keyword
https://read.qxmd.com/read/38534664/efficacy-of-continuous-vs-intermittent-administration-of-cefepime-in-adult-icu-patients-with-gram-negative-bacilli-bacteremia-a-randomized-double-blind-clinical-study
#21
JOURNAL ARTICLE
Carlos Arturo Álvarez-Moreno, Laura Cristina Nocua-Báez, Guillermo Ortiz, Juan Carlos Torres, Gabriel Montenegro, Williams Cervera, Luis Fernando Zuluaga, Alonso Gómez
INTRODUCTION: The objective of this study was to compare the continuous infusion of cefepime with the intermittent infusion in patients with sepsis caused by Gram-negative bacilli (GNB). METHODS: Randomized 1:1 multicenter double-blinded placebo-controlled study with allocation concealment; multicenter study in the intensive care units of Colombia. Patients with sepsis, severe sepsis or septic shock, and GNB-suspected bacteremia. Cefepime was administered for 7 to 14 days over 30 m intermittently every 8 h over 24 h plus continuous saline solution (0...
February 29, 2024: Antibiotics
https://read.qxmd.com/read/38534294/in-vitro-risk-assessment-of-dental-acid-erosion-caused-by-long-term-exposure-to-oral-liquid-bandages
#22
JOURNAL ARTICLE
Ryouichi Satou, Naoki Sugihara
Oral mucosa inflammation can cause severe pain and interfere with eating, reducing quality of life. However, few options for self-care are available. An oral liquid bandage forms a protective film over the affected area. We aimed to assess the acid erosion risk when a newly developed oral liquid bandage (ORAPLA) is accidentally deposited on teeth and to examine the relative acid erosion risk at multiple time points of the maximum recommended duration of continuous use. ORAPLA was applied to both enamel and dentin blocks from 45 bovine anterior mandibular teeth, and an acid challenge was performed in a simulated oral cavity with artificial saliva, with one exposure cycle lasting 6 h...
March 6, 2024: Dentistry Journal
https://read.qxmd.com/read/38534255/continuous-and-non-invasive-lactate-monitoring-techniques-in-critical-care-patients
#23
REVIEW
Jose-Luis Lafuente, Samuel González, Clara Aibar, Desirée Rivera, Eva Avilés, Juan-Jose Beunza
Lactate, once merely regarded as an indicator of tissue hypoxia and muscular fatigue, has now gained prominence as a pivotal biomarker across various medical disciplines. Recent research has unveiled its critical role as a high-value prognostic marker in critical care medicine. The current practice of lactate detection involves periodic blood sampling. This approach is invasive and confined to measurements at six-hour intervals, leading to resource expenditure, time consumption, and patient discomfort. This review addresses non-invasive sensors that enable continuous monitoring of lactate in critical care patients...
March 18, 2024: Biosensors
https://read.qxmd.com/read/38534237/plasmonic-fluorescence-sensors-in-diagnosis-of-infectious-diseases
#24
REVIEW
Juiena Hasan, Sangho Bok
The increasing demand for rapid, cost-effective, and reliable diagnostic tools in personalized and point-of-care medicine is driving scientists to enhance existing technology platforms and develop new methods for detecting and measuring clinically significant biomarkers. Humanity is confronted with growing risks from emerging and recurring infectious diseases, including the influenza virus, dengue virus (DENV), human immunodeficiency virus (HIV), Ebola virus, tuberculosis, cholera, and, most notably, SARS coronavirus-2 (SARS-CoV-2; COVID-19), among others...
March 2, 2024: Biosensors
https://read.qxmd.com/read/38534233/detection-of-cannabinoids-in-oral-fluid-specimens-as-the-preferred-biological-matrix-for-a-point-of-care-biosensor-diagnostic-device
#25
REVIEW
Călin Trif, Dorin Harpaz, Evgeni Eltzov, Yardnapar Parcharoen, Chiravoot Pechyen, Robert S Marks
An increasing number of countries have started to decriminalize or legalize the consumption of cannabis for recreational and medical purposes. The active ingredients in cannabis, termed cannabinoids, affect multiple functions in the human body, including coordination, motor skills, memory, response time to external stimuli, and even judgment. Cannabinoids are a unique class of terpeno-phenolic compounds, with 120 molecules discovered so far. There are certain situations when people under the influence of cannabis may be a risk to themselves or the public safety...
February 27, 2024: Biosensors
https://read.qxmd.com/read/38534135/chronic-rhinosinusitis-with-nasal-polyposis-and-biological-agents-the-aria-italy-survey
#26
JOURNAL ARTICLE
C Lombardi, G Passalacqua, F Menzella, R F Mauritz Canevari, G Danesi, A M Pusateri, M Carone, C Vancheri, F Di Marco, C Micheletto, G Manzotti, M Di Gioacchino, M B Bilò, M Gelardi, G Senna, G W Canonica
Background. Chronic rhinosinusitis (CRS) is an inflammatory disease that affects the nasal mucosa and the paranasal sinuses. CRS can be associated by nasal polyposis (CRSwNP phenotype) in up to 30% of patients and it is frequently associated with bronchial asthma. CRSwNP shows predominantly an underlying activation of type 2 inflammatory pathways with the involvement of eosinophils, IgE, interleukin (IL)-4, IL-5 and IL-13. Biological drugs that target these inflammatory cytokines are currently a therapeutic option recognized by guidelines for the treatment of uncontrolled form of the disease...
March 27, 2024: European Annals of Allergy and Clinical Immunology
https://read.qxmd.com/read/38534046/the-late-effects-of-haematopoietic-stem-cell-transplants-in-paediatric-patients-a-25-year-review
#27
JOURNAL ARTICLE
Samantha Lai-Ka Lee, Quynh-Nhu Nguyen, Cindy Ho, Simon James, Amreeta Kaur, Angelina Lim, Karin Tiedemann, Margaret Zacharin
CONTEXT: A rare, large single centre study covering all long-term health outcomes of paediatric allogeneic HSCT survivors, to provide comprehensive local data, and identify gaps and future directions for improved care. OBJECTIVE: To document endocrine sequelae and other late effects of all HSCT recipients. DESIGN: Retrospective review. SETTING: Royal Children's Hospital Melbourne. PATIENTS: 384 children and adolescents received HSCT...
March 27, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38533825/the-effect-of-an-electronic-medical-record-based-clinical-decision-support-system-on-adherence-to-clinical-protocols-in-inflammatory-bowel-disease-care-interrupted-time-series-study
#28
JOURNAL ARTICLE
Reed Taylor Sutton, Kaitlyn Delaney Chappell, David Pincock, Daniel Sadowski, Daniel C Baumgart, Karen Ivy Kroeker
BACKGROUND: Clinical decision support systems (CDSSs) embedded in electronic medical records (EMRs), also called electronic health records, have the potential to improve the adoption of clinical guidelines. The University of Alberta Inflammatory Bowel Disease (IBD) Group developed a CDSS for patients with IBD who might be experiencing disease flare and deployed it within a clinical information system in 2 continuous time periods. OBJECTIVE: This study aims to evaluate the impact of the IBD CDSS on the adherence of health care providers (ie, physicians and nurses) to institutionally agreed clinical management protocols...
March 22, 2024: JMIR Medical Informatics
https://read.qxmd.com/read/38533818/patient-centered-chronic-wound-care-mobile-apps-systematic-identification-analysis-and-assessment
#29
JOURNAL ARTICLE
Tassilo Dege, Bernadette Glatzel, Vanessa Borst, Franziska Grän, Simon Goller, Caroline Glatzel, Matthias Goebeler, Astrid Schmieder
BACKGROUND: The prevalence of chronic wounds is predicted to increase within the aging populations in industrialized countries. Patients experience significant distress due to pain, wound secretions, and the resulting immobilization. As the number of wounds continues to rise, their adequate care becomes increasingly costly in terms of health care resources worldwide. eHealth support systems are being increasingly integrated into patient care. However, to date, no systematic analysis of such apps for chronic wounds has been published...
March 21, 2024: JMIR MHealth and UHealth
https://read.qxmd.com/read/38533728/the-multifaceted-roles-of-gp-trainers-in-guiding-trainee-transition-to-portfolio-general-practice
#30
JOURNAL ARTICLE
Waseem Jerjes
The journey of transitioning from a GP trainee to a portfolio GP is a complex and transformative process. This article explores the multi-dimensional roles that GP trainers play in guiding trainees through this key transition. This article, also, aims to challenge readers to consider how GP trainers can further enhance their role in minimising barriers and maximising opportunities for trainees, inviting contributions to the educational discussion on this topic.Serving as mentors, GP trainers navigate trainees through the particulars of general practice, ensuring they are equipped with both skills and resilience...
March 27, 2024: Education for Primary Care
https://read.qxmd.com/read/38533725/feasibility-and-acceptability-of-a-primary-care-mentoring-programme-for-undergraduate-students
#31
JOURNAL ARTICLE
Eva Pfarrwaller, Pawan Prasad, Sylvain De Lucia, Dagmar M Haller
Mentoring plays a crucial role in increasing the attractiveness of primary care careers for medical students. Based on a literature review and structured group discussions, the authors developed a primary care mentoring platform centred on undergraduate medical students' needs. All second- to sixth-year students were invited to enrol into the programme by choosing a mentor from an online platform, which was pilot tested during one academic year (2021-2022) with 16 mentors. Fifteen mentees enrolled into the pilot programme...
March 27, 2024: Education for Primary Care
https://read.qxmd.com/read/38533717/examining-the-relationship-between-head-trauma-and-opioid-use-disorder-a-systematic-review
#32
JOURNAL ARTICLE
Ali Abid, Maria Paracha, Iva Çepele, Awais Paracha, Joseph Rueve, Akbar Fidahussain, Humza Rehman, McKimmon Engelhardt, Noor Alyasiry, Zohair Siddiqui, Satvik Vasireddy, Bishal Kadariya, Nikith Rao, Rohan Das, Wilson Rodriguez, Dixie Meyer
OBJECTIVE: To examine recent literature and determine common clinical risk factors between antecedent traumatic brain injury (TBI) and the following development of opioid misuse and provide a framework for clinical identification of at-risk subjects and evaluate potential treatment implications within this association. DESIGN: A comprehensive systematic literature search of PubMed was conducted for articles between 2000 and December 2022. Studies were included if the human participant had any head trauma exposure and any chronic opioid use or dependence...
2024: Journal of Opioid Management
https://read.qxmd.com/read/38533713/opioid-stewardship-program-implementation-in-rural-and-critical-access-hospitals-in-arizona
#33
JOURNAL ARTICLE
Benjamin R Brady, Bianca SantaMaria, Kathryn Tucker Ortiz Y Pino, Bridget S Murphy
OBJECTIVE: The objective of this study is to examine rural hospitals' status in implementing opioid stewardship program (OSP) elements and assess differences in implementation in emergency department (ED) and acute inpatient departments. DESIGN: Health administrator survey to identify the number and type of OSP elements that each hospital has implemented. SETTING: Arizona critical access hospitals (CAHs). PARTICIPANTS: ED and acute inpatient department heads at 17 Arizona CAHs (total of 34 assessments)...
2024: Journal of Opioid Management
https://read.qxmd.com/read/38533699/business-continuity-plan-in-the-management-and-operations-of-hospitals-first-experience-to-certify-the-pdta-processes-with-the-requirements-defined-by-iso-22301-2019-in-emergency-medical-services
#34
JOURNAL ARTICLE
Lucio Dell'Atti, Roberto Papa, Leonardo Incicchitti, Maria Katia Zanni, Andrea Zampa, Michele Caporossi
BACKGROUND: A business continuity plan (BCP) facilitates the performance of primary functions during emergencies or other situations that can disrupt normal operations. If risk management is done analytically, a business impact analysis (BIA), according to ISO 22301 certification, makes it possible to define the best strategy for supporting the company's assets and image, optimizing the operational efficiency of service recovery and redesigning spaces for health. Since 2015, our healthcare company has embarked on a certification process for all sectors and activities through the implementation and development of diagnostic and therapeutic paths for operational diagnos-tic-therapeutic-assistance pathways (PDTAs)...
2024: Journal of Emergency Management: JEM
https://read.qxmd.com/read/38533428/continuity-or-change-platforms-and-the-hybridization-of-neoliberal-institutional-contexts
#35
JOURNAL ARTICLE
Aleksandra Piletić
In recent years, a wide range of contributions have sought to conceptualize the emergent effects of platforms on contemporary capitalism(s). One strand of literature has emphasized the novelty of platforms, stressing their disruptive features and proclaiming the rise of a new era - platform/digital capitalism. Another strand has tended to position platforms within the longue durée of capitalist transformation, focusing on the continuities and historical recurrences of platform-led transformations. In contrast to both strands of literature, this paper argues that platforms should be understood as reworking existing, neoliberal institutions from within, engendering a process of hybridization...
2024: Review of International Political Economy
https://read.qxmd.com/read/38533293/a-new-dosing-frontier-retrospective-assessment-of-effluent-flow-rates-and-residual-renal-function-among-critically-ill-patients-receiving-continuous-renal-replacement-therapy
#36
JOURNAL ARTICLE
Damini Lakshmipathy, Xiaoyi Ye, Joseph L Kuti, David P Nicolau, Tomefa E Asempa
OBJECTIVES: In 2020, cefiderocol became the first Food and Drug Administration-approved medication with continuous renal replacement therapy (CRRT) dosing recommendations based on effluent flow rates ( Q E ). We aimed to evaluate the magnitude and frequency of factors that may influence these recommendations, that is, Q E intrapatient variability and residual renal function. DESIGN: Retrospective observational cohort study. SETTING: ICUs within Hartford Hospital (890-bed, acute-care hospital) in Connecticut from 2017 to 2023...
April 2024: Critical care explorations
https://read.qxmd.com/read/38533291/accuracy-of-a-non-invasive-home-glucose-monitor-for-measurement-of-blood-glucose
#37
JOURNAL ARTICLE
Himel Mondal, Sairavi Kiran Biri, Neha Pipil, Shaikat Mondal
INTRODUCTION: Patients with diabetes mellitus monitor their blood glucose at home with monitors that require a drop of blood or use a continuous glucose monitoring device that implants a small needle in the body. However, both cause discomfort to the patients which may inhibit them for regular blood glucose checks. Photoplethysmogram (PPG) sensing technology is an approach for non-invasive blood glucose measurement and PPG sensors can be used to predict hypoglycaemic episodes. InChcek is a PPG-based non-invasive glucose monitor...
2024: Indian Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/38533279/sglt2-inhibitors-paradigm-shift-from-diabetes-care-to-metabolic-care-an-indian-perspective
#38
REVIEW
K M Prasanna Kumar, A G Unnikrishnan, Pankaj Jariwala, Ashwani Mehta, Richa Chaturvedi, Sagar Panchal, Preet Lakhani, Rachana Acharya, Jitendra Dixit
The prevalence and burden of diabetes are on the rise in India, making it 'the diabetes capital of the world'. Comorbidities such as obesity, cardiovascular (CV) complications, chronic kidney disease (CKD), non-alcoholic fatty liver disease (NAFLD), and neurodegenerative diseases are common in patients with diabetes. Recent breakthroughs in diabetes medications and continuous glucose monitoring have resulted in a paradigm shift in diabetes care. Hence, a review in the Indian context is warranted. This review focuses on the existing evidence (gathered by a systematic literature search utilising online databases such as PubMed) on the metabolic, cardio-renoprotective, and hepatoprotective effects of sodium-glucose co-transporter 2 (SGLT2) inhibition, particularly in the Indian setting...
2024: Indian Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/38533163/rehabilitation-techniques-before-and-after-total-knee-arthroplasty-for-a-better-quality-of-life
#39
REVIEW
Sushmita Dutta, Ratnakar Ambade, Dhanashree Wankhade, Palak Agrawal
The most important gold standard treatment following advanced knee osteoarthritis is total knee arthroplasty. Following surgery of total knee replacement, the majority of patients report decreased pain and successful long-term results, but recovery is unpredictable, and most patients continue to exhibit muscle weakness in their lower limbs and functional limitations in comparison to similarly aged control individuals. The goal of this review article was to systematically review different articles containing controlled and randomized studies to find out the effectiveness of outpatient care postoperatively on short- and long-term functional recovery...
February 2024: Curēus
https://read.qxmd.com/read/38533003/canadian-midwives-perspectives-on-the-clinical-impacts-of-point-of-care-ultrasound-in-obstetrical-care-a-concurrent-mixed-methods-study
#40
JOURNAL ARTICLE
Bronte K Johnston, Elizabeth K Darling, Anne Malott, Laura Thomas, Beth Murray-Davis
INTRODUCTION: Point of Care Ultrasound (POCUS) is used globally in obstetrics to conduct real time bedside ultrasound scans to answer a clinical question, and it may be conducted by a non-sonography healthcare practitioner. The College of Midwives of Ontario expanded the scope of practice in 2018 to allow registered midwives to perform POCUS during clinical assessments. In response, a POCUS training curriculum for practicing midwives was developed. This paper reports on the perceptions of learners about the impact of this training on their clinical practice...
March 30, 2024: Heliyon
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