keyword
https://read.qxmd.com/read/38485911/different-gene-expression-patterns-of-il-1-family-members-in-parkinson-s-disease-results-from-bayesian-regression-model
#1
JOURNAL ARTICLE
Negin Jafariaghdam, Majid Khoshmirsafa, Alireza Zamani, Elahe Talebi-Ghane, Shadi Moradi, Faezeh Shahba, Mehrdokht Mazdeh, Mohammad Mahdi Eftekharian
Parkinson's disease, the second most prevalent neurodegenerative disorder lacking a recognized etiology, is influenced by oxidative stress and alterations in inflammatory cytokine levels. This study aimed to investigate the expression levels of Interleukin(IL)1 receptor accessory protein (IL-1RAcP), IL1β, IL1α, IL33, and IL36 genes in blood cells and serum IL-1β levels in Parkinson's disease patients compared to healthy controls (HCs).I n this case-control study, 44 Parkinson's disease patients and 44 age- and sex-matched HCs were included...
February 11, 2024: Iranian Journal of Allergy, Asthma, and Immunology
https://read.qxmd.com/read/38360807/immune-endotyping-and-gene-expression-profile-of-patients-with-chronic-rhinosinusitis-with-nasal-polyps-in-the-aspirin-exacerbated-respiratory-disease-aerd-and-the-non-aerd-subgroups
#2
JOURNAL ARTICLE
Javad Nazari, Faezeh Shahba, Negin Jafariaghdam, Saleh Mohebbi, Saba Arshi, Mohammad Hassan Bemanian, Morteza Fallahpour, Sima Shokri, Fatemeh Atashrazm, Saeed Amini, Maryam Roomiani, Mahnaz Jamee, Pegah Babaheidarian, Majid Khoshmirsafa, Mohammad Nabavi
BACKGROUND: Chronic Rhinosinusitis (CRS) is a paranasal sinus inflammatory disease and is divided into two subgroups defined as CRS with nasal polyps (CRSwNP) and CRS without nasal polyps (CRSsNP). CRSwNP displays a T helper (Th)2 biased phenotype, and based on sensitivity or tolerance to aspirin or non-steroidal anti-inflammatory drugs (NSAID), is further subdivided into Aspirin-exacerbated respiratory disease (AERD) and non-AERD groups. Considering the challenge of diagnosis and treatment in patients with CRSwNP, particularly the AERD subtype, and the significance of endotyping in these patients, we examined the immune profile and endotyping based on gene expression analysis in the AERD and the non-AERD groups of patients with CRSwNP...
February 15, 2024: Allergy, Asthma, and Clinical Immunology
https://read.qxmd.com/read/38329477/il1rap-exacerbates-sepsis-induced-pulmonary-and-spleen-injury-through-regulating-cd4-t-lymphocyte-differentiation
#3
JOURNAL ARTICLE
Liou Huang, Chunrong Wu, Dan Xu, Yuhui Cui, Jianguo Tang
BACKGROUND: Complex pathophysiological the specific mechanism of sepsis on CD4+ T-cell responses is less well understood. IL1 receptor accessory protein (IL1RAP) was found to be involved in activating host immune responses. METHOD: Cecum ligation and puncture (CLP) was utilized to build a mouse sepsis model. The experiment was randomly divided into four groups: Sham, CLP, CLP + shNC, and CLP + shIL1RAP group. RESULTS: qRT-PCR suggested mRNA levels of IL1RAP were decreased when IL1RAP was knocked down with the mRNA levels of IL-1β, NF-κB, and p38 decreased...
February 8, 2024: Immunological Investigations
https://read.qxmd.com/read/37981104/interleukin-1-receptor-accessory-protein-il-1rap-a-magic-bullet-candidate-for-immunotherapy-of-human-malignancies
#4
REVIEW
Ali Zarezadeh Mehrabadi, Faezeh Shahba, Hossein Khorramdelazad, Nazanin Aghamohammadi, Milad Karimi, Kowsar Bagherzadeh, Majid Khoshmirsafa, Ramin Massoumi, Reza Falak
IL-1, plays a role in some pathological inflammatory conditions. This pro-inflammatory cytokine also has a crucial role in tumorigenesis and immune responses in the tumor microenvironment (TME). IL-1 receptor accessory protein (IL-1RAP), combined with IL-1 receptor-1, provides a functional complex for binding and signaling. In addition to the direct role of IL-1, some studies demonstrated that IL1-RAP has essential roles in the progression, angiogenesis, and metastasis of solid tumors such as gastrointestinal tumors, lung carcinoma, glioma, breast and cervical cancers...
January 2024: Critical Reviews in Oncology/hematology
https://read.qxmd.com/read/36457850/activation-of-il1-signaling-molecules-by-kaposi-s-sarcoma-associated-herpesvirus
#5
JOURNAL ARTICLE
Jungang Chen, Jiao Song, Jennifer James, Karlie Plaisance-Bonstaff, Steven R Post, Zhiqiang Qin, Lu Dai
OBJECTIVE: Kaposi's Sarcoma-associated Herpesvirus (KSHV) is the etiologic agent of several human cancers, including Kaposi's sarcoma (KS) and Primary effusion lymphoma (PEL), which are usually seen in immunocompromised patients while lack of effective therapeutic options. Interleukin1 (IL1) family is a major mediator for inflammation response and has functional role in both innate and adaptive immunity. In contrast to the well-studied IL1 molecules, the activation and functional role of IL1 receptor/co-receptor and other related ligands, such as the IL1 receptor accessory protein (IL1RAP), in KSHV pathogenesis and tumorigenesis remain almost unknown...
2022: Frontiers in Cellular and Infection Microbiology
https://read.qxmd.com/read/34768376/altered-mrna-expression-of-interleukin-1-receptors-in-myocardial-tissue-of-patients-with-left-ventricular-assist-device-support
#6
JOURNAL ARTICLE
Naima Niazy, Linus Mrozek, Mareike Barth, Moritz Benjamin Immohr, Nikolaos Kalampokas, Diyar Saeed, Hug Aubin, Yukiharu Sugimura, Ralf Westenfeld, Udo Boeken, Artur Lichtenberg, Payam Akhyari
Serum levels of cytokines interleukin 1 beta ( IL-1β ) and interleukin 33 (IL-33) are highly abnormal in heart failure and remain elevated after mechanical circulatory support (MCS). However, local cytokine signaling induction remains elusive. Left (LV) and right ventricular (RV) myocardial tissue specimens of end-stage heart failure (HF) patients without ( n = 24) and with MCS ( n = 39; 594 ± 57 days) were analyzed for cytokine mRNA expression level of IL-1B , interleukin 1 receptor 1/2 ( IL-1R1/2 ), interleukin 1 receptor-like 1 ( IL-1RL1 ), IL-33 and interleukin-1 receptor accessory protein ( IL-1RaP )...
October 22, 2021: Journal of Clinical Medicine
https://read.qxmd.com/read/34725089/il1rap-pulls-a-double-shift-in-the-cysteine-factory
#7
COMMENT
Sang Jun Yoon, Gina M DeNicola
Anoikis is a critical barrier to cancer cell metastasis. In this issue of Cancer Discovery , Zhang and colleagues identify that IL1 receptor accessory protein suppresses anoikis in Ewing sarcoma by promoting both the activity of the system Xc - cystine/glutamate antiporter and cystathionine γ-lyase (CTH) transcription to sustain cysteine levels for reactive oxygen species detoxification. See related article by Zhang et al., p. 2884 .
November 2021: Cancer Discovery
https://read.qxmd.com/read/32324480/sleep-and-time-of-day-linked-rna-transcript-expression-in-wild-type-and-il1-receptor-accessory-protein-null-mice
#8
JOURNAL ARTICLE
Vladyslav Oles, Khia Min Sabrina Koh, Cheryl J Dykstra-Aiello, Marina Savenkova, Cody M Gibbons, Joseph T Nguyen, Ilia Karatsoreos, Alexander Panchenko, James Martin Krueger
Sleep regulation involves IL1 family members, TNF, and circadian clock genes. Previously, we characterized spontaneous sleep and sleep after eight hours of sleep deprivation (SD) ending at zeitgeber time (ZT) 4 and ZT16 in wild type (WT) and IL1 receptor accessory protein (AcP) and brain specific AcP (AcPb) knockout (KO) mice. Herein, we applied RT/qPCR and Spearman gene pair expression correlation methods to characterize IL1, IL1 receptor 1 (IL1R1), AcP, AcPb, Period 1 (Per1), Clock, adenosine deaminase (Ada), peptidoglycan recognition protein 1 (Pglyrp1), and TNF mRNA expressions under conditions with distinct sleep phenotypes...
April 23, 2020: Journal of Applied Physiology
https://read.qxmd.com/read/31295066/interleukin-1-receptor-accessory-proteins-are-required-for-normal-homeostatic-responses-to-sleep-deprivation
#9
JOURNAL ARTICLE
Joseph Nguyen, Cody M Gibbons, Cheryl Dykstra-Aiello, Riley Ellingsen, Khia Min Sabrina Koh, Ping Taishi, James Martin Krueger
Interleukin-1β (IL1) is a sleep regulatory substance. The IL1 - IL1 type 1 receptor complex requires a receptor accessory protein (AcP) to signal. There are three isoforms of AcP. In the current experiments, mice lacking a neuron-specific isoform, called AcPb knockout (AcPb KO), or mice lacking AcP + AcPb isoforms (AcP KO) or wild-type (WT) mice were used. Spontaneous sleep and sleep responses to sleep deprivation (SD) between zeitgeber time 20 [ZT20] - ZT4 and ZT8 - ZT16 were characterized. Further, somatosensory cortical protein extracts were examined for phosphorylated (p) Src and p38MAPK levels at ZT4 and ZT16 and after SD...
July 11, 2019: Journal of Applied Physiology
https://read.qxmd.com/read/31106280/the-neuron-specific-interleukin-1-receptor-accessory-protein-alters-emergent-network-state-properties-in-vitro
#10
JOURNAL ARTICLE
Joseph T Nguyen, Dinuka Sahabandu, Ping Taishi, Mengran Xue, Kathryn Jewett, Cheryl Dykstra-Aiello, Sandip Roy, James M Krueger
Small in vitro neuronal/glial networks exhibit sleep-like states. Sleep regulatory substance interleukin-1β (IL1) signals via its type I receptor and a receptor accessory protein (AcP). AcP has a neuron-specific isoform called AcPb. After sleep deprivation, AcPb, but not AcP, upregulates in brain, and mice lacking AcPb lack sleep rebound. Herein we used action potentials (APs), AP burstiness, synchronization of electrical activity (SYN), and delta wave (0.5-3.75 Hz) power to characterize cortical culture network state...
January 2019: Neurobiology of Sleep and Circadian Rhythms
https://read.qxmd.com/read/27440742/interleukin-il-1-in-rat-parturition-il-1-receptors-1-and-2-and-accessory-proteins-abundance-in-pregnant-rat-uterus-at-term-regulation-by-progesterone
#11
JOURNAL ARTICLE
Tomohito Ishiguro, Jun Takeda, Xin Fang, Heather Bronson, David M Olson
The role of interleukin-1 (IL-1), a pro-inflammatory cytokine, in parturition is typically noted by changes in its concentrations. Studying the expression of its receptor family, IL-1 receptor (IL-1R) 1, IL-1R2, IL-1R accessory protein (IL-1RAcP), and its predominantly brain isoform, IL-1RAcPb, during late gestation in the uterus in the Long-Evans rat is another. We assessed changes in their mRNA and protein relative abundance in the uterus and compared IL-1RAcP and IL-1RAcPb mRNA abundance in uterus, cervix, ovaries, placenta, and whole blood of Long-Evans rats during late gestation or in RU486 and progesterone-treated dams using quantitative real-time PCR and western immunoblotting...
July 2016: Physiological Reports
https://read.qxmd.com/read/26406983/expression-of-interleukin-1-and-interleukin-1-receptors-type-1-and-type-2-in-hodgkin-lymphoma
#12
JOURNAL ARTICLE
Elisabeth Oelmann, Harald Stein, Wolfgang E Berdel, Hermann Herbst
Signaling through the IL-1-receptor type 1 (IL-1R1), IL-1 is required for initiation and maintenance of diverse activities of the immune system. A second receptor, IL-1R2, blocks IL-1 signal transduction. We studied expression of IL-1beta, IL-1R1, and IL-1R2 in 17 Hodgkin lymphomas (HL) by in situ hybridization (ISH). IL-1beta expressing cells, morphologically consistent with endothelial cells and fibroblasts, occurred in all HL tissues with elevated transcript levels in areas of active fibrosis. Hodgkin and Reed-Sternberg (HRS) cells of all cases expressed low IL-1R1 transcript levels in some tumor cells, and high levels of IL-1R2 in large proportions of HRS cells...
2015: PloS One
https://read.qxmd.com/read/25449578/the-neuron-specific-interleukin-1-receptor-accessory-protein-is-required-for-homeostatic-sleep-and-sleep-responses-to-influenza-viral-challenge-in-mice
#13
JOURNAL ARTICLE
Christopher J Davis, Danielle Dunbrasky, Marcella Oonk, Ping Taishi, Mark R Opp, James M Krueger
Interleukin-1β (IL1) is involved in sleep regulation and sleep responses induced by influenza virus. The IL1 receptor accessory protein (AcP) and an alternatively spliced isoform of AcP found primarily in neurons, AcPb, form part of the IL1 signaling complex. IL1-induced sleep responses depend on injection time. In rat cortex, both IL1 mRNA and AcPb mRNA peak at Zeitgeber Time (ZT) 0 then decline over the daylight hours. Sleep deprivation enhances cortical IL1 mRNA and AcPb mRNA levels, but not AcP mRNA. We used wild type (WT) and AcPb knockout (KO) mice and performed sleep deprivation between ZT10 and 20 or between ZT22 and 8 based on the time of day expression profiles of AcPb and IL1...
July 2015: Brain, Behavior, and Immunity
https://read.qxmd.com/read/24935223/blood-soluble-interleukin-1-receptor-accessory-protein-levels-are-consistently-low-throughout-the-menstrual-cycle-of-women-with-endometriosis
#14
JOURNAL ARTICLE
Nadège Michaud, Mahera Al-Akoum, Ali Akoum
BACKGROUND: A deficiency in the counter-regulatory mechanisms of interleukin 1 (IL1) may play a significant role in endometriosis pathogenesis and associated chronic inflammation. The aim of this study was to investigate peripheral blood levels of soluble IL1 receptor accessory protein (sIL1RAP), a potent natural inhibitor of IL1, in women with and without endometriosis. METHODS: Peripheral blood samples were collected from women with endometriosis (n = 47) consulting for infertility, pelvic pain or tubal ligation, in whom the disease was diagnosed at laparoscopy...
June 16, 2014: Reproductive Biology and Endocrinology: RB&E
https://read.qxmd.com/read/22572995/regulatory-mechanism-for-expression-of-il1b-receptors-in-the-uterine-endometrium-and-effects-of-il1b-on-prostaglandin-synthetic-enzymes-during-the-implantation-period-in-pigs
#15
JOURNAL ARTICLE
Heewon Seo, Yohan Choi, Jangsoo Shim, Youngsok Choi, Hakhyun Ka
During the implantation period, the porcine conceptus secretes interleukin-1beta (IL1B) that may be involved in the establishment of pregnancy in pigs. However, the regulatory mechanism for IL1B receptor expression and the function of IL1B in the uterine endometrium are not well elucidated. In this study, we determined IL1B receptor expression in the uterine endometrium of pigs during pregnancy. IL1B receptor subtypes, IL1 receptor type I (IL1R1) and IL1 receptor accessory protein (IL1RAP) were expressed in the uterine endometrium with the expression being most abundant on Day 12 of pregnancy primarily in the luminal and glandular epithelial cells...
August 2012: Biology of Reproduction
https://read.qxmd.com/read/21958553/decreased-concentrations-of-soluble-interleukin-1-receptor-accessory-protein-levels-in-the-peritoneal-fluid-of-women-with-endometriosis
#16
JOURNAL ARTICLE
Nadège Michaud, Mahéra Al-Akoum, Geneviève Gagnon, Karine Girard, Pierre Blanchet, Julie Anne Rousseau, Ali Akoum
Interleukin 1 (IL1) may play an important role in endometriosis-associated pelvic inflammation, and natural specific inhibitors, including soluble IL1 receptor accessory protein (sIL1RAcP) and soluble IL1 receptor type 2 (sIL1R2), are critical for counterbalancing the pleiotropic effects of IL1. The objective of this study was to evaluate the levels of sIL1RAcP, together with those of sIL1R2 and IL1β, in the peritoneal fluid of women with and without endometriosis. Peritoneal fluid samples were obtained at laparoscopy and assessed by ELISA...
December 2011: Journal of Reproductive Immunology
https://read.qxmd.com/read/21926414/the-x-linked-intellectual-disability-protein-il1rapl1-regulates-excitatory-synapse-formation-by-binding-ptp%C3%AE-and-rhogap2
#17
JOURNAL ARTICLE
Pamela Valnegri, Chiara Montrasio, Dario Brambilla, Jaewon Ko, Maria Passafaro, Carlo Sala
Mutations of the Interleukin-1-receptor accessory protein like 1 (IL1RAPL1) gene are associated with cognitive impairment ranging from non-syndromic X-linked mental retardation to autism. IL1RAPL1 belongs to a novel family of IL1/Toll receptors, which is localized at excitatory synapses and interacts with PSD-95. We previously showed that IL1RAPL1 regulates the synaptic localization of PSD-95 by controlling c-Jun N-terminal kinase activity and PSD-95 phosphorylation. Here, we show that the IgG-like extracellular domains of IL1RAPL1 induce excitatory pre-synapse formation by interacting with protein tyrosine phosphatase delta (PTPδ)...
December 15, 2011: Human Molecular Genetics
https://read.qxmd.com/read/21600927/engagement-of-il-1-receptor-accessory-protein-il-1racp-with-the-monoclonal-antibody-ay19-provides-co-activating-signals-and-prolongs-the-cd2-induced-proliferation-of-peripheral-blood-lymphocytes
#18
JOURNAL ARTICLE
Indra-Gusti Mansur, Valérie Schiavon, Jérôme Giustiniani, Martine Bagot, Armand Bensussan, Anne Marie-Cardine
IL-1 receptor accessory protein (IL-1RAcP) is the second subunit required to form a functional receptor complex for IL-1α and β, IL-1F6, IL-1F8, IL1-F9 and IL-33. While it does not directly interact with the cytokines, IL-1RAcP is necessary to mediate signal transduction. We previously reported a monoclonal antibody with an unknown specificity, termed AY19, that was capable to induce a significant increase in the size of CFU-GM colonies when added to cultures of human cord blood CD34(+) hematopoietic progenitors...
September 30, 2011: Immunology Letters
https://read.qxmd.com/read/21281968/inorganic-arsenic-alters-expression-of-immune-and-stress-response-genes-in-activated-primary-human-t-lymphocytes
#19
JOURNAL ARTICLE
Corinne Martin-Chouly, Claudie Morzadec, Mélodie Bonvalet, Marie-Dominique Galibert, Olivier Fardel, Laurent Vernhet
Inorganic arsenic, a carcinogenic environmental contaminant, exerts immunosuppressive effects on human T lymphocytes. In particular, interleukin-2 (IL2) secretion and T cell proliferation are reduced when peripheral blood mononuclear cells (PBMC) from individuals chronically exposed to arsenic are stimulated ex vivo with lectins such as phytohemaglutinin (PHA). However, it is not clear whether the metalloid directly acts on T cells or blocks monocyte-dependent accessory signals activated by PHA. We report that in vitro pre-treatment of PBMC with sodium arsenite (NaAs) reduces IL2 secretion and T cell proliferation induced by PHA, but does not prevent expression of monocyte-derived cytokines (IL1, IL6, TNFα) functioning as lymphocyte-activating factors...
March 2011: Molecular Immunology
https://read.qxmd.com/read/21272866/distinct-expression-of-the-soluble-and-the-membrane-bound-forms-of-interleukin-1-receptor-accessory-protein-in-the-endometrium-of-women-with%C3%A2-endometriosis
#20
COMPARATIVE STUDY
Sophie Guay, Nadège Michaud, Nathalie Bourcier, Mathieu Leboeuf, Madeleine Lemyre, Jacques Mailloux, Ali Akoum
OBJECTIVE: To investigate interleukin (IL) 1 receptor accessory protein (IL1RAcP) expression in the eutopic endometrium of women with endometriosis. DESIGN: Retrospective study. SETTING: Human reproduction research laboratory. PATIENT(S): Sixty-six women with endometriosis and 60 healthy women with no laparoscopic evidence of endometriosis. INTERVENTION(S): Endometrial tissue samples were obtained during laparoscopic surgery...
March 15, 2011: Fertility and Sterility
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