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Coffee derivatives

Mingli Zhu, Lizhong Yang, Weifeng Zhang, Chengyuan Cai, Xiangdong Zhou
A method using ultra high performance liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry (UHPLC-APCI-MS/MS) was developed for the determination of acrylamide in coffee. The coffee samples spiked with 13 C3 -acrylamide as the internal standard were extracted with methanol, and cleaned using HLB solid phase extraction (SPE) cartridges. The liquid chromatography separation was performed on a Brownlee validated AQ C18 column with isocratic elution. Methanol and 0.1% (volume percentage) formic acid aqueous solution were used as the mobile phase...
February 8, 2019: Se Pu, Chinese Journal of Chromatography
Raffaella Colombo, Adele Papetti
Coffee is reported to be among the most widely consumed beverages in the world and coffee consumption has been associated with reductions in the risk of several chronic diseases. Among its constituents, caffeine represents the most investigated component. The main impact of caffeine on health is associated with the central nervous system, the cardiovascular system, the inflammatory mechanisms, the metabolism of carbohydrates, and the cancer. Current research is devoted to the role of this compound and its analogs or derivatives on neuroinflammation and neurodegenerative disorders, mainly Alzheimer's Disease and Parkinson's Disease...
January 7, 2019: Critical Reviews in Food Science and Nutrition
Thammarat Aree
This work reports the elusive structural evidence for the [4]pseudorotaxane of β-cyclodextrin (β-CD) with coffee chlorogenic acid (CGA), a conjugate of caffeic acid (CFA) and quinic acid (QNA). A single-crystal X-ray structure analysis of the inclusion complex β-cyclodextrin-chlorogenic acid-water (2/2/17), 2C42 H70 O35 ·2C16 H18 O9 ·17H2 O, reveals that CGA threads through β-CD and assembles via O-H...O hydrogen bonds and parallel-displaced π-π interactions in the twofold symmetry-related dimer yielding a [4]pseudorotaxane, which is crystallographically observed for the first time in CD inclusion complexes...
January 1, 2019: Acta Crystallographica. Section C, Structural Chemistry
Virginie Merot-L'Anthoene, Rémi Tournebize, Olivier Darracq, Vimel Rattina, Maud Lepelley, Laurence Bellanger, Christine Tranchant-Dubreuil, Manon Coulee, Marie Pegard, Sylviane Metairon, Coralie Fournier, Piet Stoffelen, Steven B Janssens, Catherine Kiwuka, Pascal Musoli, Ucu Sumirat, Hyacinthe Legnate, Jean-Léon Kambale, Clara Revel, Alexandre De Kochko, Patrick Descombes, Dominique Crouzillat, Valérie Poncet
Coffee species such as Coffea canephora P. (Robusta) and C. arabica L. (Arabica) are important cash crops in tropical regions around the world. C. arabica is an allotetraploid (2n=4x=44) originating from a hybridization event of the two diploid species C. canephora and C. eugenioides (2n= 2x=22). Interestingly, these progenitor species harbor a greater level of genetic variability and are an important source of genes to broaden the narrow Arabica genetic base. Here, we describe the development, evaluation and use of a single-nucleotide polymorphism (SNP) array for coffee trees...
December 24, 2018: Plant Biotechnology Journal
Juan C Sanchez-Hernandez, Juan Manuel Ríos, Andrés Maximiliano Attademo, Alessio Malcevschi, Ximena Andrade Cares
Potential harmful effects of spent coffee grounds (SCGs)-derived biochar on earthworms (Lumbricus terrestris) were investigated through two complementary experiments, which assessed the avoidance response of earthworms to biochar-amended soils (experiment 1), and the response of oxidative stress biomarkers and digestive enzymes (experiment 2). The main results were: 1) the highest dose of biochar (5% w/w) caused a significant avoidance response of earthworms (75% individuals avoided these treated soils after 48 h); 2) signs of oxidative stress were early detected in earthworms exposed to biochar (1 and 5% w/w) as indicated by the integrated biological response index; 3) earthworms exposed to biochar-amended soils for 30 d experienced a significant increase of digestive enzyme activities measured in both the gastrointestinal tissue and the luminal content; 4) interaction between earthworms and biochar led to a higher soil extracellular enzyme activities in the 1% biochar treatment than that of control and 5% biochar treatments...
December 11, 2018: Journal of Hazardous Materials
Run Yan, Jie Zhang, Hye-Jin Park, Eun S Park, Stephanie Oh, Haiyan Zheng, Eunsung Junn, Michael Voronkov, Jeffry B Stock, M Maral Mouradian
Hyperphosphorylated α-synuclein in Lewy bodies and Lewy neurites is a characteristic neuropathological feature of Parkinson's disease (PD) and Dementia with Lewy bodies (DLB). The catalytic subunit of the specific phosphatase, protein phosphatase 2A (PP2A) that dephosphorylates α-synuclein, is hypomethylated in these brains, thereby impeding the assembly of the active trimeric holoenzyme and reducing phosphatase activity. This phosphatase deficiency contributes to the accumulation of hyperphosphorylated α-synuclein, which tends to fibrillize more than unmodified α-synuclein...
December 18, 2018: Proceedings of the National Academy of Sciences of the United States of America
Rosimeire Resende Dos Santos, Lívia Dias Vidotti Leal, Zenilda de Lourdes Cardeal, Helvécio Costa Menezes
Polycyclic aromatic hydrocarbons (PAHs) are food contaminants; besides, their oxygenated (oxy-PAHs) and nitrated (nitro-PAHs) derivatives have also been detected in some foods. This is worrying because these derivatives may be more toxic than PAHs. This study presents a new method for the determination of PAHs and their oxygenated and nitrated derivatives in coffee brew. The analytes were extracted by cold fiber solid phase microextraction (CF-SPME) with analysis by gas chromatography/mass spectrometry. The developed method presented good precision with intra-assay and inter-assay, ranged from 4...
November 26, 2018: Journal of Chromatography. A
Hervé Etienne, David Breton, Jean-Christophe Breitler, Benoît Bertrand, Eveline Déchamp, Rayan Awada, Pierre Marraccini, Sophie Léran, Edgardo Alpizar, Claudine Campa, Philippe Courtel, Frédéric Georget, Jean-Paul Ducos
Since the 1990s, somatic embryogenesis (SE) has enabled the propagation of selected varieties, Arabica F1 hybrid and Robusta clones, originating from the two cultivated coffee species, Coffea arabica and Coffea canephora , respectively. This paper shows how mostly empirical research has led to successful industrial transfers launched in the 2000s in Latin America, Africa, and Asia. Coffee SE can be considered as a model for other woody perennial crops for the following reasons: (i) a high biological efficiency has been demonstrated for propagated varieties at all developmental stages, and (ii) somaclonal variation is understood and mastered thanks to intensive research combining molecular markers and field observations...
2018: Frontiers in Plant Science
Huan-Cheng Chang, Chuan-Fa Hsieh, Yi-Chin Lin, Disline Manli Tantoh, Pei-Chieh Ko, Ya-Yu Kung, Mei-Chi Wang, Shu-Yi Hsu, Yi-Ching Liaw, Yung-Po Liaw
BACKGROUND: Results from studies investigating the association between coffee consumption and osteoporosis or bone mineral density (BMD) have been inconsistent. This longitudinal study was performed to assess the effect of coffee drinking on bone health of Taiwanese adults. METHODS: Data were retrieved from the Li-Shin (Landseed) Hospital in Taoyuan City. In 2006, 6152 participants completed a questionnaire on coffee drinking and other lifestyle factors. In 2014, 5077 of them were followed up...
November 20, 2018: BMC Public Health
Renata Zawirska-Wojtasiak, Paulina Piechowska, Elżbieta Wojtowicz, Krzysztof Przygoński, Sylwia Mildner-Szkudlarz
Epidemiological studies have suggested that coffee consumption is negatively correlated with the incidence of Parkinson's disease. Coffee contains relatively high levels of β-carbolines, which have been ascribed neuroactive effects in humans however the positive or negative effect has not been confirmed yet. Two ingredients with applications as coffee substitutes-chicory, which is traditionally used in this way, and artichoke-were considered in this study both from the neuroactive point of view but also in relation to the other bioactive compounds that result from their thermal processing...
2018: PloS One
Quynh Anh Nguyen, Eun Jin Cho, Dae-Seok Lee, Hyeun-Jong Bae
Spent coffee grounds (SCG) or coffee residue wastes (CRW) provide excellent raw material for mannose and bioethanol production. In this study, SCG were used to produce valuable biosugars, including oligosaccharides (OSs), manno-oligosaccharides (MOSs), mannose, and bioethanol. SCG were subjected to delignification and defatting, producing SCG-derived polysaccharides. Two-stage enzymatic hydrolysis (short- and long-term) was performed to produce short-chain manno-oligosaccharides (MOSs) and monosaccharides (MSs), respectively...
October 6, 2018: Bioresource Technology
Ling-Wei Chen, Roisin Fitzgerald, Celine M Murrin, John Mehegan, Cecily C Kelleher, Catherine M Phillips
Background: Maternal caffeine intake is associated with adverse birth outcomes, but in most studies the primary caffeine source is coffee; the influence of tea caffeine remains unclear. Objective: The aim of the study was to examine the association between maternal caffeine intake and birth outcomes in a population with tea as the predominant caffeine source. Design: Data from 941 Irish mother-child pairs of the Lifeways Cross Generation Cohort Study were examined...
December 1, 2018: American Journal of Clinical Nutrition
Antonia Costa-Bauza, Felix Grases, Paula Calvó, Adrian Rodriguez, Rafael M Prieto
The purpose of this study was to determine the effects of consumption of different cocoa-derived products on uric acid crystallization in urine of 20 healthy volunteers. Participants were requested to select the specific diet that they wished to follow during the 12 h prior to collection of urine. The only restriction was that the diet could not include any product with cocoa, coffee, or caffeine. On the first day, each volunteer followed their selected diet, and an overnight 12 h urine sample was collected as the baseline urine...
October 16, 2018: Nutrients
Anja Rahn, Chahan Yeretzian
This study examined the influence of consumer behavior on furan, 2-methylfuran, 3-methylfuran, 2,5-dimethylfuran and 2,3-dimethylfuran exposure in coffee. Coffees brewed using a filter, fully automatic, capsule machine or reconstituted instant coffee were found to have a significant different cup concentrations of furan derivatives. Coffee brewed with the fully automatic machine contained the highest furan and furan derivative concentrations (99.05 µg/L furan, 263.91 µg/L 2-methylfuran, 13.15 µg/L 3-methylfuran and 8...
January 30, 2019: Food Chemistry
Gilberto V de Melo Pereira, Dão P de Carvalho Neto, Antonio I Magalhães Júnior, Zulma S Vásquez, Adriane B P Medeiros, Luciana P S Vandenberghe, Carlos R Soccol
The aim of this review is to describe the volatile aroma compounds of green coffee beans and evaluate sources of variation in the formation and development of coffee aroma through postharvest processing. The findings of this survey showed that the volatile constituents of green coffee beans (e.g., alcohols, aldehydes, and alkanes) have no significant influence on the final coffee aroma composition, as only a few such compounds remain in the beans after roasting. On the other hand, microbial-derived, odor-active compounds produced during removal of the fruit mucilage layer, including esters, higher alcohols, aldehydes, and ketones, can be detected in the final coffee product...
January 30, 2019: Food Chemistry
Nivedita Singh, Ashwinee Kumar Shreshtha, M S Thakur, Sanjukta Patra
Medicinal plants have been the basis for discovery of various important marketed drugs. Xanthine is one such lead molecule. Xanthines in various forms (caffeine, theophylline, theobromine, etc) are abode in tea, coffee, cocoa, chocolate etc. giving them popular recognition. These compounds are best known for their diverse pharmaceutical applications as cyclic nucleotide phosphodiesterase inhibition, antagonization of adenosine receptor, anti-inflammatory, anti-microbial, anti-oxidant and anti-tumor activities...
October 2018: Heliyon
Cees J M van Rijn
We show that emanating jets can be regarded as growing liquid towers, which are shaped by the twofold action of surface tension: first the emanated fluid is being accelerated back by surface tension force, herewith creating the boundary conditions to solve the shape of the liquid tower as a solution of an equation mathematically related to the hydrostatic Young-Laplace equation, known to give solutions for the shape of pending and sessile droplets, and wherein the only relevant forces are gravity g and surface tension γ...
November 20, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Ningjian Liang, David D Kitts
Understanding the potential effects of chlorogenic acid (CGA) isomers on the intestinal epithelium is important because coffee intake exposes consumers to the six major CGA isomers: 3-caffeoylquinic acid (3-CQA), 4-caffeoylquinic acid (4-CQA), 5-caffeoylquinic acid (5-CQA), 3,4-dicaffeoylquinic acid (3,4-diCQA), 3,5-dicaffeoylquinic acid (3,5-diCQA), and 4,5-dicaffeoylquinic acid (4,5-diCQA). The present study determined the relative effects of CGA isomers on the antioxidant status of inflamed Caco-2 intestinal cells by investigating the oxidative-stress-responsive pathway and nuclear-factor-erythroid-derived-2-like 2 (Nrf2) signaling...
October 24, 2018: Journal of Agricultural and Food Chemistry
Xiumin Chen, Kaiwen Mu, David D Kitts
Our previous study reported that different tea processing methods along with the age of coffee leaves affected antioxidant and anti-inflammatory bioactivities; however, identification of phytochemical components or associated mixtures that contribute to the anti-/pro-inflammatory activities was not determined. Herein, we report results of additional experiments designed to characterize the phytochemical composition of fractionated coffee leaf extract, derived from Japanese-style-green-tea-process-young (JGTP-Y) and black-tea-process-mature (BTP-M) leaves and related these data to anti-/pro-inflammatory activities...
January 15, 2019: Food Chemistry
Cheol Soo Yoon, Min Keun Kim, Yeon Sook Kim, Suk Keun Lee
RAW 264.7 cells and HUVECs were compared to evaluate the effects of dialyzed coffee extract (DCE) and artificial coffee (AC). Immunoprecipitation high performance liquid chromatography (IP-HPLC) showed DCE-2.5- (equivalent to 2.5 cups of coffee a day) and DCE-5-induced protein expression that was beneficial to human health, i.e., they led to significant increases in proliferation-, immunity-, cellular protection-, antioxidant signaling-, and osteogenesis-related proteins but decreases in inflammation-, NFkB signaling-, cellular apoptosis-, and oncogenic signaling-related proteins in RAW 264...
September 14, 2018: Scientific Reports
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