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skin senescence

Chye Ling Tan, Toby Chin, Christina Yan Ru Tan, Holly A Rovito, Ling Shih Quek, John E Oblong, Sophie Bellanger
Nicotinamide (NAM) is the main precursor of NAD+ , a co-enzyme essential for DNA repair, glycolysis and oxidative phosphorylation (OXPHOS). NAM has anti-aging activity on human skin, but the underlying mechanisms of action are unclear. Using 3D organotypic skin models, we show that NAM inhibits differentiation of the upper epidermal layers and maintains proliferation in the basal layer. In 2D culture, NAM reduces the expression of early and late epidermal differentiation markers and increases the proliferative capacity of human primary keratinocytes (HPKs)...
February 15, 2019: Journal of Investigative Dermatology
Adriana Nowak, Małgorzata Zakłos-Szyda, Janusz Błasiak, Agnieszka Nowak, Zhuo Zhang, Bolin Zhang
Schisandra chinensis (Turcz.) Baill. (SCE) is a plant with high potential for beneficial health effects, confirmed by molecular studies. Its constituents exert anti-cancer effects through the induction of cell cycle arrest and apoptosis, as well as inhibition of invasion and metastasis in cancer cell lines and experimental animals. SCE displays antimicrobial effects against several pathogenic strains. It has anti-diabetic potential, supported by hypoglycemic activity. A diet rich in SCE improves pancreatic functions, stimulates insulin secretion, and reduces complications in diabetic animals...
February 4, 2019: Nutrients
Daíse Raquel Maldaner, Verônica Farina Azzolin, Fernanda Barbisan, Moisés Henrique Mastela, Cibele Ferreira Teixeira, Alexandre Dihel, Thiago Duarte, Neida Luiza Pellenz, Luiz Fernando Cuozzo Lemos, Carla Maria Uggeri Negretto, Ivana Beatrice Mânica da Cruz, Marta Maria Medeiros Frescura Duarte
Skin aging is a complex biological process induced by intrinsic and extrinsic factors which is characterized by clinical and cellular changes, especially dermal fibroblasts. It is possible that, some procedures, such as low-level laser therapy (LLLT), could decelerate this process. To test this hypothesis, this study evaluated the in vitro LLLT on dermal fibroblast cell line (HFF-1) with premature senescence H2 O2 -induced. HFF-1 cells were cultured in standardized conditions, and initially H2 O2 exposed at different concentrations...
February 2, 2019: Lasers in Medical Science
Hann W Tam, Jonathan R Hall, Zachary J Messenger, Dereje D Jima, John S House, Keith Linder, Robert C Smart
p53 is activated by DNA damage and oncogenic stimuli to regulate senescence, apoptosis and cell cycle arrest which are essential to prevent cancer. Here, we utilized UVB radiation, a potent inducer of DNA damage, p53, apoptosis and skin cancer to investigate the mechanism of C/EBPβ in regulating p53-mediated apoptosis in keratinocytes and to test whether the deletion of C/EBPβ in epidermis can protect mice from UVB-induced skin cancer. UVB-treatment of C/EBPβ skin conditional knockout (CKOβ) mice increased p53 protein levels in epidermis and enhanced p53-dependent apoptotic activity 3-fold compared to UVB-treated control mice...
January 29, 2019: Carcinogenesis
Holly N Wilkinson, Christopher Clowes, Kayleigh L Banyard, Paolo Matteuci, Kimberly Mace, Matthew J Hardman
Cellular senescence can be broadly defined as a stable, yet essentially irreversible, loss of proliferative capacity. Historically, senescence is described as a negative outcome of advanced cellular age. It is now clear, however, that senescence represents a dynamic autonomous stress response, integral to long-term tumour suppression. Intriguingly, transient induction of a senescent phenotype has actually been suggested to promote regeneration in both liver and skin. Here we explored the role of senescence in pathological aged and diabetic murine wound healing...
January 23, 2019: Journal of Investigative Dermatology
Xīn Gào, Yan Zhang, Barbara Burwinkel, Yang Xuan, Bernd Holleczek, Hermann Brenner, Ben Schöttker
BACKGROUND: Reactive oxygen species may be involved in epigenetic gene activation or silencing. We aimed to identify CpG sites, at which DNA methylation is related to urinary 8-isoprostane levels (biomarker of lipid peroxidation) and cancer or mortality outcomes. This investigation was based on a German, population-based cohort with linkage to cancer and mortality registry data (2000-2016). RESULTS: Blood DNA methylation in promoter regions of 519 genes, known to be involved in pathways from oxidative stress (OS) to cancer, was obtained at the cohort's baseline examination...
January 24, 2019: Clinical Epigenetics
Nick Zimmermann, Christine Wolf, Reiner Schwenke, Anne Lüth, Franziska Schmidt, Kerstin Engel, Min Ae Lee-Kirsch, Claudia Günther
Importance: Familial chilblain lupus is a monogenic autosomal dominant form of cutaneous lupus erythematosus that in most cases is caused by mutations in the 3 prime repair exonuclease 1 (TREX1). Familial chilblain lupus presents in early childhood with cold-induced painful erythematous infiltrates leading to mutilation and is associated with systemic involvement illustrated by an elevated type I interferon (IFN) signature in the skin and blood. Effective treatment is currently not available...
January 23, 2019: JAMA Dermatology
Julie Despres, Yasmina Ramdani, Marine di Giovanni, Magalie Bénard, Abderrakib Zahid, Maité Montero-Hadjadje, Florent Yvergnaux, Thibaut Saguet, Azeddine Driouich, Marie-Laure Follet-Gueye
It is well recognized that the world population is aging rapidly. Therefore, it is important to understand aging processes at the cellular and molecular levels to predict the onset of age-related diseases and prevent them. Recent research has focused on the identification of aging biomarkers, including those associated with the properties of the Golgi apparatus. In this context, Golgi-mediated glycosylation of proteins has been well characterized. Additionally, other studies show that the secretion of many compounds, including pro-inflammatory cytokines and extracellular matrix degrading enzymes, is modified during aging, resulting in physical and functional skin degradation...
January 19, 2019: Experimental Dermatology
Michael Burkard, Susan Bengtson Nash, Gessica Gambaro, Deanne Whitworth, Kristin Schirmer
Marine mammals, such as whales, have a high proportion of body fat and so are susceptible to the accumulation, and associated detrimental health effects, of lipophilic environmental contaminants. Recently, we developed a wild-type cell line from humpback whale fibroblasts (HuWa). Extensive molecular assessments with mammalian wild-type cells are typically constrained by a finite life span, with cells eventually becoming senescent. Thus, the present work explored the possibility of preventing senescence in the HuWa cell line by transfection with plasmids encoding the simian virus large T antigen (SV40T) or telomerase reverse transcriptase (TERT)...
January 10, 2019: Cell Biology and Toxicology
Jamie N Justice, Anoop M Nambiar, Tamar Tchkonia, Nathan K LeBrasseur, Rodolfo Pascual, Shahrukh K Hashmi, Larissa Prata, Michal M Masternak, Stephen B Kritchevsky, Nicolas Musi, James L Kirkland
BACKGROUND: Cellular senescence is a key mechanism that drives age-related diseases, but has yet to be targeted therapeutically in humans. Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal cellular senescence-associated disease. Selectively ablating senescent cells using dasatinib plus quercetin (DQ) alleviates IPF-related dysfunction in bleomycin-administered mice. METHODS: A two-center, open-label study of intermittent DQ (D:100 mg/day, Q:1250 mg/day, three-days/week over three-weeks) was conducted in participants with IPF (n = 14) to evaluate feasibility of implementing a senolytic intervention...
January 4, 2019: EBioMedicine
Clayre Grumiaux, Mads Kuhlmann Andersen, Hervé Colinet, Johannes Overgaard
Drosophila suzukii, an invasive species recently introduced in Europe, lays eggs in thin-skinned fruits and causes huge financial losses to fruit growers. One potential way to control this pest is the sterile insect technique (SIT) which demands a large stock of reproductive females to produce millions of sterile males to be released on demand. Unfortunately, Drosophila stocks age quickly, show declining fecundity when maintained at warm temperatures and conversely, they die from chill injury if they are maintained at constant low temperature...
January 4, 2019: Journal of Insect Physiology
Jon Holmes, Sandra Schuh, Frank Lee Bowling, Raj Mani, Julia Welzel
Chronic wounds such as venous leg ulcers invariably heal slowly and recur. In the case of venous leg ulcers, poor healing of chronic wounds is variously attributed to ambulatory hypertension, impaired perfusion and diffusion, presence of chronic inflammation at wound sites, lipodermatosclerosis, and senescence. The aim of this study was to investigate whether a new technique, optical coherence tomography (OCT), which permits imaging of blood capillaries in the peri-wound skin, can provide new insights into the pathology...
January 7, 2019: International Journal of Lower Extremity Wounds
X Wu, J Huang, L Jiang, H Wu, Y Cheng, C Chen, H Xue
Congenital self-healing reticulohistiocytosis (CSHR) is a rare disorder characterized by benign skin lesions with a tendency to self-heal. Multiple skin lesions are usually present in CSHR. It is very difficult to distinguish between CSHR and an invasive Langerhans cell histiocytosis. We present a case of a 5-month-old infant girl who had hypopigmented skin lesions distributed over her neck, thorax and torso. The skin lesions regressed spontaneously 2 months after the diagnosis of CSHR and the child has remained in complete remission without any sign of recurrence over a 2-year follow-up...
January 4, 2019: Clinical and Experimental Dermatology
Misun Kim, So Min Kim, Soohyun Kwon, Tae Jun Park, Hee Young Kang
It has been proposed that melasma is a photoageing skin disorder. The photoaged fibroblasts have been suggested as an important source of melanogenic factors which are involved in the regulation of pigmentation. To investigate whether melasma includes senescent cells, lesional and perilesional normal skin from 38 melasma patients was assessed using a cell senescence marker, p16INK4A . The results showed that lesional dermal skin had more p16INK4A -positive senescent cells than perilesional skin. The impact of senescent fibroblasts was further investigated in a pilot study using radiofrequency (RF) intervention for melasma...
October 29, 2018: Experimental Dermatology
U Blume-Peytavi, M Bagot, D Tennstedt, M Saint Aroman, E Stockfleth, A Zlotogorski, V Mengeaud, A M Schmitt, C Paul, H W Lim, V Georgescu, B Dréno, T Nocera
For many decades and until recently, medical approach to dermatologic diseases has been based on the physician's ability to recognize and treat symptoms. Nowadays, advances in the understanding of the biology of diseases and in technologies for intervening against them have allowed physicians to diagnose and treat underlying disease processes rather than simply addressing the symptoms. This means that rather than addressing 'the disease in humans', physicians can now address the particular pathologic (biologic, molecular) disturbance as it presents in the individual patient, i...
January 2019: Journal of the European Academy of Dermatology and Venereology: JEADV
Yi-Fang Li, Shu-Hua Ouyang, Long-Fang Tu, Xi Wang, Wei-Lin Yuan, Guo-En Wang, Yan-Ping Wu, Wen-Jun Duan, Hong-Min Yu, Zhong-Ze Fang, Hiroshi Kurihara, Youwei Zhang, Rong-Rong He
Skin cells are vulnerable to oxidative stress-induced senescence, which may lead to abnormal aging or aging-related disorders. Therefore, strategies that can ameliorate oxidative stress-induced senescence are expected to protect skin from damage, holding the promise of treating skin diseases in the clinic. This study aims to investigate whether caffeine, a well-known purine alkaloid, is able to prevent skin from oxidative stress-induced senescence, and to explore the underlying molecular mechanisms. Methods : A free radical inducer 2,2'-Azobis (2-amidinopropane) dihydrochloride (AAPH) was used to induce oxidative stress and cellular senescence in both transformed skin cells and in normal human epidermal keratinocytes (NHEKs)...
2018: Theranostics
Donata Orioli, Elena Dellambra
Skin undergoes continuous renewal throughout an individual's lifetime relying on stem cell functionality. However, a decline of the skin regenerative potential occurs with age. The accumulation of senescent cells over time probably reduces tissue regeneration and contributes to skin aging. Keratinocytes and dermal fibroblasts undergo senescence in response to several intrinsic or extrinsic stresses, including telomere shortening, overproduction of reactive oxygen species, diet, and sunlight exposure. Epigenetic mechanisms directly regulate skin homeostasis and regeneration, but they also mark cell senescence and the natural and pathological aging processes...
December 12, 2018: Cells
X-D Zhao, C Huang, R-X Wang, S-A Wang
OBJECTIVE: Skin cancer severely threatens the public health. Dual-specificity protein phosphatase 22 (DUSP22) characterizes with multiple roles regulating cell growth, proliferation and gaining. This study aims to investigate the regulatory role of DUSP22 on aging of skin cancer cells and clarify molecular mechanisms, along with potential application value. PATIENTS AND METHODS: HS-1 skin cancer cells were transfected with DUSP22 by liposome transfection approach...
November 2018: European Review for Medical and Pharmacological Sciences
Shin-Hae Lee, Ji-Hyeon Lee, Hye-Yeon Lee, Kyung-Jin Min
Sirtuin is an essential factor that delays cellular senescence and extends the organismal lifespan through the regulation of diverse cellular processes. Suppression of cellular senescence by Sirtuin is mainly mediated through delaying the age-related telomere attrition, sustaining genome integrity and promotion of DNA damage repair. In addition, Sirtuin modulates the organismal lifespan by interacting with several lifespan regulating signaling pathways including insulin/IGF-1 signaling pathway, AMP-activated protein kinase, and forkhead box O...
January 2019: BMB Reports
Hee-Jun Na, Chung Eun Yeum, Han-Seop Kim, Jungwoon Lee, Jae Yun Kim, Yee Sook Cho
Testis-specific protein, Y-encoded like (TSPYL) family proteins (TSPYL1-6), which are members of the nucleosome assembly protein superfamily, have been determined to be involved in the regulation of various cellular functions. However, the potential role of TSPYL family proteins in endothelial cells (ECs) has not been determined. Here, we demonstrated that the expression of TSPYL5 is highly enriched in human ECs such as human umbilical vein endothelial cells (HUVECs) and human pluripotent stem cell-differentiated ECs (hPSC-ECs)...
November 23, 2018: Angiogenesis
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