keyword
https://read.qxmd.com/read/37020505/hemangioblastoma-of-the-medulla-oblongata-that-caused-isolated-fourth-ventricle-after-stereotactic-radiosurgery-a-case-report
#21
Yuya Hama, Takahiro Sasaki, Toshikazu Yamoto, Junya Fukai, Hiroki Nishibayashi, Naoyuki Nakao
Isolated fourth ventricle is a rare complication following shunt insertion of the lateral ventricles for hydrocephalus. The present report describes a rare case of a hemangioblastoma of the medulla oblongata that caused isolated fourth ventricle due to intraventricular deposition of fibrin. A 34-year-old man presented with headache a month before admission. Magnetic resonance imaging indicated multiple tumors in the medulla oblongata and the bilateral cerebellar hemisphere with surrounding edema, and the patient was diagnosed with hemangioblastoma...
May 2023: Molecular and Clinical Oncology
https://read.qxmd.com/read/36479256/expression-of-muc1-in-different-tumours-and-its-clinical-significance-review
#22
REVIEW
Yue Lan, Weihua Ni, Guixiang Tai
Mucin 1 (MUC1) was the first discovered transmembrane protein of the mucin family; it normally covers epithelial cells of the mucous membrane, providing lubrication and protection. However, aberrant expression of MUC1 is involved in cancer development, invasion and metastasis. It has been reported that MUC1 upregulation is highly associated with the progression of different epithelial cancer types, such as lung, liver, pancreatic and breast cancer. Therefore, MUC1 can be used as a specific marker and a target for immunotherapy in clinical applications, and the detection of MUC1 expression levels can be used to diagnose the occurrence, metastasis, prognosis and recurrence of cancer...
December 2022: Molecular and Clinical Oncology
https://read.qxmd.com/read/36446477/increased-seizure-frequency-in-an-epilepsy-patient-receiving-medium-cut-off-dialysis
#23
JOURNAL ARTICLE
Maria Lean, Stephen May, Michael McLucas, Malcolm Green
This paper presents the case of a male dialysis patient, with generalised epilepsy, who experienced complications after starting medium cut-off (MCO) dialysis. While receiving haemodiafiltration, the patient's epilepsy had been relatively well controlled using two antiseizure medications (brivaracetam and sodium valproate). However, the patient's seizure frequency increased when he was changed to MCO dialysis. MCO is a new dialysis method that has been developed to allow for better clearance of uraemic toxins through its larger pore size...
November 29, 2022: BMJ Case Reports
https://read.qxmd.com/read/36420938/comparison-of-2-medium-cutoff-dialyzers-versus-on-line-hemodiafiltration-regarding-depurative-ability-and-albumin-loss-an-uncontrolled-clinical-research
#24
JOURNAL ARTICLE
Patricia Martínez-Miguel, Rocío Gimena Muñoz, Marta Barrionuevo González, Susana López-Ongil, María Ángeles Moro, Ignacio Lizasoain, Diego Rodríguez-Puyol, Juan Manuel García Segura
BACKGROUND: Hemodialysis (HD) techniques that best remove molecules in the middle to high molecular weight range are on-line hemodiafiltration (OL-HDF) and HD with medium cut-off (MCO) membranes. The aim of this study was to compare efficacy and safety of OL-HDF with FxCordiax HDF 800™, with HD with 2 MCO dialyzers: Theranova 500® and the new Elisio 21HX™ dialyzer. METHODS: Fourteen patients following treatment with OL-HDF using FxCordiax HDF 800™ were randomized to receive a consecutive 1-week HD treatment with Theranova 500® and Elisio 21HX™...
November 24, 2022: Artificial Organs
https://read.qxmd.com/read/36356029/the-medium-cut-off-membrane-does-not-lower-protein-bound-uremic-toxins
#25
JOURNAL ARTICLE
Yang Gyun Kim, Sang Ho Lee, Su Woong Jung, Gun Tae Jung, Hyun Ji Lim, Kwang Pyo Kim, Young-Il Jo, KyuBok Jin, Ju Young Moon
The accumulation of protein-bound uremic toxins (PBUT) is associated with increased cardiovascular outcomes in patients on dialysis. However, the efficacy of PBUT removal for a medium-cutoff (MCO) membrane has not been clarified. This study was designed to assess the efficacy of PBUT clearance according to dialysis modalities. In this prospective and cross-over study, we enrolled 22 patients who received maintenance hemodiafiltration (HDF) thrice weekly from three dialysis centers. The dialysis removal of uremic toxins, including urea, beta 2-microglobulin (B2MG), lambda free light chain (λ-FLC), indoxyl sulfate (IS), and p-cresyl sulfate (pCS), was measured in the 22 patients on high-flux HD (HF-HD), post-dilution online HDF (post-OL-HDF), and MCO-HD over 3 weeks...
November 10, 2022: Toxins
https://read.qxmd.com/read/36316065/expanded-hemodialysis-a-new-concept-of-renal-replacement-therapy
#26
JOURNAL ARTICLE
Jonny Jonny, Maria Teressa
Expanded hemodialysis (HDx) is an innovation that can increase the effectiveness of hemodialysis. The dialysis process is expected to promote more uremic toxins removal without causing significant hypoalbuminemia using the medium cut-off (MCO) membrane or also known as the high retention onset membrane. Compared with conventional membranes such as those of low-flux hemodialysis, high-flux hemodialysis, and hemodiafiltration, the MCO membrane in HDx is considered to be the closest to the physiology of the glomerular membrane...
January 2023: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://read.qxmd.com/read/36215951/comparison-of-high-flux-super-high-flux-medium-cut-off-hemodialysis-and-online-hemodiafiltration-on-the-removal-of-uremic-toxins
#27
JOURNAL ARTICLE
Mohamed Belmouaz, Guillaume Goussard, Florent Joly, Audrey Sibille, Cecile Martin, Thomas Betous, Antoine Thierry, Marc Bauwens, Frank Bridoux
INTRODUCTION: Online hemodiafiltration (OL-HDF) and hemodialysis (HD) using high-performance membranes such as adsorptive, medium cut-off (MCO), and super high-flux (SHF) dialyzers have been implemented to enhance the removal of middle molecules (MM). The aim of this study was to compare the efficacy of different dialysis strategies and dialyzers on small solutes and MM reduction ratio (RR) and mass removal. METHODS: We performed a prospective study in 8 HD patients...
2023: Blood Purification
https://read.qxmd.com/read/36180564/a-randomized-prospective-cross-over-study-on-the-effects-of-medium-cut-off-membranes-on-t-cellular-and-serologic-immune-phenotypes-in-hemodialysis
#28
RANDOMIZED CONTROLLED TRIAL
Georg Lorenz, Yuli Shen, Renate Ilona Hausinger, Caroline Scheid, Marie Eckermann, Sophia Hornung, Joana Cardoso, Maciej Lech, Andrea Ribeiro, Bernhard Haller, Christopher Holzmann-Littig, Dominik Steubl, Matthias C Braunisch, Roman Günthner, Andreas Poschenrieder, Britt Freitag, Mario Weber, Peter Luppa, Uwe Heemann, Christoph Schmaderer
Extended cut-off filtration by medium cut-off membranes (MCO) has been shown to be safe in maintenance hemodialysis (HD). The notion of using them for the control of chronic low-grade inflammation and positively influencing cellular immune aberrations seems tempting. We conducted an open label, multicenter, randomized, 90 day 2-phase cross over clinical trial (MCO- vs. high flux-HD). 46 patients underwent randomization of which 34 completed the study. Dialysate- or pre- and post-dialysis serum inflammatory mediators were assayed for each study visit...
September 30, 2022: Scientific Reports
https://read.qxmd.com/read/36172002/methanol-extraction-revealed-anticancer-compounds-quinic-acid-2-5h-%C3%A2-furanone-and-phytol-in-andrographis-paniculata
#29
JOURNAL ARTICLE
Pawan Kumar Anoor, A Nichita Yadav, Karthik Rajkumar, Ramesh Kande, Chaturvedula Tripura, K Srinivas Naik, Sandeepta Burgula
Andrographis paniculata (Ap) has been a part of traditional medicine for its anti-inflammatory effects, treatment of snake bites and liver abnormalities. Several investigations have revealed its bioactive components to be andrographolides. The methanolic extracts of leaves from Ap were characterized, the non-andrographolides were identified and screened for anti-proliferative activity. The extracts showed significant toxicity against numerous cancer cells including HeLa, MCF7, BT549, 293 and A549 cells. Anti-proliferative activity and effect on cancer cell invasion (metastatic potential) and cell migration were examined...
November 2022: Molecular and Clinical Oncology
https://read.qxmd.com/read/35686486/impact-of-medium-cut-off-membranes-on-s100a12-and-soluble-receptor-for-advanced-glycation-end-products
#30
JOURNAL ARTICLE
Berfu Korucu, Hasan Yeter, Sevim Gonen, Mehmet Kursat Derici, Claudio Ronco, Ulver Derici
INTRODUCTION: Of the most remarkable molecules associated with atherosclerosis and the cardiovascular outcome are S100A12 (10,379.5 Da) and soluble receptor for advanced glycation end products (sRAGE-42,803 Da) in the hemodialysis (HD) population. We designed a study investigating the effects of the medium cut-off (MCO) dialyzers focusing on S100A12 and sRAGE in HD patients compared with low-flux and high-flux dialyzers. METHODS: This single-site, prospective, observational study comprises age and sex-matched HD groups (low-flux, high-flux, and MCO)...
2023: Seminars in Dialysis
https://read.qxmd.com/read/35629769/effects-of-medium-cut-off-polyarylethersulfone-and-polyvinylpyrrolidone-blend-membrane-dialyzers-in-hemodialysis-patients-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#31
REVIEW
Yu-Hui Hung, Tai-Shuan Lai, Mohamed Belmouaz, Ya-Chun Tu, Chun-Fu Lai, Shuei-Liong Lin, Yung-Ming Chen
The use of medium cut-off (MCO) polyarylethersulfone and polyvinylpyrrolidone blend membrane is an emerging mode in hemodialysis. Recent studies have shown that MCO membranes exhibit a middle high molecular weight uremic toxin clearance superior to standard high flux hemodialysis. We conducted a systematic literature review and meta-analysis of randomized controlled trials to investigate whether MCO membranes efficiently increase the reduction ratio of middle molecules, and to explore the potential clinical applications of MCO membranes...
April 20, 2022: Membranes
https://read.qxmd.com/read/35492142/medium-cutoff-versus-high-flux-hemodialysis-membranes-and-clinical-outcomes-a-cohort-study-using-inverse-probability-treatment-weighting
#32
JOURNAL ARTICLE
Alejandra P Molano, Colin A Hutchison, Ricardo Sanchez, Angela S Rivera, Giancarlo Buitrago, María P Dazzarola, Mario Munevar, Mauricio Guerrero, Jasmín I Vesga, Mauricio Sanabria
RATIONALE & OBJECTIVE: This study investigated the effects on patients' outcomes of using medium cutoff (MCO) versus high-flux (HF) dialysis membranes. STUDY DESIGN: A retrospective, observational, multicenter, cohort study. SETTING & PARTICIPANTS: Patients aged greater than 18 years receiving hemodialysis at the Baxter Renal Care Services dialysis network in Colombia. The inception of the cohort occurred from September 1, 2017, to November 30, 2017, with follow-up to November 30, 2019...
April 2022: Kidney medicine
https://read.qxmd.com/read/35479864/biocidal-activity-of-ba-2-doped-ceo-2-nps-against-streptococcus-mutans-and-staphylococcus-aureus-bacterial-strains
#33
JOURNAL ARTICLE
Natarajan Sisubalan, Chandrasekaran Karthikeyan, Venugopal Senthil Kumar, Kokkarachedu Varaprasad, Abdulrahman Syed Ahamed Haja Hameed, Ramar Vanajothi, Rotimi Sadiku
Mishandling of antibiotics often leads to the development of multiple drug resistance (MDR) among microbes, resulting in the failure of infection treatments and putting human health at great risk. As a response, unique nanomaterials with superior bioactivity must be developed to combat bacterial infections. Herein, CeO2 -based nanomaterials (NMs) were synthesized by employing cerium(iii) nitrate and selective alkaline ions. Moreover, the influence of alkaline ions on CeO2 was investigated, and their characteristics, viz...
September 14, 2021: RSC Advances
https://read.qxmd.com/read/35456352/clinical-safety-of-expanded-hemodialysis-compared-with-hemodialysis-using-high-flux-dialyzer-during-a-three-year-cohort
#34
JOURNAL ARTICLE
Nam-Jun Cho, Seung-Hyun Jeong, Ka Young Lee, Jin Young Yu, Samel Park, Eun Young Lee, Hyo-Wook Gil
Expanded hemodialysis (HD) equipped with a medium cut-off (MCO) membrane provides superior removal of larger middle molecules. However, there is still little research on the long-term benefits of expanded HD. Over a three-year period, this observational study evaluated the efficacy and safety profile of expanded HD for inflammatory cytokines, including IL-6. We conducted a prospective cohort study to investigate the inflammatory cytokine changes and a retrospective observational cohort study to investigate long-term clinical efficacy and safety over a three-year period...
April 18, 2022: Journal of Clinical Medicine
https://read.qxmd.com/read/35402469/a-novel-mutation-in-the-membrane-frizzled-related-protein-gene-for-posterior-microphthalmia-non-pigmented-retinitis-pigmentosa-optic-nerve-drusen-and-retinoschisis-in-a-consanguineous-family
#35
JOURNAL ARTICLE
Xiang Ren, Yunxia Gao, Yu Lin, Xiangyu Fu, Lirong Xiao, Xiaoyue Wang, Zhibing Zeng, Li Bao, Naihong Yan, Ming Zhang, Li Tang
Background: Microphthalmos (MCO) is a rare developmental defect characterized by small malformed eyes. Our study aimed to describe the clinical characteristics of posterior microphthalmos syndrome caused by a novel variant in MFRP gene in a Chinese patient. Methods: Complete ophthalmologic examinations were performed for the proband and proband's family members. Whole exon sequencing (WES) and Sanger sequencing were used to identify the mutated genes, and bioinformatic analysis was undertaken to predict the effect of this variant...
2022: Frontiers in Medicine
https://read.qxmd.com/read/35340002/extracorporeal-removal-of-myoglobin-in-patients-with-rhabdomyolysis-and-acute-kidney-injury-comparison-of-high-and-medium-cut-off-membrane-and-an-adsorber-cartridge
#36
JOURNAL ARTICLE
Alexander Jerman, Milena Andonova, Vanja Persic, Jakob Gubensek
INTRODUCTION: The role of extracorporeal myoglobin removal in the treatment of rhabdomyolysis-associated severe acute kidney injury (AKI) is not yet fully established. High cut-off (HCO) and medium cut-off (MCO) dialysis membrane and cytokine adsorber (CytoSorb®) have been used to this purpose in clinical practice. The data on comparative effectiveness of those methods are scarce. METHODS: In this single-center retrospective study, we included patients with AKI and concomitant rhabdomyolysis (myoglobin >20,000 μg/L), who underwent at least one extracorporeal myoglobin removal procedure...
2022: Blood Purification
https://read.qxmd.com/read/35323729/effects-of-expanded-hemodialysis-with-medium-cut-off-membranes-on-maintenance-hemodialysis-patients-a-review
#37
REVIEW
Zhuyun Zhang, Tinghang Yang, Yupei Li, Jiameng Li, Qinbo Yang, Liya Wang, Luojia Jiang, Baihai Su
Kidney failure is associated with high morbidity and mortality. Hemodialysis, the most prevalent modality of renal replacement therapy, uses the principle of semipermeable membranes to remove solutes and water in the plasma of patients with kidney failure. With the evolution of hemodialysis technology over the last half century, the clearance of small water-soluble molecules in such patients is adequate. However, middle molecules uremic toxins are still retained in the plasma and cause cardiovascular events, anemia, and malnutrition, which significantly contribute to poor quality of life and high mortality in maintenance hemodialysis patients...
February 23, 2022: Membranes
https://read.qxmd.com/read/35083060/clinical-outcomes-with-medium-cut-off-versus-high-flux-hemodialysis-membranes-a-systematic-review-and-meta-analysis
#38
JOURNAL ARTICLE
Maryam Kandi, Romina Brignardello-Petersen, Rachel Couban, Celina Wu, Gihad Nesrallah
BACKGROUND: A novel medium cut-off (MCO) dialyzer (Theranova, Baxter Healthcare, Deerfield, IL, USA) enhances large middle molecule clearance while retaining selectivity for molecules >45 000 Da. OBJECTIVE: We undertook a systematic review and meta-analysis evaluating clinical outcomes with MCO vs high-flux membranes. METHODS: We searched MEDLINE, EMBASE, CINAHL, Cochrane Library, and Web of Science through July 2020, and gray literature sources from 2017...
2022: Canadian Journal of Kidney Health and Disease
https://read.qxmd.com/read/35070336/effects-of-medium-cut-off-versus-high-flux-hemodialysis-membranes-on-biomarkers-a-systematic-review-and-meta-analysis
#39
JOURNAL ARTICLE
Maryam Kandi, Romina Brignardello-Petersen, Rachel Couban, Celina Wu, Gihad Nesrallah
BACKGROUND: Medium cut-off (MCO) membranes enhance large middle-molecule clearance while selectively retaining molecules >45 000 Da. OBJECTIVES: We undertook a systematic review and meta-analysis comparing the effects of MCO versus high-flux membranes on biomarkers. METHODS: We searched MEDLINE, Embase, CINAHL, Cochrane Library, and Web of Science from January 2015 to July 2020, and gray literature sources from 2017. We included randomized (RS) and nonrandomized studies (NRS) comparing MCO and high-flux membranes in adults (>18 years) receiving maintenance hemodialysis...
2022: Canadian Journal of Kidney Health and Disease
https://read.qxmd.com/read/34984102/prognostic-value-of-the-immunohistochemistry-markers-cd56-ttf-1-synaptophysin-cea-ema-and-nse-in-surgically-resected-lung-carcinoid-tumors
#40
JOURNAL ARTICLE
Vasiliki Epameinondas Georgakopoulou, Eleftherios Zygouris, Christos Damaskos, Aikaterini Pierrakou, Petros Papalexis, Nikolaos Garmpis, Aikaterini Aravantinou-Fatorou, Serafeim Chlapoutakis, Evangelos Diamantis, Christos Nikokiris, Aikaterini Gkoufa, Pagona Sklapani, Nikolaos Trakas, Jim Janinis, Demetrios A Spandidos, Jubrail Dahabreh
Lung carcinoid tumor is a type of neuroendocrine tumor, which is subdivided into typical carcinoid (TC) and atypical carcinoid (AT), based on the rate of mitosis and the presence of necrosis. Several prognostic factors for lung carcinoids have been reported in the literature, including the type, Ki67 index, stage, chemotherapy and radiation therapy. In the present study, 108 cases with resected carcinoid lung tumors were enrolled and the expression of CD56, thyroid transcription factor 1, synaptophysin, carcinoembryonic antigen, epithelial membrane antigen and neuron-specific enolase (NSE) in the resected tissue specimens was immunohistochemically analyzed...
February 2022: Molecular and Clinical Oncology
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