Read by QxMD icon Read

Prostate, urology

Markos Karavitakis, Iason Kyriazis, Muhammad Imran Omar, Stavros Gravas, Jean-Nicolas Cornu, Marcus J Drake, Mauro Gacci, Christian Gratzke, Thomas R W Herrmann, Stephan Madersbacher, Malte Rieken, Mark J Speakman, Kari A O Tikkinen, Yuhong Yuan, Charalampos Mamoulakis
CONTEXT: Practice patterns for the management of urinary retention (UR) secondary to benign prostatic obstruction (BPO; UR/BPO) vary widely and remain unstandardized. OBJECTIVE: To review the evidence for managing patients with UR/BPO with pharmacological and nonpharmacological treatments included in the European Association of Urology guidelines on non-neurogenic male lower urinary tract symptoms. EVIDENCE ACQUISITION: Search was conducted up to April 22, 2018, using CENTRAL, MEDLINE, Embase, ClinicalTrials...
February 14, 2019: European Urology
Zaid A Siddiqui, Gary S Gustafson, Hong Ye, Alvaro A Martinez, Beth Mitchell, Evelyn Sebastian, Amy Limbacher, Daniel J Krauss
PURPOSE: To update outcome and toxicity results of a prospective trial of 19 Gy single-fraction high-dose-rate (HDR) brachytherapy for men with low- and intermediate-risk prostate cancer. MATERIALS AND METHODS: Patients were treated on a prospective study of single-fraction HDR brachytherapy. All patients had low- or intermediate-risk prostate cancer. Patients with prostate volumes > 50 cc, taking alpha-blockers for urinary symptoms, or baseline American Urologic Association (AUA) symptom scores > 12 were ineligible...
February 13, 2019: International Journal of Radiation Oncology, Biology, Physics
S Rajanahally, O Raheem, M Rogers, W Brisbane, K Ostrowski, T Lendvay, T Walsh
BACKGROUND: In the United States of America (USA), cannabis is legal in 28 states for medical purposes and 8 states for recreational use. In 2016, the legal marijuana industry reached nearly $7 billion in sales in the USA alone. Although consumption continues to increase, the medical effects of marijuana remain understudied. Young males comprise the demographic most likely to consume cannabis, and these individuals will be most vulnerable to its short- and long-term consequences. OBJECTIVE: The purpose of this manuscript is to systematically review the available literature describing the effects of marijuana on male infertility, sexual health, and urologic neoplasms...
February 15, 2019: Andrology
I O Meshkov, E V Kulchavenya, S Yu Shevchenko, A I Neimark
The study aimed to characterize patients with newly diagnosed benign prostatic hyperplasia (BPH) and identify patterns that lead to late diagnosis of the disease. STUDY DESIGN: Simple open retrospective non-comparative study. MATERIAL AND METHODS: To determine the frequency of requests for medical care for BPH, the study analyzed medical records of 3544 patients who sought outpatient urological care at the municipal polyclinic # 26 in Novosibirsk in 2013. Outpatient medical cards of 165 patients with newly diagnosed BPH were analyzed...
October 2018: Urologii︠a︡
Eu Chang Hwang, Jae Hung Jung, Michael Borofsky, Myung Ha Kim, Philipp Dahm
BACKGROUND: New, minimally invasive surgeries have emerged as alternatives to transurethral resection of the prostate (TURP) for the management of lower urinary tract symptoms (LUTS) in men with benign prostatic hyperplasia (BPH). Aquablation is a novel, minimally invasive, water-based therapy, combining image guidance and robotics for the removal of prostatic tissue. OBJECTIVES: To assess the effects of Aquablation for the treatment of lower urinary tract symptoms in men with benign prostatic hyperplasia...
February 13, 2019: Cochrane Database of Systematic Reviews
Shivashankar Damodaran, Joshua M Lang, David F Jarrard
PURPOSE: Androgen deprivation therapy(ADT) alone has been the standard of care for metastatic hormone sensitive prostate cancer(mHSPC) for the last 75 years. This review focuses on recent trials and mechanisms that highlight a new paradigm, combining ADT with other agents, changing the management of prostate cancer patients with advanced disease. METHODS: A PubMed and Web of Science database search on peer-reviewed literature was performed through January 2018 using the keywords "metastatic hormone sensitive prostate cancer", " metastatic castration sensitive prostate cancer", "docetaxel", "abiraterone" and "senescence in cancer"...
February 7, 2019: Journal of Urology
Samuel W D Merriel, Liz Hetherington, Andrew Seggie, Joanna T Castle, William Cross, Monique J Roobol, Vincent Gnanapragasam, Caroline M Moore
OBJECTIVES: To develop a consensus statement on current best practice of active surveillance (AS) in the UK, informed by patients and clinical experts. SUBJECTS AND METHODS: A consensus statement was drafted on the basis of three sources of data: systematic literature search of national and international guidelines; data arising from a Freedom of Information (FOI) Act request to UK urology departments regarding their current practice of AS; survey and interview responses from men with localised prostate cancer regarding their experiences and views of AS...
February 11, 2019: BJU International
M I Kogan, Yu L Naboka, R S Ismailov, I I Belousov, I A Gudima
Prostatitis is considered as heterogeneous group of the diseases attracting broad interest of researchers worldwide. The acute and chronic stages of the process, as particular categories of bacterial prostatitis, remain in the realities of modern practical and scientific urology with lively discussions. Despite a large number of domestic and international publications, consensus on many topical issues of bacterial prostatitis is currently not achieved. The true incidence and prevalence of bacterial prostatitis in various regions of the world has not been finally determined...
December 2018: Urologii︠a︡
S Alkan, M Sungur
INTRODUCTION: Benign prostate hyperplasia is one of the most common disease in elderly men. The patients usually present lower urinary tract symptoms including frequency, urgency, nocturia and interittancy. The prostate symptom scores are usually used for daily urology practice. We aimed to compare the International Prostate Symptom Score and Visual Prostate Symptom Score in Turkish patients. METHOD: s. The study protocol was conducted from from February to August 2017...
December 2018: Urologii︠a︡
Julián Oñate-Celdrán, Julián J Arense-Gonzalo, Jaime Mendiola, Paula Samper-Mateo, Carlos Sánchez-Rodríguez, Damián García-Escudero, Marcos Torres-Roca, Marcos Torres-Roca, Olimpia Molina-Hernández, Olimpia Molina-Hernández, Evdochia Adoamnei, Alberto M Torres-Cantero
OBJECTIVE: To evaluate the associationbetween anogenital distance (AGD), as a biomarker ofprenatal androgen milieu, and risk of prostate cancer(PCa). METHODS: A case-control study was conducted on260 men attending a university hospital where theyunderwent physical and andrological examination andcompleted a brief questionnaire. PCa patients were confirmedby biopsy of the tumor. Controls were men withoutPCa attending the urology outpatient clinic for routineexaminations...
January 2019: Archivos Españoles de Urología
Matthew Smith, Chris Parker, Fred Saad, Kurt Miller, Bertrand Tombal, Quan Sing Ng, Martin Boegemann, Vsevolod Matveev, Josep Maria Piulats, Luis Eduardo Zucca, Oleg Karyakin, Go Kimura, Nobuaki Matsubara, William Carlos Nahas, Franco Nolè, Eli Rosenbaum, Axel Heidenreich, Yoshiyuki Kakehi, Amily Zhang, Heiko Krissel, Michael Teufel, Junwu Shen, Volker Wagner, Celestia Higano
BACKGROUND: Abiraterone acetate plus prednisone or prednisolone improves progression-free survival and overall survival in patients with metastatic castration-resistant prostate cancer. Radium-223 improves overall survival and delays the onset of symptomatic skeletal events in patients with castration-resistant prostate cancer and bone metastases. We assessed concurrent treatment with abiraterone acetate plus prednisone or prednisolone and radium-223 in such patients. METHODS: We did a randomised, double-blind, placebo-controlled, phase 3 trial at 165 oncology and urology centres in 19 countries...
February 6, 2019: Lancet Oncology
Liang Dong, Richard C Zieren, Yanqing Wang, Theo M de Reijke, Wei Xue, Kenneth J Pienta
Urological malignancies, including prostate cancer, bladder cancer and kidney cancer are major causes of morbidity and mortality worldwide. Because of the high incidence, diversity in biology, and especially direct interaction with urine, urological cancers are an important resource for both scientists and clinicians for novel diagnostic and therapeutic discovery. Extracellular vesicles (EVs) are lipid bilayer encapsulated particles released by cells into the extracellular space. Since EVs work as a safe way to transport important biological information through the whole body, they are now recognized as an important mechanism of cell-cell communication and have opened a new window for us to gain a better understanding of cancer biology, novel diagnostics, and/or therapeutic options...
February 6, 2019: Biochimica et biophysica acta. Reviews on cancer
Kimio Sugaya, Katsumi Kadekawa, Yoshihiro Unten, Saori Nishijima, Katsuhiro Ashitomi, Hideyuki Yamamoto
PURPOSE: The relationship between blood flow and lower urinary tract disease was explored by measuring blood flow in the common iliac vein to examine the influence of pelvic congestion on lower urinary tract symptoms. METHODS: Color Doppler ultrasonography of the right common iliac vein was performed in 113 men and 60 women, who were outpatients of two Japanese hospitals. Average blood flow velocity and cross-sectional area of the vein were measured, and blood flow volume was calculated...
February 8, 2019: Journal of Medical Ultrasonics
Louis Potters, Zaker Rana, Lucille Lee, Brett W Cox
INTRODUCTION: This study presents a prospective phase I, IRB-approved dose-escalated stereotactic body radiotherapy (SBRT) trial for prostate cancer (CaP) to assess the impact of dose level on quality of life, toxicity, and clinical outcomes. MATERIALS/METHODS: From 2011-2016, 26 patients with low and intermediate-risk CaP received 40, 45, and 50 Gy in five fractions to the prostate in cohorts of 9, 10, and 7 patients. Self-reported QOL was prospectively measured from the Expanded Prostate Cancer Index Composite (EPIC) and American Urological Association (AUA)...
February 2, 2019: International Journal of Radiation Oncology, Biology, Physics
Mahesh Botejue, Daniel Abbott, John Danella, Claudette Fonshell, Serge Ginzburg, Thomas J Guzzo, Thomas Lanchoney, Bret Marlowe, Jay D Raman, Marc Smaldone, Jeffrey J Tomaszewski, Edouard J Trabulsi, Robert G Uzzo, Adam C Reese
PURPOSE: We describe contemporary active surveillance utilization and variation in a regional prostate cancer collaborative. We identified demographic and disease specific factors associated with active surveillance in men with newly diagnosed prostate cancer. MATERIALS AND METHODS: We analyzed data from the PURC (Pennsylvania Urologic Regional Collaborative), a cooperative effort of urology practices in southeastern Pennsylvania and New Jersey. We determined the rates of active surveillance among men with newly diagnosed NCCN (National Comprehensive Cancer Network®) very low, low or intermediate prostate cancer and compared the rates among participating practices and providers...
January 31, 2019: Journal of Urology
Haifeng Song, Guanyu Kuang, Zhenan Zhang, Binglei Ma, Jie Jin, Qian Zhang
Objective: Growing evidence suggests pretreatment fibrinogen can serve as a prognostic marker in various malignancies. However, there are contradictory results about the prognostic role of fibrinogen in urological cancers. We conducted a meta-analysis to evaluate the association between pretreatment plasma fibrinogen and survival outcomes in urological cancers. Methods: After a systematic search of PubMed and Embase, we included 14 studies in our meta-analysis, and estimated hazard ratios (HRs) for overall survival (OS) and cancer-specific survival (CSS) using a fixed-effect model...
2019: Journal of Cancer
Qi-Zhong Lu, Xiang Li, Jun Ouyang, Jin-Quan Li, Gang Chen
Hyperbaric oxygen therapy (HBOT) has been used as an adjuvant treatment for multiple pathological states, which involves hypoxic conditions. Over the past 50 years, HBOT has been recommended and used in a wide variety of medical conditions, clinically in the treatment of ischemic or nonhealing wounds and radiation-injured tissue, and in the treatment of malignancy. The mechanism of this treatment is providing oxygen under pressure which is higher than the atmosphere thus increasing tissue oxygen concentration...
October 2018: Medical Gas Research
Carina Jensen, Jesper Carl, Lars Boesen, Niels Christian Langkilde, Lasse Riis Østergaard
PURPOSE: To automatically assess the aggressiveness of prostate cancer (PCa) lesions using zonal-specific image features extracted from diffusion weighted imaging (DWI) and T2W MRI. METHODS: Region of interest was extracted from DWI (peripheral zone) and T2W MRI (transitional zone and anterior fibromuscular stroma) around the center of 112 PCa lesions from 99 patients. Image histogram and texture features, 38 in total, were used together with a k-nearest neighbor classifier to classify lesions into their respective prognostic Grade Group (GG) (proposed by the International Society of Urological Pathology 2014 consensus conference)...
February 3, 2019: Journal of Applied Clinical Medical Physics
Enrico Checcucci, Daniele Amparore, Stefano De Luca, Riccardo Autorino, Cristian Fiori, Francesco Porpiglia
Over the past few years several new technologies have become available for the management of PCa. The implementation of robotic surgery allowed an unprecedented refinement of surgical techniques, and the RARP procedure is constantly evolving. Nowadays research is mainly focused towards a "tailored" case-specific surgical approach that might allow to achieve PCa control while preserving urinary continence and erectile function. Therefore, in contemporary urology era, several new tools have been introduced to optimize surgical planning, to aid surgical navigation, and to refine surgical execution...
January 28, 2019: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
Kevin B Ginsburg, Rohith Arcot, Ji Qi, Susan M Linsell, Deborah R Kaye, Arvin K George, Michael L Cher
PURPOSE: To investigate how MRI and post-MRI biopsy (pMRI-Bx) impact decision-making in men considering active surveillance (AS). MATERIALS AND METHODS: We reviewed men in the Michigan Urological Surgery Improvement Collaborative with newly diagnosed favorable risk prostate cancer. Following the diagnostic biopsy (dBx), men were classified into three groups: 1) no MRI, 2) MRI only, and 3) MRI/pMRI-Bx. For the purpose of counseling and shared decision-making, MRI results were deemed reassuring (RA) (PIRADS ≤3) or nonRA (PIRADS ≥4)...
January 25, 2019: Journal of Urology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"