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Eagle criteria

Syabira I Yusoff, Marius Roman, Florence Y Lai, Bryony Eagle, Gavin J Murphy, Tracy Kumar, Marcin Wozniak
The clinical efficacy of organ protection interventions are limited by the redundancy of cellular activation mechanisms. Interventions that target epigenetic mechanisms overcome this by eliciting genome wide changes in transcription and signaling. We aimed to review preclinical studies evaluating the organ protection effects of histone deacetylase inhibitors (HDACi) with a view to informing the design of early phase clinical trials. A systematic literature search was performed. Methodological quality was assessed against prespecified criteria...
November 22, 2018: Translational Research: the Journal of Laboratory and Clinical Medicine
Rafik Shereen, Brady Gardner, Juan Altafulla, Emily Simonds, Joe Iwanaga, Zachary Litvack, Marios Loukas, R Shane Tubbs
INTRODUCTION: Debilitating facial pain can seriously affect an individual's daily living. Given that the pathophysiology behind neuropathic and myofascial pain is not fully understood, when chronic facial pain goes undiagnosed, it has been proposed that one of the two is the likely cause. Since their discovery, glossopharyngeal neuralgia (GN) and Eagle's syndrome have been considered mostly conditions afflicting the adult population. However, when pediatric patients present with symptoms resembling GN or Eagle's syndrome, physicians are less apt to include these as a differential diagnosis simply due to the low prevalence and incidence in the pediatric population...
October 25, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
A Viswanathan, T Leffler, N Paloian, M Cain, P H McKenna
INTRODUCTION: Management of severe antenatally detected oligohydramnios with and without obstruction is improving with the result that more fetuses are surviving with early renal failure. Significant advances have occurred in all specialties involved in the management of these patients. All these specialties working together have resulted in the survival of more patients born with renal failure. OBJECTIVE: The aim of this study is to highlight the medical advances in antenatal management of fetal oligohydramnios and pulmonary hypoplasia and to demonstrate that transplantation into a diverted urinary system is safe and leads to good outcomes...
August 8, 2018: Journal of Pediatric Urology
Mauro Cerea, Giorgio Andrea Dolcini
Purpose: To present a digital technique for the fabrication of custom-made subperiosteal implants and to report on the survival and complication rates encountered when using these fixtures. Methods: The data used for this retrospective clinical study were derived from the medical records of five different private dental practices. Inclusion criteria were patients over the age of 60, treated with custom-made direct metal laser sintering (DMLS) titanium subperiosteal implants (Eagle-Grid®, BTK, Dueville, Vicenza) during a two-year period (2014-2015) and restored with fixed restorations; all enrolled patients needed to have complete pre- and postoperative clinical and radiographic documentation, with at least 2 years of follow-up...
2018: BioMed Research International
Jurij R Bilyk, Ann P Murchison, Benjamin T Leiby, Robert C Sergott, Ralph C Eagle, Laurence Needleman, Peter J Savino
Purpose: To evaluate the diagnostic yield and concordance of color duplex ultrasound (CDU) of the superficial temporal artery (STA), temporal artery biopsy (TAB), and American College of Rheumatology (ACR) criteria in the diagnosis of giant cell arteritis (GCA). Methods: Prospective, masked study of all patients evaluated in one institution suspected of having GCA. All patients with a suspected diagnosis of GCA were admitted for pulsed intravenous corticosteroids...
August 2017: Transactions of the American Ophthalmological Society
Denis Zofou, Fanny Fri Fombad, Narcisse V T Gandjui, Abdel Jelil Njouendou, Arnaud Jonas Kengne-Ouafo, Patrick W Chounna Ndongmo, Fabrice R Datchoua-Poutcheu, Peter A Enyong, Dizzle Tayong Bita, Mark J Taylor, Joseph D Turner, Samuel Wanji
BACKGROUND: Suitable and scalable in vitro culture conditions for parasite maintenance are needed to foster drug research for loiasis, one of the neglected tropical diseases which has attracted only limited attention over recent years, despite having important public health impacts. The present work aims to develop adequate in vitro culture systems for drug screening against both microfilariae (mf) and infective third-stage larvae (L3) of Loa loa. METHODS: In vitro culture conditions were evaluated by varying three basic culture media: Roswell Park Memorial Institute (RPMI-1640), Dulbecco's modified Eagle's medium (DMEM) and Iscove's modified Dulbecco's medium (IMDM); four sera/proteins: newborn calf serum (NCS), foetal bovine serum (FBS), bovine serum albumin (BSA) and the lipid-enriched BSA (AlbuMax® II, ALB); and co-culture with the Monkey Kidney Epithelial Cell line (LLC-MK2) as a feeder layer...
May 2, 2018: Parasites & Vectors
James Robertson, Catherine Yoshida, Peter Kruczkiewicz, Celine Nadon, Anil Nichani, Eduardo N Taboada, John Howard Eagles Nash
Public health and food safety institutions around the world are adopting whole genome sequencing (WGS) to replace conventional methods for characterizing Salmonella for use in surveillance and outbreak response. Falling costs and increased throughput of WGS have resulted in an explosion of data, but questions remain as to the reliability and robustness of the data. Due to the critical importance of serovar information to public health, it is essential to have reliable serovar assignments available for all of the Salmonella records...
January 17, 2018: Microbial Genomics
Arthur Darmon, Deepak L Bhatt, Yedid Elbez, Victor Aboyans, Sonia Anand, Jackie Bosch, Kelley R Branch, Stuart J Connolly, Leanne Dyal, John W Eikelboom, Keith A A Fox, Katalin Keltai, Jeffrey Probstfield, Salim Yusuf, Jérémie Abtan, Emmanuel Sorbets, Kim A Eagle, Gregory Ducrocq, Philippe Gabriel Steg
Aims: The aims of the present study were to describe the proportion of patients eligible for the COMPASS trial within the Reduction of Atherothrombosis for Continued Health (REACH) registry, the reasons for ineligibility, and to put in perspective the characteristics and outcomes of trial-eligible patients from the REACH registry compared with those of patients enrolled in the reference aspirin arm of the COMPASS trial. Methods and results: The COMPASS selection and exclusion criteria were applied to REACH patients with either coronary artery disease (CAD) or peripheral artery disease (PAD)...
March 1, 2018: European Heart Journal
Debra Eagles, Krishan Yadav, Jeffrey J Perry, Marie Josée Sirois, Marcel Emond
OBJECTIVES: We wished to determine the impact of emergency department (ED) mobility assessments for older patients on hospitalization, return visits, future falls, and frailty. METHODS: We searched MEDLINE, Embase, CINAHL, Cochrane Library, PEDro, and OTseeker (September 2016). Two independent reviewers identified studies of patients ≥65 years with ED physical mobility assessments and outcomes of hospitalization, return to ED, falls, and frailty. Language was not restricted...
May 2018: CJEM
Anubodh Varshney, Ph Gabriel Steg, Yedid Elbez, Emmanuel Sorbets, Kim A Eagle, Deepak L Bhatt
BACKGROUND: The optimal blood pressure (BP) target to reduce the risk of cardiovascular (CV) events remains uncertain, especially in patients with coronary artery disease (CAD). Results from the Systolic Blood Pressure Intervention Trial (SPRINT) suggest that targeting a systolic BP<120mmHg decreases the rate of death and CV events in patients with hypertension and increased CV risk. We sought to evaluate the real-world applicability of SPRINT to patients with atherothrombosis. METHODS: We divided 35,411 hypertensive patients from the REACH registry into SPRINT-eligible and SPRINT-ineligible based on the trial's inclusion and exclusion criteria...
September 15, 2017: International Journal of Cardiology
Jens Frank, Ann Eklund
Large carnivore conservation may be considered as successful in Sweden, as wolf (Canis lupus), lynx (Lynx lynx), brown bear (Ursus arctos), golden eagles (Aquila chrysaetos), and wolverine (Gulo gulo) populations have recovered from extinction or near extinction to viable populations during the last three decades. Particularly the wolf and lynx populations have returned at the cost of an increasing number of carnivore attacks on domestic livestock. To support coexistence between carnivores and livestock production, the Swedish authorities subsidise interventions to prevent or reduce the number of carnivore attacks...
2017: PloS One
Arnoud V Kamman, Frederik H W Jonker, Udo Sechtem, Kevin M Harris, Arturo Evangelista, Daniel G Montgomery, Himanshu J Patel, Kim A Eagle, Santi Trimarchi
BACKGROUND: We aimed to identify predictors of stable aortic dimensions in medically managed type B aortic dissections (TBAD). METHODS: Medically managed TBAD patients from the International Registry of Acute Aortic Dissection with available aortic measurements at up to 24 months were included. Growth rate was calculated by dividing the largest descending diameter at the latest end point not influenced by intervention minus initial descending diameter, by the recorded time interval...
July 2017: Annals of Vascular Surgery
Firas F Mussa, Joseph S Coselli, Kim A Eagle
The trial we propose will be the first multicenter, randomized, trial investigating the role of thoracic endovascular aortic repair (TEVAR) of uncomplicated type B aortic dissection (TBAD) compared to conservative (medical) management. To document the current management approaches for uncomplicated TBAD, we performed an international survey in 130 centers (in US and worldwide), of whom 114 (89%) responded. Sixty-three (54.8%) respondents do not routinely stent uncomplicated TBAD, and 43 (37.4%) perform TEVAR based on various imaging criteria...
November 2016: American Heart Journal
Singh Abha, Shrivastava Chandrashekhar, Dube Sonal
BACKGROUND: MMR has always been recognized as an important indicator of quality of health services. The MMR in India has so far not reached up to the required MDG 2015. If we look into this matter with the eagle's eye view, then there are certain gray areas which need attention. For this, it is not the maternal mortality but the maternal near miss which has to be focused. OBJECTIVES: To audit the maternal near miss in our institution and to review the pathways that lead to severe maternal morbidity and death...
October 2016: Journal of Obstetrics and Gynaecology of India
Woo-Ho Kim, Lourdes Gomez-Izquierdo, Felip Vilardell, Kent-Man Chu, Geneviève Soucy, Lucas V Dos Santos, Geneviève Monges, Giuseppe Viale, Maria José Brito, Stuart Osborne, Johannes Noé, Xiang Du
Human epidermal growth factor receptor 2 (HER2) dysregulation is associated with tumorigenesis in gastric/gastroesophageal junction cancer; however, the number of patients with HER2-positive disease is unclear, possibly due to differing scoring criteria/assays. Data are also lacking for early disease. We aimed to assess the HER2-positivity rate using approved testing criteria in a large, real-life multinational population. HER2-positivity was defined as an immunohistochemistry staining score of 3+, or immunohistochemistry 2+ and HER2 amplification detected by in situ hybridization...
April 2018: Applied Immunohistochemistry & Molecular Morphology: AIMM
Jonathan W Weinsaft, Richard B Devereux, Liliana R Preiss, Attila Feher, Mary J Roman, Craig T Basson, Alexi Geevarghese, William Ravekes, Harry C Dietz, Kathryn Holmes, Jennifer Habashi, Reed E Pyeritz, Joseph Bavaria, Karianna Milewski, Scott A LeMaire, Shaine Morris, Dianna M Milewicz, Siddharth Prakash, Cheryl Maslen, Howard K Song, G Michael Silberbach, Ralph V Shohet, Nazli McDonnell, Tabitha Hendershot, Kim A Eagle, Federico M Asch
BACKGROUND: Aortic dissection (AoD) is a serious complication of thoracic aortic aneurysm (TAA). Relative risk for AoD in relation to TAA etiology, incidence, and pattern after prophylactic TAA surgery are poorly understood. OBJECTIVES: This study sought to determine the incidence, pattern, and relative risk for AoD among patients with genetically associated TAA. METHODS: The population included adult GenTAC participants without AoD at baseline...
June 14, 2016: Journal of the American College of Cardiology
Julie A Beston, Jay E Diffendorfer, Scott R Loss, Douglas H Johnson
Recent growth in the wind energy industry has increased concerns about its impacts on wildlife populations. Direct impacts of wind energy include bird and bat collisions with turbines whereas indirect impacts include changes in wildlife habitat and behavior. Although many species may withstand these effects, species that are long-lived with low rates of reproduction, have specialized habitat preferences, or are attracted to turbines may be more prone to declines in population abundance. We developed a prioritization system to identify the avian species most likely to experience population declines from wind facilities based on their current conservation status and their expected risk from turbines...
2016: PloS One
Morten Juhl, Josefine Tratwal, Bjarke Follin, Rebekka H Søndergaard, Maria Kirchhoff, Annette Ekblond, Jens Kastrup, Mandana Haack-Sørensen
BACKGROUND: The utility of mesenchymal stromal cells (MSCs) in therapeutic applications for regenerative medicine has gained much attention. Clinical translation of MSC-based approaches requires in vitro culture-expansion to achieve a sufficient number of cells. The ideal cell culture medium should be devoid of any animal derived components. We have evaluated whether human Platelet Lysate (hPL) could be an attractive alternative to animal supplements. METHODS: MSCs from bone marrow (BMSCs) and adipose tissue-derived stromal cells (ASCs) obtained from three donors were culture expanded in three different commercially available hPL fulfilling good manufacturing practice criteria for clinical use...
2016: Scandinavian Journal of Clinical and Laboratory Investigation
Alexander Neale Eagles, Mark Gregory Leigh Sayers, Matthew Bousson, Dale Ingham Lovell
BACKGROUND: The vertical jump (VJ) is considered a key indicator of lower limb explosive strength. Previous research has established that rate of force development and time to peak force are linked closely to athletic ability and hence the ability to extract these accurately is of significance. OBJECTIVES: The objectives of this study were to (1) review the literature to ascertain what methods are currently used to extract jump phases from the force platform data and (2) compare identified methods on neutral data...
September 2015: Sports Medicine
Haw Yen, Ryan T Bailey, Mazdak Arabi, Mehdi Ahmadi, Michael J White, Jeffrey G Arnold
Watershed models typically are evaluated solely through comparison of in-stream water and nutrient fluxes with measured data using established performance criteria, whereas processes and responses within the interior of the watershed that govern these global fluxes often are neglected. Due to the large number of parameters at the disposal of these models, circumstances may arise in which excellent global results are achieved using inaccurate magnitudes of these "intra-watershed" responses. When used for scenario analysis, a given model hence may inaccurately predict the global, in-stream effect of implementing land-use practices at the interior of the watershed...
September 2014: Journal of Environmental Quality
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