keyword
https://read.qxmd.com/read/38501422/-parecoxib-sodium-down-regulates-cxcl8-cxcr1-2-to-improve-inflammatory-microenvironment-and-promote-patient-recovery-following-laparoscopic-radical-resection-of-rectal-cancer
#1
JOURNAL ARTICLE
R Wu, R Liu, Y Zhang, X Li
OBJECTIVE: To study the effect of parecoxib sodium on tumor microenvironment in patients undergoing laparoscopic radical resection of rectal cancer. METHODS: Sixty patients undergoing laparoscopic surgery for radical rectal cancer resection were randomized into test group and control group ( n =30). The patients in test control group received intravenous injections of 40 mg parecoxib sodium at the time of anesthesia induction, immediately after and at 12 h after the surgery, and those in the control group were injected with an equal volume of physiological saline at the same time points...
February 20, 2024: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://read.qxmd.com/read/38477426/parecoxib-decreases-cellular-growth-and-bcl-2-protein-levels-in-primary-cultures-of-keloid-fibroblasts
#2
JOURNAL ARTICLE
Roberto Grella, Giuseppe Lanzano, Mario Faenza, Giuseppe Ferraro, Gorizio Pieretti
Keloids seem to overexpress cyclo-oxygenase-2 (COX-2), suggesting a role in its deregulated pathway in inducing an altered epithelial-mesenchymal interaction, which may be responsible for the overgrowth of dermal components resulting in scars or keloid lesions. This study aimed to evaluate the effect of Parecoxib, a COX-2 inhibitor, on cell growth in fibroblast primary cultures obtained from human keloid tissues. Tissue explants were obtained from patients who underwent intralesional excision of untreated keloids; central fractions were isolated from keloid tissues and used for establishing distinct primary cultures...
March 2024: International Wound Journal
https://read.qxmd.com/read/38447626/addition-of-preoperative-ultrasound-guided-suprascapular-nerve-block-and-axillary-nerve-block-to-parecoxib-is-more-effective-in-early-postoperative-pain-control-following-arthroscopic-rotator-cuff-repair-a-prospective-randomized-controlled-study
#3
JOURNAL ARTICLE
Yu-Yi Huang, Yuet-Tong Ng, Chih-Hao Chiu, Chieh-An Chuang, Huan Sheu, Cheng-Pang Yang, Hao-Che Tang
PURPOSE: The purpose of the study was to prospectively compare the pain intensity and patient-reported outcomes (PROs) following arthroscopic rotator cuff repair (ARCR) between patients who received ultrasound-guided suprascapular nerve block (SSNB) and axillary nerve block (ANB) as well as preincisional parecoxib and patients who received preincisional parecoxib only. METHODS: Sixty-one patients receiving ARCR between March 2020 and March 2021 were prospectively enrolled...
March 4, 2024: Arthroscopy
https://read.qxmd.com/read/38441574/incidence-characteristics-and-risk-factors-of-drug-associated-muscle-adverse-reaction-a-retrospective-real-world-study-of-inpatients
#4
JOURNAL ARTICLE
Anqi Zhao, Daihong Guo, Man Zhu, Ao Gao, Peng Li, An Fu
OBJECTIVE: To analyze the clinical characteristics, incidence, and distribution of drug-associated muscle adverse reactions (DAMAR) in real-world inpatients, to provide valuable references for clinical medication use. METHODS: We conducted an automatic retrospective monitoring of inpatients from May 1, 2022, to April 30, 2023, to collect information on adverse drug reactions (ADR) of patients and conducted subsequent analyses. RESULTS: Among 102,430 hospitalizations, 1106 cases of DAMARs were identified, yielding an incidence of 1...
March 5, 2024: European Journal of Clinical Pharmacology
https://read.qxmd.com/read/38365106/parecoxib-sodium-attenuates-acute-lung-injury-following-burns-by-regulating-m1-m2-macrophage-polarization-through-the-tlr4-nf-%C3%AE%C2%BAb-pathway
#5
JOURNAL ARTICLE
Dongxiao Huang, Zhongjun Zhang, Jinjin Jian, Xuliang Jiang, Jie Gao, Minlie Yang, Xian Ding
High temperature-induced burn injury often leads to an excessive inflammatory cascade resulting in multiple organ dysfunction syndrome, such as acute lung injury (ALI), in addition to skin tissue damage. As a specific COX2 inhibitor, parecoxib sodium suppresses the inflammatory response during burn injury. The effect of parecoxib sodium on ALI induced by burn injury and the associated molecular mechanism still need to be investigated. The role of parecoxib sodium in burn injury-induced ALI through the TLR4/NF-κB pathway was explored in the present study...
April 5, 2024: European Journal of Pharmacology
https://read.qxmd.com/read/38342495/risk-factors-of-chronic-kidney-disease-in-cisplatin-based-hyperthermia-intraperitoneal-chemotherapy
#6
JOURNAL ARTICLE
Chih-Chung Cheng, Hung-Chieh Yeh, Pei-Wen Su, Chien-Lin Ho, Sheng-Chi Chang
PURPOSE: Cisplatin is commonly prescribed in hyperthermic intraperitoneal chemotherapy (HIPEC) for peritoneal malignancy. Acute kidney injury (AKI) is regarded as a common complication after HIPEC combined with cytoreductive surgery (CRS). However, post-HIPEC chronic kidney disease (CKD) is scarce and less investigated. This study aims to investigate the incidence of CKD following cisplatin-based HIPEC and to analyse the associated risk factors. MATERIALS AND METHODS: From January 2016 to August 2021, a total of 55 patients treated with CRS and cisplatin-based HIPEC for peritoneal carcinomatosis were categorized retrospectively into groups, with and without CKD...
2024: International Journal of Hyperthermia
https://read.qxmd.com/read/38235879/effects-of-parecoxib-on-postoperative-cognitive-dysfunction-and-serum-levels-of-nse-and-s100%C3%AE-in-elderly-patients-undergoing-surgery
#7
JOURNAL ARTICLE
W-Y Yin, T Peng, B-C Guo, C-C Fan, J Xu, X-M Liu, X Li
OBJECTIVE: To investigate the effects of parecoxib on postoperative cognitive dysfunction, and serum levels of neuron-specific enolase (NSE) and S100β protein (S100β) in elderly patients undergoing surgery. PATIENTS AND METHODS: The retrospective cohort study method was used to collect the clinical data of 94 elderly patients who underwent elective orthopedic and general anesthesia surgery in our hospital from September 2020 to February 2022. 94 patients were divided into the control group (47 cases) and the study group (47 cases), according to different intervention methods...
January 2024: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/38189874/correction-to-cyclooxygenase-2-inhibitor-parecoxib-reduces-lps-induced-activation-of-bv2-microglia-cells
#8
X Li, J X Zhou, Y D Qu, X Kuang
No abstract text is available yet for this article.
January 8, 2024: Bulletin of Experimental Biology and Medicine
https://read.qxmd.com/read/38182131/superior-analgesic-efficacy-of-preemptive-low-dose-ketorolac-compared-with-parecoxib-after-total-knee-arthroplasty-a-retrospective-propensity-score-matching-study
#9
JOURNAL ARTICLE
Khanin Iamthanaporn, Nuttawut Rojjanasirisawat, Varah Yuenyongviwat
BACKGROUND: Total knee arthroplasty (TKA) is a routine orthopedic procedure often associated with significant postoperative pain. Efficient pain management is paramount for patient recovery, with nonsteroidal anti-inflammatory drugs (NSAIDs) being a common choice. Nevertheless, the specific NSAID and its dosing regimen can have varying impacts on outcomes. METHODS: In this retrospective cohort study spanning from January 2016 to December 2020, we analyzed patients who underwent TKA...
2024: Journal of Orthopaedic Surgery
https://read.qxmd.com/read/38150709/iodobenzene-catalyzed-synthesis-of-fully-functionalized-nh-pyrazoles-and-isoxazoles-from-%C3%AE-%C3%AE-unsaturated-hydrazones-and-oximes-via-1-2-aryl-shift
#10
JOURNAL ARTICLE
Vikram Singh, Deepak Kumar, Bal Krishna Mishra, Bhoopendra Tiwari
An iodine(III)-catalyzed general method for the synthesis of fully functionalized NH-pyrazoles and isoxazoles from α,β-unsaturated hydrazones and oximes, respectively, via cyclization/1,2-aryl shift/aromatization/detosylation, has been developed. The reaction progresses through an anti -Baldwin 5- endo - trig cyclization. It gives direct access to an advanced intermediate for the preparation of valdecoxib and parecoxib, drugs used for COX-inhibition. In addition, a method for N -alkynylation of pyrazoles has also been developed in the presence of TIPS-EBX...
December 27, 2023: Organic Letters
https://read.qxmd.com/read/38124957/retracted-effect-of-parecoxib-sodium-combined-with-dexmedetomidine-on-analgesia-and-postoperative-pain-of-patients-undergoing-hysteromyomectomy
#11
Computational And Mathematical Methods In Medicine
[This retracts the article DOI: 10.1155/2022/5123933.].
2023: Computational and Mathematical Methods in Medicine
https://read.qxmd.com/read/37719650/effect-of-platelet-parameters-on-linezolid-related-thrombocytopenia-in-hospitalized-patients
#12
JOURNAL ARTICLE
Lu Zhang, Yan Yan, Ru Liao, Haiyan Dong
BACKGROUND: Linezolid-induced thrombocytopenia incidence varies considerably. Linezolid-related thrombocytopenia in patients has received few studies which have investigated risk factors including platelet parameters except for platelet counts. The study aims to analyze the effect of platelet parameters, including mean platelet volume and platelet large cell ratio, on linezolid-related thrombocytopenia in patients. METHODS: The effect of platelet parameters on linezolid-related thrombocytopenia was identified by univariate and multivariate logistic regressions...
2023: Infection and Drug Resistance
https://read.qxmd.com/read/37667953/the-effect-of-parecoxib-sodium-combined-with-perioperative-psychological-care-on-postoperative-pain-in-elderly-patients-with-hip-fractures
#13
JOURNAL ARTICLE
H-Y Ai, M-Y Cheng
OBJECTIVE: This study aimed to investigate the effect of parecoxib sodium combined with perioperative psychological nursing on postoperative pain in elderly patients with hip fractures. PATIENTS AND METHODS: 80 elderly patients with hip fractures who received surgical treatment in our hospital were selected as the research subjects. According to the different interventions received by the patients, they were divided into a control group (CG) (n=40) who received intravenous parecoxib sodium intervention before surgery, and an observation group (OG) (n=40) who received perioperative psychological nursing intervention in addition to the intervention received by the CG...
August 2023: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/37529243/efficacy-and-safety-of-parecoxib-and-flurbiprofen-axetil-for-perioperative-analgesia-in-children-a-network-meta-analysis
#14
JOURNAL ARTICLE
Xi Chen, Pan Chen, Xiao Chen, Min Huang, Kejing Tang, Qiuyi He
OBJECTIVE: The aim of this study was to systematically review the efficacy and safety of parecoxib and flurbiprofen axetil for perioperative analgesia in children through Bayesian network meta-analysis. METHODS: We systematically searched PubMed, Embase, Cochrane Library, Web of Science, Sinomed, CNKI, VIP, and Wanfang Data databases on 18 July 2022 to obtain randomized controlled trials comparing perioperative parecoxib or flurbiprofen with placebo or standard treatment for pediatric analgesia...
2023: Frontiers in Medicine
https://read.qxmd.com/read/37525785/perioperative-challenges-of-heroin-addiction-a-case-report-of-opioid-free-anesthesia-in-tongue-carcinoma-excision-with-free-flap-reconstruction
#15
Roberto J Ameiro, Sara S Neves, Rita P Oliveira, Beatriz B Marques, Paulo-Roberto C Ferreira
Anesthesia for major head and neck surgery is historically heavily reliant on opioids with deleterious consequences. We reported a case of a patient with a history of heroin abuse submitted to a tongue carcinoma excision, followed by free-flap reconstruction under opioid-free anesthesia. We used a propofol total intravenous anesthesia and perfusions of ketamine, dexmedetomidine, lidocaine, and magnesium sulfate for analgesia, complemented by boluses of dexamethasone, acetaminophen, parecoxib, and metamizole...
June 2023: Curēus
https://read.qxmd.com/read/37442403/efficacy-and-safety-of-transdermal-buprenorphine-for-acute-postoperative-pain-a-systematic-review-and-meta-analysis
#16
REVIEW
Brydget Aguilar, Jonathan Penm, Shania Liu, Asad E Patanwala
Transdermal buprenorphine (TBUP) may have some advantages for the management of acute postoperative pain. The aim of this systematic review and meta-analysis was to investigate the efficacy and safety of TBUP compared to other analgesics or placebo for acute postoperative pain. A systematic search was conducted using Embase, MEDLINE, and Cochrane Central Register of Controlled Trials (CENTRAL) until December 26, 2022. The search included randomized controlled trials comparing TBUP versus other analgesics or placebo for acute postoperative pain...
November 2023: Journal of Pain
https://read.qxmd.com/read/37438661/comparing-the-effectiveness-of-betamethasone-and-triamcinolone-acetonide-in-multimodal-cocktail-intercostal-injection-for-chest-pain-after-harvesting-costal-cartilage-a-prospective-double-blind-randomized-controlled-study
#17
JOURNAL ARTICLE
Xin Wang, Wenfang Dong, Zhen Song, Huan Wang, Jianjun You, Ruobing Zheng, Yihao Xu, Xulong Zhang, Junsheng Guo, Le Tian, Fei Fan
BACKGROUND: There has been no previous study on the availability of different glucocorticoid varieties used in the multimodal cocktail for harvesting autologous costal cartilage. This randomized controlled trial (RCT) was to compare the significance and complications of betamethasone and triamcinolone acetonide as a component of the cocktail for harvesting costal cartilage in patients. MATERIALS AND METHODS: The patients were randomized to two groups. The group A used multimodal cocktail: ropivacaine, parecoxib sodium, epinephrine, and triamcinolone acetonide; group B used multimodal cocktail: ropivacaine, parecoxib sodium, epinephrine, and betamethasone...
July 12, 2023: Aesthetic Plastic Surgery
https://read.qxmd.com/read/37431799/effects-of-anesthetic-adjunctive-agents-on-postoperative-cognitive-dysfunction-in-elderly-patients-undergoing-noncardiac-surgery-a-bayesian-network-meta-analysis
#18
REVIEW
Lichi Xu, Shuxiang Xu, Yuelun Zhang, Yuguang Huang
BACKGROUND: Elderly patients are prone to postoperative cognitive dysfunction (POCD). The comparison of the effects of anesthetic adjuvant drugs on POCD in elderly patients undergoing noncardiac surgery remains controversial. METHODS: The final search took place on June 10, 2023. Randomized controlled trials including ketamine, ulinastatin, dexmedetomidine, parecoxib, and midazolam on the prevention and treatment of POCD in elderly undergoing noncardiac surgery were collected...
August 2023: Brain and Behavior
https://read.qxmd.com/read/37426819/pharmacological-interventions-for-preventing-opioid-induced-hyperalgesia-in-adults-after-opioid-based-anesthesia-a-systematic-review-and-network-meta-analysis
#19
Wei-Ji Xie, Ji-Shuang Hong, Cheng-Fei Feng, Hao-Feng Chen, Wei Li, Yong-Chun Li
Background: Opioid-induced hyperalgesia (OIH) is an adverse event of prolonged opioid use that increases pain intensity. The optimal drug to prevent these adverse effects is still unknown. We aimed to conduct a network meta-analysis to compare different pharmacological interventions for preventing the increase in postoperative pain intensity caused by OIH. Methods: Several databases were searched independently for randomized controlled trials (RCTs) comparing various pharmacological interventions to prevent OIH...
2023: Frontiers in Pharmacology
https://read.qxmd.com/read/37284928/the-efficacy-and-safety-of-parecoxib-multimodal-preemptive-analgesia-in-artificial-joint-replacement-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#20
REVIEW
Zhuoqi Ge, Mingnian Li, Yu Chen, Yufeng Sun, Rui Zhang, Jiaxing Zhang, Xue Bai, Yanyan Zhang, Qi Chen
BACKGROUND: Postoperative pain after artificial joint replacement is intense and remains an unsolved problem. Some studies have shown that parecoxib can provide better analgesia in postoperative multimodal analgesia, however, doubts arise about whether its multimodal preemptive analgesia can reduce postoperative pain. OBJECTIVES: The purpose of this systematic review and meta-analysis was to evaluate the impact of preoperative injection of parecoxib on postoperative pain in patients undergoing artificial joint replacement...
June 7, 2023: Pain and Therapy
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