Na Xu, Xiaoyan Jiang, Wenting Zhang, Yejie Shi, Rehana K Leak, Richard F Keep, Qing Ye, Tuo Yang, Sicheng Li, Xiaoming Hu, R Anne Stetler, Michael V L Bennett, Jun Chen
The endothelial lining of cerebral microvessels is damaged relatively early after cerebral ischemia/reperfusion (I/R) injury and mediates blood-brain barrier (BBB) disruption, neurovascular injury, and long-term neurological deficits. I/R induces BBB leakage within 1 h due to subtle structural alterations in endothelial cells (ECs), including reorganization of the actin cytoskeleton and subcellular redistribution of junctional proteins. Herein, we show that the protein peroxiredoxin-4 (Prx4) is an endogenous protectant against endothelial dysfunction and BBB damage in a murine I/R model...
March 12, 2024: Proceedings of the National Academy of Sciences of the United States of America