Jieyu Guo, Jingjing Qiu, Mengping Jia, Qinhan Li, Xiangxiang Wei, Liliang Li, Qi Pan, Jiayu Jin, Fei Ge, Siyu Ma, Yunquan He, Jiayi Lin, Yongbo Li, Jinghua Ma, Nan Jiang, Xiuling Zhi, Lindi Jiang, Jianyi Zhang, Elena Osto, Qing Jing, Xinhong Wang, Dan Meng
The transcription factor BTB and CNC homology 1(BACH1) has been linked to coronary artery disease risk by human genome-wide association studies, but little is known about the role of BACH1 in vascular smooth muscle cell (VSMC) phenotype switching and neointima formation following vascular injury. Therefore, this study aims to explore the role of BACH1 in vascular remodeling and its underlying mechanisms. BACH1 was highly expressed in human atherosclerotic plaques and has high transcriptional factor activity in VSMCs of human atherosclerotic arteries...
March 2, 2023: Nucleic Acids Research