keyword
https://read.qxmd.com/read/20811394/inhibition-of-nf-%C3%AE%C2%BAb-signaling-retards-eosinophilic-dermatitis-in-sharpin-deficient-mice
#21
JOURNAL ARTICLE
Yanhua Liang, Rosemarie E Seymour, John P Sundberg
The NF-κB pathway performs pivotal roles in diverse physiological processes such as immunity, inflammation, proliferation, and apoptosis. NF-κB is kept inactive in the cytoplasm through association with inhibitors (IκB), and translocates to the nucleus to activate its target genes after the IκBs are phosphorylated and degraded. Here, we demonstrate that loss of function of SHANK-associated RH domain interacting protein (SHARPIN) leads to activation of NF-κB signaling in skin, resulting in the development of an idiopathic hypereosinophilic syndrome (IHES) with eosinophilic dermatitis in C57BL/KaLawRij-Sharpin(cpdm)/RijSunJ mice, and clonal expansion of B-1 B cells and CD3(+)CD4(-)CD8(-) T cells...
January 2011: Journal of Investigative Dermatology
https://read.qxmd.com/read/19996325/expression-of-interleukin-1-like-cytokine-interleukin-33-and-its-receptor-complex-st2l-and-il1racp-in-human-pancreatic-myofibroblasts
#22
JOURNAL ARTICLE
Atsushi Nishida, Akira Andoh, Hirotsugu Imaeda, Osamu Inatomi, Hisanori Shiomi, Yoshihide Fujiyama
OBJECTIVE: Interleukin 33 (IL33) is a cytokine belonging to the IL1 family and it binds to a complex of the ST2L/IL1 receptor accessory protein (IL1RAcP). To define the role of IL33 in fibrogenesis of the pancreas, the expression of IL33, ST2L and IL1RAcP was examined in chronic pancreatitis tissues. The effects of IL33 on the functions of human pancreatic myofibroblasts were also investigated. METHODS: Tissue samples were obtained surgically. The expression of IL33, ST2L and IL1RAcP was evaluated by standard immunohistochemical procedures...
April 2010: Gut
https://read.qxmd.com/read/18657618/zebrafish-orthologue-of-mental-retardation-protein-il1rapl1-regulates-presynaptic-differentiation
#23
JOURNAL ARTICLE
Tomoyuki Yoshida, Masayoshi Mishina
IL1-receptor accessory protein-like 1 (IL1RAPL1), a member of interleukin-1/toll receptor (TIR) family, is responsible for a nonsyndromic form of mental retardation (MR). The zebrafish orthologue of mammalian IL1RAPL1, designated as Il1rapl1b, was expressed widely in the brain and in the olfactory placode. We employed an olfactory sensory neuron-specific gene manipulation system in combination with in vivo imaging of transparent zebrafish embryos to examine the functional role of Il1rapl1b in synaptic vesicle accumulation and subsequent morphological remodeling of axon terminals, the characteristic features of presynaptic differentiation of zebrafish olfactory sensory neurons during synapse formation...
October 2008: Molecular and Cellular Neurosciences
https://read.qxmd.com/read/17949817/a-novel-alternatively-spliced-interleukin-1-receptor-accessory-protein-mil-1racp687
#24
JOURNAL ARTICLE
Hsin-Lin Lu, Chih-Yung Yang, Hui-Chun Chen, Chia-Sui Hung, Yu-Chi Chiang, Ling-Pai Ting
The 570-amino acid membrane form of IL-1RAcP (mIL-1RAcP) plays a pivotal role in the IL-1 signal transduction and response. We have identified another membrane form of IL-1RAcP with 687 amino acids (named as mIL-1RAcP687 hereon). Its except the last amino acid N-terminal 448 amino acid portion, containing three extracellular immunoglobulin domains, one transmembrane domain, and Box 1 and Box 2 of Toll/IL1 Receptor (TIR) domain, is identical to that of mIL-1RAcP. In contrast, the C-terminal 239 amino acid portion of mIL-1RAcP687, containing Box 3 of TIR domain, is unique...
March 2008: Molecular Immunology
https://read.qxmd.com/read/17502602/il1-receptor-accessory-protein-like-1-il1rapl1-a-protein-involved-in-cognitive-functions-regulates-n-type-ca2-channel-and-neurite-elongation
#25
JOURNAL ARTICLE
Frédéric Gambino, Alice Pavlowsky, Aurélie Béglé, Jean-Luc Dupont, Nadia Bahi, Raphael Courjaret, Robert Gardette, Hassen Hadjkacem, Henriette Skala, Bernard Poulain, Jamel Chelly, Nicolas Vitale, Yann Humeau
Null mutations in the IL1-receptor accessory protein-like 1 gene (IL1RAPL1) are responsible for an inherited X-linked form of cognitive impairment. IL1RAPL1 protein physically interacts with neuronal calcium sensor-1 (NCS-1), but the functional impact of the IL1RAPL1/NCS-1 interaction remains unknown. Here, we demonstrate that stable expression of IL1RAPL1 in PC12 cells induces a specific silencing of N-type voltage-gated calcium channels (N-VGCC) activity that explains a secretion deficit observed in these IL1RAPL1 cells...
May 22, 2007: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/16034474/surveillance-of-transcriptomes-in-basic-military-trainees-with-normal-febrile-respiratory-illness-and-convalescent-phenotypes
#26
JOURNAL ARTICLE
D C Thach, B K Agan, C Olsen, J Diao, B Lin, J Gomez, M Jesse, M Jenkins, R Rowley, E Hanson, C Tibbetts, D A Stenger, E Walter et al.
Gene expression profiles permit analysis of host immune response at the transcriptome level. We used the Pax gene Blood RNA (PAX) System and Affymetrix microarrays (HG-U133A&B) to survey profiles in basic military trainees and to classify them as healthy, febrile respiratory illness (FRI) without adenovirus, FRI with adenovirus, and convalescent from FRI with adenovirus. We assessed quality metrics of RNA processing for microarrays. Class prediction analysis discovered nested sets of transcripts that could categorize the phenotypes with optimized accuracy of 99% (nonfebrile vs febrile, P<0...
October 2005: Genes and Immunity
https://read.qxmd.com/read/15849357/interactive-sites-in-the-myd88-toll-interleukin-il-1-receptor-domain-responsible-for-coupling-to-the-il1beta-signaling-pathway
#27
JOURNAL ARTICLE
Chunsheng Li, Jozef Zienkiewicz, Jacek Hawiger
Myeloid differentiation factor MyD88 is the essential adaptor protein that integrates and transduces intracellular signals generated by multiple Toll-like receptors including receptor complex for interleukin (IL) 1beta, a key inflammatory cytokine. IL1beta receptor complex interacts with MyD88 via the Toll/IL1 receptor (TIR) domain. Here we report structure-function studies that help define the MyD88 TIR domain binding sites involved in IL1beta-induced protein-protein interactions. The MyD88 TIR domain, employed as a dominant negative inhibitor of IL1beta signaling to screen MyD88 TIR mutants, lost its suppressing activity upon truncation of its Box 3...
July 15, 2005: Journal of Biological Chemistry
https://read.qxmd.com/read/12783849/il1-receptor-accessory-protein-like-a-protein-involved-in-x-linked-mental-retardation-interacts-with-neuronal-calcium-sensor-1-and-regulates-exocytosis
#28
COMPARATIVE STUDY
Nadia Bahi, Gaelle Friocourt, Alain Carrié, Margaret E Graham, Jamie L Weiss, Philippe Chafey, Fabien Fauchereau, Robert D Burgoyne, Jamel Chelly
Previously, human genetics-based approaches allowed us to show that mutations in the IL-1 receptor accessory protein-like gene (IL1RAPL) are responsible for a non-specific form of X-linked mental retardation. This gene encodes a predicted protein of 696 amino acids that belongs to a novel class of the IL-1/Toll receptor family. In addition to the extracellular portion consisting of three Ig-like domains and the intracellular TIR domain characteristic of the IL-1/Toll receptor family, IL1RAPL contains a specific 150 amino acid carboxy terminus that has no significant homology with any protein of known function...
June 15, 2003: Human Molecular Genetics
https://read.qxmd.com/read/12525379/interleukin-7-stimulates-tumour-necrosis-factor-alpha-and-th1-cytokine-production-in-joints-of-patients-with-rheumatoid-arthritis
#29
JOURNAL ARTICLE
J A G van Roon, K A F M Glaudemans, J W J Bijlsma, F P J G Lafeber
BACKGROUND: A large number of activated T cells are found in the joints of patients with rheumatoid arthritis (RA). Interleukin 7 (IL7), a T cell growth factor and a regulator of Th1 and Th2 cytokine production, is produced by synoviocytes from patients with RA. OBJECTIVE: To investigate the effect on proinflammatory cytokine production of synovial fluid mononuclear cells (SFMC) and the mechanism by which IL7 influences CD4+ T cell activity in patients with RA. METHODS: In a cross sectional group of patients with RA, IL7 levels were compared with those of healthy controls and related to disease activity...
February 2003: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/9426216/the-il1-receptor-accessory-protein-is-responsible-for-the-recruitment-of-the-interleukin-1-receptor-associated-kinase-to-the-il1-il1-receptor-i-complex
#30
JOURNAL ARTICLE
F Volpe, J Clatworthy, A Kaptein, B Maschera, A M Griffin, K Ray
Following interleukin-1 (IL1) stimulation, an IL1 receptor associated kinase (IRAK) is rapidly recruited to the receptor complex. However, it is not understood if IRAK is able to interact directly with the intracellular portion of the IL1-RI or if its recruitment is mediated by a different molecule. Using the yeast two-hybrid system, we have analysed possible protein-protein interactions between IRAK, IL1-RI and IL1-RAcP. We found that IRAK is able to interact with the equivalent cytoplasmic region of the IL1-RAcP but is unable to interact with the cytoplasmic region of the IL1-RI...
December 8, 1997: FEBS Letters
https://read.qxmd.com/read/7901265/inducible-accessory-function-of-a-macrophage-cell-line
#31
JOURNAL ARTICLE
F B Aiello, L Gusella, D L Longo, M Birchenall-Roberts, L Takacs, F Takei, F Ruscetti, P Musiani, S K Durum
Costimulatory molecules in addition to occupancy of the T-cell antigen receptor, are required to induce T-cell proliferation. Previous work suggested that membrane molecules responsible for costimulatory activity were not constitutively expressed on the antigen presenting cell (APC) surface. In the present study, we have identified a cloned macrophage cell line (FLJ2) with inducible APC function. The unactivated FLJ2 line could not induce T-cell proliferation. FLJ2 could present alloantigen, and stimulate proliferation of either a T-cell clone or normal resting T cells following activation with IFN gamma or unexpectedly with lipopolysaccharide (LPS)-Activated FLJ2 cells could be fixed and APC function was preserved...
August 1993: Immunopharmacology and Immunotoxicology
https://read.qxmd.com/read/2901355/the-required-interaction-between-monocytes-and-peripheral-blood-t-lymphocytes-t-pbl-upon-activation-via-cd2-or-cd3-role-of-hla-class-i-molecules-from-accessory-cells-and-the-differential-response-of-t-pbl-subsets
#32
JOURNAL ARTICLE
S Huet, L Boumsell, J Dausset, L Degos, A Bernard
Previously, we have shown that paraformaldehyde-fixed monocytes are able to fully complement, in terms of [3H]dThd incorporation, a primary stimulus delivered to purified T cells by monoclonal antibodies (mAb) reacting with CD3 or CD2 molecules. Here, we show that depending on the stimulus used (CD3 mAb or different pairs of CD2 mAb) HLA class I molecules from monocytes are directly involved in complementary signals provided to T cells. This was evidenced by the following observations: (a) mAb reacting with the heavy or light chain of class I molecules, or their Fab fragments, completely blocked proliferation of peripheral blood lymphocytes (PBL) activated by CD3 mAb; (b) mAb against the heavy chain of HLA class I but not against beta 2-microglobulin partially blocked (approximately equal to 50%) PBL activation by the CD2 "GT2 + T111" mAb pair but did not block activation by CD2 "D66 + T111" mAb; (c) this pattern of inhibition was observed when anti-class I mAb were used in the soluble phase or when they were bound to monocytes subsequently fixed with paraformaldehyde and cultivated with purified autologous T cells; (d) fixed monocytes are able to restore interleukin (IL) 2 receptor expression on purified T cells stimulated by CD3 mAb or CD2 "GT2 + T111", contrary to anti-HLA class I mAb-pretreated monocytes...
August 1988: European Journal of Immunology
https://read.qxmd.com/read/2483921/growth-of-fetal-thymocytes-in-organ-culture-effect-of-recombinant-lymphokines-on-thymocyte-maturation
#33
JOURNAL ARTICLE
P S Crosier, M Skinner, G Le Gros, K Holdaway, J D Watson
Interleukin 2 (IL2) has a dose-dependent inhibitory effect on the growth and phenotypic maturation of thymocyte populations grown in fetal thymus organ culture. Addition of IL2 (100 U/ml) to 14-day fetal thymus organ cultures induces the appearance of a population of lymphokine-activated killer (LAK) cells which lyse allogeneic, syngeneic, and syngeneic tumor cell targets. The addition of the monoclonal antibody, PC-61, blocks the IL2-dependent growth and activation of LAK cells but does not influence the maturation of CD4+ CD8+ fetal thymocytes...
1989: Growth Factors
https://read.qxmd.com/read/2407536/accessory-factors-involved-in-murine-t-cell-activation-distinct-roles-of-interleukin-6-interleukin-1-and-tumor-necrosis-factor
#34
JOURNAL ARTICLE
A Vink, C Uyttenhove, P Wauters, J Van Snick
Interleukin (IL) 6 was compared to other macrophage-derived products for its capacity to support the proliferation of accessory cell-depleted T cells. Monoclonal anti-IL6 antibodies were found to inhibit completely the "accessory activity" of macrophage supernatants, thus demonstrating the central role played by IL6 in T cell activation. IL6 was apparently more critical for initiating than in maintaining T cell proliferation because anti-IL6 antibodies lost all inhibitory activity when added late to the culture...
January 1990: European Journal of Immunology
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