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"less is more"

Corey Lyon, Liza W Claus
It's time to review our dosing with ketorolac for acute pain management.
January 2019: Journal of Family Practice
Christopher M Weise, Tobias Bachmann, Matthias L Schroeter, Dorothee Saur
BACKGROUND: The term executive functions (EF) describes a set of higher cognitive abilities/skills needed for goal-oriented and flexible behavior. In contrast to a multitude of functional neuroimaging studies of EF performance, only limited and partially inconclusive data is available for the structural-neuroanatomical underpinnings of EFs, particularly in healthy adults. METHODS: Here, we applied voxel-based morphometry (VBM) and additional analyses of cortical thickness (CTH; via surface-based morphometry) to a large sample of healthy young adults from the Human Connectome Project (N = 1110; Age 28...
February 1, 2019: NeuroImage
Anne Fortin, Henri Azaïs, Catherine Uzan, Gilles Lefebvre, Geoffroy Canlorbe, Catherine Poirot
OBJECTIVE: To describe our surgical techniques for laparoscopic ovarian tissue harvesting and orthotopic ovarian cortex grafting (LOOCG). DESIGN: This video article uses surgical cases to demonstrate the detailed surgical techniques. Institutional Review Board approval was not required for this video presentation. SETTING: University hospital. PATIENT(S): Patients presenting with indication for fertility preservation by means of ovarian tissue harvesting and orthotopic ovarian cortex grafting (in case of setting up a high risk of gonadotoxicity treatment or patients presenting with a pathology with risk of premature ovarian failure)...
February 2019: Fertility and Sterility
Evelyn Cantillo, Jenna B Emerson, Cara Mathews
Surgery is a cornerstone of gynecologic oncology. Minimally invasive techniques have been adopted rapidly, in lieu of open approaches, in cervical and endometrial cancer staging. In addition, nodal assessment has undergone significant changes with the introduction of SLN biopsies. The movement toward less is more has also been seen with perioperative and postoperative care and the advent of ERAS protocols, which attempt to maintain normal physiology with the goal of improving functional recovery. It is imperative that new technology be critically evaluated to ensure that oncologic outcomes are not compromised...
March 2019: Obstetrics and Gynecology Clinics of North America
William M Abbott, Christopher P Murray, Chuan Zhong, Christopher Smith, Cormac McGuinness, Ehsan Rezvani, Clive Downing, Dermot Daly, Amanda Petford-Long, Frank Bello, David McCloskey, John F Donegan
The use of a metallic adhesion layer is known to increase the thermo-mechanical stability of Au thin films against solid-state dewetting, but in turn results in damping of the plasmonic response, reducing their utility in applications such as heat-assisted magnetic recording (HAMR). In this work, 50 nm Au films with Ti adhesion layers ranging in thickness from 0.1 - 5 nm were fabricated, and their thermal stability, electrical resistivity, and plasmonic response were measured. Sub-nanometer adhesion layers are demonstrated to significantly increase the stability of the thin films against dewetting at elevated temperatures (>200oC), compared to standard adhesion layer thicknesses that are in the range of 2 - 5 nm...
January 25, 2019: ACS Applied Materials & Interfaces
Julie Sternberg, Ralph Briner, Vincent Bourquin
Current protocols recommend an initial assessment of acute kidney injury often extensive, not very useful in the majority of cases. A review of the literature allowed us to propose a management algorithm limiting these investigations integrating a « less is more » approach. The cornerstone of this algorithm is the urinary dipstick, inexpensive and easy to perform, used as a screening test. This examination alone can, in the absence of factors suggestive of a post-renal or renal cause, guide the diagnosis and management...
January 23, 2019: Revue Médicale Suisse
Martha C Sola-Visner
New England Journal of Medicine, Volume 380, Issue 3, Page 287-288, January 2019.
January 17, 2019: New England Journal of Medicine
Rebecca A Gladdy, Jay S Wunder
No abstract text is available yet for this article.
January 15, 2019: Cancer
Clare E Death, Graeme Coulson, Jasmin Hufschmid, William K Morris, Jodie Gould, Mark Stevenson
Vegetation contaminated by industrial fluoride emissions can cause disease in herbivorous mammals. Spatially explicit exposure models offer a quantitative approach for evaluating and managing the potentially toxic effects of chronic fluoride consumption on wildlife. We monitored eastern grey kangaroos (Macropus giganteus) inhabiting a high-fluoride environment in the buffer zone of an aluminium smelter in southeastern Australia between 2010 and 2013. We measured fluoride levels at 19 pasture sites and determined the foraging range of 37 individual kangaroos...
December 14, 2018: Science of the Total Environment
Hamed Bonab, Fazli Can
The number of component classifiers chosen for an ensemble greatly impacts the prediction ability. In this paper, we use a geometric framework for a priori determining the ensemble size, which is applicable to most of the existing batch and online ensemble classifiers. There are only a limited number of studies on the ensemble size examining majority voting (MV) and weighted MV (WMV). Almost all of them are designed for batch-mode, hardly addressing online environments. Big data dimensions and resource limitations, in terms of time and memory, make the determination of ensemble size crucial, especially for online environments...
January 9, 2019: IEEE Transactions on Neural Networks and Learning Systems
Jason J Han, Pavan Atluri
No abstract text is available yet for this article.
November 27, 2018: Journal of Thoracic and Cardiovascular Surgery
Rocio Aguilar Suarez, Jörg Stülke, Jan Maarten van Dijl
The availability of complete genome sequences and the definition of essential gene sets were fundamental in the start of the genome engineering era. In a recent study, redundant and unnecessary genes were systematically deleted from the Gram-positive bacterium Bacillus subtilis, an industrial production host of high-value secreted proteins. This culminated in strain PG10, which lacks about 36% of the genome, thus representing the most minimal Bacillus chassis currently available. Here, we show that this 'miniBacillus' strain has synthetic traits that are favorable for producing 'difficult-to-produce proteins'...
December 12, 2018: ACS Synthetic Biology
Michael D Feldman
Although the exact function of the subacromial bursa as it relates to rotator cuff repair is still debatable, most surgeons would agree that the more invasive the procedure, the more likely there will be scarring and/or adhesions, which can lead to decreased motion. So, when performing subacromial bursectomy during rotator cuff repair, "Observe due measure, moderation is best in all things [subacromial]."
December 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
Barry Chan, Alasdair Nazerali-Maitland, Wilma Hopman, David Zelt, Ross Morton
No abstract text is available yet for this article.
November 2018: Canadian Medical Education Journal
Nikita A Durandin, Jussi Isokuortti, Alexander Efimov, Elina Vuorimaa-Laukkanen, Nikolai V Tkachenko, Timo Laaksonen
A green-to-blue triplet-triplet annihilation upconversion of 24.5% quantum yield was achieved at a remarkably low 600 μM annihilator concentration in a viscous polymer matrix. This was made possible by utilizing a ZnTPP-based photosensitizer with exceptionally long 11 ms phosphorescence lifetime. Higher 3 mM annihilator concentration resulted in lower 24% upconversion quantum yield.
November 29, 2018: Chemical Communications: Chem Comm
Jorge Ferreira
No abstract text is available yet for this article.
November 12, 2018: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
Robert Czaplicki, Antti Kiviniemi, Mikko Johannes Huttunen, Xiaorun Zang, Timo Stolt, Ismo Vartiainen, Jérémy Butet, Markku Kuittinen, Olivier J F Martin, Martti Kauranen
We investigate optical second-harmonic generation (SHG) from metasurfaces where noncentrosymmetric V-shaped gold nanoparticles are ordered into regular array configurations. In contrast to expectations, a substantial enhancement of the SHG signal is observed when the number density of the particles in the array is reduced. More specifically, by halving the number density, we obtain over five-fold enhancement in SHG intensity. This striking result is attributed to favorable interparticle interactions mediated by the lattice, where surface-lattice resonances lead to spectral narrowing of the plasmon resonances...
November 13, 2018: Nano Letters
Kyung E Rhee, Stephanie Kessl, Michael A Manzano, David R Strong, Kerri N Boutelle
Children with lower inhibitory control have greater weight gain over time and consume more snack food. Our goal was to test whether a pilot program based on enhancing self-regulation in preschool children could decrease consumption of energy-dense foods. Ninety-two preschool children were randomized to the intervention or control group. The intervention was a three-week, play-based program that focused on enhancing executive function skills and decreasing consumption of energy dense snack foods. Controls met for a similar length of time, but focused on dental hygiene, good sleep habits/routines, and physical activity...
November 1, 2018: Appetite
Mark A Moyad
PURPOSE OF REVIEW: To discuss the overall and latest observations of the effect of diet, lifestyle, supplements, and some prescription heart healthy medications for prostate cancer prevention. RECENT FINDINGS: The concept of maximizing heart health to prevent aggressive prostate cancer continues to be solidified with the addition of more prospective observational and randomized controlled trial data. Heart healthy is prostate healthy, but heart unhealthy is prostate unhealthy...
October 27, 2018: Current Urology Reports
Rachel E Simpson, Nathan J Cockerill, Michele T Yip-Schneider, Eugene P Ceppa, Michael G House, Nicholas J Zyromski, Attila Nakeeb, Mohammad A Al-Haddad, C M Schmidt
BACKGROUND: For pancreatic cysts with negative cytology, Integrated Molecular Pathology (IMP) is a malignancy risk score integrating clinical criteria with pancreatic cyst fluid DNA profiling. Aside from main pancreatic duct (MPD) diameter, integrated clinical criteria are not International Consensus Guidelines High-Risk Stigmata. We predicted exclusion of clinical criteria except MPD diameter could simplify the IMP and better distinguish invasive/malignant disease. METHODS: Records of >1100 patients with IPMN were reviewed retrospectively...
October 4, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
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