatrick, Calin I Prodan, Andriy Yabluchanskiy
Components that comprise our brain parenchymal and cerebrovascular structures provide a homeostatic environment for proper neuronal function to ensure normal cognition. Cerebral insults (e.g. ischaemia, microbleeds and infection) alter cellular structures and physiologic processes within the neurovascular unit and contribute to cognitive dysfunction. COVID-19 has posed significant complications during acute and convalescent stages in multiple organ systems, including the brain. Cognitive impairment is a prevalent complication in COVID-19 patients, irrespective of severity of acute SARS-CoV-2 infection...
2024: Brain communications
https://read.qxmd.com/read/38485904/the-role-of-innate-and-adaptive-immune-system-in-the-pathogenesis-of-schizophrenia
#11
JOURNAL ARTICLE
Marziyeh Soltani, Yousef Mirzaei, Ali Hussein Mer, Mina Mohammad-Rezaei, Zahra Shafaghat, Soheila Fattahi, Fatemeh Azadegan-Dehkordi, Meghdad Abdollahpour-Alitappeh, Nader Bagheri
Schizophrenia is one of the most severely debilitating mental disorders that affects 1.1% of the world's population. The exact cause of the disease is not known, but genetics, environmental factors (such as infectious agents, season and region of birth, exposure to viruses, low birth weight, advanced paternal age, and tobacco), and immune system dysfunction can all contribute to the development of schizophrenia. Recently, the role of the immune system in schizophrenia has received much attention. Both acquired and innate immune systems are involved in the pathogenesis of schizophrenia and facilitate the disease's progression...
February 11, 2024: Iranian Journal of Allergy, Asthma, and Immunology
https://read.qxmd.com/read/38485231/timp1-protects-against-blood-brain-barrier-disruption-after-subarachnoid-haemorrhage-by-inhibiting-ubiquitination-of-astrocytic-%C3%AE-1-integrin
#12
JOURNAL ARTICLE
Tianchi Tang, Huaijun Chen, Libin Hu, Jingya Ye, Chaohui Jing, Chaoran Xu, Xinyan Wu, Yike Chen, Zihang Chen, Hang Zhou, Linfeng Fan, Xiongjie Fu, Cong Qian, Jingsen Chen, Zhongju Tan, Jing Liu, Hanhai Zeng, Gao Chen, Fuyi Liu
BACKGROUND: Astrocytes regulate blood-brain barrier (BBB) integrity, whereas subarachnoid haemorrhage (SAH) results in astrocyte dysregulation and BBB disruption. Here, we explored the involvement of tissue inhibitor of matrix metalloprotease-1 (TIMP1) in astrocyte-mediated BBB protection during SAH, along with its underlying mechanisms. METHODS: C57BL/6J mice were used to establish a model of SAH. The effects of TIMP1 on SAH outcomes were analysed by intraperitoneal injection of recombinant mouse TIMP1 protein (rm-TIMP1; 250 µg/kg)...
March 14, 2024: Stroke and Vascular Neurology
https://read.qxmd.com/read/38484626/silibinin-is-a-suppressor-of-the-metastasis-promoting-transcription-factor-id3
#13
JOURNAL ARTICLE
Sara Verdura, José Antonio Encinar, Alexei Gratchev, Àngela Llop-Hernández, Júlia López, Eila Serrano-Hervás, Eduard Teixidor, Eugeni López-Bonet, Begoña Martin-Castillo, Vicente Micol, Joaquim Bosch-Barrera, Elisabet Cuyàs, Javier A Menendez
BACKGROUND: ID3 (inhibitor of DNA binding/differentiation-3) is a transcription factor that enables metastasis by promoting stem cell-like properties in endothelial and tumor cells. The milk thistle flavonolignan silibinin is a phytochemical with anti-metastatic potential through largely unknown mechanisms. HYPOTHESIS/PURPOSE: We have mechanistically investigated the ability of silibinin to inhibit the aberrant activation of ID3 in brain endothelium and non-small cell lung cancer (NSCLC) models...
March 6, 2024: Phytomedicine
https://read.qxmd.com/read/38484034/hypertension-causes-and-consequences-of-circadian-rhythms-in-blood-pressure
#14
REVIEW
Frank M Faraci, Frank A J L Scheer
Hypertension is extremely common, affecting approximately 1 in every 2 adults globally. Chronic hypertension is the leading modifiable risk factor for cardiovascular disease and premature mortality worldwide. Despite considerable efforts to define mechanisms that underlie hypertension, a potentially major component of the disease, the role of circadian biology has been relatively overlooked in both preclinical models and humans. Although the presence of daily and circadian patterns has been observed from the level of the genome to the whole organism, the functional and structural impact of biological rhythms, including mechanisms such as circadian misalignment, remains relatively poorly defined...
March 15, 2024: Circulation Research
https://read.qxmd.com/read/38476695/a-vascular-centric-approach-to-autism-spectrum-disorders
#15
JOURNAL ARTICLE
Julie Ouellette, Elizabeth E Crouch, Jean-Luc Morel, Vanessa Coelho-Santos, Baptiste Lacoste
Brain development and function are highly reliant on adequate establishment and maintenance of vascular networks. Early impairments in vascular health can impact brain maturation and energy metabolism, which may lead to neurodevelopmental anomalies. Our recent work not only provides novel insights into the development of cerebrovascular networks but also emphasizes the importance of their well-being for proper brain maturation. In particular, we have demonstrated that endothelial dysfunction in autism spectrum disorders (ASD) mouse models is causally related to altered behavior and brain metabolism...
2024: Neuroscience insights
https://read.qxmd.com/read/38476274/blood-nanoparticle-interactions-create-a-brain-delivery-superhighway-for-doxorubicin
#16
JOURNAL ARTICLE
Zhuoxuan Li, Tatyana Kovshova, Julia Malinovskaya, Julian Knoll, Saeed Shanehsazzadeh, Nadezhda Osipova, Anastasia Chernysheva, Pavel Melnikov, Svetlana Gelperina, Matthias G Wacker
PURPOSE: This study investigated the brain targeting mechanism of doxorubicin-loaded polybutyl cyanoacrylate (PBCA) nanoparticles, particularly their interactions with the blood-brain barrier (BBB). The BBB protects the brain from drugs in the bloodstream and represents a crucial obstacle in the treatment of brain cancer. METHODS: An advanced computer model analyzed the brain delivery of two distinct formulations, Doxil® and surfactant-coated PBCA nanoparticles...
2024: International Journal of Nanomedicine
https://read.qxmd.com/read/38437534/endothelial-peroxiredoxin-4-is-indispensable-for-blood-brain-barrier-integrity-and-long-term-functional-recovery-after-ischemic-stroke
#17
JOURNAL ARTICLE
Na Xu, Xiaoyan Jiang, Wenting Zhang, Yejie Shi, Rehana K Leak, Richard F Keep, Qing Ye, Tuo Yang, Sicheng Li, Xiaoming Hu, R Anne Stetler, Michael V L Bennett, Jun Chen
The endothelial lining of cerebral microvessels is damaged relatively early after cerebral ischemia/reperfusion (I/R) injury and mediates blood-brain barrier (BBB) disruption, neurovascular injury, and long-term neurological deficits. I/R induces BBB leakage within 1 h due to subtle structural alterations in endothelial cells (ECs), including reorganization of the actin cytoskeleton and subcellular redistribution of junctional proteins. Herein, we show that the protein peroxiredoxin-4 (Prx4) is an endogenous protectant against endothelial dysfunction and BBB damage in a murine I/R model...
March 12, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38420850/no-reflow-after-recanalization-in-ischemic-stroke-from-pathomechanisms-to-therapeutic-strategies
#18
REVIEW
Feiyue Sun, Jing Zhou, Xiangyu Chen, Tong Yang, Guozuo Wang, Jinwen Ge, Zhanwei Zhang, Zhigang Mei
Endovascular reperfusion therapy is the primary strategy for acute ischemic stroke. No-reflow is a common phenomenon, which is defined as the failure of microcirculatory reperfusion despite clot removal by thrombolysis or mechanical embolization. It has been reported that up to 25% of ischemic strokes suffer from no-reflow, which strongly contributes to an increased risk of poor clinical outcomes. No-reflow is associated with functional and structural alterations of cerebrovascular microcirculation, and the injury to the microcirculation seriously hinders the neural functional recovery following macrovascular reperfusion...
February 29, 2024: Journal of Cerebral Blood Flow and Metabolism
https://read.qxmd.com/read/38420777/pathogenic-soluble-tau-peptide-disrupts-endothelial-calcium-signaling-and-vasodilation-in-the-brain-microvasculature
#19
JOURNAL ARTICLE
Amreen Mughal, Adrian M Sackheim, Masayo Koide, Grace Bonson, Grace Ebner, Grant Hennig, Warren Lockette, Mark T Nelson, Kalev Freeman
The accumulation of the microtubule-associated tau protein in and around blood vessels contributes to brain microvascular dysfunction through mechanisms that are incompletely understood. Delivery of nutrients to active neurons in the brain relies on capillary calcium (Ca2+ ) signals to direct blood flow. The initiation and amplification of endothelial cell Ca2+ signals require an intact microtubule cytoskeleton. Since tau accumulation in endothelial cells disrupts native microtubule stability, we reasoned that tau-induced microtubule destabilization would impair endothelial Ca2+ signaling...
February 29, 2024: Journal of Cerebral Blood Flow and Metabolism
https://read.qxmd.com/read/38420756/monocytes-release-pro-cathepsin-d-to-drive-blood-to-brain-transcytosis-in-diabetes
#20
JOURNAL ARTICLE
Dan Zhao, Zeng-Kang Huang, Yu Liang, Zhi-Jun Li, Xue-Wei Zhang, Kun-Hang Li, Hao Wu, Xu-Dong Zhang, Chen-Sheng Li, Dong An, Xue Sun, Ming-Xin An, Jun-Xiu Shi, Yi-Jun Bao, Li Tian, Di-Fei Wang, An-Hua Wu, Yu-Hua Chen, Wei-Dong Zhao
BACKGROUND: Microvascular complications are the major outcome of type 2 diabetes progression, and the underlying mechanism remains to be determined. METHODS: High-throughput RNA sequencing was performed using human monocyte samples from controls and diabetes. The transgenic mice expressing human CTSD (cathepsin D) in the monocytes was constructed using CD68 promoter. In vivo 2-photon imaging, behavioral tests, immunofluorescence, transmission electron microscopy, Western blot analysis, vascular leakage assay, and single-cell RNA sequencing were performed to clarify the phenotype and elucidate the molecular mechanism...
February 29, 2024: Circulation Research
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