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Denis Richard
Obesity ensues from an imbalance between energy intake and expenditure that results from gene-environment interactions, which favour a positive energy balance. A society that promotes unhealthy food and encourages sedentary lifestyle (that is, an obesogenic environment) has become a major contributory factor in excess fat deposition in individuals predisposed to obesity. Energy homeostasis relies upon control of energy intake as well as expenditure, which is in part determined by the themogenesis of brown adipose tissue and mediated by the sympathetic nervous system...
August 2015: Nature Reviews. Endocrinology
Ebru Aydin, Dick-Paul Kloos, Emmanuel Gay, Willem Jonker, Lijuan Hu, Jorn Bullwinkel, Jeremy P Brown, Maria Manukyan, Martin Giera, Prim B Singh, Reinald Fundele
Mammals have three HP1 protein isotypes HP1 beta (CBX1), HP1 alpha (CBX3) and HP1 alpha (CBX5) that are encoded by the corresponding genes Cbx1, Cbx3 and Cbx5. Recent work has shown that reduction of CBX3 protein in homozygotes for a hypomorphic allele (Cbx3hypo) causes a severe postnatal mortality with around 99 percent of the homozygotes dying before weaning. It is not known what the causes of the postnatal mortality are. Here we show that Cbx3hypo/hypo conceptuses are significantly reduced in size and the placentas exhibit a haplo-insufficiency...
June 2015: Journal of Biosciences
J Cooling, J E Blundell
OBJECTIVE: This study investigated how energy expenditure may contribute to energy balance in lean male individuals consuming a diet either high or low in fat. METHODS: Fifteen high-fat phenotypes (HF) and 15 low-fat phenotypes (LF) participated in the study. Energy intake and macronutrient intake variables were assessed using a food frequency questionnaire and 3 day food diaries. Total energy expenditure (TEE) was estimated from 24h heart rate monitoring and factorial methods...
December 2000: International Journal of Obesity and related Metabolic Disorders
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