keyword
https://read.qxmd.com/read/38529017/tizanidine-advances-in-pharmacology-therapeutics-and-drug-formulations
#1
REVIEW
Ling-Ling Zhu, Yan-Hong Wang, Quan Zhou
BACKGROUND: Skeletal muscle relaxants (SMRs) are widely used in treating musculoskeletal conditions. All SMRs, with the exception of baclofen and tizanidine, are on the list of 2023 American Geriatrics Society Beers Criteria® for potentially inappropriate medication use in older adults. In our geriatric practice, off-label use of tizanidine as preemptive analgesia drove us to find recent advances in its pharmacology and therapeutics. An update review of tizanidine was thus presented, aiming to bring the latest knowledge to clinicians and promote further research and practical exploration...
2024: Journal of Pain Research
https://read.qxmd.com/read/38525062/exploring-acetaminophen-prodrugs-and-hybrids-a-review
#2
REVIEW
Vladimir V Kouznetsov
This critical review highlights the advances in developing new molecules for treating pain syndrome, an important issue for human health. Acetaminophen (APAP, known as paracetamol) and nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used in clinical practice despite their adverse effects. Research is being conducted to develop innovative drugs with improved pharmaceutical properties to mitigate these effects. A more practical way to achieve that is to study well-known and time-tested drugs in their molecular combinations...
March 20, 2024: RSC Advances
https://read.qxmd.com/read/38519397/regional-variations-in-management-and-outcomes-of-patients-with-acute-coronary-syndrome-in-china-evidence-from-the-national-chest-pain-center-program
#3
JOURNAL ARTICLE
Shuduo Zhou, Yan Zhang, Xuejie Dong, Junxiong Ma, Na Li, Hong Shi, Sidney C Smith, Yinzi Jin, Ming Xu, Dingcheng Xiang, Zhi-Jie Zheng, Yong Huo
Regional variations in acute coronary syndrome (ACS) management and outcomes have been an enormous public health issue. However, studies have yet to explore how to reduce the variations. The National Chest Pain Center Program (NCPCP) is the first nationwide, hospital-based, comprehensive, continuous quality improvement program for improving the quality of care in patients with ACS in China. We evaluated the association of NCPCP and regional variations in ACS healthcare using generalized linear mixed models and interaction analysis...
March 4, 2024: Science Bulletin
https://read.qxmd.com/read/38514229/innovations-in-stroke-recovery-and-rehabilitation-poststroke-pain
#4
REVIEW
Juliet Zakel, John Chae, Richard D Wilson
Pain can be a significant barrier to a stroke survivors' functional recovery and can also lead to a decreased quality of life. Common pain conditions after stroke include headache, musculoskeletal pain, spasticity-related pain, complex regional pain syndrome, and central poststroke pain. This review investigates the evidence of diagnostic and management guidelines for various pain syndromes after stroke and identifies opportunities for future research to advance the field of poststroke pain.
May 2024: Physical Medicine and Rehabilitation Clinics of North America
https://read.qxmd.com/read/38508678/pain-sensitisation-and-joint-inflammation-in-patients-with-active-rheumatoid-arthritis
#5
JOURNAL ARTICLE
Khaldoun Chaabo, Estee Chan, Toby Garrood, Zoe Rutter-Locher, Alex Vincent, James Galloway, Sam Norton, Bruce W Kirkham
INTRODUCTION: Despite better therapies and strategies, many people with rheumatoid arthritis (RA) have persistent pain, often from abnormal pain processing, now termed nociplastic pain. However, RA patients with fibromyalgia (FM), a central nociplastic pain syndrome, also have power doppler ultrasound (PDUS+) joint inflammation. To understand the complex causes of pain, we performed clinical examination and patient-reported outcome measures (PROMs) plus comprehensive PDUS evaluation not previously combined...
March 19, 2024: RMD Open
https://read.qxmd.com/read/38505501/contact-heat-evoked-potentials-insights-into-pain-processing-in-crps-type-i
#6
JOURNAL ARTICLE
Florin Allmendinger, Paulina Simonne Scheuren, Iara De Schoenmacker, Florian Brunner, Jan Rosner, Armin Curt, Michèle Hubli
PURPOSE: The pathophysiological mechanisms underlying the development of chronic pain in complex regional pain syndrome (CRPS) are diverse and involve both peripheral and central changes in pain processing, such as sensitization of the nociceptive system. The aim of this study was to objectively distinguish the specific changes occurring at both peripheral and central levels in nociceptive processing in individuals with chronic CRPS type I. PATIENTS AND METHODS: Nineteen individuals with chronic CRPS type I and 16 age- and sex-matched healthy controls (HC) were recruited...
2024: Journal of Pain Research
https://read.qxmd.com/read/38504661/synchronous-low-grade-central-osteosarcoma-and-ewing-sarcoma-a-rare-case-report
#7
JOURNAL ARTICLE
Daniel Christensen, Jeffrey A Belair, Atrayee BasuMallick, Scot A Brown, Michael Klein, Wei Jiang
A 23-year-old female patient presented with radicular back pain, perineal numbness, and urinary retention. The patient was diagnosed with cauda equina syndrome and magnetic resonance imaging (MRI) of the spine revealed an enhancing osseous lumbar lesion causing severe central stenosis. A core needle biopsy of the lumbar spine showed microscopic features compatible with a small round blue cell tumor. CD99 and FLI1 were positive in the tumor cells. Next-generation sequencing demonstrated a EWSR1::FLI1 fusion...
March 20, 2024: International Journal of Surgical Pathology
https://read.qxmd.com/read/38504389/current-understanding-of-nociplastic-pain
#8
JOURNAL ARTICLE
Yeong-Min Yoo, Kyung-Hoon Kim
Nociplastic pain by the "International Association for the Study of Pain" is defined as pain that arises from altered nociception despite no clear evidence of nociceptive or neuropathic pain. Augmented central nervous system pain and sensory processing with altered pain modulation are suggested to be the mechanism of nociplastic pain. Clinical criteria for possible nociplastic pain affecting somatic structures include chronic regional pain and evoked pain hypersensitivity including allodynia with after-sensation...
March 20, 2024: Korean Journal of Pain
https://read.qxmd.com/read/38500673/no-efficacy-with-noninvasive-brain-stimulation-for-painful-legs-and-moving-toes-a-case-report
#9
Anna Brück, Jaakko Pullinen, Janne Nummelin, Saara Lehto, Juho Joutsa
INTRODUCTION: Painful legs and moving toes (PLMT) is a rare neurological disorder characterized by neuropathic pain and involuntary movements in the lower limbs. The pathophysiological mechanisms are unclear, but central mechanisms might be involved, suggesting that noninvasive brain stimulation might be helpful. Thus far, no reports have been published on noninvasive brain stimulation to treat PLMT. CASE PRESENTATION: A 70-year-old female had a 1-year history of PLMT...
2024: Case Reports in Neurology
https://read.qxmd.com/read/38499303/therapist-guided-remote-versus-in-person-cognitive-behavioural-therapy-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#10
JOURNAL ARTICLE
Sara Zandieh, Seyedeh Maryam Abdollahzadeh, Behnam Sadeghirad, Li Wang, Randi E McCabe, Liam Yao, Briar E Inness, Ananya Pathak, Rachel J Couban, Holly Crandon, Kian Torabiardakani, Peter Bieling, Jason W Busse
BACKGROUND: Cognitive behavioural therapy (CBT) has been shown to be effective for several psychiatric and somatic conditions; however, most randomized controlled trials (RCTs) have administered treatment in person and whether remote delivery is similarly effective remains uncertain. We sought to compare the effectiveness of therapist-guided remote CBT and in-person CBT. METHODS: We systematically searched MEDLINE, Embase, PsycINFO, CINAHL, and the Cochrane Central Register of Controlled Trials from inception to July 4, 2023, for RCTs that enrolled adults (aged ≥ 18 yr) presenting with any clinical condition and that randomized participants to either therapist-guided remote CBT (e...
March 17, 2024: Canadian Medical Association Journal: CMAJ
https://read.qxmd.com/read/38497190/covid-19-vaccine-related-cervical-radiculitis-and-parsonage-turner-syndrome-case-report-and-review-of-the-literature
#11
REVIEW
Zachary C Taylor, Ravi S Nunna, Angela Tran, Matías Costa, Maxwell Gruber, Periklis Godolias, Zachary Litvack
Parsonage-Turner Syndrome, or neuralgic amyotrophy, is an acute-onset upper limb and shoulder girdle palsy that can occur in a post-viral, post-surgical or idiopathic setting. There have also been some reported cases of the syndrome occurring following vaccinations. The pathophysiology of neuralgic amyotrophy is not completely understood and many of the commonly used diagnostic imaging modalities we use to try and diagnose this syndrome are inaccurate and misleading. We present the case of a 40-year-old gentleman who presented with acute onset burning pain and fasciculations in his right upper extremity following vaccination with the second dose of the Pfizer-BioNTech COVID-19 vaccine...
2024: Turkish Neurosurgery
https://read.qxmd.com/read/38497039/effect-of-scapular-stabilization-exercises-on-subacromial-pain-impingement-syndrome-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#12
Ziyi Zhong, Wanli Zang, Ziyue Tang, Qiaodan Pan, Zhen Yang, Bin Chen
OBJECTIVE: To evaluate the effectiveness of scapular stabilization exercises (SSE) in the treatment of subacromial pain syndrome (SAPS). METHODS: Clinical randomized controlled trials (RCTs) on SSE in the treatment of SAPS were searched electronically in PubMed, Science Direct, Cochrane Central Register of Controlled Trials (CENTRAL), EBSCOhost, Physiotherapy Evidence Database (PEDro), Web of Science, and other databases from 2000 to 2022, supplemented by manual search...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38496621/thalamic-stimulation-induced-changes-in-effective-connectivity
#13
Nicholas M Gregg, Gabriela Ojeda Valencia, Harvey Huang, Brian N Lundstrom, Jamie J Van Gompel, Kai J Miller, Gregory A Worrell, Dora Hermes
Deep brain stimulation (DBS) is a viable treatment for a variety of neurological conditions, however, the mechanisms through which DBS modulates large-scale brain networks are unresolved. Clinical effects of DBS are observed over multiple timescales. In some conditions, such as Parkinson's disease and essential tremor, clinical improvement is observed within seconds. In many other conditions, such as epilepsy, central pain, dystonia, neuropsychiatric conditions or Tourette syndrome, the DBS related effects are believed to require neuroplasticity or reorganization and often take hours to months to observe...
March 4, 2024: medRxiv
https://read.qxmd.com/read/38495363/concurrent-acute-sensorimotor-axonal-neuropathy-and-disseminated-encephalitis-associated-with-chlamydia-pneumoniae-in-an-adult-patient-with-anti-mog-and-anti-sulfatide-antibodies-a-case-report
#14
Michail Papantoniou, Grigorios Panagopoulos
Acute disseminated encephalomyelitis and Guillain-Barré syndrome refer to post-infectious or post-vaccination inflammatory demyelinating disorders of central and peripheral nervous system, respectively. We report the case of a 60-year-old male patient presenting with irritability, gait difficulty, asymmetric quadriparesis (mostly in his left extremities), distal sensory loss for pain and temperature in left limbs, and reduced tendon reflexes in his upper limbs and absent in his lower limbs, following an upper respiratory tract infection, 3 weeks earlier...
2024: Therapeutic Advances in Neurological Disorders
https://read.qxmd.com/read/38479922/a-case-report-of-lactobacillus-bacteremia-in-a-patient-on-chronic-parenteral-nutrition
#15
JOURNAL ARTICLE
Hannah W Fiske, Breton Roussel, Marion Winkler, Benjamin Hall
BACKGROUND AND AIMS: Short bowel syndrome is a malabsorption disorder typically caused by the physical loss of a portion of the intestine, whereafter the body is unable to adequately absorb nutrients, fluids, and electrolytes. Many patients with short bowel syndrome are reliant on home parenteral nutrition through a tunneled or peripherally inserted central catheter to ensure sufficient hydration and nutrition. Central venous catheters are a nidus for bacteria, and patients are at risk for infections associated with high levels of morbidity and mortality...
April 2024: Clinical Nutrition ESPEN
https://read.qxmd.com/read/38470657/whole-body-cryostimulation-a-new-adjuvant-treatment-in-central-sensitization-syndromes-an-expert-opinion
#16
JOURNAL ARTICLE
Angelo Alito, Federica Verme, Gian Paolo Mercati, Paolo Piterà, Jacopo Maria Fontana, Paolo Capodaglio
Central sensitisation is defined as a multifactorial etiopathogenetic condition involving an increase in the reactivity of nociceptive neurons and alterations in pain transmission and perception in the central nervous system. Patients may present with widespread chronic pain, fatigue, sleep disturbance, dizziness, psychological (e.g., depression, anxiety, and anger) and social impairment. Pain can be spontaneous in onset and persistence, characterised by an exaggerated response and spread beyond the site of origin, and sometimes triggered by a non-painful stimulus...
February 25, 2024: Healthcare (Basel, Switzerland)
https://read.qxmd.com/read/38468316/the-diagnostic-accuracy-of-cardiac-ultrasound-for-acute-myocardial-ischemia-in-the-emergency-department-a-systematic-review-and-meta-analysis
#17
REVIEW
Virginia Zarama, María Camila Arango-Granados, Ramiro Manzano-Nunez, James P Sheppard, Nia Roberts, Annette Plüddemann
BACKGROUND: Chest pain is responsible for millions of visits to the emergency department (ED) annually. Cardiac ultrasound can detect ischemic changes, but varying accuracy estimates have been reported in previous studies. We synthetized the available evidence to yield more precise estimates of the accuracy of cardiac ultrasound for acute myocardial ischemia in patients with chest pain in the ED and to assess the effect of different clinical characteristics on test accuracy. METHODS: A systematic search for studies assessing the diagnostic accuracy of cardiac ultrasound for myocardial ischemia in the ED was conducted in MEDLINE, EMBASE, CENTRAL, CINAHL, LILACS, Web of Science, two trial registries and supplementary methods, from inception to December 6th, 2022...
March 11, 2024: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://read.qxmd.com/read/38465808/-features-of-fibromyalgia-in-patients-with-rheumatoid-arthritis
#18
JOURNAL ARTICLE
N A Melikova, E G Filatova, E S Filatova
OBJECTIVE: To determine the features of fibromyalgia (FM) in patients with rheumatoid arthritis (RA). MATERIAL AND METHODS: Seventy-six patients participated in the study. The patients were divided into 2 groups: RA+FM ( n =55), FM ( n =21). Anamnesis of life and disease was carefully collected in all patients. The intensity (according to VAS) and phenotype (Pain DETECT, DN4) of pain syndrome (PS), the presence of symptoms of central sensitization (CSI), fatigue (FSS), signs of anxiety and depression (HADS), sleep quality (PSQI), cognitive functions (DSST) and quality of life (QoL) (EQ-5D, FIQR) were also evaluated...
2024: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://read.qxmd.com/read/38456175/surgical-management-of-cubital-tunnel-syndrome-a-systematic-review-and-meta-analysis-of-randomised-trials
#19
REVIEW
Eslam Abourisha, Ananth S Srinivasan, Ahmed Barakat, Han Hong Chong, Harvinder P Singh
BACKGROUND: Cubital tunnel syndrome (CUTS) is a common upper limb compression neuropathy with significant consequences when left untreated. Surgical decompression remains gold-standard treatment for moderate to severe disease, however the optimal operative technique remains unclear. This network meta-analysis (NMA) of Level I and II randomised prospective studies aims to discern superiority between open in-situ, endoscopic and anterior transposition (subcutaneous or submuscular techniques) with respect to the primary outcome of response-to-treatment and secondary outcomes which include complications, post-operative chronic pain VAS scale, return to work and re-operation...
July 2024: Journal of Orthopaedics
https://read.qxmd.com/read/38452215/peripheral-and-central-neurobiological-effects-of-botulinum-toxin-a-bont-a-in-neuropathic-pain-a-systematic-review
#20
JOURNAL ARTICLE
Nathan Moreau, Sohaib Ali Korai, Giovanna Sepe, Fivos Panetsos, Michele Papa, Giovanni Cirillo
Botulinum toxin (BoNT), a presynaptic inhibitor of acetylcholine (Ach) release at the neuromuscular junction (NMJ), is a successful and safe drug for the treatment of several neurological disorders. However, a wide and recent literature review has demonstrated that BoNT exerts its effects not only at the "periphery" but also within the central nervous system (CNS). Studies from animal models, in fact, have shown a retrograde transport to the CNS, thus modulating synaptic function. The increasing number of articles reporting efficacy of BoNT on chronic neuropathic pain (CNP), a complex disease of the CNS, demonstrates that the central mechanisms of BoNT are far from being completely elucidated...
March 5, 2024: Pain
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