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Claudio Gonzalez Vargas, Hugo F Miranda, Fernando Sierralta, Viviana Noriega, Juan Carlos Prieto
Nonsteroidal anti-inflammatory drugs (NSAIDs) possess as primary action mechanism the inhibition of cyclooxygenases (COX-1, COX-2, and COX-3), thus producing a decreasing prostaglandin synthesis. This study was designed to evaluate whether the antinociception induced by NSAIDs could be modulated by clomipramine or risperidone using a chemical model of inflammatory acute visceral pain, the abdominal acetic acid induced a writhing test in mice. Dose-response curves, intraperitoneal, or intrathecal for the antinociceptive activity displayed by ketoprofen, piroxicam, nimesulide, parecoxib, and paracetamol were analyzed in order to obtain the ED50 of each drug...
February 14, 2019: Drug Development Research
S M Liu, Y Yue
Objective: To compare the analgesic efficacy between preoperative single-dose ketamine, a short-acting medicine and parecoxib, a long-acting medicine for reducing analgesic consumption in the first 24 h after-operation. Methods: Eighty-one patients from Beijing Chaoyang Hospital undergoing laparoscopic uterus surgery between April and December 2015 were randomly divided into three groups: control group (group C), ketamine group (group K) and parecoxib sodium group (group P). All patients were anesthetized with general anesthesia and received sufentanil-based patient-controlled intravenous analgesia (PCIA)...
December 25, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Xi Tang, Chang Liu, Lin Chen, Zhiyong Yang, Karine Belguise, Xiaobo Wang, Kaizhi Lu, Hong Yan, Bin Yi
Hepatopulmonary syndrome (HPS) is a serious complication in patients with advanced liver disease. The pathological pulmonary angiogenesis contributes to the progression of HPS. Importantly, directional collective migration of endothelial cells is a critical event for pathological angiogenesis. Previously, we have demonstrated that the over-expression of Cyclooxygenase-2 (COX-2) was an important factor in the experimental HPS. However, the role of COX-2 in the directional collective migration of human pulmonary microvascular endothelial cells (HPMVECs) is unclear...
January 17, 2019: Gene
Caitlin Landwehr, Jennifer Richardson, Lewis Bint, Richard Parsons, Bruce Sunderland, Petra Czarniak
OBJECTIVES: To evaluate the prevalence of off-label and unlicensed prescribing in inpatients at a major paediatric teaching hospital in Western Australia and to identify which drugs are commonly prescribed off-label or unlicensed, including factors influencing such prescribing. METHODS: A retrospective cross-sectional study was conducted in June, 2013. Patient and prescribing data were collected from 190 inpatient medication chart records which had been randomly selected from all admissions during the second week of February 2013...
2019: PloS One
Song Huang, Haijun Hu, Yue-Hong Cai, Fuzhou Hua
BACKGROUND: Parecoxib is a selective cyclooxygenase (COX)-2 inhibitor widely used as an analgesia technique in perioperative period for its potent anti-inflammatory and analgesic effects. However, litter is known about its effect on postoperative cognitive dysfunction (POCD). The purpose of this meta-analysis of randomized controlled trials (RCTs) was to evaluate the effect of parecoxib in the treatment of postoperative cognitive dysfunction. METHODS: We searched PubMed, Cochrane Library and Embase databases for relevant studies up to October 2017...
January 2019: Medicine (Baltimore)
Jiangbo Zheng, Zhaoming Feng, Junfeng Zhu
Objective: The objective of this study was to investigate the effect of preintravenous injection of parecoxib, combined with transversus abdominis plane (TAP) block and postoperative patient-controlled intravenous analgesia (PCIA) pump, in strategy of enhanced recovery after surgery for patients with radical resection of colorectal cancer. Materials and Methods: In this prospective study, 80 patients that underwent radical resection for colorectal cancer were randomly divided into four groups: (1) the parecoxib group, with preintravenous injection of parecoxib and postoperative PCIA after surgery; (2) the TAP group, with TAP block and postoperative PCIA; (3) the parecoxib + TAP group, with parecoxib combined with TAP block and postoperative PCIA; and (4) the control group, with only postoperative PCIA and preinjection of normal saline...
2018: Journal of Cancer Research and Therapeutics
Yu-Cih Lin, Chien-Yu Chen, Yuan-Mei Liao, Pi-Chu Lin, Chuen-Chau Chang
OBJECTIVE: The aim of this meta-analysis is to verify the effectiveness of postoperative pain relief by perioperative parecoxib, a selective intravenous cyclooxygenase-2 (COX-2) inhibitor, for patients receiving laparoscopic cholecystectomy (LC) surgery. METHODS: Electronic databases were searched for the randomized controlled trials (RCTs) to evaluate the effectiveness of pain relief by parecoxib or placebo for patients receiving LC surgery. The primary outcomes was the pain score evaluation using visual analogue scale (VAS)...
September 2018: Asian Journal of Anesthesiology
Yuan-Yuarn Liu, Hung-Tsung Hsiao, Jeffrey Chi-Fei Wang, Yen-Chin Liu, Sheng-Nan Wu
Parecoxib, a prodrug of valdecoxib, is a selective inhibitor of cyclooxygenase-2 and widely used for traumatic and postoperative patients to avoid opioid-induced side effects. It is a potent analgesic and has a role in multimodal analgesic and enhanced recovery after surgery. Whether parecoxib exerts any actions on these types of ionic currents remains unclear. In this study, we investigated whether it exerts any effects on ion currents in differentiated NG108-15 neuronal cells. Cell exposure to parecoxib (1-30 μM) caused a reversible reduction in the amplitude of IK(DR) with an IC50 value of 9...
December 6, 2018: European Journal of Pharmacology
Yan-Yan Bian, Long-Chao Wang, Wen-Wei Qian, Jin Lin, Jin Jin, Hui-Ming Peng, Xi-Sheng Weng
OBJECTIVE: Total knee arthroplasty (TKA) is an established surgical technique and is the standard treatment for degenerative knee joint diseases. However, severe pain after TKA makes it difficult for many patients to perform early postoperative rehabilitation and functional exercise, which might result in subsequent unsatisfactory recovery of knee joint function and great reduction in patients' satisfaction and quality of life. Orthopaedic surgeons have tried a large variety of analgesics and analgesic modes to relieve patients' pain after TKA...
November 2018: Orthopaedic Surgery
Yufeng Liu, Xuan Song, Dan Sun, Jiabei Wang, Yaliang Lan, Guangchao Yang, Fanzheng Meng, Yan Wang, Yifeng Cui, Bo Zhang, Xianying Li, Lianxin Liu
BACKGROUND As laparoscopic liver resection is becoming a commonly used method for hepatic surgery, postoperative pain management is emerging as one of the trickiest problems after surgery. The ideal method of pain management is controversial and the optimal strategy for postoperative pain management after surgery remains unclear. The present study evaluated the postoperative analgesic efficacy of parecoxib and fentanyl, and the benefit of a new intravenous parecoxib infusion pump with patient-controlled analgesia after laparoscopic liver resection...
November 15, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Jiansong Fang, Chuipu Cai, Yanting Chai, Jingwei Zhou, Yujie Huang, Li Gao, Qi Wang, Feixiong Cheng
Despite recent advance of therapeutic development, coronary artery disease (CAD) remains one of the major issues to public health. The use of genomics and systems biology approaches to inform drug discovery and development have offered the possibilities for new target identification and in silico drug repurposing. In this study, we propose a network-based, systems pharmacology framework for target identification and drug repurposing in pharmacologic treatment and chemoprevention of CAD. Specifically, we build in silico models by integrating known drug-target interactions, CAD genes derived from the genetic and genomic studies, and the human protein-protein interactome...
January 1, 2019: European Journal of Medicinal Chemistry
Xingye Du, Jiaye Gu
BACKGROUND: The goal of the current meta-analysis is to make a credible and overall assessment about the efficacy and safety of parenteral parecoxib for pain control in total knee arthroplasty (TKA). METHODS: The following online electronic databases, such as PubMed, Cochrane, Embase, were searched to identify the qualified studies updated to August 2018 according to the index words. Weight mean difference (WMD) or risk difference (RD) along with 95% confidence interval (CI) was utilized to analyze the main outcomes...
November 2018: International Journal of Surgery
Hui-Ming Peng, Long-Chao Wang, Wei Wang, Qi-Heng Tang, Wen-Wei Qian, Jin Lin, Jin Jin, Bin Feng, Xing-Hua Yin, Xi-Sheng Weng, Yi-Xin Zhou
BACKGROUND: Total hip arthroplasty (THA) is a well-accepted surgical treatment for terminal hip diseases. OBJECTIVE: To evaluate the effect of preemptive analgesia with parecoxib in patients undergoing primary unilateral THA. STUDY DESIGN: A randomized, double-blind, placebo-controlled study. SETTING: This study was conducted at Peking Union Medical College Hospital and Beijing Jishuitan Hospital in Beijing, China. METHODS: A total of 94 patients scheduled for primary unilateral THA in 2 centers (Peking Union Medical College Hospital and Beijing Jishuitan Hospital) were randomly assigned to receive 40 mg parecoxib (n = 48) or 0...
September 2018: Pain Physician
Rayakorn Moonla, Adisorn Threetipayarak, Chininthon Panpaisarn, Nida Pattayaruk, Unchana Kaewkam, Nipawan Jumpalee, Jatupong Panwilai
STUDY DESIGN: Prospective randomized, double-blind controlled trial. PURPOSE: Here, we aim to compare the efficacy and safety of pain control between pre- and postoperative parecoxib administration in patients who have undergone major spine surgery. OVERVIEW OF LITERATURE: Several studies have compared the efficacy of pre- and postoperative administration of parecoxib, which led to inconclusive results owing to variation in operative time...
October 2018: Asian Spine Journal
Izabela Zakrocka, Katarzyna M Targowska-Duda, Artur Wnorowski, Tomasz Kocki, Krzysztof Jóźwiak, Waldemar A Turski
Significant body of evidence suggests that abnormal kynurenic acid (KYNA) level is involved in the pathophysiology of central nervous system disorders. In the brain, KYNA is synthesized from kynurenine (KYN) by kynurenine aminotransferases (KATs), predominantly by KAT II isoenzyme. Blockage of ionotropic glutamate (GLU) receptors is a main cellular effect of KYNA. High KYNA levels have been linked with psychotic symptoms and cognitive dysfunction in animals and humans. As immunological imbalance and impaired glutamatergic neurotransmission are one of the crucial processes in neurological pathologies, we aimed to analyze the effect of anti-inflammatory agents, inhibitors of cyclooxygenase-2 (COX-2): celecoxib, niflumic acid, and parecoxib, on KYNA synthesis and KAT II activity in rat brain in vitro...
September 3, 2018: Neurotoxicity Research
Jian-Guo Guo, Lu-Ping Zhao, Yue-Feng Rao, Yin-Ping Gao, Xue-Jiao Guo, Tan-Yang Zhou, Zhi-Ying Feng, Jun-Hui Sun, Xiao-Yang Lu
BACKGROUD: Transarterial chemoembolization (TACE) is the primary palliative treatment for patients with unresectable hepatocellular carcinoma (HCC). However, it is often accompanied by postoperative pain which hinder patient recovery. This study was to examine whether preemptive parecoxib and sufentanil-based patient controlled analgesia (PCA) could improve the pain management in patients receiving TACE for inoperable HCC. METHODS: From June to December 2016, 84 HCC patients undergoing TACE procedure were enrolled...
August 3, 2018: Hepatobiliary & Pancreatic Diseases International: HBPD INT
(no author information available yet)
No abstract text is available yet for this article.
August 2018: Medicine (Baltimore)
D Dahlgren, C Roos, A Lundqvist, C Tannergren, M Sjöblom, E Sjögren, H Lennernäs
The small intestine mucosal barrier is physiologically regulated by the luminal conditions, where intestinal factors, such as diet and luminal tonicity, can affect mucosal permeability. The intestinal barrier may also be affected by absorption-modifying excipients (AME) in oral drug delivery systems. Currently, there is a gap in the understanding of how AMEs interact with the physiological regulation of intestinal electrolyte transport and fluid flux, and epithelial permeability. Therefore, the objective of this single-pass perfusion study in rat was to investigate the effect of three AMEs on the intestinal mucosal permeability at different luminal tonicities (100, 170, and 290 mOsm)...
October 5, 2018: International Journal of Pharmaceutics
Yong Yang, Xinyuan Lin, Ting Zeng, Yuanyuan Liu, Yong Li
OBJECTIVE: To observe the analgesic and sedative effects of acupuncture combined with local anesthesia for percutaneous vertebroplasty (PVP). METHODS: Sixty patients of single segmental osteoporotic vertebral compression fractures who were prepared to receive PVP were randomly divided into an observation group, a control 1 group, a control 2 group, 20 cases in each group. The patients in the observation group were treated with electroacupuncture (EA) at Hegu (LI 4), Neiguan (PC 6) and Zusanli (ST 36) 20 min before operation; during operation, EA was given combined with regular anesthesia...
July 12, 2018: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
Ali Jendoubi, Wafa Aissi, Ahmed Abbes, Abderrazek Bouzouita, Sami Fourati, Hatem Necib, Salma Ghedira, Mohamed Houissa
Background and Aims: Catheter-related bladder discomfort (CRBD) is the urge to void or discomfort in the suprapubic region secondary to an indwelling urinary catheter. We aimed to evaluate the safety and efficacy of single-dose of intravenous parecoxib in reducing the incidence and severity of CRBD in patients undergoing transurethral resection of bladder tumor (TURBT). Methods: Sixty-one adult patients, American Society of Anesthesiologists physical status I or II, undergoing elective TURBT under spinal anaesthesia, were randomly allocated to receive 40 mg of IV parecoxib (group P; n = 29) or an equal volume of normal saline (control group C; n = 32)...
June 2018: Indian Journal of Anaesthesia
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