keyword
https://read.qxmd.com/read/37909960/exploring-tbl1xr1-and-ncor1-expression-in-b-cell-lymphoma-subtypes-interaction-with-dna-damage-repair-genes
#21
JOURNAL ARTICLE
Adnan Mansoor, Ariz Akhter, Mahboobsadat Hamidi, Tariq Mahmood Roshan, Meer-Taher Shabani-Rad, Douglas Stewart
BACKGROUND/AIM: B-cell lymphomas are characterized by diverse genetic anomalies affecting B-cell differentiation. To expand targeted therapies, an in-depth grasp of the molecular dynamics in the germinal center (GC) is vital. Transducin β-like 1 X-linked receptor 1 (TBL1XR1) and nuclear receptor corepressor 1 (NCOR1) are instrumental within the GC, modulating myriad oncogenic pathways. Their prognostic roles in various cancers are established, yet their precise impact on B-cell lymphoma is elusive...
November 2023: Anticancer Research
https://read.qxmd.com/read/37869229/a-challenging-diagnosis-of-plasmablastic-lymphoma-importance-of-integrating-morpholgy-immunohistochemistry-and-flow-cytometry-findings-case-report
#22
Zahra Kmira, Gereisha Ahmed, Cherif Wided, Moatamri Wided, Nfikha Zeineb, Abdessaied Nihed, Ben Youssef Yosra, Haifa Regaieg, Brahem Nejia, Khelif Abderrahim
Plasmablastic lymphoma (PBL) is a rare clinicopathological entity that still raises many diagnostic and management difficulties, particularly due to the overlap between plasmablastic lymphomas and myeloma features. We report a clinical presentation of PBL affecting bone marrow in a 43-year-old patient who was admitted for B symptoms, hepatosplenomegaly, and bicytopenia investigation. Based on these findings, acute leukemia was suspected. Bone marrow morphology immunohistochemistry and flow cytometry contributed to establishing the diagnosis of medullary PBL...
2023: Pan African Medical Journal
https://read.qxmd.com/read/37846723/-newest-advances-in-diagnosis-and-treatment-of-plasmablastic-lymphoma-review
#23
JOURNAL ARTICLE
Hui Lin Peng, Hai Yan Yang
Plasmablastic lymphoma (PL/PBL) is a rare type of lymphoma with strong aggressive ability and poor prognosis. Currently,there is a lack of strict diagnostic and therapeutic criteria. In addition to traditional plasma cell markers, SLAMF7 may be a useful adjunct to diagnostic markers for PBL. High-dose chemotherapy combined with bortezomib or lenalidomide may be a promising first-line option for PBL. In second-line therapy, novel therapies such as immune checkpoint inhibitors, CAR-T, and novel targeted agents appear to further improve the survival of patients with PBL...
2023: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://read.qxmd.com/read/37832030/the-influence-of-immunodeficiency-disease-features-and-patient-characteristics-on-survival-in-plasmablastic-lymphoma
#24
JOURNAL ARTICLE
Pietro R Di Ciaccio, Mark N Polizzotto, Kate Cwynarski, Alina S Gerrie, Catherine Burton, Mark Bower, John Kuruvilla, Silvia Montoto, Pamela McKay, Christopher P Fox, Samuel Milliken, Awachana Jiamsakul, Wendy Osborne, Graham P Collins, Kate Manos, Kim M Linton, Sunil Iyengar, Shireen Kassam, Michelle Poon Limei, David S Kliman, Nicole Wong Doo, Anne-Marie Watson, Pasquale Fedele, Costas K Yannakou, Stewart Hunt, Matthew Ku, Laurie H Sehn, Alexandra Smith, Hanna Renshaw, Alice Maxwell, Qin Liu, Rageshri Dhairyawan, Graeme Ferguson, Keir Pickard, Daniel Painter, Nisha Thakrar, Kevin W Song, Nada Hamad
Plasmablastic lymphoma (PBL) is a rare and aggressive non-Hodgkin lymphoma associated with immunodeficiency, characterized by uncertain treatment approaches and an unfavourable prognosis. We conducted a multicenter, international, retrospective cohort study, aiming to characterize the clinical features, risk factors, and outcomes of patients with PBL. Data were collected from 22 institutions across four countries regarding patients diagnosed with PBL between 1 January 1999 and 31 December 2020. Survival risk factors were analyzed using both univariate and multivariate regression models...
October 13, 2023: Blood
https://read.qxmd.com/read/37803288/proliferative-glomerulonephritis-with-monoclonal-igg-lambda-deposits-caused-by-plasmablastic-lymphoma-a-case-report
#25
JOURNAL ARTICLE
Ling-Yan Ren, Qi Chen, Feng-Ping Qiu, Zhen-Yu Jiang, Xiao-Yi Wang, Xiao-Lan Zhang, Zhan-Qin Shi
INTRODUCTION: As a very rare form of B-cell lymphoma, plasmablastic lymphoma (PBL) typically occurs in patients with underlying immunosuppression, including human immunodeficiency virus (HIV), organ transplantation, and autoimmune diseases. For HIV-positive patients, PBL normally originates in the gastrointestinal tract, especially from the oral cavity in most cases. It is extremely rare to find abdominal cavity involvement in PBL, and there has been no previously reported instance of proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID) attributed to monoclonal IgG (MIgG) lambda secreted by PBL...
October 6, 2023: BMC Nephrology
https://read.qxmd.com/read/37777745/duodenal-plasmablastic-lymphoma-in-an-human-immunodeficency-virus-negative-patient-a-case-report
#26
REVIEW
Abbas Ali Hussain, Aresha Masood Shah, Sumeet Kumar
BACKGROUND: Plasmablastic lymphoma is a rare type of non-Hodgkin lymphoma that generally presents an aggressive clinical course. It is strongly associated with human immunodeficency virus (HIV) infection, and the most common site of involvement is the oral cavity. Although extraoral PBL has been reported in several places, small intestine involvement is extremely rare. CASE PRESENTATION: Here, we describe an exceptionally rare case of a 24-year-old immunocompetent Asian Male patient with newly diagnosed plasmablastic lymphoma of the duodenum...
October 1, 2023: Journal of Medical Case Reports
https://read.qxmd.com/read/37639839/primary-plasmablastic-lymphoma-of-the-gastrointestinal-tract-a-series-of-13-hiv-negative-cases-and-a-review-of-literature
#27
REVIEW
Zhiyan Fu, Haibo Wang, Gregory Y Lauwers, Kun Jiang, Nushani L Jayaratne, Sanjay Bridglal, Ning Dong, Endi Wang, Lugen Chen, Deniz Peker Barclift, Ling Zhang
CONTEXT: Primary gastrointestinal plasmablastic lymphoma (GI-PBL) is a rare variant of diffuse B-cell lymphoma with an aggressive clinical course. PBL was initially reported among HIV-positive patients; however, subsequent studies have shown that it also occurs among HIV-negative patients. Its clinical characteristics remain poorly understood. This study aims to retrospectively analyze the clinicopathological findings of primary GI-PBLs in HIV-negative patients. DESIGN: Primary HIV-negative GI-PBL cases from 2008 to 2022 were reviewed...
December 2023: Annals of Diagnostic Pathology
https://read.qxmd.com/read/37568745/skin-involvement-by-hematological-neoplasms-with-blastic-morphology-lymphoblastic-lymphoma-blastoid-variant-of-mantle-cell-lymphoma-and-differential-diagnoses
#28
REVIEW
Magda Zanelli, Francesca Sanguedolce, Maurizio Zizzo, Valentina Fragliasso, Giuseppe Broggi, Andrea Palicelli, Giuseppe Gaetano Loscocco, Camilla Cresta, Cecilia Caprera, Matteo Corsi, Giovanni Martino, Alessandra Bisagni, Marialisa Marchetti, Nektarios Koufopoulos, Paola Parente, Rosario Caltabiano, Stefano Ascani
Hematological neoplasms sharing a blastic morphology may involve the skin. The skin may be either the primary site of occurrence of hematological malignancies with blastic features or cutaneous lesions are the first manifestation of an underlying systemic malignancy. The assessment of skin biopsies of hematological neoplasms with blastic features poses diagnostic problems and requires expert hematopathologists considering a wide range of differential diagnoses. The precise diagnosis of diseases sharing blastic features but with different outcomes and requiring distinct therapies is essential for patient management...
August 2, 2023: Cancers
https://read.qxmd.com/read/37566952/cytological-features-of-oral-malignant-lymphoma-in-scraping-liquid-based-cytology-cases-of-plasmablastic-lymphoma-and-anaplastic-lymphoma-kinase-positive-anaplastic-large-cell-lymphoma
#29
JOURNAL ARTICLE
Kaori Oya, Yuko Kondo, Mitsunobu Kishino, Satoru Toyosawa
The main purpose of cytological examination in the oral region is to screen for squamous cell carcinoma or intraepithelial neoplasms; thus, the background tends to be considered a deterrent for microscopy. From this perspective, liquid-based cytology (LBC) is favorable for preparing clear samples with few backgrounds. However, background hemocytes are sometimes of critical importance in the diagnosis. We report two cases of oral malignant lymphoma, plasmablastic lymphoma, and anaplastic large cell lymphoma in which careful observation of the background in scraping LBC sample contributed to the early diagnosis...
July 17, 2023: Annals of Diagnostic Pathology
https://read.qxmd.com/read/37561194/lymphomas-with-plasmablastic-features-a-report-of-the-lymphoma-workshop-of-the-20th-meeting-of-the-european-association-for-haematopathology
#30
JOURNAL ARTICLE
Snjezana Dotlic, Sarah E Gibson, Sylvia Hartmann, Eric D Hsi, Monika Klimkowska, Socorro Maria Rodriguez-Pinilla, Elena Sabattini, Thomas A Tousseyn, Daphne de Jong, Stefan Dojcinov
Lymphomas with plasmablastic features are a heterogeneous group of aggressive and mostly uncommon neoplasms of varied aetiologies, presenting in immunocompetent individuals as well as in immunodeficiency, associated with EBV and Kaposi sarcoma virus infections, and some as progression from indolent B-cell lymphomas. They show overlapping diagnostic features and pose a differential diagnosis with other aggressive B-cell lymphomas that can downregulate the B-cell expression programme. The spectrum of rare reactive proliferations and all lymphomas defined by plasmablastic features, together with an expanding range of poorly characterised, uncommon conditions at the interface between reactive lymphoid proliferations and neoplasia submitted to the session V of the 20th European Association for Haematopathology/Society for Hematopathology lymphoma workshop are summarised and discussed in this paper...
August 10, 2023: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/37555981/cavity-based-lymphomas-challenges-and-novel-concepts-a-report-of-the-2022-ea4hp-sh-lymphoma-workshop
#31
JOURNAL ARTICLE
Arianna Di Napoli, Lori Soma, Leticia Quintanilla-Martinez, Laurence de Leval, Lorenzo Leoncini, Alberto Zamò, Siok-Bian Ng, Sarah L Ondrejka, Fina Climent, Andrew Wotherspoon, Stefan Dirnhofer
The 2022 European Association for Haematopathology/Society for Hematopathology lymphoma workshop session on cavity-based lymphomas included sixty-eight cases in seven sections. The disease entities discussed include primary effusion lymphomas (PEL), extracavitary primary effusion lymphomas and confounding entities (ECPEL), HHV8-negative B-lineage lymphomas-effusion based (EBV-negative, EBV-positive, and plasmablastic types), diffuse large B-cell lymphoma associated with chronic inflammation, fibrin-associated diffuse large B-cell lymphoma (FA-DLBCL), breast implant-associated anaplastic large cell lymphoma (BIA-ALCL), and other lymphomas presenting as an effusion...
September 2023: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/37555980/emerging-entities-high-grade-large-b-cell-lymphoma-with-11q-aberration-large-b-cell-lymphoma-with-irf4-rearrangement-and-new-molecular-subgroups-in-large-b-cell-lymphomas-a-report-of-the-2022-ea4hp-sh-lymphoma-workshop
#32
REVIEW
Leticia Quintanilla-Martinez, Camille Laurent, Lorinda Soma, Siok-Bian Ng, Fina Climent, Sarah L Ondrejka, Alberto Zamo, Andrew Wotherspoon, Laurence de Leval, Stefan Dirnhofer, Lorenzo Leoncini
Emerging entities and molecular subgroups in large B-cell lymphomas (LBCLs) were discussed during the 2022 European Association for Haematopathology/Society for Hematopathology workshop in Florence, Italy. This session focused on newly recognized diseases and their diagnostic challenges. High-grade/large B-cell lymphoma with 11q aberration (HG/LBCL-11q) is defined by chromosome 11q-gains and telomeric loss. FISH analysis is recommended for the diagnosis. HG/LBCL-11q can occur in the setting of immunodeficiency, including ataxia-telangiectasia, and predominates in children...
August 9, 2023: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/37541853/from-the-archives-of-md-anderson-cancer-center-plasmablastic-lymphoma-presenting-as-a-kidney-mass-in-an-immunocompetent-patient-case-report-and-literature-review
#33
REVIEW
Rachelle Gietzen, Vidarshi Muthukumarana, Peeyush Bhargava, Dmitrii Vozniuk, Beenu Thakral, L Jeffrey Medeiros, Kirill A Lyapichev
BACKGROUND: Plasmablastic lymphoma (PBL) is a rare, aggressive large B-cell lymphoma with plasmablastic or immunoblastic morphology and a terminally differentiated B-cell immunophenotype. PBL often presents at extranodal sites, commonly the oral cavity of immunocompromised patients with human immunodeficiency virus (HIV) and/or Epstein-Barr virus (EBV) infection. Cases of PBL arising outside the oral cavity in previously healthy immunocompetent patients are rare. CASE REPORT: We report a 65-year-old HIV- and EBV-negative man who presented with abdominal pain, fatigue, and vomiting...
July 29, 2023: Annals of Diagnostic Pathology
https://read.qxmd.com/read/37526395/plasmablastic-lymphoma-in-a-human-immunodeficiency-virus-positive-child-with-a-suspicion-of-concomitant-primary-immunodeficiency-disorder
#34
JOURNAL ARTICLE
Nausheen Yaqoob, Sabiha Anis, Neelum Mansoor, Naema Khayyam, Saba Jamal
Plasmablastic lymphoma (PBL) occurs in the setting of immunodeficiency, in association with human immunodeficiency virus (HIV) infection, in elderly patients, and in the posttransplantation state. It is exceptionally rare in children. PBL is an aggressive lymphoma with a poor prognosis. We present a case of pediatric PBL in an HIV-positive child with suspicion of a concomitant underlying immune deficiency state other than HIV. A 7-year-old girl presented to the pediatric emergency department with complaints of fever and painful swelling on the left side of her face for 15 days, associated with headache, snoring, and difficulty in breathing...
October 1, 2023: Journal of Pediatric Hematology/oncology
https://read.qxmd.com/read/37524252/-unraveling-the-molecular-landscape-a-comparative-analysis-of-pi3k-and-mapk-signaling-pathways-in-plasmablastic-lymphoma-and-diffuse-large-b-cell-lymphoma-with-therapeutic-implications
#35
JOURNAL ARTICLE
Adnan Mansoor, Ariz Akhter, Hamza Kamran, Parham Minoo, Douglas Stewart
Plasmablastic Lymphoma (PBL) is a rare and aggressive subtype of non-Hodgkin Lymphoma that shares features with Diffuse large B-cell Lymphoma (DLBCL). While significant progress has been made in treating DLBCL, the prognosis for PBL remains poor, highlighting the need to identify new therapeutic targets. Using RNA expression analysis, we compared the expression of genes involved in the Phosphatidylinositol-3-kinase (PI3K) and Mitogen-activated protein kinase (MAPK) signaling pathways between PBL and DLBCL. We employed critical PI3K (n=201) and MAPK (n=57) signaling probe sets to achieve this objective...
July 29, 2023: Human Pathology
https://read.qxmd.com/read/37471301/lymphomas-affecting-the-submandibular-glands
#36
JOURNAL ARTICLE
G-R Araújo, A-L Morais-Perdigão, C-V Lopez-de-Cáceres, O-P Almeida, P-A Vargas, E-M Roman-Tager, B-A Andrade, C-D Soares, C-C Ramos, M-M Andrade, A-D Sales, H-A Pontes
BACKGROUND: Lymphomas affecting the submandibular glands are very uncommon and few reports are currently available in the literature. Therefore, the aim of the current study is to describe the clinical and microscopic features of an original series of lymphomas affecting the submandibular glands. MATERIAL AND METHODS: The pathology files of two institutions were searched for lymphoma cases affecting the submandibular glands. The original hematoxylin and eosin, and immunohistochemical slides were revised by a pathologist for diagnosis confirmation following the revised 4th edition of the World Health Organization classification of tumours of haematopoietic and lymphoid tissues...
July 20, 2023: Medicina Oral, Patología Oral y Cirugía Bucal
https://read.qxmd.com/read/37453866/plasmablastic-lymphoma-past-present-and-future
#37
REVIEW
Supreet Kaur, Sudarsan Kollimuttathuillam
Plasmablastic Lymphoma is a rare large B-cell lymphoma with unique immunohistochemical and morphological features. It was most commonly associated with HIV infection; however, it's now seen in other immunosuppressed states like autoimmune conditions, post-transplant settings, and even in elderly immunocompetent individuals. Although rare, it is an aggressive lymphoma with unfavorable outcomes. The aim of this manuscript is to have an in-depth review of the current knowledge of epidemiology, pathophysiology, prognostic markers, and treatment approaches currently in use and in clinical trials for this challenging disease...
June 14, 2023: Clinical Lymphoma, Myeloma & Leukemia
https://read.qxmd.com/read/37449962/plasmablastic-transformation-of-chronic-lymphocytic-leukemia-a-review-of-literature-and-report-on-2-cases
#38
JOURNAL ARTICLE
Anurag Khanna, Bradley R Drumheller, George Deeb, Ethan Wade Tolbert, Saja Asakrah
Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) is the most common leukemia in adults in Western countries. Transformation of CLL/SLL to plasmablastic lymphoma (PBL) is exceedingly rare and often has an extremely poor response to treatment. A thorough molecular workup may help in determining clonality-relatedness and prognosis. We describe two cases of CLL/SLL that transformed into PBL, with an extensive molecular workup in one case, and a review of the literature.
July 14, 2023: Laboratory Medicine
https://read.qxmd.com/read/37425541/clinical-importance-of-differentiating-epstein-barr-virus-ebv-positive-plasmacytoma-from-plasmablastic-lymphoma-another-unique-case-of-ebv-positive-plasmacytoma-in-an-immunocompetent-patient
#39
Adrian M Alonso, Alyssa S Saxton, Rick Y Lin, Eric J Basile, Yu Yang
Epstein-Barr virus (EBV)-positive plasmacytoma is a rare and unique plasma cell neoplasm that could arise in immunocompetent individuals. Given the molecular and immunohistochemical similarity of EBV-positive plasmacytomas to their significantly more aggressive counterpart, plasmablastic lymphoma (PBL), providers must distinguish between the two neoplasms. This case elucidates a presentation of EBV-positive plasmacytomas in a healthy, immunocompetent individual originating in the C4/C5 cervical neck region...
June 2023: Curēus
https://read.qxmd.com/read/37326123/alk-positive-large-b-cell-lymphoma-with-multiple-epithelial-antigen-expression-and-pabpc1-alk-fusion-a-novel-molecular-alteration
#40
JOURNAL ARTICLE
Jian Jeff Fu, Anjali Seth, Nadia Ali, Ashwin Chandar, Ashish Bains
Anaplastic lymphoma kinase (ALK)-positive large B-cell lymphoma (LBCL) is a very rare type of LBCL with an aggressive clinical course and poor prognosis. This diagnosis can be challenging given the varied morphology (immunoblastic, plasmablastic, or anaplastic), frequent lack of B-cell antigens, and especially in cases with expression of epithelial antigens. Here, we report a case of ALK-positive LBCL with unusual expression of 4 epithelial-associated markers (AE1/AE3, CK8/18, EMA, and GATA3) and novel poly(A) binding protein cytoplasmic 1 (PABPC1) :: ALK fusion which has not been previously reported in this entity...
August 1, 2023: American Journal of Surgical Pathology
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