keyword
https://read.qxmd.com/read/38490010/identification-of-core-gene-in-chronic-rhinosinusitis-with-nasal-polyps-and-correlations-with-inflammation-related-genes
#1
JOURNAL ARTICLE
Jingpu Yang, Chang Liu, Jinzhang Cheng, Yunmeng Wang, Zonggui Wang, Wei Zhong
OBJECTIVE: Our aim in this study is to identify the core genes of chronic rhinosinusitis with nasal polyps and analyze the correlations between it and inflammation-related genes. METHODS: GSE72713 dataset containing gene expression data of ECRSwNP, nonECRSwNP and healthy samples was obtained from Gene Expression Omnibus (GEO) and filtered by limma to identify DEGs among three groups, then the functions and correlated pathways of DEGs were analyzed using GO and KEGG...
March 1, 2024: Brazilian Journal of Otorhinolaryngology
https://read.qxmd.com/read/38360807/immune-endotyping-and-gene-expression-profile-of-patients-with-chronic-rhinosinusitis-with-nasal-polyps-in-the-aspirin-exacerbated-respiratory-disease-aerd-and-the-non-aerd-subgroups
#2
JOURNAL ARTICLE
Javad Nazari, Faezeh Shahba, Negin Jafariaghdam, Saleh Mohebbi, Saba Arshi, Mohammad Hassan Bemanian, Morteza Fallahpour, Sima Shokri, Fatemeh Atashrazm, Saeed Amini, Maryam Roomiani, Mahnaz Jamee, Pegah Babaheidarian, Majid Khoshmirsafa, Mohammad Nabavi
BACKGROUND: Chronic Rhinosinusitis (CRS) is a paranasal sinus inflammatory disease and is divided into two subgroups defined as CRS with nasal polyps (CRSwNP) and CRS without nasal polyps (CRSsNP). CRSwNP displays a T helper (Th)2 biased phenotype, and based on sensitivity or tolerance to aspirin or non-steroidal anti-inflammatory drugs (NSAID), is further subdivided into Aspirin-exacerbated respiratory disease (AERD) and non-AERD groups. Considering the challenge of diagnosis and treatment in patients with CRSwNP, particularly the AERD subtype, and the significance of endotyping in these patients, we examined the immune profile and endotyping based on gene expression analysis in the AERD and the non-AERD groups of patients with CRSwNP...
February 15, 2024: Allergy, Asthma, and Clinical Immunology
https://read.qxmd.com/read/38329477/il1rap-exacerbates-sepsis-induced-pulmonary-and-spleen-injury-through-regulating-cd4-t-lymphocyte-differentiation
#3
JOURNAL ARTICLE
Liou Huang, Chunrong Wu, Dan Xu, Yuhui Cui, Jianguo Tang
BACKGROUND: Complex pathophysiological the specific mechanism of sepsis on CD4+ T-cell responses is less well understood. IL1 receptor accessory protein (IL1RAP) was found to be involved in activating host immune responses. METHOD: Cecum ligation and puncture (CLP) was utilized to build a mouse sepsis model. The experiment was randomly divided into four groups: Sham, CLP, CLP + shNC, and CLP + shIL1RAP group. RESULTS: qRT-PCR suggested mRNA levels of IL1RAP were decreased when IL1RAP was knocked down with the mRNA levels of IL-1β, NF-κB, and p38 decreased...
February 8, 2024: Immunological Investigations
https://read.qxmd.com/read/37859946/genome-wide-association-study-of-mammary-gland-tumors-in-maltese-dogs
#4
JOURNAL ARTICLE
Keon Kim, Jung Eun Song, Jae Beom Joo, Hyeon A Park, Chang Hyeon Choi, Chang Yun Je, Ock Kyu Kim, Sin Wook Park, Yoon Jung Do, Tai-Young Hur, Sang-Ik Park, Chang-Min Lee
BACKGROUND: A genome-wide association study (GWAS) is a valuable tool for investigating genetic and phenotypic variation in many diseases. OBJECTIVE: The objective of this study was to identify variations in the genomes of Maltese dogs that are associated with the mammary gland tumor (MGT) phenotype and to assess the association between each biological condition and MGT phenotype in Maltese dogs. METHODS: DNA was extracted from 22 tumor samples and 11 whole blood samples from dogs with MGTs...
2023: Frontiers in Veterinary Science
https://read.qxmd.com/read/37812652/surface-and-global-proteome-analyses-identify-enpp1-and-other-surface-proteins-as-actionable-immunotherapeutic-targets-in-ewing-sarcoma
#5
JOURNAL ARTICLE
Brian Mooney, Gian Luca Negri, Taras Shyp, Alberto Delaidelli, Hai-Feng Zhang, Sandra E Spencer Miko, Amber K Weiner, Alexander B Radaoui, Rawan Shraim, Michael M Lizardo, Christopher S Hughes, Amy Li, Amal M El-Naggar, Melanie Rouleau, Wei Li, Dimiter S Dimitrov, Raushan T Kurmasheva, Peter J Houghton, Sharon J Diskin, John M Maris, Gregg B Morin, Poul H Sorensen
PURPOSE: Ewing sarcoma (EwS) is the second most common bone sarcoma in children, with 1 case per 1.5 million in the United States. While the survival rate of patients diagnosed with localized disease is ~70%, this decreases to ~30% for patients with metastatic disease and only ~10% for treatment refractory disease, which have not changed for decades. Therefore new therapeutic strategies are urgently needed for metastatic and refractory EwS. EXPERIMENTAL DESIGN: This study analyzed 19 unique EwS patient or cell line-derived xenografts (from 14 primary and 5 metastatic specimens) using proteomics to identify surface proteins for potential immunotherapeutic targeting...
October 9, 2023: Clinical Cancer Research
https://read.qxmd.com/read/37700160/constitutive-photomorphogenic-protein-1-ubiquitinates-interleukin-1-receptor-accessory-protein-in-human-liver-cancer
#6
JOURNAL ARTICLE
Kuan Cao, Zhiyi Liu, Jin Liu, Qinghe Hu, Wengang Shan, Bin Hu, Hengliang Shi, Bin Zhang
BACKGROUND: Constitutive photomorphogenic protein 1 (COP1) plays a pivotal role in the development and progression of several human cancers and is reported to be upregulated in liver cancer. However, the role of COP1 in human liver cancer is unclear. METHODS: We analyzed the COP1 expression in normal liver and liver cancer tissue samples using western blot and immunohistochemical analysis. We overexpressed and silenced COP1 in HepG2 and Huh7 cells and analyzed the effect on liver cancer cell proliferation...
September 12, 2023: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/37634084/angptl3-negatively-regulates-il-1%C3%AE-induced-nf-%C3%AE%C2%BAb-activation-by-inhibiting-the-il1r1-associated-signaling-complex-assembly
#7
JOURNAL ARTICLE
Yu Zhang, Zi-Tong Zhang, Shi-Yuan Wan, Jing Yang, Yu-Juan Wei, Hui-Jing Chen, Wan-Zhu Zhou, Qiu-Yi Song, Shu-Xuan Niu, Ling Zheng, Kun Huang
Interleukin-1β (IL-1β)-induced signaling is one of the most important pathways in regulating inflammation and immunity. The assembly of the receptor complex, consisting of the ligand IL-1β, the IL-1 receptor (IL-1R) type 1 (IL1R1), and the IL-1R accessory protein (IL1RAP), initiates this signaling. However, how the IL1R1-associated complex is regulated remains elusive. Angiopoietin like 3 (ANGPTL3), a key inhibitor of plasma triglyceride clearance, is mainly expressed in the liver and exists in both intracellular and extracellular secreted forms...
August 26, 2023: Journal of Molecular Cell Biology
https://read.qxmd.com/read/37595869/neuronal-sam68-differentially-regulates-alternative-last-exon-splicing-and-ensures-proper-synapse-development-and-function
#8
JOURNAL ARTICLE
Mohamed Darwish, Masatoshi Ito, Yoko Iijima, Akinori Takase, Noriko Ayukawa, Satoko Suzuki, Masami Tanaka, Kanae Komori, Daisuke Kaida, Takatoshi Iijima
Alternative splicing in the 3' untranslated region (3'UTR) of mammalian genes plays a crucial role in diverse biological processes, including cell differentiation and development. SAM68 is a key splicing regulator that controls the diversity of 3'UTR isoforms through alternative last exon (ALE) selection. However, the tissue/cell type-specific mechanisms underlying the splicing control at the 3' end and its functional significance remain unclear. Here, we show that SAM68 regulates ALE splicing in a dose-dependent manner and the neuronal splicing is differentially regulated depending on the characteristics of the target transcript...
August 16, 2023: Journal of Biological Chemistry
https://read.qxmd.com/read/37498674/genetic-modification-of-inflammation-and-clonal-hematopoiesis-associated-cardiovascular-risk
#9
JOURNAL ARTICLE
Zhi Yu, Trevor P Filder, Yunfeng Ruan, Caitlyn Vlasschaert, Tetsushi Nakao, Md Mesbah Uddin, Taralynn Mack, Abhishek Niroula, J Brett Heimlich, Seyedeh M Zekavat, Christopher J Gibson, Gabriel K Griffin, Yuxuan Wang, Gina M Peloso, Nancy Heard-Costa, Daniel Levy, Ramachandran S Vasan, François Aguet, Kristin G Ardlie, Kent D Taylor, Stephen S Rich, Jerome I Rotter, Peter Libby, Siddhartha Jaiswal, Benjamin L Ebert, Alexander G Bick, Alan R Tall, Pradeep Natarajan
Clonal hematopoiesis of indeterminate potential (CHIP) is associated with an increased risk of cardiovascular diseases (CVD), putatively via inflammasome activation. We pursued an inflammatory gene modifier scan for CHIP-associated CVD risk among 424,651 UK Biobank participants. CHIP was identified using whole exome sequencing data of blood DNA and modeled both as a composite and for common drivers (DNMT3A, TET2, ASXL1, and JAK2) separately. We developed predicted gene expression scores for 26 inflammasome-related genes and assessed how they modify CHIP-associated CVD risk...
July 27, 2023: Journal of Clinical Investigation
https://read.qxmd.com/read/37400364/extremely-low-frequency-electromagnetic-field-exposure-alters-dna-methylation-levels-in-the-endometrium-of-pigs-during-the-peri-implantation-period
#10
JOURNAL ARTICLE
Pawel Jozef Wydorski, Wiktoria Kozlowska, Ewa Monika Drzewiecka, Agata Zmijewska, Anita Franczak
CONTEXT: Extremely low-frequency electromagnetic field (ELF-EMF) emission is increasing due to substantial technological progress. The results of previous research provided evidence that ELF-EMF may exert changes in molecular mechanisms that control female reproduction. AIMS: We hypothesised that short-term ELF-EMF treatment alters the DNA methylation level of genes in the endometrium. Hence, the research aimed to determine the methylation level of selected genes whose expression was altered in response to ELF-EMF radiation in the endometrium of pigs during the peri-implantation period (days 15-16 of pregnancy)...
July 4, 2023: Reproduction, Fertility, and Development
https://read.qxmd.com/read/37382169/circcrim1-mediates-proliferation-migration-and-invasion-of-trophoblast-cell-through-regulating-mir-942-5p-il1rap-axis
#11
JOURNAL ARTICLE
Fen Yu, Jie Xing, Lingyun Li, Mi Xiang
BACKGROUND: Preeclampsia (PE) is a severe complication that occurs during pregnancy and a main cause of perinatal mortality of mothers as well as infants, which is characterized by abnormal placental trophoblast. Previous study reported that aberrant circular RNA (circRNA) was involved in the pathogenesis and progression of PE. Herein, we aimed to investigate the role of circCRIM1 and explore the mechanism of circCRIM1 in PE. METHODS: The quantitative real-time PCR (qRT-PCR) was conducted to determine the relative expression of circCRIM1, miR-942-5p, and IL1RAP in tissues and cells...
July 2023: American Journal of Reproductive Immunology: AJRI
https://read.qxmd.com/read/37345579/impact-of-rehydration-following-systemic-dehydration-on-vocal-fold-gene-expression
#12
JOURNAL ARTICLE
Taylor W Bailey, Naila Cannes do Nascimento, Andrea P Santos, Abigail Cox, M Preeti Sivasankar
OBJECTIVE: Biological data on the beneficial effects of vocal fold rehydration are lacking. This study aimed to examine the effects of acute systemic dehydration on vocal fold gene expression and determine whether rehydration would reverse these changes. METHODS: Male New Zealand White rabbits (N = 24, n = 8/group) provided the animal model. Systemic dehydration was induced by 5 days of water volume restriction. Rehydration was provided by ad-lib water for 3 days following dehydration...
June 22, 2023: Laryngoscope
https://read.qxmd.com/read/37333017/circulating-neutrophils-activated-by-cancer-cells-and-m2-macrophages-promote-gastric-cancer-progression-during-pd-1-antibody-based-immunotherapy
#13
JOURNAL ARTICLE
Chenfei Zhou, Liting Guo, Qu Cai, Wenqi Xi, Fei Yuan, Huan Zhang, Chao Yan, Lei Huang, Zhenggang Zhu, Jun Zhang
Aims: To analyze the correlation between the neutrophil-to-lymphocyte ratio (NLR) and prognosis of advanced gastric cancer (AGC) patients treated by PD-1 antibody-based therapy and to delineate molecular characteristics of circulating neutrophils by single-cell RNA sequencing (scRNA-seq). Methods: The clinicopathological information of 45 AGC patients receiving PD-1 antibody-based regimens at the Department of Oncology, Ruijin Hospital, was reviewed. Treatment outcomes including objective response rate (ORR), progression-free survival (PFS), and overall survival (OS) were recorded...
2023: Frontiers in Molecular Biosciences
https://read.qxmd.com/read/36982998/metabolite-and-proteomic-profiling-of-serum-reveals-the-differences-in-molecular-immunity-between-min-and-large-white-pig-breeds
#14
JOURNAL ARTICLE
Liyu Yang, Xin Liu, Xiaoyu Huang, Longchao Zhang, Hua Yan, Xinhua Hou, Lixian Wang, Ligang Wang
Pig diseases seriously threaten the health of pigs and the benefits of pig production. Previous research has indicated that Chinese native pigs, such as the Min (M) pig, has a better disease resistance ability than Large White (LW) pigs. However, the molecular mechanism of this resistance is still unclear. In our study, we used serum untargeted metabolomics and proteomics, interrogated to characterize differences in the molecular immunities between six resistant and six susceptible pigs raised in the same environment...
March 21, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/36958512/changes-in-cytokine-and-cytokine-receptor-levels-during-postnatal-development-of-the-human-dorsolateral-prefrontal-cortex
#15
JOURNAL ARTICLE
Rachel E H Sager, Adam K Walker, Frank Middleton, Kate Robinson, Maree J Webster, Karen Gentile, Ma-Li Wong, Cynthia Shannon Weickert
In addition to their traditional roles in immune cell communication, cytokines regulate brain development. Cytokines are known to influence neural cell generation, differentiation, maturation, and survival. However, most work on the role of cytokines in brain development investigates rodents or focuses on prenatal events. Here, we investigate how mRNA and protein levels of key cytokines and cytokine receptors change during postnatal development in the human prefrontal cortex. We find that most cytokine transcripts investigated (IL1B, IL18, IL6, TNF, IL13) are lowest at birth and increase between 1...
March 21, 2023: Brain, Behavior, and Immunity
https://read.qxmd.com/read/36790759/chemoresistance-in-acute-myeloid-leukemia-an-alternative-single-cell-rna-sequencing-approach
#16
JOURNAL ARTICLE
Po-Liang Cheng, Tzu-Hung Hsiao, Chung-Hsing Chen, Miao-Neng Hung, Pei-Pei Jhan, Li-Wen Lee, Ting-Shuan Wu, Jia-Rung Tsai, Chieh-Lin Jerry Teng
Our previous study demonstrated that myc, mitochondrial oxidative phosphorylation, mTOR, and stemness are independently responsible for chemoresistance in acute myeloid leukemia (AML) cells. This study aimed to identify potential mechanisms of chemoresistance of the "7 + 3" induction in AML by using a single-cell RNA sequencing (scRNA-seq) approach. In the present study, 13 untreated patients with de novo AML were enrolled and stratified into two groups: complete remission (CR; n = 8) and non-CR (n = 5)...
February 15, 2023: Hematological Oncology
https://read.qxmd.com/read/36713475/lps-induced-acute-neuroinflammation-involving-interleukin-1-beta-signaling-leads-to-proteomic-cellular-and-network-level-changes-in-the-prefrontal-cortex-of-mice
#17
JOURNAL ARTICLE
Dániel Mittli, Vanda Tukacs, Lilla Ravasz, Éva Csősz, Tímea Kozma, József Kardos, Gábor Juhász, Katalin Adrienna Kékesi
Neuroinflammation induced by peripheral infections leads to various neuropsychiatric symptoms both in humans and laboratory animals, e.g., to the manifestation of sickness behavior that resembles some features of clinical depression. However, in addition to depression-like behavior, there are other symptoms of acute systemic inflammation that can be associated with the impairment of prefrontal cortex (PFC)-regulated cognitive functions. Thus, we investigated the electrophysiological and proteomic alterations of the PFC using brain slices and the lipopolysaccharide (LPS) model of acute peripheral infection in male mice...
March 2023: Brain, behavior, & immunity health
https://read.qxmd.com/read/36682035/the-survival-rate-of-laryngeal-squamous-cell-carcinoma-impact-of-il1rap-rs4624606-il1rl1-rs1041973-il-6-rs1800795-blk-rs13277113-and-timp3-rs9621532-single-nucleotide-polymorphisms
#18
JOURNAL ARTICLE
Agne Pasvenskaite, Rasa Liutkeviciene, Greta Gedvilaite, Alvita Vilkeviciute, Vykintas Liutkevicius, Virgilijus Uloza
PURPOSE: Results of laryngeal squamous cell carcinoma (LSCC) treatment and the 5 year survival rate of these patients remain poor. To purify therapeutic targets, investigation of new specific and prognostic blood-based markers for LSCC development is essential. METHODS: In the present study, we evaluated five single nucleotide polymorphisms (SNPs): IL1RAP rs4624606, IL1RL1 rs1041973, IL-6 rs1800795, BLK rs13277113, and TIMP3 rs9621532, and determined their associations with the patients' 5 year survival rate...
January 22, 2023: Discover. Oncology
https://read.qxmd.com/read/36502418/il1rap-knockdown-in-lps-stimulated-normal-human-astrocytes-suppresses-lps-induced-reactive-astrogliosis-and-promotes-neuronal-cell-proliferation
#19
JOURNAL ARTICLE
Jiahui Zhou, Weineng Xiang, Kexiang Zhang, Qun Zhao, Zhewei Xu, Zhiyue Li
The reactivation of astrocytes plays a critical role in spinal cord injury (SCI) repairment. In this study, IL1RAP expression has been found to be upregulated in SCI mice spinal cord, SCI astrocytes, and LPS-stimulated NHAs. Genes correlated with IL1RAP were significantly enriched in cell proliferation relative pathways. In LPS-stimulated NHAs, IL1RAP overexpression promoted NHA cell proliferation, decreased PTEN protein levels, and increased the phosphorylation of Akt and mTOR. IL1RAP overexpression promoted LPS-induced NHA activation and NF-κB signaling activation...
December 11, 2022: Neurochemical Research
https://read.qxmd.com/read/36457850/activation-of-il1-signaling-molecules-by-kaposi-s-sarcoma-associated-herpesvirus
#20
JOURNAL ARTICLE
Jungang Chen, Jiao Song, Jennifer James, Karlie Plaisance-Bonstaff, Steven R Post, Zhiqiang Qin, Lu Dai
OBJECTIVE: Kaposi's Sarcoma-associated Herpesvirus (KSHV) is the etiologic agent of several human cancers, including Kaposi's sarcoma (KS) and Primary effusion lymphoma (PEL), which are usually seen in immunocompromised patients while lack of effective therapeutic options. Interleukin1 (IL1) family is a major mediator for inflammation response and has functional role in both innate and adaptive immunity. In contrast to the well-studied IL1 molecules, the activation and functional role of IL1 receptor/co-receptor and other related ligands, such as the IL1 receptor accessory protein (IL1RAP), in KSHV pathogenesis and tumorigenesis remain almost unknown...
2022: Frontiers in Cellular and Infection Microbiology
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