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Central pain syndrome

Trang T H Tu, Miho Takenoshita, Hirofumi Matsuoka, Takeshi Watanabe, Takayuki Suga, Yuma Aota, Yoshihiro Abiko, Akira Toyofuku
Burning Mouth Syndrome (BMS), a chronic intraoral burning sensation or dysesthesia without clinically evident causes, is one of the most common medically unexplained oral symptoms/syndromes. Even though the clinical features of BMS have been astonishingly common and consistent throughout the world for hundreds of years, BMS remains an enigma and has evolved to more intractable condition. In fact, there is a large and growing number of elderly BMS patients for whom the disease is accompanied by systemic diseases, in addition to aging physical change, which makes the diagnosis and treatment of BMS more difficult...
2019: BioPsychoSocial Medicine
Yuhong Zhou, Shutang Han, Yamin He
Background. Tongxieyaofang (TXYF), a prescription originated from traditional Chinese medicine (TCM), has been widely used on treating Diarrhea Predominant Irritable Bowel Syndrome (IBS-D). The purpose of this meta-analysis was to investigate whether TXYF was effective and safe for IBS-D. Methods. We searched seven electronic databases including CENTRAL, MEDLINE, PubMed, CNKI, VIP, CBM, and Wanfang Data up to 26 July 2017. Randomized controlled trails (RCTs) were eligible, regardless of blinding. Risk of bias of included trials was evaluated according to the Cochrane Handbook...
2019: Evidence-based Complementary and Alternative Medicine: ECAM
Ana Paula Aquistapase Dagnino, Rodrigo Braccini Madeira da Silva, Pedro Cesar Chagastelles, Talita Carneiro Brandão Pereira, Gianina Venturin Teribele, Samuel Greggio, Jaderson Costa da Costa, Maurício Reis Bogo, Maria Martha Campos
Generalized pain and fatigue are both hallmarks of fibromyalgia, a syndrome with an indefinite aetiology. The treatment options for fibromyalgia are currently limited, probably due to its intricate pathophysiology. Thus, further basic and clinical research on this condition is currently needed. This study investigated the effects of nociceptin/orphanin FQ (N/OFQ) receptor (NOPr) ligands and the modulation of the NOP system in the preclinical mouse model of reserpine-induced fibromyalgia. The effects of administration of the natural agonist N/OFQ and the selective NOPr antagonists (UFP-101 and SB-612111) were evaluated in fibromyalgia-related symptoms in reserpine-treated mice...
January 31, 2019: Pain
V Dimova, F Birklein
The acute phase of complex regional pain syndrome (CRPS) is pathophysiologically characterized by an activation of the immune system and its associated inflammatory response. During the course of CRPS, central nervous symptoms like mechanical hyperalgesia, loss of sensation, and body perception disorders develop. Psychological factors such as pain-related anxiety and traumatic events might have a negative effect on the treatment outcome. While the visible inflammatory symptoms improve, the pain often persists...
February 4, 2019: Der Anaesthesist
F I Devlikamova
AIM: The "PARUS" program included investigation of the analgesic, muscle relaxant and sedative effects of Mydocalm-Richter which acts as central muscle relaxant in patients with myofascial pain syndrome, taking into account its registered indication for use - the hypertonus and cross-striated muscle spasm. MATERIALS AND METHODS: Fifty patients with myofascial trigger points, the mean age of 41.67±11.86 years, have been enrolled in the study. All patients had undergone clinical examination that allowed the diagnosis of myofascial pain syndrome...
June 20, 2018: Terapevticheskiĭ Arkhiv
Kevin Phan, Vignesh Ramachandran, Hiva Fassihi, Deshan F Sebaratnam
Importance: Phototherapy is one of the mainstays of treatment for early mycosis fungoides (MF). The most common modalities are psoralen-UV-A (PUVA) and narrowband UV-B (NBUVB). Objective: To compare the efficacy and adverse effects of PUVA vs NBUVB in early-stage MF. Data Sources: A systematic review was performed by searching Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, Ovid Medline, PubMed, Cochrane Library, American College of Physicians ACP Journal Club, and Database of Abstracts of Review of Effectiveness from inception to March 30, 2018...
January 30, 2019: JAMA Dermatology
Susanne Bejerot, Eva Hesselmark, Fariborz Mobarrez, Håkan Wallén, Max Albert Hietala, Rolf Nybom, Lennart Wetterberg
BACKGROUND: Neuromyelitis optica spectrum disorders are severe autoimmune inflammatory diseases of the central nervous system associated with the presence of immunoglobulin G antibodies against the water channel protein aquaporin-4. During exacerbation, specific aquaporin-4 immunoglobulin G may be produced intrathecally. We measured extracellular aquaporin-4 microparticles in the cerebrospinal fluid of a patient who later developed the typical symptoms and signs of a neuromyelitis optica spectrum disorder...
January 30, 2019: Journal of Medical Case Reports
John Teijido, Amy L Drendel
BACKGROUND: Blastomycosis is caused by a fungus endemic to states and providences bordering the Lawrence Rivers and the Great Lakes. It can lead to significant pathology in both immunocompetent and immunocompromised hosts. This case report describes disseminated blastomycosis in an otherwise healthy 16-year-old patient. CASE REPORT: A 16-year-old male presented with a chief complaint of flank pain. In the Emergency Department he described additional symptoms of emesis, cough, and weight loss...
January 25, 2019: Journal of Emergency Medicine
Samuel D Banister, Jonathon C Arnold, Mark Connor, Michelle Glass, Iain S McGregor
Cannabis (Cannabis sativa) is the most widely used illicit drug in the world, with an estimated 192 million users globally. The main psychoactive component of cannabis is (-)-trans-Δ9 -tetrahydrocannabinol (Δ9 -THC), a molecule with a diverse range of pharmacological actions. The unique and distinctive intoxication caused by Δ9 -THC primarily reflects partial agonist action at central cannabinoid type 1 (CB1 ) receptors. Δ9 -THC is an approved therapeutic treatment for a range of conditions, including chronic pain, chemotherapy-induced nausea and vomiting, and is being investigated in indications such as anorexia nervosa, agitation in dementia, and Tourette's syndrome...
January 28, 2019: ACS Chemical Neuroscience
Sadiya Ravat, Benita Olivier, Nadia Gillion, Francoise Lewis
BACKGROUND: Treatment of chronic pain is challenging and there is often failure of recovery, with the need to look at different approaches in its management. Central mechanisms may contribute to chronicity (i.e. disturbance in body schema). Laterality judgment is dependent on body schema and can determine affected central mechanisms. OBJECTIVE: This review aimed to determine whether there are laterality judgment differences between chronic pain and pain-free individuals...
January 27, 2019: Physiotherapy Theory and Practice
Robyn Rexwinkel, Judith Zeevenhooven, Faridi S van Etten-Jamaludin, Marc A Benninga, Merit M Tabbers
To systematically review the literature regarding the side effects of pharmacotherapy in children with irritable bowel syndrome (IBS) and functional abdominal pain - not otherwise specified (FAP-NOS). Areas covered: The Cochrane Library, PubMed, and Embase databases were searched from inception to May 2018. The following inclusion criteria were applied: (1) randomized controlled trials (RCTs), cohort studies or case control studies; (2) in children aged 4 - 18 years, or adult studies if children are reported separately; (3) reporting a diagnosis of IBS or FAP-NOS as defined by the authors; and (4) reporting the occurrence of side effects of pharmacotherapy...
January 24, 2019: Expert Opinion on Drug Safety
F F Gellrich, C Günther
Schnitzler syndrome is a very rare acquired systemic disease with many similarities to hereditary autoinflammatory syndromes. The main characteristics are generalized exanthema and a monoclonal gammopathy with IgM. Other clinical features include fever, muscle, bone and/or joint pain, and lymphadenopathy. About 15-20% of patients with Schnitzler syndrome develop lymphoproliferative diseases and, in rare cases, amyloid A (AA) amyloidosis can occur if the disease is not treated. Activation of the innate immune system, especially interleukin(IL)-1β, is central in the pathogenesis of the disease...
January 21, 2019: Zeitschrift Für Rheumatologie
Ian Kudel, Markay Hopps, Joseph C Cappelleri, Alesia Sadosky, Kristen King-Concialdi, Ryan Liebert, Bruce Parsons, Patrick Hlavacek, Andrea H Alexander, Marco D DiBonaventura, John D Markman, John T Farrar, Brett R Stacey
Background: The aim of this study was to identify the clinical characteristics, treatment usage, and health outcomes of US adults diagnosed with neuropathic pain (NeP) by experienced physicians. Methods: Adults with scores exceeding the threshold for probable NeP (painDETECT ≥19) and diagnosed with NeP by a qualified physician completed a questionnaire that included comorbid conditions, pain symptoms and experiences, medication use, health status (3-level EuroQol 5 Dimensions (EQ-5D-3L]: health utilities index and visual analog scale), pain severity and interference with functioning (Brief Pain Inventory), and work and activity impairment (Work Productivity and Activity Impairment questionnaire)...
2019: Journal of Pain Research
N Alammar, L Wang, B Saberi, J Nanavati, G Holtmann, R T Shinohara, G E Mullin
BACKGROUND: Peppermint oil (PO) has intrinsic properties that may benefit patients with irritable bowel syndrome (IBS) symptoms. The study objective was to determine the effect of peppermint oil in the treatment of the IBS. METHODS: We systematically searched MEDLINE (PubMed), Cochrane Central Register of Controlled Trials (Cochrane CENTRAL),, EMBASE (Ovid), and Web of Science for randomized controlled trials (RCTs) of PO for IBS. We appraised the eligible studies by the Cochrane risk of bias tool...
January 17, 2019: BMC Complementary and Alternative Medicine
Abraham Goldstein, Maor Zeev-Wolf, Noa Herz, Jacob N Ablin
OBJECTIVES: We investigated whether the central pain symptoms in fibromyalgia syndrome (FM) are related to defective top-down sensorimotor regulation. The pain matrix was activated in a top-down manner by presenting pictures of painful situations while recording brain activity using magnetoencephalography (MEG). We investigated alpha desynchronisation in FM patients and healthy controls in response to pictures depicting pain. METHODS: 19 FM patients and 14 age-matched healthy controls (age 20-60) were recruited...
January 9, 2019: Clinical and Experimental Rheumatology
Selaiman A Noori, Abdullah Rasheed, Rohit Aiyer, Boyoun Jung, Nitin Bansal, Ke-Vin Chang, Einar Ottestad, Amitabh Gulati
Background: Low back pain (LBP) and neck pain are major causes of pain and disability that are experienced across all ages. The primary goals of treatment are to improve patient function and facilitate a return to the patient's desired level of daily activity. Therapeutic ultrasound is a noninvasive modality widely utilized in the management of musculoskeletal disorders, but there continues to be controversy regarding its use due to insufficient evidence of effectiveness. The objective of this systematic review was to evaluate the effectiveness of therapeutic ultrasound in the management of patients with chronic LBP and neck pain...
January 12, 2019: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
Tuomas Lähdeoja, Teemu Karjalainen, Jarkko Jokihaara, Paul Salamh, Lauri Kavaja, Arnav Agarwal, Marinus Winters, Rachelle Buchbinder, Gordon Guyatt, Per Olav Vandvik, Clare L Ardern
OBJECTIVE: To determine the benefits and harms of subacromial decompression surgery in adult patients with subacromial pain syndrome lasting for more than 3 months. DESIGN: Systematic review with meta-analysis. MAIN OUTCOME MEASURES: Pain, physical function and health-related quality of life. DATA SOURCES: Systematic searches for benefits and harms were conducted to 23 July 2018 in MEDLINE, Embase, PubMed, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, Cumulative Index to Nursing and Allied Health Literature, Physiotherapy Evidence Database, ClinicalTrials...
January 15, 2019: British Journal of Sports Medicine
G Vicenti, D Bizzoca, V S Nappi, F Moretti, M Carrozzo, V Belviso, B Moretti
Clinical biophysics investigates the relationship between non-ionizing physical energy and the human body. Although several types of electrical stimulation devices have received US FDA approval for orthopaedic application, the use of Pulsed Electromagnetic Field (PEMFs) play a central role in joint biophysics. This narrative review aims to summarize the current evidences on the efficacy of PEMF-therapy in the treatment of knee articular diseases. Preclinical studies have assessed the effects of PEMFs on chondrocytes, synoviocytes, articular cartilage explants and animal models, showing positive effects of PEMF-therapy on cells proliferation, extracellular matrix (ECM) production, chondrocytes apoptosis and inflammatory cytokines down-regulation...
November 2018: Journal of Biological Regulators and Homeostatic Agents
Kenya Nishioka, Michimasa Suzuki, Madoka Nakajima, Takeshi Hara, Masako Iseki, Nobutaka Hattori
Painful legs and moving toes (PLMT) syndrome is a clinical entity characterized by persistent pain in the feet or legs and involuntary movements of one or more toes. The precise patho-mechanisms of PLMT still remain unknown. Herein, we examined ten patients clinically identified with PLMT syndrome. All patients first presented persistent pain prior to the onset of motor symptoms. Each patient was examined by neurological investigation, neuro-imaging methods including brain magnetic resonance imaging (MRI) and electrophysiological methods...
January 14, 2019: Journal of Neurology
Felipe C K Duarte, Mark Hurtig, Andrea Clark, Jeremy Simpson, John Z Srbely
OBJECTIVE: This study aimed to investigate the association between naturally occurring spinal osteoarthritis (OA) (L3-L5), the expression of substance P (SP) centrally (L4-L5) and the presence of neurogenic inflammation within the neurosegmentally linked quadriceps (L2-L5) in elderly rats versus young controls. DESIGN: Eight aged (27 ± 3.2 months) and six young (4 ± 0.0 months) male Wistar Kyoto rats were euthanized and submitted to micro-computerized tomography for determination of spine OA...
January 4, 2019: Experimental Gerontology
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