Tra-My Doan Ngoc, Gaëlle Tilly, Richard Danger, Orianne Bonizec, Christophe Masset, Pierrick Guérif, Sarah Bruneau, Alexandre Glemain, Jean Harb, Marion Cadoux, Anaïs Vivet, Hoa Le Mai, Alexandra Garcia, David Laplaud, Roland Liblau, Magali Giral, Stéphanie Blandin, Magalie Feyeux, Laurence Dubreuil, Claire Pecqueur, Matthew Cyr, Weiming Ni, Sophie Brouard, Nicolas Degauque
BACKGROUND: The mechanisms regulating CD8+ T cell migration to nonlymphoid tissue during inflammation have not been fully elucidated, and the migratory properties of effector memory CD8+ T cells that re-express CD45RA (TEMRA CD8+ T cells) remain unclear, despite their roles in autoimmune diseases and allotransplant rejection. METHODS: We used single-cell proteomic profiling and functional testing of CD8+ T cell subsets to characterize their effector functions and migratory properties in healthy volunteers and kidney transplant recipients with stable or humoral rejection...
October 24, 2022: Journal of the American Society of Nephrology: JASN