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Gordon Cook, Kara-Louise Royle, Charlotte Pawlyn, Anna Hockaday, Vallari Shah, Martin F Kaiser, Sarah R Brown, Walter M Gregory, J Anthony Child, Faith E Davies, Gareth J Morgan, David A Cairns, Graham H Jackson
BACKGROUND: Tolerability of treatments for multiple myeloma can depend on the characteristics of the patient being treated. We aimed to develop and validate a risk profile, using routinely collected data, that could predict overall survival in patients with multiple myeloma who were ineligible for stem-cell transplantation. METHODS: We used patient data from two randomised controlled trials done in patients with newly diagnosed multiple myeloma who were ineligible for stem-cell transplantation (the NCRI Myeloma XI study [NCRI-XI, n=1852] and the MRC Myeloma IX study [MRC-IX, n=520]), to develop the UK Myeloma Research Alliance Risk Profile (MRP) for overall survival...
February 6, 2019: Lancet Haematology
Vinay Kumaraswamy, Arun G Ramaswamy, Shyam Sundar, David V Rajan, Karthik Selvaraj, Santosh Sahanand, S Deebak
PURPOSE: Traditionally, MRI has not been used to predict meniscus tear reparability. An attempt has been made in this study to predict meniscal reparability using MRI, and a new scoring system to help with the same has been developed and tested. METHODS: Thirty repaired menisci were compared with equal number of meniscectomy cases retrospectively. Various clinical and radiological (radiographs and MRI) characteristics like chronicity of tear, pattern of tear, etc, were tabulated...
February 8, 2019: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
Alexis Leonard, Lauren Hittson Boal, Philippe Pary, Y Delores Mo, Cyril Jacquot, Naomi L Luban, Deepika S Darbari, Jennifer Webb
BACKGROUND: Alloantibodies against more than 50 non-ABO blood group antigens have been implicated in hemolytic disease of the fetus and newborn (HDFN) and are expected to wane within weeks after delivery. Persistent anemia leads to the hypothesis of continued exposure to red blood cell (RBC) alloantibodies via breast milk, which has been shown in a murine model and suggested in rare case reports. CASE REPORT: We report three cases of prolonged HDFN in two neonates with anti-D HDFN and one with anti-Jka HDFN...
February 5, 2019: Transfusion
Mehmet Arican, Mehmet Arican, Yalçin Turhan, Zekerya Okan Karaduman
BACKGROUND: Heel pain is a complaint frequently encountered in ortho¬paedic clinics that has peculiar symptoms and may have various etiological causes. Fracture of calcaneal spurs are extremely rare causes for heel pain and only four cases had previously been reported in the English literature. METHODS: We present a 45 years old woman who had a heel pain on her right foot after fell from a height onto the heel. Radiographic examination of her right foot showed a fractured calcaneal spur and successfully treated with conservative methods...
January 16, 2019: Journal of the American Podiatric Medical Association
Qi Tan, Alex Lk Ng, George Pm Cheng, Victor Cp Woo, Pauline Cho
PURPOSE: To present the study design and one month's preliminary results of a two-year randomized trial, Combined Atropine with Orthokeratology (AOK) for myopia control study. METHODS: Children aged 6-<11 years and with 1.00-4.00 D myopia were randomly assigned to AOK Group or ortho-k alone (OK) group. Subjects are required to attend routine ortho-k aftercare visits (first-overnight, 1-week, 2-week, 3-week, 1-month, and every 3 months after commencement of lens wear)...
January 11, 2019: Current Eye Research
Ugo Salvadori, Roberto Melotti, Daniela L'Altrella, Massimo Daves, Ahmad Al-Khaffaf, Laura Milizia, Rossana Putzulu, Renata Filippi, Aurelio Carolo, Giuseppe Lippi, Ivo Gentilini
The increase of immunization against blood group antigens has reinforced the need for automated extensive blood typing. The aim of this study was to assess both the validity and reliability of red blood cell (RBC) automated agglutination technology in testing for antigens of Kidd (Jk), Duffy (Fy), and MNS (Ss) blood systems. ORTHO Sera (Ortho Clinical Diagnostics, Raritan, NJ) anti-Jka, anti-Jkb, Anti-Fya, anti-Fyb, anti-S, and anti-s reagents were each tested on RBC samples previously typed. Replicates were performed on three separate testing sessions with three consecutive repetitions within each session, thus obtaining 486 test results...
December 2018: Immunohematology
Mahmoud Dastoori, Joseph P Bouserhal, Demetrios J Halazonetis, Athanasios E Athanasiou
Background: To assess the accuracy of digital models generated using commercially available software to predict anterior teeth root inclination characteristics and compare the results to relevant data obtained from CBCT images. Material and Methods: Following sample size calculation and after application of inclusion and exclusion criteria, pre-treatment maxillary and mandibular plaster models and the corresponding CBCT scans of 31 patients attending a private orthodontic clinic were selected...
November 2018: Journal of Clinical and Experimental Dentistry
Pan-Fen Wang, Alicia Neiner, Thomas R Lane, Kimberly M Zorn, Sean Ekins, Evan D Kharasch
Ketamine is analgesic at anesthetic and subanesthetic doses, and used recently to treat depression. Biotransformation mediates ketamine effects, influencing both systemic elimination and bioactivation. CYP2B6 is the major catalyst of hepatic ketamine N-demethylation and metabolism at clinically relevant concentrations. Numerous CYP2B6 substrates contain halogens. CYP2B6 readily forms halogen-protein (particularly Cl-π) bonds, which influence substrate selectivity and active site orientation. Ketamine is chlorinated, but little is known about metabolism of halogenated analogs...
December 27, 2018: Molecular Pharmaceutics
Steven R Feldman, Haijun Tian, Xinyue Wang, Rebecca Germino
BACKGROUND: Discontinuation or switching of biologic treatment among patients with psoriasis imposes a great economic burden. OBJECTIVE: To assess the health care utilization and costs associated with nonswitchers, switchers, and discontinuers of biologics among patients with moderate to severe psoriasis. METHODS: Patients aged ≥ 18 years with ≥ 1 pharmacy claim for a biologic (adalimumab, etanercept, infliximab, and ustekinumab) between January 1, 2012, and June 30, 2015 (identification period), were identified in the Truven Health Analytics MarketScan Commercial and Medicare Supplemental databases...
December 17, 2018: Journal of Managed Care & Specialty Pharmacy
Randall W Velliquette, Judith Aeschlimann, Julie Kirkegaard, Gayane Shakarian, Christine Lomas-Francis, Connie M Westhoff
BACKGROUND: Anti-CD47 (Hu5F9-G4) is a human monoclonal immunoglobulin G (IgG)4 antibody that is in clinical trials to treat hematologic or solid malignancies. CD47, a glycoprotein expressed on all cells, binds to signal-regulatory protein α on macrophages and regulates phagocytosis. Blocking CD47 is thought to enhance phagocytosis and promote antitumor responses. Here, we evaluate drug interference in pretransfusion testing, determine mitigation strategies, and compare interference with anti-CD38 (Daratumumab)...
February 2019: Transfusion
Deborah K VanderVeen, Raymond T Kraker, Stacy L Pineles, Amy K Hutchinson, Lorri B Wilson, Jennifer A Galvin, Scott R Lambert
OBJECTIVE: To review the published evidence to evaluate the ability of orthokeratology (Ortho-K) treatment to reduce myopic progression in children and adolescents compared with the use of spectacles or daytime contact lenses for standard refractive correction. METHODS: Literature searches of the PubMed database, the Cochrane Library, and the databases of clinical trials were last conducted on May 23, 2017 with no date restrictions but limited to articles published in English...
November 23, 2018: Ophthalmology
Chourouk Ibrahim, Salah Hammami, Nadia Chérif, Selma Mejri, Pierre Pothier, Abdennaceur Hassen
The efficiency of rotating biodisks and natural oxidizing lagoon procedures is investigated at a Tunisian semi-industrial pilot plant, El Menzeh I, where the wastewater is mainly provided by three different neighbouring hospital clinics. Throughout 2011, 102 wastewater samples were collected from the two mentioned wastewater treatment procedures. Results showed that the Sapovirus (SaV) frequency was approximately 29.4% using the real-time reverse transcription polymerase chain reaction (RT-PCR) technique, and about 16...
November 26, 2018: International Journal of Environmental Health Research
Colin P Murphy, Anthony Sanchez, Liam A Peebles, Matthew T Provencher
The decision to incorporate ortho-biologics into a clinical practice will ultimately depend on physicians' preferences and the resources available to their practice. It is important to emphasize that different biologics are used for different pathologies/injuries and in different settings, such as the operating room or in the office. Physicians thinking about using biologics in their practices should consider the time commitment required to learn and use the technique, insurance coverage, and informed consent...
January 2019: Clinics in Sports Medicine
Ruijuan Liu, Fang Zhou, He He, Jingyao Wei, Xin Tian, Li Ding
Corynoline (CRL), an isoquinoline alkaloid, is the major constituent derived from Corydalis bungeana Herba, which is a well-known Chinese herbal medicine widely used in many prescriptions. The purpose of this study was to comprehensively investigate the metabolism and bioactivation of CRL, and identify the CYP450 isoforms involved in reactive ortho -benzoquinone metabolites formation and evaluate its hepatotoxicity in mice. Here, high resolution and triple quadrupole mass spectrometry were used for studying the metabolism of CRL...
2018: Frontiers in Pharmacology
Renata Smulik-Izydorczyk, Michał Rostkowski, Angelika Gerbich, Dominika Jarmoc, Jan Adamus, Agnieszka Leszczyńska, Radosław Michalski, Andrzej Marcinek, Karol Kramkowski, Adam Sikora
The recent interest in the clinical applications of Piloty's acid derivatives as HNO donors for the treatment of cardiovascular system dysfunction has led us to the examination of factors controlling HNO release from selected ortho-substituted N-hydroxysulfonamides. Here we present the kinetic and quantum mechanical studies on the mechanism of HNO release from selected ortho-substituted N-hydroxysulfonamides and in vivo examination of the antiaggregatory properties of N-hydroxy-(2-bromobenzene)sulfonamide complex with sodium salt of β-cyclodextrin sulfobutyl ethers-ethyl ethers as compared with Angeli's salt...
November 15, 2018: Archives of Biochemistry and Biophysics
Moaza Ghuloom Mohammad, Shazia Naser-Ud Din, Amar Hassan Khamis, Athanasios E Athanasiou
Objectives: The aims of this investigation in a group of Emiratis were ( 1 ) To study overall and anterior tooth size ratios in Class I normal occlusion, ( 2 ) To estimate overall and anterior tooth size ratios in different malocclusion groups, ( 3 ) To compare overall and anterior tooth size ratios in Class I normal occlusion with the Bolton standards, and ( 4 ) To determine the distribution of overall and anterior tooth size ratios ± 2 SD from Bolton mean values in all occlusion groups...
2018: Open Dentistry Journal
Sean W L Ho, Lynn Thwin, Ernest B K Kwek
BACKGROUND: Occult hip fractures in the elderly are challenging to diagnose and often result in surgical delays which may worsen outcomes. However, the minimally displaced nature of these fractures may conversely lead to better outcomes. The aim of this study was to determine if surgically treated occult hip fractures have better short to mid term functional outcomes when compared to non-occult fractures. The secondary aim was to determine if there are any differences in clinical characteristics of patients who present with occult hip fractures...
October 15, 2018: Injury
I Gusti Aju Wahju Ardani, Bintiana Susanti, Irwadi Djaharu'ddin
Background: Two types of orthodontic elastics exist based on their material, latex and nonlatex, each of which has different properties in clinical use. Some of the differences include their initial force and force degradation over time. This study was conducted to compare the force changes in both materials. Aim: To evaluate the force degradation of latex and nonlatex elastics under moderate stretching over time. Methods: Medium-force orthodontic latex and nonlatex elastics from American Orthodontics (AO) and Ortho Technology (OT) of lumen size 1/4 inches and 3/16 inches (total sample 110 elastics) were submerged in artificial saliva (pH 6...
2018: Clinical, Cosmetic and Investigational Dentistry
Zhouyue Li, Yin Hu, Dongmei Cui, Wen Long, Mingguang He, Xiao Yang
PURPOSE: To investigate changes in subfoveal choroidal thickness (SFChT) during orthokeratology (Ortho-K) lens wear and after its cessation and the association of short-term change in SFChT with the long-term eye elongation in Ortho-K subjects. DESIGN: A prospective clinical trial. METHODS: Fifty myopic children aged between 9 and 14 years were enrolled. Twenty-nine subjects continuously wore Ortho-K lens for 12 months and discontinued for 1 month...
October 4, 2018: Acta Ophthalmologica
Massimo De Paschale, Maria Teresa Manco, Annalisa Cianflone, Luisa Belvisi, Debora Cagnin, Teresa Cerulli, Alessia Paganini, Carlo Agrappi, Paola Mirri, Pierangelo Clerici
BACKGROUND: Simultaneous detection of HIV 1 and 2 antibodies and HIV-1 p-24 antigen in the 4th generation tests is particularly effective for the identification of early acute HIV infections while maintaining accurate detection of long-established infections. OBJECTIVES: The aim of this study was to evaluate the new 4th generation VITROS HIV Combo test from Ortho-Clinical Diagnostics by comparing its results with those obtained using a 3rd generation HIV 1/2 antibody test (VITROS Anti HIV 1 + 2 from Ortho-Clinical Diagnostics) and a 4th generation test (LIAISON XL HIV Ab/Ag, DiaSorin) currently used in the Microbiology Unit of Legnano Hospital...
September 17, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
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