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https://read.qxmd.com/read/30772872/-clinical-assessment-of-fourteen-cases-of-thoracic-endometriosis
#1
Naoya Ishibashi, Toshiharu Tabata, Akira Koyanagi, Ryo Nonomura, Takanobu Sasaki, Hideki Mitomo, Takafumi Sugawara, Takashi Kondo, Kazuhiro Murakami, Motoyasu Sagawa
We retrospectively assessed the clinical and pathological features of 14 patients with thoracic endometriosis who were treated at our hospital from 2007 to 2017. Thirteen patients presented pneumothorax and 1 patient presented bloody sputum. All were treated surgically. Pneumothorax occurs on the right side in all 13 cases and bloody sputum was from left side lesion. Ten patients presented symptoms closely related with their menstrual cycle (days -2 to 5). At surgery, dark red or dark brown spots, small hiatus and scar-like findings on the surface of the visceral pleura or diaphragm were identified in all cases...
February 2019: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://read.qxmd.com/read/30772863/paramedics-experiences-of-administering-fascia-iliaca-compartment-block-to-patients-in-south-wales-with-suspected-hip-fracture-at-the-scene-of-injury-results-of-focus-groups
#2
Bridie Angela Evans, Alan Brown, Jenna Bulger, Greg Fegan, Simon Ford, Katy Guy, SIan Jones, Leigh Keen, Ashrafunnesa Khanom, Mirella Longo, Ian Pallister, Nigel Rees, Ian T Russell, Anne C Seagrove, Alan Watkins, Helen Snooks
OBJECTIVES: To explore paramedics' experience of delivering fascia iliaca compartment block ( FICB) to patients with suspected hip fracture at the scene of injury. DESIGN: Focus groups within a randomised controlled trial. SETTING: Paramedics based at ambulance stations in the catchment area of one Emergency Department in South Wales, recruited and trained in a feasibility study about an alternative to routine prehospital pain management for patients with suspected hip fracture...
February 15, 2019: BMJ Open
https://read.qxmd.com/read/30772419/putting-participants-at-the-centre-of-hiv-cure-research
#3
Karine Dubé, Liz Barr, David Palm, Brandon Brown, Jeff Taylor
No abstract text is available yet for this article.
February 13, 2019: Lancet HIV
https://read.qxmd.com/read/30772357/essential-research-priorities-in-renal-cancer-a-modified-delphi-consensus-statement
#4
Sabrina H Rossi, Christopher Blick, Catherine Handforth, Janet E Brown, Grant D Stewart
BACKGROUND: Identification of clear and focused research priorities is crucial to drive research forward. OBJECTIVE: To identify research priorities in renal cell carcinoma (RCC) through a multidisciplinary collaboration between clinicians, researchers, and patients. DESIGN, SETTING, AND PARTICIPANTS: In phase I, 44 RCC experts provided 24 literature reviews within their field, summarising research gaps (RGs). Three expert discussion meetings and patient interviews were performed, and 39 potential RGs were identified...
February 13, 2019: European Urology Focus
https://read.qxmd.com/read/30772257/the-brown-adipose-tissue-glucagon-receptor-is-functional-but-not-essential-for-control-of-energy-homeostasis-in-mice
#5
Jacqueline L Beaudry, Kiran Deep Kaur, Elodie M Varin, Laurie L Baggio, Xiemin Cao, Erin E Mulvihill, Jennifer H Stern, Jonathan E Campbell, Phillip E Scherer, Daniel J Drucker
OBJECTIVE: Administration of glucagon (GCG) or GCG-containing co-agonists reduces body weight and increases energy expenditure. These actions appear to be transduced by multiple direct and indirect GCG receptor (GCGR)-dependent mechanisms. Although the canonical GCGR is expressed in brown adipose tissue (BAT) the importance of BAT GCGR activity for the physiological control of body weight, or the response to GCG agonism, has not been defined. METHODS: We studied the mechanisms linking GCG action to acute increases in oxygen consumption using wildtype (WT), Ucp1-/- and Fgf21-/- mice...
February 5, 2019: Molecular Metabolism
https://read.qxmd.com/read/30772130/flexible-nasotracheal-intubation-compared-to-blind-nasotracheal-intubation-in-the-setting-of-simulated-angioedema
#6
Seth Parkey, Thomas Erickson, Emily M Hayden, Calvin A Brown Iii, Jestin N Carlson
BACKGROUND: Nasotracheal intubation is rarely performed in the emergency department (ED) but may be required in specific situations such as angioedema. Both blind and flexible nasal intubation (FNI) may be utilized; however, the preferred technique is unknown. METHODS: We performed a randomized, crossover manikin study using a convenience sample of emergency physicians and medical students from a local community teaching hospital. Using a simulated angioedema model, we sought to compare the time required to successfully perform nasotracheal intubation between traditional blind nasotracheal intubation and FNI...
February 11, 2019: American Journal of Emergency Medicine
https://read.qxmd.com/read/30772081/the-spatial-structure-of-neural-encoding-in-mouse-posterior-cortex-during-navigation
#7
Matthias Minderer, Kristen D Brown, Christopher D Harvey
Navigation engages many cortical areas, including visual, parietal, and retrosplenial cortices. These regions have been mapped anatomically and with sensory stimuli and studied individually during behavior. Here, we investigated how behaviorally driven neural activity is distributed and combined across these regions. We performed dense sampling of single-neuron activity across the mouse posterior cortex and developed unbiased methods to relate neural activity to behavior and anatomical space. Most parts of the posterior cortex encoded most behavior-related features...
February 11, 2019: Neuron
https://read.qxmd.com/read/30772026/milk-protein-fractions-strongly-affect-the-patterns-of-coagulation-curd-firming-and-syneresis
#8
Nicolò Amalfitano, Claudio Cipolat-Gotet, Alessio Cecchinato, Massimo Malacarne, Andrea Summer, Giovanni Bittante
The aim of this study was to assess the role of milk protein fractions in the coagulation, curd firming, and syneresis of bovine milk. Analyses were performed on 1,271 individual milk samples from Brown Swiss cows reared in 85 herds classified into 4 types of farming systems, from the very traditional (tied cows, feed manually distributed, summer highland pasture) to the most modern (loose cows, use of total mixed rations with or without silage). Fractions αS1 -casein (CN), αS2 -CN, β-CN, κ-CN, β-lactoglobulin (LG), and α-lactalbumin (LA) and genotypes at CSN2,CSN3, and BLG were obtained by reversed-phase HPLC...
February 13, 2019: Journal of Dairy Science
https://read.qxmd.com/read/30771665/perpetration-of-sexual-aggression-among-adolescents-in-south-africa
#9
Caroline Kuo, Catherine Mathews, Ashleigh LoVette, Abigail Harrison, Lindsay Orchowski, Jennifer A Pellowski, Millicent Atujuna, Dan J Stein, Larry K Brown
INTRODUCTION: In South Africa, one in three men have reported perpetrating rape. Adolescence presents a unique developmental period for primary prevention of violence. However, few studies characterize the epidemiology of sexual violence among adolescents in South Africa. METHOD: We evaluated rates of sexual violence behaviors using a baseline survey of N = 200 South African adolescents, age 13-15, recruited for participation in an intervention trial. The intervention focused on preventing onset of depression and sexual risk behavior among adolescents...
February 13, 2019: Journal of Adolescence
https://read.qxmd.com/read/30771553/regulatory-t-lymphocytes-are-associated-with-increased-nasopharyngeal-colonization-in-children
#10
Jessica Jane Browne, Evan Howard Matthews, Andrew William Taylor-Robinson, Jennelle Maree Kyd
OBJECTIVES: Regulatory T lymphocytes (Treg ) have been linked to survival of commensal bacteria at mucosal sites, but their presence and role in chronic otitis media (COM) and their response to otopathogens has not been evaluated previously. We investigated the association between Treg lymphocytes and otopathogens in COM prone and non-COM prone children. METHODS: Forty children, 2-7 years of age, scheduled for adenoidectomy were enrolled into COM (n = 20) or non-COM (n = 20) groups...
February 5, 2019: International Journal of Pediatric Otorhinolaryngology
https://read.qxmd.com/read/30771362/improving-child-weight-management-uptake-through-enhanced-national-child-measurement-programme-parental-feedback-letters-a-randomised-controlled-trial
#11
A Sallis, L Porter, K Tan, R Howard, L Brown, A Jones, L Ells, A Adamson, R Taylor, I Vlaev, T Chadborn
This single-blind, pragmatic, cluster randomised controlled trial aims to investigate uptake of children's weight management services in response to enhanced National Child Measurement Programme (NCMP) letters providing weight status feedback to parents in three English counties in 2015. Parents of 2642 overweight or very overweight (obese) children aged 10-11 years received an intervention or control letter informing them of their child's weight status. Intervention letters included (i) a visual tool to help weight status recognition, (ii) a social norms statement, and for very overweight children, (iii) a prepopulated booking form for weight management services...
February 13, 2019: Preventive Medicine
https://read.qxmd.com/read/30771333/randomized-trial-of-treat-extend-ranibizumab-with-without-navigated-laser-versus-monthly-dosing-for-dme-trex-dme-2-year-outcomes
#12
John F Payne, Charles C Wykoff, W Lloyd Clark, Beau B Bruce, David S Boyer, David M Brown
PURPOSE: To prospectively evaluate a treat & extend algorithm of ranibizumab with and without navigated laser to monthly dosing for center-involving diabetic macular edema. DESIGN: Multicenter, randomized, clinical trial METHODS: 150 eyes were randomized into three cohorts: Monthly (n=30), TReat and EXtend without laser photocoagulation (TREX; n=60), and treat and extend with angiography-GuIded LAser photocoagulation (GILA; n=60). Monthly cohort eyes received ranibizumab 0...
February 13, 2019: American Journal of Ophthalmology
https://read.qxmd.com/read/30771314/effects-of-aerobic-exercise-on-the-inflammatory-cytokine-profile-and-expression-of-lipolytic-and-thermogenic-genes-in-%C3%AE-1-ar-mice-adipose-tissue
#13
Aurora Corrêa Rodrigues, Tiago Ferreira Leal, Alexandre Jayme Lopes Dantas Costa, Franciany de Jesus Silva, Leôncio Lopes Soares, Patrícia Chakur Brum, Helen Hermana Miranda Hermsdorff, Maria do Carmo Gouveia Peluzio, Thales Nicolau Prímola-Gomes, Antônio José Natali
AIM: Investigate the effects of moderate continuous aerobic exercise (MCAE) on the inflammatory cytokine profile and expression of lipolytic and thermogenic genes in β1 -AR-/- mice adipose tissue. MAIN METHODS: Four- to five-month-old male wild type (WT) and β1 -AR-/- mice were divided into groups: WT control (WTc) and trained (WTt); and β1 -AR-/- control (β1 -AR-/- c) and trained (β1 -AR-/- t). Animals from trained groups were submitted to a MCAE regimen (60 min/day; 60% of maximal speed, 5 days/week) on a treadmill, for 8 weeks...
February 13, 2019: Life Sciences
https://read.qxmd.com/read/30771279/psychometric-properties-of-the-self-sufficiency-matrix-among-homeless-and-vulnerably-housed-individuals-and-families
#14
Camilla Cummings, Molly Brown
Homeless service systems have been implementing assessment tools to inform service provision for individuals and families. Although a variety of assessments are available, their psychometric evidence base is limited. The self-sufficiency matrix (SSM) is one assessment that demonstrates promising reliability and validity. However, the SSM's factor structure has been inconsistent across studies. This study explored the factor structure of the SSM, using exploratory factor analysis and confirmatory factor analysis in a sample of individuals (N = 427) and families ( N = 428) at risk of or experiencing homelessness...
February 16, 2019: Journal of Community Psychology
https://read.qxmd.com/read/30771250/amelogenin-domain-containing-nlchp38-is-necessary-for-normal-ovulation-in-the-brown-planthopper
#15
Yi-Han Lou, Jia-Bao Lu, Dan-Ting Li, Yu-Xuan Ye, Xu-Mei Luo, Chuan-Xi Zhang
The brown planthopper (BPH), Nilaparvata lugens, is a major threat to rice production. The eggshell plays an important role in insect reproduction. The constituents and formation process of BPH eggshells remains largely unknown. Here we report a novel eggshell associated protein, NlChP38, containing an amelogenin domain, is essential for normal ovulation in the brown planthopper. NlChP38 is specifically expressed in the follicular cells from egg chambers at both RNA and protein levels. RNA interference (RNAi) of NlChP38 resulted in oocytes with loose and thin eggshell structure and caused ovulation difficulties...
February 16, 2019: Insect Molecular Biology
https://read.qxmd.com/read/30770980/the-role-of-sloths-and-anteaters-as-leishmania-spp-reservoirs-a-review-and-a-newly-described-natural-infection-of-leishmania-mexicana-in-the-northern-anteater
#16
REVIEW
Claudia I Muñoz-García, Sokani Sánchez-Montes, Claudia Villanueva-García, Evangelina Romero-Callejas, Hilda M Díaz-López, Elías J Gordillo-Chávez, Carlos Martínez-Carrasco, Eduardo Berriatua, Emilio Rendón-Franco
For years, mammals of the order Pilosa have been considered Leishmania reservoirs. But while most studies have focused on sloth species, anteaters have been overlooked, and in many Leishmania endemic countries like Mexico, no studies have been carried out. The aims of this work were to identify the presence of Leishmania spp. in tissue samples from road-killed northern tamanduas (Tamandua mexicana), using PCR amplification and sequencing of ITS1 DNA, and to discuss the role of Pilosa mammals as reservoirs of Leishmania based on available scientific records...
February 15, 2019: Parasitology Research
https://read.qxmd.com/read/30770932/aging-alters-phenotypic-traits-of-thyroid-dysfunction-in-male-mice-with-divergent-effects-on-complex-systems-but-preserved-thyroid-hormone-action-in-target-organs
#17
Kathrin Engels, Helena Rakov, Georg Sebastian Hönes, Klaudia Brix, Josef Köhrle, Denise Zwanziger, Lars Christian Moeller, Dagmar Führer
Clinical manifestation of hyperthyroidism and hypothyroidism vary with age, with an attenuated, oligosymptomatic presentation of thyroid dysfunction (TD) in older patients. We asked, whether in rodents TD phenotypes are influenced by age and whether this involves changes in systemic and/or organ thyroid hormone (TH) signaling. Chronic hyper- or hypothyroidism was induced in male mice at different life stages (5, 12, 20 months). TH excess resulted in pronounced age-specific body weight changes (increase in youngest and decrease in old mice), neither explained by changes in food intake (similar increase at all ages), nor by thermogenic gene expression in brown adipose tissue (BAT) or TH serum concentrations...
February 16, 2019: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://read.qxmd.com/read/30770771/considerations-for-the-use-of-cre-recombinase-for-conditional-gene-deletion-in-the-mouse-lens
#18
Phuong T Lam, Stephanie L Padula, Thanh V Hoang, Justin E Poth, Lin Liu, Chun Liang, Adam S LeFever, Lindsay M Wallace, Ruth Ashery-Padan, Penny K Riggs, Jordan E Shields, Ohad Shaham, Sheldon Rowan, Nadean L Brown, Tom Glaser, Michael L Robinson
BACKGROUND: Despite a number of different transgenes that can mediate DNA deletion in the developing lens, each has unique features that can make a given transgenic line more or less appropriate for particular studies. The purpose of this work encompasses both a review of transgenes that lead to the expression of Cre recombinase in the lens and a comparative analysis of currently available transgenic lines with a particular emphasis on the Le-Cre and P0-3.9GFPCre lines that can mediate DNA deletion in the lens placode...
February 15, 2019: Human Genomics
https://read.qxmd.com/read/30770493/correction-her2-overexpressing-breast-cancers-amplify-fgfr-signaling-upon-acquisition-of-resistance-to-dual-therapeutic-blockade-of-her2
#19
Ariella B Hanker, Joan T Garrett, Mónica Valeria Estrada, Preston D Moore, Paula González Ericsson, James P Koch, Emma Langley, Sharat Singh, Phillip S Kim, Garrett M Frampton, Eric Sanford, Philip Owens, Jennifer Becker, M Reid Groseclose, Stephen Castellino, Heikki Joensuu, Jens Huober, Jan C Brase, Samira Majjaj, Sylvain Brohée, David Venet, David Brown, José Baselga, Martine Piccart, Christos Sotiriou, Carlos L Arteaga
No abstract text is available yet for this article.
February 15, 2019: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://read.qxmd.com/read/30770466/vismet-a-passive-efficient-and-sensitive-assessment-of-visuospatial-memory-in-healthy-aging-mild-cognitive-impairment-and-alzheimer-s-disease
#20
Rafi U Haque, Cecelia M Manzanares, Lavonda N Brown, Alvince L Pongos, James J Lah, Gari D Clifford, Allan I Levey
The entorhinal-hippocampal circuit is one of the earliest sites of cortical pathology in Alzheimer's disease (AD). Visuospatial memory paradigms that are mediated by the entorhinal-hippocampal circuit may offer a means to detect memory impairment during the early stages of AD. In this study, we developed a 4-min visuospatial memory paradigm called VisMET (Visuospatial Memory Eye-Tracking Task) that passively assesses memory using eye movements rather than explicit memory judgements. We had 296 control or memory-impaired participants view a set of images followed by a modified version of the images with either an object removed, or a new object added...
March 2019: Learning & Memory
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