Peiqiang Yuan, Rongman Ma, Liang Hu, Ran Li, Peng Wang, Sen Lin, Jiancai Huang, Hongmei Wen, Lingjie Huang, Hua Li, Bin Feng, Hong Chen, Yuntao Liu, Xiaoling Zhang, Yan Lin, Shengyu Xu, Jian Li, Yong Zhuo, Lun Hua, Lianqiang Che, De Wu, Zhengfeng Fang
Zearalenone (ZEN) is a mycotoxin that is harmful to humans and animals. In this study, female and male rats were exposed to ZEN, and the results showed that ZEN reduced the farnesoid X receptor (FXR) expression levels in the liver and disrupted the enterohepatic circulation of bile acids (BAs). A decrease in food intake induced by ZEN was negatively correlated with an increase in the level of total BAs. BA-targeted metabolomics revealed that ZEN increased glycochenodeoxycholic acid levels and decreased the ratio of conjugated BAs to unconjugated BAs, which further increased the hypothalamic FXR expression levels...
April 1, 2024: Journal of Agricultural and Food Chemistry