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neointimal proliferation

Wen Wu, Wei Zhang, Mihyun Choi, Jinjing Zhao, Ping Gao, Min Xue, Harold A Singer, David Jourd'heuil, Xiaochun Long
Injury-induced stenosis is a serious vascular complication. We previously reported that p38α (MAPK14), a redox-regulated p38MAPK family member was a negative regulator of the VSMC contractile phenotype in vitro. Here we evaluated the function of VSMC-MAPK14 in vivo in injury-induced neointima hyperplasia and the underlying mechanism using an inducible SMC-MAPK14 knockout mouse line (iSMC-MAPK14-/- ). We show that MAPK14 expression and activity were induced in VSMCs after carotid artery ligation injury in mice and ex vivo cultured human saphenous veins...
February 6, 2019: Redox Biology
Jiankun Li, Hairong Wang, Xiaowei Shi, Lili Zhao, Tao Lv, Qi Yuan, Wenyang Hao, Jing Zhu
ETHNOPHARMACOLOGICAL RELEVANCE: The abnormal increase in vascular smooth muscle cell (VSMC) proliferation and migration are critical events in the pathogenesis of cardiovascular diseases (CVDs) including restenosis and atherosclerosis. The dried roots of Scutellaria baicalensis Georgi (common name: Huangqin in China) have been confirmed to possess beneficial effects on CVD by clinical and modern pharmacological studies. Flavonoids in Huangqin exert anti-proliferative and anti-migratory effects...
February 11, 2019: Journal of Ethnopharmacology
Ken Ling, Ancong Xu, Yunfei Chen, Xueyin Chen, Yiqing Li, Weici Wang
Restenosis is liable to occur following treatment with endovascular interventional therapy. Increasing evidence indicates that hydrogen sulfide (H2S) exhibits numerous physiological properties, including antioxidative and cardioprotective disease properties. Thus, the present study aimed to investigate the anti‑restenosis effects of H2S and its protective mechanisms. A balloon dilatation restenosis model was used, in which model Sprague‑Dawley rats were treated with sodium hydrosulfide (NaHS: A donor of H2S, 30 µmol/kg) by intraperitoneal injection for 4 weeks...
January 23, 2019: International Journal of Molecular Medicine
Bo-Jun Cao, Lei Zhu, Xiao-Wen Wang, Rong-Jiang Zou, Zhi-Qian Lu
The high rate of autologous vein graft failure caused by neointimal hyperplasia remains an unresolved issue in the field of cardiovascular surgery; therefore, it is important to explore new methods for protecting against neointimal hyperplasia. MicroRNA-365 has been reported to inhibit the proliferation of vascular smooth muscle cells (SMCs). This study aimed to test whether adenovirus-mediated miR-365 was able to attenuate neointimal formation in rat vein grafts. We found that miR-365 expression was substantially reduced in vein grafts following engraftment...
February 11, 2019: IUBMB Life
Zhengfan Gong, Yu Han, Lianpan Wu, Tianyang Xia, Hongmei Ren, Donghai Yang, Daqian Gu, He Wang, Cuimei Hu, Duofen He, Lin Zhou, Chunyu Zeng
AIMS: The proliferation of VSMCs is the pathologic basis for intimal hyperplasia after angioplasty in diabetic patients. Translocator protein (TSPO), located in the outer mitochondrial membrane, has been found to regulate redox intermediate components in cell dysfunction. We hypothesized that TSPO may regulate VSMC proliferation and migration, and be involved in the intimal hyperplasia after angioplasty in diabetes. MATERIALS AND METHODS: Cell proliferation was measured by cell counting and MTT assays...
February 7, 2019: Life Sciences
Florah Tshepo Moshapa, Kirsten Riches-Suman, Timothy Martin Palmer
Type 2 diabetes mellitus (T2DM) is increasing worldwide, and it is associated with increased risk of coronary artery disease (CAD). For T2DM patients, the main surgical intervention for CAD is autologous saphenous vein grafting. However, T2DM patients have increased risk of saphenous vein graft failure (SVGF). While the mechanisms underlying increased risk of vascular disease in T2DM are not fully understood, hyperglycaemia, insulin resistance, and hyperinsulinaemia have been shown to contribute to microvascular damage, whereas clinical trials have reported limited effects of intensive glycaemic control in the management of macrovascular complications...
2019: Cardiology Research and Practice
Bo-Jun Cao, Xiao-Wen Wang, Lei Zhu, Rong-Jiang Zou, Zhi-Qian Lu
OBJECTIVE: The high rate of vein graft failure due to neointimal hyperplasia is a major challenge for cardiovascular surgery. Finding novel approaches to prevent neointimal hyperplasia is important. Thus, the purpose of this study was to investigate whether dedicator of cytokinesis 2 (DOCK2) plays a role in the development of neointima formation in the vein grafts. METHODS AND RESULTS: We found that DOCK2 levels were significantly elevated in the vein grafts following grafting surgery...
February 1, 2019: Journal of Molecular and Cellular Cardiology
Jie Lu, Mingshu Sun, Xinjiang Wu, Xuan Yuan, Zhen Liu, Xiaojie Qu, Xiaopeng Ji, Tony R Merriman, Changgui Li
Hyperuricemia (HU) is a cause of gout. Clinical studies show a link between HU and cardiovascular disease. However, the role of soluble serum urate (SU) on atherosclerosis development remains elusive. We aimed to use a new HU mouse model [Uricase/Uox knockout (KO)] to further investigate the relationship between HU and atherosclerosis. A mouse model by perivascular collar placement of induced carotid atherosclerosis was established in male Uox-KO mice. The Uox-KO mice had elevated SU levels and enhanced levels of atherosclerosis inflammatory response proteins...
January 28, 2019: FEBS Journal
Rajiv Rampat, Timothy Williams, Thomas Mayo, Manuela Mengozzi, Pietro Ghezzi, David Hildick-Smith, James Cockburn
INTRODUCTION: The ABSORB bioresorbable vascular scaffold (BVS) is associated with greater neointimal proliferation and thrombotic rate than the metal stent. The role of inflammatory biomarkers on neointimal proliferation has not been studied in the setting of BVS implantation. PATIENTS AND METHODS: Thirty patients had arterial blood sampling before elective percutaneous coronary intervention with the ABSORB BVS and at 9-months follow-up. Plasma levels of interleukin-6, soluble CD40 ligand, monocyte chemotactic protein-1 and C-reactive protein were measured using enzyme-linked immunosorbent assay...
January 22, 2019: Coronary Artery Disease
Hangqi Luo, Changzuan Zhou, Jufang Chi, Sunlei Pan, Hui Lin, Feidan Gao, Tingjuan Ni, Liping Meng, Jie Zhang, Chengjian Jiang, Zheng Ji, Haitao Lv, Hangyuan Guo
PURPOSE: The role of endoplasmic reticulum (ER) stress in cardiovascular disease is now recognized. Tauroursodeoxycholic acid (TUDCA) is known to have cardiovascular protective effects by decreasing ER stress. This study aimed to assess the ability of TUDCA to decrease ER stress, inhibit dedifferentiation of vascular smooth muscle cells (VSMCs), and reduce in-stent restenosis. METHODS: The effect of TUDCA on dedifferentiation of VSMCs and ER stress was investigated in vitro using wound-healing assays, MTT assays, and western blotting...
January 21, 2019: Cardiovascular Drugs and Therapy
Hongqiang Li, Jinlong Zhao, Baoxin Liu, Jiachen Luo, Zhiqiang Li, Xiaoming Qin, Yidong Wei
This study shows that microRNA-320 (miR-320) is associated with many important cell functions, including cell differentiation, proliferation, migration, and apoptosis. However, the role of miR-320 in vascular smooth muscle cells (VSMCs) and proliferative vascular diseases is still completely unclear. In our study, we found that the expression of miR-320 in human VSMCs after PDGF stimulation was significantly down-regulated in time- and dose-dependent manner. Function analyses identified that miR-320 could inhibit the proliferation and migration of VSMCs in both basal and PDGF-stimulated conditions...
2019: International Journal of Medical Sciences
Qihong Yu, Wei Li, Rong Jin, Shiyong Yu, Dawei Xie, Xichuan Zheng, Wei Zhong, Xiang Cheng, Shaobo Hu, Min Li, Qichang Zheng, Guohong Li, Zifang Song
Objective- Vascular smooth muscle cells (VSMCs) phenotype modulation is critical for the resolution of vascular injury. Genetic and pharmacological inhibition of PI3Kγ (phosphoinositide 3-kinase γ) exerts anti-inflammatory and protective effects in multiple cardiovascular diseases. This study investigated the role of PI3Kγ and its downstream effector molecules in the regulation of VSMC phenotypic modulation and neointimal formation in response to vascular injury. Approach and Results- Increased expression of PI3Kγ was found in injured vessel wall as well in cultured, serum-activated wild-type VSMCs, accompanied by a reduction in the expression of calponin and SM22α, 2 differentiation markers of VSMCs...
January 17, 2019: Arteriosclerosis, Thrombosis, and Vascular Biology
Suresh V Patted, Rajendra Kumar Jain, P A Jiwani, Satish Suryavanshi, T R Raghu, Hema Raveesh, S Rajalakshmi, Ashok S Thakkar, Prakash Kumar Turiya, Priyanka J Desai, Anmol Suresh Patted, Kamal H Sharma
Background: When coronary lesions involve segments > 48 mm, the only treatment possibility is stent overlapping which is associated with higher neointimal proliferation that lead to more restenosis. Furthermore, tapering of coronary arteries is a major challenge observed with long diffuse coronary lesions. This study attempted to assess the safety and performance of world's first commercialised long-tapered (60 mm) sirolimus-eluting coronary stent (SES) system for the treatment of long diffused de novo coronary lesions in real world scenario...
December 2018: Cardiology Research
Siyu Li, Guiquan Yu, Fuyu Jing, Hui Chen, Aoyi Liu, Minghao Luo, Wei Huang, Peng Pu, Ming Chen
Vascular smooth muscle cell (VSMC) hyperproliferation is the main pathological process in various cardiovascular diseases, such as vascular restenosis. This process may be repressed by RING finger protein 10 (RNF10) in metabolic syndrome (MetS) rats. The aim of this study is to evaluate the inhibitory effects and molecular mechanisms of RNF10 on VSMC hyperproliferation. Neointimal hyperplasia in MetS and high-glucose-induced VSMC hyperproliferation were measured after infection with adenoviruses encoding RNF10 (Ad-RNF10), short hairpin RNF10 (Ad-shRNF10), or green fluorescent protein (Ad-GFP)...
December 30, 2018: IUBMB Life
Yi Xie, Allison C Ostriker, Yu Jin, Haidi Hu, Ashley J Sizer, Gang Peng, Aaron H Morris, Changwan Ryu, Erica L Herzog, Themis Kyriakides, Hongyu Zhao, Alan Dardik, Jun Yu, John Hwa, Kathleen A Martin
BACKGROUND: Vascular smooth muscle cells (SMC) synthesize extracellular matrix (ECM) that contributes to tissue remodeling following revascularization interventions. The cytokine transforming growth factor-β (TGF-β) is induced upon tissue injury and regulates tissue remodeling and wound healing, but dysregulated signaling results in excess ECM deposition and fibrosis. The LIM domain protein LMO7 is a TGF-β target gene in hepatoma cells, but its role in vascular physiology and fibrosis is unknown...
October 2, 2018: Circulation
Jie-Hong Wu, Yi-Fan Zhou, Can-Dong Hong, An-Qi Chen, Yan Luo, Ling Mao, Yuan-Peng Xia, Quan-Wei He, Hui-Juan Jin, Ming Huang, Ya-Nan Li, Bo Hu
BACKGROUND: Neointimal hyperplasia is a prominent pathological event during in-stent restenosis. Phenotype switching of vascular smooth muscle cells (VSMCs) from a differentiated/contractile to a dedifferentiated/synthetic phenotype, accompanied by migration and proliferation of VSMCs play an important role in neointimal hyperplasia. However, the molecular mechanisms underlying phenotype switching of VSMCs have yet to be fully understood. METHODS: The mouse carotid artery ligation model was established to evaluate Sema3A expression and its role during neointimal hyperplasia in vivo...
December 19, 2018: EBioMedicine
Aleksandr E Vendrov, Arihiro Sumida, Chandrika Canugovi, Andrey Lozhkin, Takayuki Hayami, Nageswara R Madamanchi, Marschall S Runge
Increased reactive oxygen species (ROS) production and inflammation are key factors in the pathogenesis of atherosclerosis. We previously reported that NOX activator 1 (NOXA1) is the critical functional homolog of p67phox for NADPH oxidase activation in mouse vascular smooth muscle cells (VSMC). Here we investigated the effects of systemic and SMC-specific deletion of Noxa1 on VSMC phenotype during atherogenesis in mice. Neointimal hyperplasia following endovascular injury was lower in Noxa1-deficient mice versus the wild-type following endovascular injury...
November 29, 2018: Redox Biology
Hong Yue, Maria Febbraio, Philip A Klenotic, David J Kennedy, Yueheng Wu, Shaoxian Chen, Amira F Gohara, Oliver Li, Adam Belcher, Bin Kuang, Thomas M McIntyre, Roy L Silverstein, Wei Li
Objective- Dysregulated proliferation of vascular smooth muscle cells (VSMC) plays an essential role in neointimal hyperplasia. CD36 functions critically in atherogenesis and thrombosis. We hypothesize that CD36 regulates VSMC proliferation and contributes to the development of obstructive vascular diseases. Approach and Results- We found by immunofluorescent staining that CD36 was highly expressed in human vessels with obstructive diseases. Using guidewire-induced carotid artery injury and shear stress-induced intima thickening models, we compared neointimal hyperplasia in Apoe -/- , Cd36 -/- /Apoe -/- , and CD36 specifically deleted in VSMC (VSMC cd36 -/- ) mice...
December 20, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
Kelly Wun, Betty R Theriault, Joseph F Pierre, Edmund B Chen, Vanessa A Leone, Katharine G Harris, Liqun Xiong, Qun Jiang, Melanie Spedale, Owen M Eskandari, Eugene B Chang, Karen J Ho
BACKGROUND: The microbiome has a functional role in a number of inflammatory processes and disease states. While neointimal hyperplasia development has been linked to inflammation, a direct role of the microbiota in neointimal hyperplasia has not yet been established. Germ-free (GF) mice are an invaluable model for studying causative links between commensal organisms and the host. We hypothesized that GF mice would exhibit altered neointimal hyperplasia following carotid ligation compared to conventionally raised (CONV-R) mice...
2018: PloS One
Yoshihisa Makino, Takuya Miyahara, Jun Nitta, Kazuhiro Miyahara, Akihiko Seo, Masaru Kimura, Masamitsu Suhara, Atsushi Akai, Daisuke Akagi, Kota Yamamoto, Katsuyuki Hoshina
BACKGROUND: Specialized proresolving mediators from ω-3 polyunsaturated fatty acid may control resolution of inflammation. We evaluated the influence of two specialized proresolving mediators, resolvin D1 (RvD1) and protectin D1 isomer (PD1 iso) on neointimal hyperplasia after balloon injury. MATERIALS AND METHODS: Sprague Dawley male rats at 12-14 wk of age were injured as a model of balloon angioplasty. Then, 1 μg/rat of RvD1 or PD1 iso was administered intravenously via the tail vein immediately and 2 d after angioplasty...
January 2019: Journal of Surgical Research
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