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Cardiovascular diagnosis

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https://read.qxmd.com/read/30892701/noncancer-mortality-among-adolescents-and-young-adults-with-cancer
#1
Chelsea Anderson, Jennifer L Lund, Mark A Weaver, William A Wood, Andrew F Olshan, Hazel B Nichols
BACKGROUND: Relative to the general population, cancer patients and survivors may have an elevated risk of mortality from noncancer causes, such as cardiovascular disease and infections, but few studies have examined rates of noncancer mortality among patients diagnosed as adolescents and young adults (AYAs) (ages 15-39 years). METHODS: The Surveillance, Epidemiology, and End Results database was used to identify AYA patients who were diagnosed with a first malignant cancer between 1973 and 2015...
March 20, 2019: Cancer
https://read.qxmd.com/read/30892234/point-of-care-testing-devices-for-heart-failure-analyzing-blood-and-saliva-samples
#2
Evanthia Eleftherios Tripoliti, Penelope Ioannidou, Petros Toumpaniaris, Aidonis Rammos, Dominique Pacitto, Jean-Christophe Lourme, Yorgos Goletsis, Katerina K Naka, Abdelhamid Errachid, Dimitrios I I Fotiadis
Heart failure (HF) is the most rapidly growing cardiovascular condition with an estimated prevalence of >37.7 million individuals globally. HF is associated with increased mortality and morbidity and confers a substantial burden, in terms of cost and quality of life, for the individuals and the healthcare systems, highlighting thus the need for early and accurate diagnosis of HF. The accuracy of HF diagnosis, severity estimation and prediction of adverse events has been improved by the utilization of blood tests measuring biomarkers...
March 18, 2019: IEEE Reviews in Biomedical Engineering
https://read.qxmd.com/read/30890578/rates-of-cardiac-rhythm-abnormalities-in-patients-with-ckd-and-diabetes
#3
Nazem Akoum, Leila R Zelnick, Ian H de Boer, Irl B Hirsch, Dace Trence, Connor Henry, Nicole Robinson, Nisha Bansal
BACKGROUND AND OBJECTIVES: Cardiac arrhythmias increase mortality and morbidity in CKD. We evaluated the rates of subclinical arrhythmias in a population with type 2 diabetes and patients with moderate to severe CKD who were not on dialysis. DESIGN, SETTING, PARTICIPANTS & MEASUREMENTS: This is a prospective observational study, using continuous ambulatory cardiac monitors to determine the rate of atrial and ventricular arrhythmias, as well as conduction abnormalities in this group...
March 19, 2019: Clinical Journal of the American Society of Nephrology: CJASN
https://read.qxmd.com/read/30890169/weight-change-and-mortality-and-cardiovascular-outcomes-in-patients-with-new-onset-diabetes-mellitus-a-nationwide-cohort-study
#4
Mee Kyoung Kim, Kyungdo Han, Eun Sil Koh, Eun Sook Kim, Min-Kyung Lee, Ga Eun Nam, Hyuk-Sang Kwon
BACKGROUND: Because weight control is a cornerstone of diabetes management, it is important to understand the relationship of weight change to risk of cardiovascular disease (CVD) among patients with type 2 diabetes mellitus (DM). We aimed to investigate whether changes in weight early after diagnosis influence the incidence of CVD and all-cause mortality in patients with type 2 DM. METHODS: Using nationally representative data from the Korean National Health Insurance System, 173,246 subjects with new-onset DM who underwent health examinations during 2007-2012 were included...
March 19, 2019: Cardiovascular Diabetology
https://read.qxmd.com/read/30889974/apolipoprotein-profiling-as-a-personalized-approach-to-the-diagnosis-and-treatment-of-dyslipidaemia
#5
L Renee Ruhaak, Arnoud van der Laarse, Christa M Cobbaert
An elevated low-density lipoprotein cholesterol concentration is a classical risk factor for cardiovascular disease. This has led to pharmacotherapy in patients with atherosclerotic heart disease or high heart disease risk with statins to reduce serum low-density lipoprotein cholesterol. Even in patients in whom the target levels of low-density lipoprotein cholesterol are reached, there remains a significant residual cardiovascular risk; this is due, in part, to a focus on low-density lipoprotein cholesterol alone and neglect of other important aspects of lipoprotein metabolism...
March 19, 2019: Annals of Clinical Biochemistry
https://read.qxmd.com/read/30889791/the-epidemiology-risk-profiling-and-diagnostic-challenges-of-nonalcoholic-fatty-liver-disease
#6
REVIEW
Umair Iqbal, Brandon J Perumpail, Daud Akhtar, Donghee Kim, Aijaz Ahmed
Nonalcoholic fatty liver disease (NAFLD) encompasses a wide spectrum of liver damage from the more prevalent (75%⁻80%) and nonprogressive nonalcoholic fatty liver (NAFL) category to its less common and more ominous subset, nonalcoholic steatohepatitis (NASH). NAFLD is now the most common cause of chronic liver disease in the developed world and is a leading indication for liver transplantation in United States (US). The global prevalence of NAFLD is estimated to be 25%, with the lowest prevalence in Africa (13...
March 18, 2019: Medicines (Basel, Switzerland)
https://read.qxmd.com/read/30889217/diagnosing-cardiovascular-disease-in-western-lowland-gorillas-gorilla-gorilla-gorilla-with-brain-natriuretic-peptide
#7
Suzan Murray, Jennifer C Kishbaugh, Lee-Ann C Hayek, Ilana Kutinsky, Patricia M Dennis, William Devlin, Katharine L Hope, Marietta D Danforth, Hayley W Murphy
Cardiovascular disease is a leading cause of death in zoo-housed great apes, accounting for 41% of adult gorilla death in North American zoological institutions. Obtaining a timely and accurate diagnosis of cardiovascular disease in gorillas is challenging, relying on echocardiography which generally requires anesthetic medications that may confound findings and can cause severe side effects in cardiovascularly compromised animals. The measurement of brain natriuretic peptide (BNP) has emerged as a modality of interest in the diagnosis, prognosis and treatment of human patients with heart failure...
2019: PloS One
https://read.qxmd.com/read/30887129/ultrasound-molecular-imaging-principles-and-applications-in-cardiovascular-medicine
#8
REVIEW
Eran Brown, Jonathan R Lindner
PURPOSE OF REVIEW: Non-invasive molecular imaging is currently used as a research technique to better understand disease pathophysiology. There are also many potential clinical applications where molecular imaging may provide unique information that allows either earlier or more definitive diagnosis, or can guide precision medicine-based decisions on therapy. Contrast-enhanced ultrasound (CEU) with targeted microbubble contrast agents is one such technique that has been developed that has the unique properties of providing rapid information and revealing information only on events that occur within the vascular space...
March 18, 2019: Current Cardiology Reports
https://read.qxmd.com/read/30885856/igg4-related-sclerosing-pericarditis-in-a-young-male-with-recurrent-chest-pain
#9
Usama Yassi, Fatima Iqbal, Heather L Stevenson
Many cases of immunoglobulin G4-related disease (IgG4-RD) involving different organ systems have been reported in the literature since it was first described in patients with sclerosing pancreatitis. We report an interesting case of IgG4-related cardiovascular disease that involved the pericardium and resulted in reoccurring chest pain in a 36 year-old male. The challenging diagnosis was made using established diagnostic criteria for other tissue sites and included the presence of elevated serum IgG4, pericardial infiltration by IgG4+ plasma cells, focal phlebitis, and fibrosis...
March 15, 2019: Annals of Thoracic Surgery
https://read.qxmd.com/read/30885171/hyperuricemia-and-its-related-histopathological-features-on-renal-biopsy
#10
Shulei Fan, Ping Zhang, Amanda Ying Wang, Xia Wang, Li Wang, Guisen Li, Daqing Hong
BACKGROUND: Hyperuricemia (HUA) is very common in chronic kidney disease (CKD). HUA is associated with an increased risk of cardiovascular events and accelerates the progression of CKD. Our study aimed to explore the relationship between baseline serum uric acid levels and renal histopathological features. METHODS: One thousand seventy patients receiving renal biopsy in our center were involved in our study. The baseline characteristics at the time of the kidney biopsy were collected from Renal Treatment System (RTS) database, including age, gender, serum uric acid (UA), glomerular filtration rate (eGFR), serum creatinine (Cr), urea, albumin (Alb), 24 h urine protein quantitation (24 h-u-pro) and blood pressure (BP)...
March 18, 2019: BMC Nephrology
https://read.qxmd.com/read/30878415/meta-analysis-of-the-prognostic-role-of-late-gadolinium-enhancement-and-global-systolic-impairment-in-left-ventricular-noncompaction
#11
Chrysanthos Grigoratos, Andrea Barison, Alexander Ivanov, Daniele Andreini, Mihaela-Silvia Amzulescu, Lukasz Mazurkiewicz, Antonio De Luca, Jacek Grzybowski, Pier Giorgio Masci, Magdalena Marczak, John F Heitner, Juerg Schwitter, Bernhard L Gerber, Michele Emdin, Giovanni Donato Aquaro
OBJECTIVES: The objective of this meta-analysis was to assess the predictive value of late gadolinium enhancement (LGE) and global systolic impairment for future major adverse cardiovascular events in left ventricular noncompaction (LVNC). BACKGROUND: The prognosis of patients with LVNC, with and without left ventricular dysfunction and LGE, is still unclear. METHODS: A systematic review of published research and a meta-analysis reporting a combined endpoint of hard (cardiac death, sudden cardiac death, appropriate defibrillator firing, resuscitated cardiac arrest, cardiac transplantation, assist device implantation) and minor (heart failure hospitalization and thromboembolic events) events was performed...
March 8, 2019: JACC. Cardiovascular Imaging
https://read.qxmd.com/read/30878394/molecular-and-clinical-implications-of-natriuretic-peptides-in-aortic-valve-stenosis
#12
REVIEW
Giovanna Gallo, Vivianne Presta, Massimo Volpe, Speranza Rubattu
Aortic valve stenosis (AS) is the most common heart valve disease in North America and Europe leading to an increased risk of heart failure and death. A multidisciplinary evaluation of symptoms, individual risk profile, echocardiographic parameters, biomarkers assessment is required for an appropriate clinical and therapeutic management of AS. The natriuretic peptides (NPs) represent an important biomarker for diagnostic, prognostic and therapeutic purposes in several cardiovascular diseases. The present review article provides an overview of the current knowledge on the role of NPs in the pathogenesis, diagnosis, risk stratification and potential therapeutic implications in AS...
March 13, 2019: Journal of Molecular and Cellular Cardiology
https://read.qxmd.com/read/30877235/review-of-the-scientific-evolution-of-gene-therapy-for-the-treatment-of-homozygous-familial-hypercholesterolaemia-past-present-and-future-perspectives
#13
Ricardo Rodriguez-Calvo, Luis Masana
Familial hypercholesterolaemia (FH) is a devastating genetic disease that leads to extremely high cholesterol levels and severe cardiovascular disease, mainly caused by mutations in any of the main genes involved in low-density lipoprotein cholesterol (LDL-C) uptake. Among these genes, mutations in the LDL receptor ( LDLR ) are responsible for 80%-90% of the FH cases. The severe homozygous variety (HoFH) is not successfully treated with standard cholesterol-lowering therapies, and more aggressive strategies must be considered to mitigate the effects of this disease, such as weekly/biweekly LDL apheresis...
March 15, 2019: Journal of Medical Genetics
https://read.qxmd.com/read/30877220/acute-coronary-syndrome-in-idiopathic-inflammatory-myopathies-a-population-based-study
#14
Valérie Leclair, John Svensson, Ingrid E Lundberg, Marie Holmqvist
OBJECTIVE: Evidence suggest an increased risk of cardiovascular diseases including acute coronary syndrome (ACS) in idiopathic inflammatory myopathies (IIM). The aim of this study was to investigate the risk of ACS in an incident IIM cohort compared to the general Swedish population. METHODS: A cohort of 655 incident IIM individuals and 6813 general population comparators were identified from national registries. IIM subjects were diagnosed from 2002 to 2011. Followup started at IIM diagnosis and corresponding date in the general population...
March 15, 2019: Journal of Rheumatology
https://read.qxmd.com/read/30877213/increased-risk-of-ischemic-stroke-in-systemic-sclerosis-a-national-cohort-study-of-us-veterans
#15
David Ying, Milena A Gianfrancesco, Laura Trupin, Jinoos Yazdany, Eric Greidinger, Gabriela Schmajuk
OBJECTIVE: Previously thought to involve primarily the microvasculature, systemic sclerosis (SSc) has been increasingly linked to macrovascular disease. Cardiovascular and cerebrovascular disease are responsible for 20-30% of mortality in SSc, but few studies have shown an independent association between SSc and stroke. In this study, we assessed whether SSc was an independent risk factor for ischemic stroke. METHODS: We conducted a retrospective cohort study using the national Veterans Affairs administrative database containing records from 1999 to 2014...
March 15, 2019: Journal of Rheumatology
https://read.qxmd.com/read/30876612/current-concepts-in-hemodialysis-vascular-access-infections
#16
REVIEW
Lalathaksha Kumbar, Jerry Yee
Infection-related causes are second only to cardiovascular events for mortality among end-stage renal disease patients. This review will provide an overview of hemodialysis catheter-, graft-, and fistula-related infections with emphasis on diagnosis and management in specific settings. Use of catheters at the initiation of dialysis has remained unchanged at 80%. Of all access-related bloodstream infections (BSIs), 70% occur in patients with catheters. The risk factors for BSIs in tunneled, cuffed catheters include the duration of the catheter, past catheter-related bacteremia, left-sided internal jugular vein catheters, hypoalbuminemia, and immunosuppression...
January 2019: Advances in Chronic Kidney Disease
https://read.qxmd.com/read/30876531/investigating-the-association-between-familial-hypercholesterolemia-and-perceived-depression
#17
Nien-Tzu Chang, Ta-Chen Su
BACKGROUND AND AIMS: Inherited familial hypercholesterolemia (FH) increases cardiovascular risks, but perceived depression in FH is unknown. This study aims to explore the association between the FH and perceived depression. METHODS: This study was a hospital-based design, we started to recruit clinical diagnosis of phenotypic FH since 2014 for the Ten Countries Study in the Asia-Pacific region. We consecutively recruited 302 FH patients and other 414 comparison subjects (214 subjects with hypertriglyceridemia and 200 subjects with normal lipid controls) from the special lipid clinic of National Taiwan University Hospital, Taipei...
March 2019: Atherosclerosis. Supplements
https://read.qxmd.com/read/30876527/familial-hypercholesterolemia-in-china-half-a-century-a-review-of-published-literature
#18
Jie Peng, Xue Wu, Shilong Wang, Shuang Zhang, Xumin Wang, Zesen Liu, Jing Hong, Pucong Ye, Jie Lin
AIMS: To investigate the status of familial hypercholesterolemia (FH) research and the characteristics of patients with FH in China. METHODS: Published papers in Chinese or English language from PubMed, SinoMed and CNKI databases from 1971 to March 2018 were searched using 'Familial hypercholesterolemia', 'Chinese' and 'Han' as keywords. A systematic review of studies on familial hypercholesterolemia was then conducted. RESULTS: A total of 391 articles were found, in which 22% were in English and 78% were in Chinese; approximately 43% are case reports and 34% are genetic reports according to the study type; 52% discussed the status of the disease and 11% investigated the subclinical status according to the study content...
March 2019: Atherosclerosis. Supplements
https://read.qxmd.com/read/30876393/long-term-statin-adherence-in-patients-after-hospital-discharge-for-new-onset-of-atherosclerotic-cardiovascular-disease-a-population-based-study-of-real-world-prescriptions-in-taiwan
#19
Shu-Ting Chen, Shih-Ting Huang, Wen-Yi Shau, Chao-Lun Lai, Jim Z Li, Selwyn Fung, Vicki C Tse, Mei-Shu Lai
BACKGROUND: Despite the recommendations of statins treatment for secondary prevention of atherosclerotic cardiovascular disease (ASCVD), treatment adherence and persistence are still a concern. This study examined the real world practice of long-term adherence and persistence to statins treatment initiated after hospital discharge for ASCVD, and their associated factors in a nationwide cohort. METHODS: Post discharge statin prescriptions between 2006 and 2012 were extracted from the Taiwan National Health Insurance claims database...
March 15, 2019: BMC Cardiovascular Disorders
https://read.qxmd.com/read/30873600/molecular-imaging-of-the-heart
#20
Nabil E Boutagy, Attila Feher, Imran Alkhalil, Nsini Umoh, Albert J Sinusas
Multimodality cardiovascular imaging is routinely used to assess cardiac function, structure, and physiological parameters to facilitate the diagnosis, characterization, and phenotyping of numerous cardiovascular diseases (CVD), as well as allows for risk stratification and guidance in medical therapy decision-making. Although useful, these imaging strategies are unable to assess the underlying cellular and molecular processes that modulate pathophysiological changes. Over the last decade, there have been great advancements in imaging instrumentation and technology that have been paralleled by breakthroughs in probe development and image analysis...
March 14, 2019: Comprehensive Physiology
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