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https://read.qxmd.com/read/30709772/incidence-of-atrial-fibrillation-in-conjunction-with-breast-cancer
#1
Maria D'Souza, Lærke Smedegaard, Christian Madelaire, Dorte Nielsen, Christian Torp-Pedersen, Gunnar Gislason, Morten Schou, Emil Fosbøl
BACKGROUND: Patients with breast cancer may have an increased incidence of atrial fibrillation (AF) because of the systemic inflammation induced by the cancer and side effects of treatments. OBJECTIVE: The purpose of this study was to estimate the long-term incidence of AF in patients with breast cancer compared with the background population. METHODS: We identified patients diagnosed with breast cancer from 1998 to 2015 by using nationwide registries...
January 24, 2019: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://read.qxmd.com/read/30701759/clinical-features-of-cardiac-lesion-in-patients-with-generalized-sarcoidosis
#2
E N Popova, L A Strizhakov, V I Sholomova, A B Ponomarev, S V Moiseev, M U Brovko, I B Bondarenko, L A Ponomareva, V V Fomin
The article presents a clinical observation of two patients with generalized sarcoidosis. The woman typical granulomatous changes in the lungs and lymph nodes combined with atrial fibrillation, kidney failure and hereditary thrombophilia, men with atherosclerotic coronary arteries, re-myocardial infarction, cholestasis, tubulointerstitial nephritis. The accession of systemic manifestations was accompanied by increase of level of angiotensin-converting enzyme in the blood serum, morphological examination of lung tissue in both cases there were high histological activity of vasculitis and granulomatous inflammation...
February 14, 2018: Terapevticheskiĭ Arkhiv
https://read.qxmd.com/read/30691323/obstructive-sleep-apnoea-and-comorbidity-an-overview-of-the-association-and-impact-of-continuous-positive-airway-pressure-therapy
#3
Walter T McNicholas
Obstructive sleep apnoea (OSA) is highly prevalent and there is considerable evidence supporting an independent association with a wide range of co-morbidities including cardiovascular, endocrine and metabolic, neuropsychiatric, pulmonary, and renal. Areas covered: A PubMed search of all the recent literature relating to OSA and co-morbidities was undertaken to critically evaluate the potential relationships and possible benefit of continuous positive airway pressure (CPAP) therapy. Expert Commentary: The evidence supporting an independent association is stronger for some co-morbidities than others and in cardiovascular diseases is strongest for hypertension and atrial fibrillation...
January 28, 2019: Expert Review of Respiratory Medicine
https://read.qxmd.com/read/30680588/fdg-atrial-uptake-is-associated-with-an-increased-prevalence-of-stroke-in-patients-with-atrial-fibrillation
#4
Mathieu Sinigaglia, Besma Mahida, Eve Piekarski, Renata Chequer, Nidaa Mikail, Khadija Benali, Fabien Hyafil, Dominique Le Guludec, François Rouzet
PURPOSE: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and is associated with an increased risk of stroke. Indeed, silent AF is frequently identified in unexplained ischemic stroke. 18 F-FDG-PET/CT is a powerful tool for assessing myocardial metabolic shift and inflammation, both potentially at stake in AF. This case-control study investigated whether AF could promote FDG uptake in atria after physiological myocardial glucose uptake suppression, and the potential relationship between FDG atrial uptake and prevalence of stroke...
January 25, 2019: European Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/30665477/hidradenitis-suppurativa-is-associated-with-higher-heart-rate-but-not-atrial-fibrillation-a-comparative-cross-sectional-study-of-462-individuals-with-hidradenitis-suppurativa-in-denmark
#5
Iben Marie Miller, Ole Ahlehoff, Gabrielle Vinding, Helene Rytgaard, Ulla Brasch Mogensen, Hans Christian Ring, Christina Ellervik, Gregor B E Jemec
Hidradenitis suppurativa (HS) is a chronic inflammatory dermatological disease with inflammatory mechanisms overlapping those of psoriasis, and both diseases have been associated with cardiovascular risk factors i.e. smoking and metabolic syndrome. Two studies have recently linked psoriasis with Atrial Fibrillation (AF). AF is the most frequently occurring cardiac arrhythmia in the general population and is typically accompanied by increased heart rate. Both AF and heart rate are linked with inflammation. The aim of the study was to investigate a potential association between HS and increased heart rate as well as AF...
December 2018: Acta Dermatovenerologica Croatica: ADC
https://read.qxmd.com/read/30661725/investigating-potential-correlations-between-endodontic-pathology-and-cardiovascular-diseases-using-epidemiological-and-genetic-approaches
#6
Maria Messing, Letícia Chaves de Souza, Franco Cavalla, Krishna Kumar Kookal, Gabriella Rizzo, Muhammad Walji, Renato Silva, Ariadne Letra
INTRODUCTION: Apical periodontitis (AP) and cardiovascular diseases (CVDs) are chronic conditions triggered by an inflammatory process and sharing similar pathogeneses and molecular players. Previous studies have suggested that AP may perpetuate a systemic inflammation state and, in turn, contribute to CVD. In this study, we investigated the potential association between endodontic pathology and CVD using epidemiological and genetic approaches. METHODS: Epidemiologic analysis was performed by querying the medical and dental records of >2 million patients...
January 17, 2019: Journal of Endodontics
https://read.qxmd.com/read/30654134/calcium-calmodulin-dependent-protein-kinase-ii-causes-atrial-structural-remodeling-associated-with-atrial-fibrillation-and-heart-failure
#7
Zhao Liu, J Emanuel Finet, Julie A Wolfram, Mark E Anderson, Xun Ai, J Kevin Donahue
BACKGROUND: - Atrial fibrillation (AF) is sustained by reentrant mechanisms that depend, in part, on atrial structural remodeling. Increased Ca2+ /calmodulin-dependent protein kinase II (CaMKII) activity occurs in persistent AF. A general consensus has been that electrophysiological actions of CaMKII must be the contributing factor, but electrical remodeling in AF differs considerably with electrophysiological effects of CaMKII. CaMKII has been associated with structural remodeling in several tissues, but not the cardiac atria...
January 14, 2019: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://read.qxmd.com/read/30626765/associations-between-multiple-circulating-biomarkers-and-the-presence-of-atrial-fibrillation-in-hypertrophic-cardiomyopathy-with-or-without-left-ventricular-outflow-tract-obstruction
#8
Limin Liu, Lingmin Wu, Lihui Zheng, Ligang Ding, Gang Chen, Xiaohan Fan, Yan Yao
Atrial fibrillation (AF) is the most common arrhythmia in patients with hypertrophic cardiomyopathy (HCM). Data regarding the correlations of biomarkers and AF in HCM patients are rather limited. We sought to explore the associations between the presence of AF and circulating biomarkers reflecting cardiovascular function (N-terminal pro-brain natriuretic peptide, NT-pro BNP), endothelial function (big endothelin-1, big ET-1), inflammation (high-sensitivity C-reactive protein), and myocardial damage (cardiac troponin I, cTnI) in HCM patients with and without left ventricular outflow tract obstruction (LVOTO)...
January 10, 2019: International Heart Journal
https://read.qxmd.com/read/30625345/cardioprotective-actions-of-relaxin
#9
REVIEW
Brian Martin, Guillermo Romero, Guy Salama
Relaxin is a hormone of pregnancy first discovered for its ability to induce ligament relaxation in nonpregnant guinea pig and is important for softening of the birth canal during parturition, decidualization, implantation, nipple development and increased maternal renal perfusion, glomerular filtration, and cardiac output. Subsequently, relaxin has been shown to exert multiple beneficial cardiovascular effects during pathological events such as hypertension, atrial fibrillation, heart failure and myocardial infarction, including suppression of arrhythmia and inflammation, and reversal of fibrosis...
January 6, 2019: Molecular and Cellular Endocrinology
https://read.qxmd.com/read/30605407/getting-to-the-heart-of-alzheimer-disease
#10
Joshua M Tublin, Jeremy M Adelstein, Federica Del Monte, Colin K Combs, Loren E Wold
In a somewhat narrow diagnostic lens, Alzheimer disease (AD) has been considered a brain-specific disease characterized by the presence of Aβ (β-amyloid) plaques and tau neural fibrillary tangles and neural inflammation; these pathologies lead to neuronal death and consequently clinical symptoms, such as memory loss, confusion, and impaired cognitive function. However, for decades, researchers have noticed a link between various cardiovascular abnormalities and AD-such as heart failure, coronary artery disease, atrial fibrillation, and vasculopathy...
January 4, 2019: Circulation Research
https://read.qxmd.com/read/30604858/atrial-fibrillation-and-rapid-atrial-pacing-are-linked-to-enhanced-inflammation-and-altered-fibrinolysis-in-patients-undergoing-pulmonary-vein-isolation
#11
Maciej T Wybraniec, Joanna Wieczorek, Iwona Woźniak-Skowerska, Seweryn Nowak, Anna Wnuk-Wojnar, Anetta Undas, Katarzyna Mizia-Stec
No abstract text is available yet for this article.
January 3, 2019: Kardiologia Polska
https://read.qxmd.com/read/30580643/immunopathogenesis-and-biomarkers-of-recurrent-atrial-fibrillation-following-ablation-therapy-in-patients-with-preexisting-atrial-fibrillation
#12
John H Rosenberg, John H Werner, Gilman D Plitt, Victoria V Noble, Jordan T Spring, Brooke A Stephens, Aleem Siddique, Helenmari L Merritt-Genore, Michael J Moulton, Devendra K Agrawal
Recurrent atrial fibrillation (RAF) following ablation therapy occurs in about 50% of patients. The pathogenesis of RAF is unknown, but is believed to be driven by atrial remodeling in the setting of background inflammation. Structural, electrophysiological and mechanical remodeling has been associated with atrial fibrillation (AF). Inflammation and fibrotic remodeling are the major factors perpetuating AF, as mediators released from the atrial tissues and cardiomyocytes due to mechanical and surgical injury could initiate the inflammatory process...
December 22, 2018: Expert Review of Cardiovascular Therapy
https://read.qxmd.com/read/30571523/inflammation-inflammasome-activation-and-atrial-fibrillation
#13
EDITORIAL
David R Van Wagoner, Mina K Chung
No abstract text is available yet for this article.
November 13, 2018: Circulation
https://read.qxmd.com/read/30568603/linking-arrhythmias-and-adipocytes-insights-mechanisms-and-future-directions
#14
REVIEW
Maria A Pabon, Kevin Manocha, Jim W Cheung, James C Lo
Obesity and atrial fibrillation have risen to epidemic levels worldwide and may continue to grow over the next decades. Emerging evidence suggests that obesity promotes atrial and ventricular arrhythmias. This has led to trials employing various strategies with the ultimate goal of decreasing the atrial arrhythmic burden in obese patients. The effectiveness of these interventions remains to be determined. Obesity is defined by the expansion of adipose mass, making adipocytes a prime candidate to mediate the pro-arrhythmogenic effects of obesity...
2018: Frontiers in Physiology
https://read.qxmd.com/read/30564139/chronic-kidney-disease-increases-atrial-fibrillation-inducibility-involvement-of-inflammation-atrial-fibrosis-and-connexins
#15
Huiliang Qiu, Chunlan Ji, Wei Liu, Yuchi Wu, Zhaoyu Lu, Qizhan Lin, Zheng Xue, Xusheng Liu, Huanlin Wu, Wei Jiang, Chuan Zou
Chronic kidney disease (CKD) causes atrial structural remodeling and subsequently increases the incidence of atrial fibrillation (AF). Atrial connexins and inflammatory responses may be involved in this remodeling process. In this study, nephrectomy was used to produce the CKD rat model. Three months post-nephrectomy, cardiac structure, function and AF vulnerability were quantified using echocardiography and electrophysiology methods. The left atrial tissue was tested for quantification of fibrosis and inflammation, and for the distribution and expression of connexin (Cx) 40 and Cx43...
2018: Frontiers in Physiology
https://read.qxmd.com/read/30502048/relation-of-neutrophil-to-lymphocyte-ratio-to-risk-of-incident-atrial-fibrillation
#16
Anat Berkovitch, Arwa Younis, Yoni Grossman, Shlomo Segev, Shaye Kivity, Yechezkel Sidi, Roy Beinart, Ilan Goldenberg, Elad Maor
Clinical and experimental data support a critical role for inflammation in cardiovascular disease. The purpose of the current study was to examine the relation between an inflammatory marker, neutrophil-to-lymphocyte ratio (NLR), and incident atrial fibrillation (AF) in asymptomatic adults. We investigated 21,118 self-referred men and women who were annually screened in a tertiary medical center. All subjects were free of AF at baseline and had their serum NLR calculated at the first annual visit. Subjects were divided into 2 groups based on their baseline NLR: Low (<2...
November 7, 2018: American Journal of Cardiology
https://read.qxmd.com/read/30496173/circulating-proteomic-patterns-in-af-related-left-atrial-remodeling-indicate-involvement-of-coagulation-and-complement-cascade
#17
Jelena Kornej, Petra Büttner, Elke Hammer, Beatrice Engelmann, Borislav Dinov, Philipp Sommer, Daniela Husser, Gerhard Hindricks, Uwe Völker, Andreas Bollmann
BACKGROUND: Left atrial (LA) electro-anatomical remodeling and diameter increase in atrial fibrillation (AF) indicates disease progression and is associated with poor therapeutic success. Furthermore, AF leads to a hypercoagulable state, which in turn promotes the development of a substrate for AF and disease progression in the experimental setting. The aim of this study was to identify pathways associated with LA remodeling in AF patients using untargeted proteomics approach. METHODS: Peripheral blood samples of 48 patients (62±10 years, 63% males, 59% persistent AF) undergoing AF catheter ablation were collected before ablation...
2018: PloS One
https://read.qxmd.com/read/30487982/obesity-paradox-on-outcome-in-atrial-fibrillation-maintained-even-considering-the-prognostic-influence-of-biomarkers-insights-from-the-aristotle-trial
#18
Roopinder K Sandhu, Justin A Ezekowitz, Ziad Hijazi, Johan Westerbergh, Julia Aulin, John H Alexander, Christopher B Granger, Sigrun Halvorsen, Michael S Hanna, Renato D Lopes, Agneta Siegbahn, Lars Wallentin
Objective: We investigated the association between obesity and biomarkers indicating cardiac or renal dysfunction or inflammation and their interaction with obesity and outcomes. Methods: A total of 14 753 patients in the Apixaban for Reduction In STroke and Other ThromboemboLic Events in Atrial Fibrillation (ARISTOTLE) trial provided plasma samples at randomisation to apixaban or warfarin. Median follow-up was 1.9 years. Body Mass Index (BMI) was measured at baseline and categorised as normal, 18...
2018: Open Heart
https://read.qxmd.com/read/30480808/cholinergic-activity-regulates-the-secretome-of-epicardial-adipose-tissue-association-with-atrial-fibrillation
#19
Marinela Couselo-Seijas, Jose N López-Canoa, Rosa M Agra-Bermejo, Esther Díaz-Rodriguez, Angel L Fernandez, Jose M Martinez-Cereijo, Dario Durán-Muñoz, Susana B Bravo, Alba Velo, Laila González-Melchor, Xesus A Fernández-López, Jose L Martínez-Sande, Javier García-Seara, Jose R González-Juanatey, Moises Rodriguez-Mañero, Sonia Eiras
Botulinum toxin injection on epicardial fat, which inhibits acetylcholine (ACh) release, reduced the presence of atrial fibrillation (AF) in patients after heart surgery. Thus, we wanted to study the profile of the released proteins of epicardial adipose tissue (EAT) under cholinergic activity (ACh treatment) and their value as AF predictors. Biopsies, explants, or primary cultures were obtained from the EAT of 85 patients that underwent open heart surgery. The quantification of muscarinic receptors (mAChR) by real-time polymerase chain reaction or western blot showed their expression in EAT...
November 27, 2018: Journal of Cellular Physiology
https://read.qxmd.com/read/30467393/indoxyl-sulphate-is-associated-with-atrial-fibrillation-recurrence-after-catheter-ablation
#20
Fumi Yamagami, Kazuko Tajiri, Kosuke Doki, Masayuki Hattori, Junya Honda, Satoshi Aita, Tomohiko Harunari, Hiro Yamasaki, Nobuyuki Murakoshi, Yukio Sekiguchi, Masato Homma, Naohiko Takahashi, Kazutaka Aonuma, Akihiko Nogami, Masaki Ieda
Renal dysfunction results in the accumulation of various uremic toxins, including indoxyl sulphate (IS), and is a major risk factor for atrial fibrillation (AF). Experimental studies have demonstrated that IS exacerbates atrial remodelling via oxidative stress, inflammation, and fibrosis. However, its clinical impact on AF-promoting cardiac remodelling has not been described. Therefore, the purpose of this study was to clarify the relationship between basal IS levels and the 1-year outcomes after catheter ablation for the treatment of AF...
November 22, 2018: Scientific Reports
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