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Pentoxyphyllin AND Radiotherapy

Orsolya Szabolcsi, Annamária Nagy-Toldi, Margit Zeher, Judit Végh
Scleroderma is the general disease of the connective tissue, which can be characterized by the proliferation of the connective tissue and fibrosis. According to the results of international studies scleroderma is frequently accompanied by neoplastic diseases, among which the most often occurring is the neoplastic pathology of the breast and the lungs. In May 2007, in the case of our 40-year-old woman patient the histological examination of the tumor we noticed in the left breast verified invasive carcinoma...
March 2012: Magyar Onkologia
Waldemar Waldeck, Anke M Strunz, Gabriele Müller, Agnes Hotz-Wagenblatt, Jürgen Wijenne, Jörg Langowski, Bernd Didinger, Jürgen Debus, Klaus Braun
Aim in cancer therapy is to increase the therapeutic ratio eliminating the disease while minimizing toxicity to normal tissues. Radiation therapy is a main component in targeting cancer. Radiosensitizing agents like pentoxyphylline (PTX) have been evaluated to improve radiotherapy. Commonly, cells respond to radiation by the activation of specific early and late response genes as well as by inhibition of genes, which are expressed under normal conditions. A display of the genetic distinctions at the level of transcription is given here to characterize the molecular events underlying the radiosensitizing mechanisms...
March 15, 2007: International Journal of Cancer. Journal International du Cancer
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