Hélène Greigert, André Ramon, Coraline Genet, Claudie Cladière, Claire Gerard, Marion Cuidad, Marc Corbera-Bellalta, Roser Alba-Rovira, Louis Arnould, Catherine Creuzot-Garcher, Laurent Martin, Georges Tarris, Thibault Ghesquière, Sethi Ouandji, Sylvain Audia, Maria C Cid, Bernard Bonnotte, Maxime Samson
Vascular smooth muscle cells (VSMCs) have been shown to play a role in the pathogenesis of giant cell arteritis (GCA) through their capacity to produce chemokines recruiting T cells and monocytes in the arterial wall and their ability to migrate and proliferate in the neointima where they acquire a myofibroblast (MF) phenotype, leading to vascular stenosis. This study aimed to investigate if MFs could also impact T-cell polarization. Confocal microscopy was used to analyze fresh fragments of temporal artery biopsies (TABs)...
November 30, 2023: Journal of Autoimmunity