One pot synthesis of core shell nanoparticles

Photoacoustic (PA) imaging is a diagnostic modality that combines the high contrast resolution of optical imaging with the high tissue penetration of ultrasound. While certain endogenous chromophores can be visualized via PA imaging, many diagnostic assessments require the administration of external probes. Anisotropic gold nanoparticles are particularly valued as contrast agents, since they produce strong PA signals and do not photobleach. However, the synthesis of anisotropic nanoparticles typically requires cytotoxic reagents, which can hinder their biological application...

Nanozymes with core@shell nanostructure are considered promising biolabeling materials for their multifunctional properties. In this work, a simple one-pot strategy has been proposed for scalable synthesis of gold@cerium dioxide core@shell nanoparticles (Au@CeO2 NPs) with strong localized surface plasmon resonance (LSPR) absorption and high peroxidase-like catalytic activity by redox reactions of Ce3+ ions and AuCl4 - ions in diluted ammonia solution under room temperature. A colorimetric lateral flow immunochromatographic assay (LFIA) has been successfully fabricated for sensitive detection of heart-type fatty acid binding protein (H-FABP, an early cardiac biomarker) by using the Au@CeO2 NPs as reporters...

Chemophotothermal therapy is an emerging treatment for metastatic and drug resistant cancer anomalies. Among various photothermal agents tested, polydopamine provides an excellent biocompatible alternative that can be used to develop novel drug delivery carriers for cancer treatment. This study explores the synthesis of starch encapsulated, polydopamine coated core-shell nanoparticles, in a one pot synthesis approach and by surfactant free approach. The nanoparticles produced are embellished with polymeric stealth coatings and are tested for their physiological stability, photothermal properties, and drug delivery in metastatic triple negative breast cancer cell (TNBC) lines...

Interest in SnS-based quantum dots (QDs) has increased due to their low toxicity, widespread natural availability, and superior electro-optical characteristics suitable for photodegradation applications. Herein, we report the synthesis of SnS-based QDs using thiourea and tin (II)chloride as salt precursors. The study explored the impact of various synthetic parameters such as pH, capping ligand, Sn:S ratio, reaction solvent, and ZnS shell on the optical characteristics of the synthesized QDs. The optimal QDs properties were observed at pH = 3 and Sn:S ratio = 1:1...

Selective oxidation of ethylbenzene to acetophenne is an important process in both organic synthesis and fine chemicals diligence. The cobalt-based catalysts combined with nitrogen-doped carbon have received great attention in ethylbenzene (EB) oxidation. Here, a series of cobalt catalysts with metallic cobalt nanoparticles (NPs) encapsulated in nitrogen-doped graphite-like carbon shells (Co@NC) have been constructed through the one-pot pyrolysis method in the presence of different nitrogen-containing compounds (urea, dicyandiamide and melamine), and their catalytic performance in solvent-free oxidation of EB with tert-butyl hydrogen peroxide (TBHP) as an oxidant was investigated...

We synthesized a stable and reusable Schiff base complex of copper immobilized on core-shell magnetic nanoparticles [Cu(II)-SB/GPTMS@SiO2 @Fe3 O4 ] with simple, efficient, and available materials. A variety of characterization analyses including Fourier transform infrared (FT-IR), X-ray photoelectron spectroscopy (XPS), field-emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), Brunauer-Emmett-Teller (BET), thermogravimetric analysis (TGA), X-ray diffraction (XRD), vibrating-sample magnetometry (VSM), energy-dispersive X-ray spectrometry (EDX), and inductively coupled plasma (ICP) confirm that our synthesized nanocatalyst was obtained...

Core@shell nanoparticles (NPs) have been widely explored to enhance catalysis due to the synergistic effects introduced by their nanoscale interface and surface structures. However, creating a catalytically functional core@shell structure is often a synthetic challenge due to the need to control the shell thickness. Here, we report a one-step synthetic approach to core-shell CuPd@Pd NPs with an intermetallic B2-CuPd core and a thin (∼0.6 nm) Pd shell. This core@shell structure shows enhanced activity toward selective hydrogenation of Ar-NO2 and allows one-pot tandem hydrogenation of Ar-NO2 to Ar-NH2 and its condensation with Ar-CHO to form Ar-N═CH-Ar...

Gold nanoclusters (AuNCs) with fluorescence in the Near Infrared (NIR) by both one- and two-photon electronic excitation were incorporated in mesoporous silica nanoparticles (MSNs) using a novel one-pot synthesis procedure where the condensation polymerization of alkoxysilane monomers in the presence of the AuNCs and a surfactant produced hybrid MSNs of 49 nm diameter. This method was further developed to prepare 30 nm diameter nanocomposite particles with simultaneous NIR fluorescence and superparamagnetic properties, with a core composed of superparamagnetic manganese (II) ferrite nanoparticles (MnFe2 O4 ) coated with a thin silica layer, and a shell of mesoporous silica decorated with AuNCs...

In the research, the core-shell procedure synthesized a novel magnetically separable heterogeneous nanocatalyst with high stability named Fe3 O4 @CPTMO@dithizone-Ni. In this method, Fe3 O4 was modified as a magnetic core using surfactant (SDS) and polyethylene glycol (PEG) coating; after functionalizing the magnetic nanoparticles with 3-chloropropyl-tri-methoxysilane and dithizone, Ni metal was immobilized. The prepared catalyst was identified and specified utilizing diverse physicochemical techniques involving FT-IR, XRD, SEM, EMA, BET, ICP, EDS, TGA, Raman, and TEM...

A green, mild and eco-friendly approach for the three component one-pot regioselective synthesis of 1,2,3-triazoles from thiiranes has been introduced in the presence of NiFe2 O4 @SiO2 -Cu as a new and recoverable nanocatalyst. First, the NiFe2 O4 nanoparticles have been produced through a solid-state reaction of hydrated nickel sulfate, hydrated iron(iii) nitrate, NaOH and NaCl salts, and then calcined at 700 °C. Next, in order to protect the ferrite particles from oxidation and aggregation, the NiFe2 O4 was core-shelled using tetraethyl orthosilicate (TEOS) and converted to NiFe2 O4 @SiO2 ...

High-sensitivity C-reactive protein (hs-CRP) is an inflammatory biomarker and can accurately predict the development of cardiovascular disease (CVD). We synthesized a core-shell structure PPy-Au nanocomposite in situ by chemically oxidizing pyrrole (Py) with HAuCl4 and the produced Au nanoparticles realized the doping in the polymerization. Analysis of morphology and energy spectrum as well as electrochemical characterization confirmed the successful one-pot synthesis. The conductive polymers with porous structure provide abundant sites for anti-CRP binding and effectively enhanced the sensitivity of the label-free BSA/anti-CRP/PPy-Au/GCE immunosensor...

Detection of cardiac troponin I (cTnI) plays a critical role in diagnosing acute myocardial infarction (AMI). In this report, a new kind of spherical AuPt@Fex Oy core@shell nanoparticles (termed as AuPt@Fex Oy NPs) were one-pot synthesized by a redox interaction-engaged strategy (RIES) without the addition of any surfactants or reducing agents. The as-synthesized AuPt@Fex Oy NPs not only retain the plasmonic activity of gold nanoparticles (AuNPs), but also possess excellent catalytic activities of platinum nanoparticles (PtNPs) and Fex Oy nanoclusters...

Diabetic wounds represent a major issue in medical care and need advanced therapeutic and tissue imaging systems for better management. The utilization of nano-formulations involving proteins like insulin and metal ions plays significant roles in controlling wound outcomes by decreasing inflammation or reducing microbial load. This work reports the easy one-pot synthesis of extremely stable, biocompatible, and highly fluorescent insulin-cobalt core-shell nanoparticles (ICoNPs) with enhanced quantum yield for their highly specific receptor-targeted bioimaging and normal and diabetic wound healing in vitro (HEKa cell line)...

The need of the synthesis of a new generation of medicines aimed at combating bacteria and biofilms that cause various infections is a great urgency. There has been a gradual decrease in the conventional techniques of treatment with the use of antibiotics. Consequently, much effort has focused on the search for new methods and approaches to obtain antibacterial drugs and determine their rational use such that microorganisms do not acquire resistance. Although silver nanoparticles (AgNPs) and silver nanoclusters (AgNCs) have exhibited certain levels of effectiveness against multidrug-resistant bacteria and biofilms, there are very few simple, cheap and easy-to-scale methods to obtain AgNPs and AgNCs with well-desired characteristics...

AMC@SiO2 core@shell nanocarriers (AMC: amikacin) are realized and contain an exceptionally high drug load of 0.8 mg mg-1 ( i.e. 80% AMC of total nanocarrier mass). They are prepared via a solvent-antisolvent approach with AMC nanoparticles formed in a first step, which are then covered and stabilised by a thin silica shell in a one-pot synthesis. In total, the core@shell nanocarriers exhibit a mean diameter of 240 nm with an inner AMC core of 200 nm and an outer silica shell of 20 nm. Subsequent to synthesis, the nanocarriers can be stored in frozen dimethylsulfoxide (DMSO) and applied directly after warming to room temperature with particle contents of 5 mg mL-1 ...

In the current study, an environmentally friendly and facile method was proposed for designing and constructing a catalyst with Ni(ii) attached to a picolylamine complex on 1,3,5-triazine-immobilized Fe3 O4 core-shell magnetic nanoparticles (NiII -picolylamine/TCT/APTES@SiO2 @Fe3 O4 ) via a stepwise procedure. The as-synthesized nanocatalyst was identified and characterized via Fourier-transform infrared (FT-IR), X-ray photoelectron spectroscopy (XPS), thermogravimetric analysis (TGA), vibrating-sample magnetometry (VSM), transmission electron microscopy (TEM), X-ray diffraction (XRD), Brunauer-Emmett-Teller (BET), field-emission scanning electron microscopy (FE-SEM), inductively coupled plasma (ICP), and energy-dispersive X-ray spectrometry (EDX)...

The presented study comprises the one-pot synthesis and the characterization of quercetin- and caffeic acid-functionalized chitosan-capped colloidal silver nanoparticles (Ch/Q- and Ch/CA-Ag NPs), and their antibacterial and anticancer activities. The formation of Ch/Q- and Ch/CA-Ag NPs has been confirmed by ultraviolet-visible (UV-vis) spectroscopy, Fourier-transform infrared (FTIR) spectroscopy, and transmission electron microscopy (TEM). The characteristic surface plasmon resonance (SPR) absorption band has been found at 417 and 424 nm for Ch/Q- and Ch/CA-Ag NPs, respectively...

Fluorescent InP-based quantum dots have emerged as valuable nanomaterials for display technologies, biological imaging, and optoelectronic applications. The inclusion of zinc can enhance both their emissive and structural properties and reduce interfacial defects with ZnS or CdS shells. However, the sub-particle distribution of zinc and the role this element plays often remains unclear, and it has previously proved challenging to synthesise Zn-alloyed InP-based nanoparticles using aminophosphine precursors...

Mesoporous silica nanoparticles have highly versatile structural properties that are suitable for a plethora of applications including catalysis, separation, and nanotherapeutics. We report a one-pot synthesis strategy that generates bimodal mesoporous silica nanoparticles via coassembly of a structure-directing Gemini surfactant (C16-3-16 ) with a tetraethoxysilane/(3-aminopropyl)triethoxysilane-derived sol additive. Synthesis temperature enables control of the nanoparticle shape, structure, and mesopore architecture...

We present a short peptide of only six amino acids that can be used in ambient conditions to simultaneously reduce either Au3+ or Ag+ ions, forming nanoparticles, and function as a stabilizing capping agent. At acidic pH, Hg2+ ions oxidize the silver nanoparticles and Fe2+ ions promote the aggregation of the gold nanoparticles. At alkaline conditions, Mn2+ ions induce the aggregation of the silver nanoparticles. Through the absorbance changes of these processes, these peptide-capped nanoparticles demonstrated a fast, selective, and sensitive pH-dependent detection system...