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Qds Photothermal

Yu Cao, Tingting Wu, Kai Zhang, Xiangdan Meng, Wenhao Dai, Dongdong Wang, HaiFeng Dong, Xueji Zhang
The limited penetration depth of photothermal agents (PTAs) active in the NIR-I biowindow and the thermo-resistance caused by heat shock protein (HSP) significantly limit the therapeutic efficiency of the photothermal therapy (PTT). To address the problem, we introduce a strategy of the low-temperature nucleus-targeted PTT in the NIR-II region achieving effective tumor killing by combing of the vanadium carbide quantum dots (V2C QDs) PTA and engineered exosomes (Ex) vector. The small fluorescent V2C QDs with good photothermal effect in the NIR-II region were modified with TAT peptides and packaged into Ex with RGD modification (V2C-TAT@Ex-RGD)...
January 24, 2019: ACS Nano
Feifei Yang, Guanbin Gao, Juncheng Wang, Rui Chen, Wenbo Zhu, Liang Wang, Zhongjie Ma, Zhuoying Luo, Taolei Sun
β-HgS quantum dots (QDs) have drawn enormous attention due to the size-tunable bandgap and the lowest quantum state in conduction band which have been applied to semiconductor transistor and photodetector. Though β-HgS is the essential component of Tibetan medicine, the potential toxicity of β-HgS limits its applications, especially in bio-application. Herein, chiral biomolecule enantiomers N-isobutyryl-L(D)-cysteine (L(D)-NIBC) and L(D)-cysteine (L(D)-Cys) were introduced into HgCl2 and Na2 S aqueous solution to synthesize chiral β-HgS QDs in one-pot, which significantly improved their water-solubility and cytocompatibility...
November 14, 2018: Journal of Colloid and Interface Science
Xianglong Li, Zexiu Liu, Kai Luo, Xiuhui Yin, Xucong Lin, Chunling Zhu
Ag2Se quantum dots (QDs) with near-infrared (NIR) fluorescence have been widely utilized in NIR fluorescence imaging in vivo because of their narrow bulk band gap and excellent biocompatibility. However, most of synthesis methods for Ag2Se QDs were expensive and the reactants were too toxic. In this paper, a new protein-templated biomimetic synthesis approach was proposed for Ag2Se QDs preparation by employing bovine serum albumin (BSA) as template and dispersant. The BSA-templated Ag2Se QDs (Ag2Se@BSA QDs) showed NIR fluorescence with high fluorescence quantum yield (≈21...
November 6, 2018: Chemistry, An Asian Journal
Wenhao Dai, Haifeng Dong, Xueji Zhang
Theranostic platforms integrating imaging diagnostic and therapeutic interventions into a single nanoplatform have attracted considerable attention for cancer-individualized therapies. However, their uncertain stability, complex pharmacokinetics, and intrinsic toxicology of multiple components hinder their practical application in clinical research. In this paper, stable and high-concentration molybdenum carbide quantum dots (Mo₂C QDs) with a diameter of approximately 6 nm and a topographic height of about 1...
September 19, 2018: Materials
Jun Yao, Pingfan Li, Lin Li, Mei Yang
According to recent research, nanotechnology based on quantum dots (QDs) has been widely applied in the field of bioimaging, drug delivery, and drug analysis. Therefore, it has become one of the major forces driving basic and applied research. The application of nanotechnology in bioimaging has been of concern. Through in vitro labeling, it was found that luminescent QDs possess many properties such as narrow emission, broad UV excitation, bright fluorescence, and high photostability. The QDs also show great potential in whole-body imaging...
July 1, 2018: Acta Biomaterialia
Bharath Bangalore Rajeeva, Majd A Alabandi, Linhan Lin, Evan P Perillo, Andrew K Dunn, Yuebing Zheng
Semiconductor quantum dots (QDs) are attractive for a wide range of applications such as displays, light-emitting devices, and sensors due to their properties such as tunable fluorescence wavelength, high brightness, and narrow bandwidth. Most of the applications require precise patterning of QDs with targeted properties on solid-state substrates. Herein, we have developed a haptic-interfaced bubble printing (HIBP) technique to enable high-resolution (510 nm) high-throughput (>104 μm s-1 ) patterning of QDs with strong emission tunability and to significantly enhance the accessibility of the technique via a smartphone device...
June 21, 2017: Journal of Materials Chemistry. C, Materials for Optical and Electronic Devices
Xinghua Yu, Xingke Cai, Haodong Cui, Seung-Wuk Lee, Xue-Feng Yu, Bilu Liu
Titanium carbide MXene quantum dots (QDs) were synthesized using an effective fluorine-free method as a biocompatible and highly efficient nanoagent for photothermal therapy (PTT) applications. In contrast to the traditional, hazardous and time-consuming process of HF pretreatment, our fluorine-free method is safe and simple. More importantly, abundant Al oxoanions were found to be modified on the MXene QD surface by the fluorine-free method, which endowed the QDs with strong and broad absorption in the NIR region...
November 23, 2017: Nanoscale
Yuqian Zhang, Weijun Xiu, Yiting Sun, Di Zhu, Qi Zhang, Lihui Yuwen, Lixing Weng, Zhaogang Teng, Lianhui Wang
The fast-developing field of nanotechnology provides unprecedented opportunities for the increasing demands of biomedicine, especially for cancer diagnostics and treatment. Here, novel multifunctional zero-dimensional-two-dimensional (0D-2D) RGD-QD-MoS2 nanosheets (NSs) with excellent fluorescence, photothermal conversion, and cancer-targeting properties were successfully prepared by functionalizing single-layer MoS2 NSs with fluorescent quantum dots (QDs) and arginine-glycine-aspartic (RGD) containing peptides...
October 26, 2017: Nanoscale
Woraphong Janetanakit, Liping Wang, Karla Santacruz-Gomez, Preston B Landon, Paul L Sud, Nirav Patel, Grace Jang, Malvika Jain, Alice Yepremyan, Sami A Kazmi, Deependra K Ban, Feng Zhang, Ratnesh Lal
Hybrid nanocarriers with multifunctional properties have wide therapeutic and diagnostic applications. We have constructed hollow silica nanogolf balls (HGBs) and gold-embedded hollow silica nanogolf balls (Au@SiO2 HGBs) using the layer-by-layer approach on a symmetric polystyrene (PS) Janus template; the template consists of smaller PS spheres attached to an oppositely charged large PS core. ζ Potential measurement supports the electric force-based template-assisted synthesis mechanism. Electron microscopy, UV-vis, and near-infrared (NIR) spectroscopy show that HGBs or Au@SiO2 HGBs are composed of a porous silica shell with an optional dense layer of gold nanoparticles embedded in the silica shell...
August 23, 2017: ACS Applied Materials & Interfaces
Wei Guo, Zhenyu Qiu, Chongshen Guo, Dandan Ding, Tianchan Li, Fei Wang, Jianzhe Sun, Nannan Zheng, Shaoqin Liu
Image-guided phototherapy is considered to be a prospective technique for cancer treatment because it can provide both oncotherapy and bioimaging, thus achieving an optimized therapeutic efficacy and higher treatment accuracy. Compared to complicated systems with multiple components, using a single material for this multifunctional purpose is preferable. In this work, we strategically fabricated poly(acrylic acid)- (PAA-) coated Cu2 (OH)PO4 quantum dots [denoted as Cu2 (OH)PO4 @PAA QDs], which exhibit a strong near-infrared photoabsorption ability...
March 22, 2017: ACS Applied Materials & Interfaces
Xiaomeng Guo, Wei Li, Jialin Zhou, Wanqing Hou, Xue Wen, Hanbo Zhang, Fenfen Kong, Lihua Luo, Qingpo Li, Yongzhong Du, Jian You
Endometriosis is difficult to treat since the side effects of the current therapeutic method and the high recurrence rate; thus, newer and safer therapeutic approaches are urgently needed. This work investigates the enhanced permeability and retention effect of CdTe quantum dots (QDs) and hollow gold nanospheres (HAuNS) in endometriosis to increase the delivery of HAuNS into lesion cells. The surface of HAuNS is successfully conjugated with a TNYL peptide that has specific affinity for the EphB4 receptor, which is a member of the Eph family of receptor tyrosine kinases...
February 1, 2017: Small
Dandan Ding, Wei Guo, Chongshen Guo, Jianzhe Sun, Nannan Zheng, Fei Wang, Mei Yan, Shaoqin Liu
A theranostic system of image-guided phototherapy is considered as a potential technique for cancer treatment because of the ability to integrate diagnostics and therapies together, thus enhancing accuracy and visualization during the treatment. In this work, we realized photoacoustic (PA) imaging-guided photothermal (PT)/photodynamic (PD) combined cancer treatment just via a single material, MoO3-x quantum dots (QDs). Due to their strong NIR harvesting ability, MoO3-x QDs can convert incident light into hyperthermia and sensitize the formation of singlet oxygen synchronously as evidenced by in vitro assay, hence, they can behave as both PT and PD agents effectively and act as a "dual-punch" to cancer cells...
February 2, 2017: Nanoscale
Gaixia Xu, Shuwen Zeng, Butian Zhang, Mark T Swihart, Ken-Tye Yong, Paras N Prasad
This review summarizes recent progress in the design and applications of cadmium-free quantum dots (Cd-free QDs), with an emphasis on their role in biophotonics and nanomedicine. We first present the features of Cd-free QDs and describe the physics and emergent optical properties of various types of Cd-free QDs whose applications are discussed in subsequent sections. Selected specific QD systems are introduced, followed by the preparation of these Cd-free QDs in a form useful for biological applications, including recent advances in achieving high photoluminescence quantum yield (PL QY) and tunability of emission color...
October 12, 2016: Chemical Reviews
Guoxian Lv, Weisheng Guo, Wei Zhang, Tingbin Zhang, Shuyi Li, Shizhu Chen, Ahmed Shaker Eltahan, Dongliang Wang, Yuqing Wang, Jinchao Zhang, Paul C Wang, Jin Chang, Xing-Jie Liang
Many theranostic nanomedicines (NMs) have been fabricated by packaging imaging and therapeutic moieties together. However, concerns about their potential architecture instability and pharmacokinetic complexity remain major obstacles to their clinical translation. Herein, we demonstrated the use of CuInS/ZnS quantum dots (ZCIS QDs) as "all-in-one" theranostic nanomedicines that possess intrinsic imaging and therapeutic capabilities within a well-defined nanostructure. ZCIS QDs were exploited for multispectral optical tomography (MSOT) imaging and synergistic PTT/PDT therapy...
September 20, 2016: ACS Nano
Jingwen Gao, Chuanli Wu, Dan Deng, Ping Wu, Chenxin Cai
Water-soluble Ag2 S near-infrared (NIR) fluorescent quantum dots (QDs) are directly synthesized at ambient temperature for specific cancer imaging and photothermal therapy (PTT) using a designed aptamer (Apt43) as template, which consists of the following two fragments: an aptamer S2.2 sequence for specifically recognizing the cancer cells and an 18-cytosine (18-C) extending spacer for growing Ag2 S QDs. The synthesized Ag2 S QDs (Apt43-Ag2 S QDs), which exhibit strong absorption and fluorescence emission in the NIR region and high photothermal conversion capabilities, can specifically recognize MCF-7 cells (human breast cancer cells) and are usable as a highly intensified imaging agent for cancer diagnosis...
September 2016: Advanced Healthcare Materials
Lauri Viitala, Saija Pajari, Tatu Lajunen, Leena-Stiina Kontturi, Timo Laaksonen, Päivi Kuosmanen, Tapani Viitala, Arto Urtti, Lasse Murtomäki
In light-activated liposomal drug delivery systems (DDSs), the light sensitivity can be obtained by a photothermal agent that converts light energy into heat. Excess heat increases the drug permeability of the lipid bilayer, and drug is released as a result. In this work, two near-IR responsive photothermal agents in a model drug delivery system are studied: either gold nanorods (GNRs) encapsulated inside the liposomes or indocyanine green (ICG) embedded into the lipid bilayer. The liposome system is exposed to light, and the heating effect is studied with fluorescent thermometers: laurdan and CdSe quantum dots (QDs)...
May 10, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
Chongyang Zhu, Feng Xu, Ling Zhang, Minli Li, Jing Chen, Shuhong Xu, Guangguang Huang, Wenhao Chen, Litao Sun
Black phosphorus quantum dots (BPQDs) have been prepared by a high turbulent shear rate generated from a household kitchen blender. A layer-by-layer disintegration mechanism of bulk BP crystals is suggested. As-synthesized BPQDs have shown excellent humidity sensing and photothermal converting properties. Importantly, this work not only explores potential applications for the BPQDs but also provides a successful paradigm for preparing the QDs of other layered materials.
May 23, 2016: Chemistry: a European Journal
Yuan Yong, Xiaju Cheng, Tao Bao, Mian Zu, Liang Yan, Wenyan Yin, Cuicui Ge, Dongliang Wang, Zhanjun Gu, Yuliang Zhao
Designing a multifunctional nanomedicine for integration of precise diagnosis and effective treatment of tumors is desirable but remains a great challenge. Here, we report a multifunctional nanomedicine based on WS2 quantum dots (QDs), which was prepared by a facile and "green" method through physical grinding and ultrasonication. The as-obtained WS2 QDs with small size (3 nm) possess not only significant X-ray computed tomography (CT)/photoaccoustic (PA) imaging signal enhancement but also remarkable photothermal therapy (PTT)/radiotherapy (RT) synergistic effect for tumor treatment...
December 22, 2015: ACS Nano
Xiaodong Zhang, Hongxia Wang, Hui Wang, Qiong Zhang, Junfeng Xie, Yupeng Tian, Jun Wang, Yi Xie
A promising, safe, and economic fluorescent probe, g-C3 N4 single-layered QDs, is introduced for two-photon fluorescence imaging of the cellular nucleus for the first time. The large two-photon absorption cross section, the high photostability, good biocompatibility and non-toxicity, negligible photothermal effect, and specific interaction with DNA render the single-layered g-C3 N4 QDs as a promising candidate for in vivo and in vitro two-photon fluorescence imaging and further biomedical applications.
July 9, 2014: Advanced Materials
Laurent Cognet, Brahim Lounis, Daniel Choquet
The plasma membrane is a fluid-mosaic structure in which some molecules seem to be randomly distributed and others show a precise compartmentalization that is related to their functional properties. These membrane domains are submicrometer in size and therefore are close to or below the optical diffraction limit. This makes their study difficult by conventional microscopy. Moreover, these compartments are usually dynamic in size and composition as their component molecules can continuously enter and exit by diffusion...
February 2014: Cold Spring Harbor Protocols
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