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Marcel Grube, Felix Neis, Sara Y Brucker, Stefan Kommoss, Jürgen Andress, Martin Weiss, Sascha Hoffmann, Florin-Andrei Taran, Bernhard Krämer
Fibroids are the most common benign tumors in women of childbearing age and can be found in almost 80-90% of all women by age 50 years. They can cause pain, excessive menstrual bleeding or infertility. The development of fibroids increases with age. Since the age of women in industrial countries who are trying to conceive is generally increasing, there has been a growing demand for minimally invasive and uterine-sparing surgical treatment of fibroids. Whereas the main focus of previous surgical techniques for the treatment of fibroids was enucleation of the tumour with subsequent closure of the uterine incision, modern devices developed over the past decade can destroy fibroids by using ultrasound or radio-frequency without incising the uterine wall...
March 18, 2019: Surgical Technology International
Jean Marc Kaufman, Bruno Lapauw, Ahmed Mahmoud, Guy T'Sjoen, Ilpo Tapani Huhtaniemi
This narrative review presents an overview of present knowledge on fertility and reproductive hormones changes in aging men, the factors driving and modulating these changes, their clinical consequences, and benefits and risks of testosterone (T) therapy. Aging is accompanied by moderate decline of gamete quality and fertility. Population mean levels show mild total T decline, SHBG increase, steeper free T decline, and moderate LH increase with important contribution of comorbidities (e.g. obesity) to these changes...
March 19, 2019: Endocrine Reviews
M J Schleedoorn, van Alfen van der Velden, Ddm Braat, R Peek, K Fleischer
Introduction Infertility is a major concern for females with Turner syndrome (TS), regardless of their age. While fertility preservation is now routinely offered to girls and young women with cancer, there are currently no recommendations on fertility preservation in girls and young women with TS who generally face an even higher risk for infertility. Despite the lack of international guidelines, preservation procedures have been performed experimentally in females with TS. Methods A systematic literature search based on the PRISMA-P methodology for systematic reviews was performed in order to collect all published data on fertility preservation options in females with TS between January 1980 and April 2018...
March 2019: Pediatric Endocrinology Reviews: PER
Jin Li
No abstract text is available yet for this article.
May 2019: Journal of Gynecologic Oncology
Jaimin S Shah, Neda D Jooya, Terri L Woodard, Pedro T Ramirez, Nicole D Fleming, Michael Frumovitz
OBJECTIVE: To evaluate patient perceptions of preoperative reproductive counseling and to evaluate complications and pregnancy outcomes in women who had radical trachelectomy (RT) for early stage cervical cancer. METHODS: Patients who underwent RT from January 1, 2004, through July 31, 2017, and had been cancer free for more than 1 year after RT were eligible; consented patients were sent a 16-item online survey. RESULTS: Of the 58 eligible patients, 39 patients (67%) completed the questionnaire...
May 2019: Journal of Gynecologic Oncology
Vincent Balaya, Fabrice Lécuru, Laurent Magaud, Charlotte Ngô, Cyrille Huchon, Anne Sophie Bats, Patrice Mathevet
OBJECTIVE: The aim of this study was to determine the predictive factors of postoperative morbidity of patients who have undergone a radical trachelectomy (RT) for early-stage cervical cancer and to assess the oncologic outcomes. METHODS: We retrospectively analysed the data of 2 prospective trials on sentinel node biopsy for cervical cancer (SENTICOL I and II). Patients having a RT for early-stage cervical cancer with negative sentinel lymph node and safe margins, were included...
May 2019: Journal of Gynecologic Oncology
Roman Gaebelein, Sarah V Schiessl, Birgit Samans, Jacqueline Batley, Annaliese S Mason
Synthetic allohexaploid Brassica hybrids (2n = AABBCC) do not exist naturally, but can be synthesized by crosses between diploid and/or allotetraploid Brassica species. Using these hybrids, we aimed to identify how novel allohexaploids restore fertility and normal meiosis after formation. Chromosome inheritance, genome structure, fertility and meiotic behaviour were assessed in three segregating allohexaploid populations derived from the cross (B. napus × B. carinata) × B. juncea using a combination of molecular marker genotyping, phenotyping and cytogenetics...
March 19, 2019: New Phytologist
Raphael Ployet, Mônica T Veneziano Labate, Thais Regiani Cataldi, Mathias Christina, Marie Morel, Hélène San Clemente, Marie Denis, Bénédicte Favreau, Mario Tomazello Filho, Jean-Paul Laclau, Carlos Alberto Labate, Gilles Chaix, Jacqueline Grima-Pettenati, Fabien Mounet
(1)Wood production in fast-growing Eucalyptus grandis trees is highly dependent on both potassium (K) fertilization and water availability but the molecular processes underlying wood formation in response to the combined effects of these two limiting factors are still unknown (2)E. grandis trees were submitted to four combinations of K-fertilization and water supply. Weighted gene co-expression network analysis (WGCNA) and MixOmics-based co-regulation networks were used to integrate xylem transcriptome, metabolome and complex wood traits...
March 18, 2019: New Phytologist
Bianca Bianco, Ramon Felix Martins Fernandes, Camila Martins Trevisan, Denise M Christofolini, Carlos Millán Sanz-Lomana, Javier Valero de Bernabe, Caio P Barbosa
The STAT4 gene is vital to signaling pathways in the immune response. Immunological alterations are involved in the pathogenesis of endometriosis, and STAT4 polymorphisms may be linked to disease development. This study's aim is to evaluate the possible association between four STAT4 polymorphisms (rs7601754/G > A, rs11889341/C > T, rs7574865/T > G, and rs7582694/C > G) and the pathogenesis of endometriosis in Brazilian women. This case-control study's sample comprised 238 women with endometriosis and 201 healthy, fertile women without endometriosis (which was surgically confirmed)...
March 19, 2019: Annals of Human Genetics
Natalia Felipe-Medina, Laura Gómez-H, Yazmine B Condezo, Manuel Sanchez-Martín, José Luis Barbero, Isabel Ramos, Elena Llano, Alberto M Pendás
Ubiquitin-specific protease 26 (USP26) is a deubiquitylating enzyme belonging to the USPs family with a transcription pattern restricted to the male germline. Since protein ubiquitination is an essential regulatory mechanism during meiosis, many efforts have been focused on elucidating the function of USP26 and its relationship with fertility. During the last decade, several studies have reported the presence of different polymorphisms in USP26 in patients with non-obstructive azoospermia (NOA) or severe oligozoospermia suggesting that this gene may be associated with human infertility...
March 18, 2019: Chromosoma
Gomaa N Abdel-Rahman, Mohamed B M Ahmed, Bassem A Sabry, Safaa S M Ali
Heavy metals are elements present in trace quantities in the environment and, in small concentrations, they play important roles for the living organisms yet it can cause toxicity if exceeded the recommended levels. Toxic metals contamination is an important environmental problem that was mainly manifested in the growing industrial cities where the levels in toxic metals exceeded the recommended levels leading to the increase of several health problems (that vary from memory disorder to carcinogenic diseases)...
2019: Toxicology Reports
Wei Zhou, Zhiping Yang, Tao Wang, Yong Fu, Yong Chen, Binhua Hu, Junko Yamagishi, Wanjun Ren
Modern rice cultivation relies heavily upon inorganic nitrogen fertilization. Effective fertilizer management is key to sustainable agricultural development. Field and pot trials were conducted in 2014-2016, including a 15 N-labeled urea pot experiment (2014) to investigate mechanism by which optimized nitrogen fertilizer application (OFA) increases nitrogen utilization efficiency (NUE). Results showed that the applied nitrogen recovery efficiencies with OFA were 71.71%, 110.17%, and 51.38% higher than those obtained with traditional nitrogen fertilizer application (TFA) in 2014, 2015, and 2016, respectively...
2019: Frontiers in Plant Science
Matteo Lambertini, François Richard, Bastien Nguyen, Giulia Viglietti, Cynthia Villarreal-Garza
Chemotherapy-induced premature ovarian insufficiency (POI) is one of the potential drawbacks of chemotherapy use of particular concern for newly diagnosed premenopausal breast cancer patients. Temporary ovarian suppression obtained pharmacologically with the administration of a gonadotropin-releasing hormone agonist (GnRHa) during chemotherapy has been specifically developed as a method to counteract chemotherapy-induced gonadotoxicity with the main goal of diminishing the risk of POI. In recent years, important clinical evidence has become available on the efficacy and safety of this strategy that should now be considered a standard option for ovarian function preservation in premenopausal breast cancer patients, including women who are not interested in conceiving after treatment or that would not be candidates for fertility preservation strategies because of their age...
2019: Clinical Medicine Insights. Reproductive Health
Xinxin Ye, Yin Ye, Rushan Chai, Junli Li, Chao Ma, Hongying Li, Qizhong Xiong, Hongjian Gao
Tillage practice and residue management play important roles in N pool in soils. This study determined the impacts of tillage practice and residue management on crop yield. It also investigated the distribution, fractionation, and stratification of N at soil at depths ranging from 0 to 60 cm under wheat-maize cropping systems. Three treatments were established in 2009: no-tillage with straw removal for winter wheat and summer maize (NT), no-tillage with straw mulching for winter wheat and summer maize (NTS), no-tillage with straw mulching for summer maize and plow tillage with straw incorporation for winter wheat (NPTS)...
March 18, 2019: Scientific Reports
Zhen Han, Shouqin Zhong, Jiupai Ni, Zhonglin Shi, Chaofu Wei
Farming plot construction engineering in hilly areas plays an important role in the mechanization, large-scale production and industrialization of agriculture. The method is undertaken to improve water and soil conservation, enhance soil fertility and extend machinery agriculture. However, the positive effects of engineering require years to mature. The properties of newly reconstructed soil are not sufficient, i.e., with poor structure and low water holding capacity, resulting in deterioration of its physical properties and erosion...
March 18, 2019: Scientific Reports
Toru Matsu-Ura, Hideki Shirakawa, Kenichi G N Suzuki, Akitoshi Miyamoto, Kotomi Sugiura, Takayuki Michikawa, Akihiro Kusumi, Katsuhiko Mikoshiba
In most species, fertilization induces Ca2+ transients in the egg. In mammals, the Ca2+ rises are triggered by phospholipase Cζ (PLCζ) released from the sperm; IP3 generated by PLCζ induces Ca2+ release from the intracellular Ca2+ store through IP3 receptor, termed IP3 -induced Ca2+ release. Here, we developed new fluorescent IP3 sensors (IRIS-2s) with the wider dynamic range and higher sensitivity (Kd = 0.047-1.7 μM) than that we developed previously. IRIS-2s employed green fluorescent protein and Halo-protein conjugated with the tetramethylrhodamine ligand as fluorescence resonance energy transfer (FRET) donor and acceptor, respectively...
March 18, 2019: Scientific Reports
Yingchao Liu, Xinhua Yin, Jingxiu Xiao, Li Tang, Yi Zheng
In order to address the question of how flavonoids affected root nodulation of faba bean in a wheat and faba bean intercropping system, we set up soil and hydroponic experiments comprising two cropping pattern treatments (intercropped and monocropped) and three nitrogen (N) supply treatments at the deficient (50% N), adequate (100% N), and excessive (150% N) levels with three replicates in a randomized complete block design. Across the three N treatments and two experiments, it was frequently observed that intercropping increased but N fertilization decreased the nodule number and nodule dry weight of faba bean...
March 18, 2019: Scientific Reports
Aline Bütikofer, David N Figlio, Krzysztof Karbownik, Christopher W Kuzawa, Kjell G Salvanes
During sensitive periods in utero, gonadal steroids help organize biological sex differences in humans and other mammals. In litter-bearing species, chromosomal females passively exposed to prenatal testosterone from male littermates exhibit altered physical and behavioral traits as adults. The consequences of such effects are less well understood in humans, but recent near-doubling of twinning rates in many countries since 1980, secondary to advanced maternal age and increased reliance on in vitro fertilization, means that an increasing subset of females in many populations may be exposed to prenatal testosterone from their male co-twin...
March 18, 2019: Proceedings of the National Academy of Sciences of the United States of America
Xingyu Liu, Meng Li, Xizeng Feng
This study aimed to investigate the protective effects of two citrus flavonoids, hesperidin and naringin, on alcohol-induced thigmotaxis behavioural and developmental defects in zebrafish. The results of behavioural assays indicated that acute exposure to 1% alcohol could induce thigmotaxis behaviour in zebrafish larvae at 3 and 5 days post-fertilization (dpf), whereas hesperidin and naringin could inhibit the thigmotaxis behaviour in zebrafish larvae. Moreover, developmental administration of hesperidin and naringin reduced the levels of morphological defects and apoptosis induced by developmental alcohol exposure...
March 15, 2019: Neurotoxicology and Teratology
Xuan Yu, Cong Gao, Caifeng Dai, Fang Yang, Xiaohui Deng
RESEARCH QUESTION: The aim of this study was to compare expression of hypoxia-inducible factor 1-alpha (HIF-1α), angiogenesis and apoptosis in endometrial tissue near the implantation window of women with recurrent implantation failure (RIF) and in fertile control women, and to describe possible mechanisms of endometrial injury. DESIGN: A controlled clinical study was conducted. Endometrial tissue specimens were obtained from 20 women undergoing IVF who had had at least three previous failed treatment cycles; normal endometrial specimens were obtained from 10 fertile control women...
December 22, 2018: Reproductive Biomedicine Online
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