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Limb ischemic preconditioning

Wangde Dai, Jianru Shi, Juan Carreno, Sharon L Hale, Robert A Kloner
PURPOSE: We investigated whether bilateral, lower limb remote ischemic preconditioning (RIPC) improved long-term survival using a rat model of hemorrhagic shock/resuscitation. METHODS: Rats were anesthetized, intubated and ventilated, and randomly assigned to RIPC, induced by inflating bilateral pressure cuffs around the femoral arteries to 200 mmHg for 5 min, followed by 5-min release of the cuffs (repeated for 4 cycles), or control group (cuffs were inflated to 30 mmHg)...
February 12, 2019: Cardiovascular Drugs and Therapy
Luke C McIlvenna, David J Muggeridge, Laura J Forrest Nee Whyte, Chris Monaghan, Luke Liddle, Mia C Burleigh, Nicholas Sculthorpe, Bernadette O Fernandez, Martin Feelisch, Chris Easton
OBJECTIVES: Dietary nitrate (NO3 - ) supplementation and ischaemic preconditioning (IPC) can independently improve exercise performance. The purpose of this study was to explore whether NO3 - supplementation, ingested prior to an IPC protocol, could synergistically enhance parameters of exercise. DESIGN: Double-blind randomized crossover trial. METHODS: Ten competitive male cyclists (age 34±6years, body mass 78.9±4.9kg, V⋅O2peak 55±4 mLkgmin-1 ) completed an incremental exercise test followed by three cycling trials comprising a square-wave submaximal component and a 16...
January 26, 2019: Journal of Science and Medicine in Sport
Zhaoyang Hu, Jin Liu, Leng Zhou, Xin Tian, Geoffrey W Abbott
Sudden cardiac death (SCD) is the leading global cause of mortality. SCD often arises from cardiac ischemia reperfusion (IR) injury, pathologic sequence variants within ion channel genes, or a combination of the two. Alternative approaches are needed to prevent or ameliorate ventricular arrhythmias linked to SCD. Here, we investigated the efficacy of remote ischemic preconditioning (RIPC) of the limb versus the liver in reducing ventricular arrhythmias in a mouse model of SCD. Mice lacking the Kcne2 gene, which encodes a potassium channel β subunit associated with acquired Long QT syndrome were exposed to IR injury via coronary ligation...
February 2019: Physiological Reports
Youn Joung Cho, Karam Nam, Tae Kyong Kim, Seong Woo Choi, Sung Joon Kim, Derek J Hausenloy, Yunseok Jeon
The effects of remote ischemic preconditioning (RIPC) in cardiac surgery have been inconsistent. We investigated whether anesthesia or beta-blockers interfere with RIPC cardioprotection. Fifty patients undergoing cardiac surgery were randomized to receive limb RIPC (four cycles of 5-min of upper arm cuff inflation/deflation) in the awake state (no-anesthesia; n = 17), or under sevoflurane ( n = 17) or propofol ( n = 16) anesthesia. In a separate crossover study, 11 healthy volunteers received either carvedilol or no medication prior to RIPC...
January 11, 2019: International Journal of Molecular Sciences
Yun-Hee Kim, Young-Sung Kim, Byung-Hwa Kim, Kuen-Su Lee, Hyung-Sun Park, Choon-Hak Lim
OBJECTIVE: Acute lung injury is responsible for mortality in seriously ill patients. Previous studies have shown that systemic inflammation is attenuated by remote ischemic preconditioning (RIPC) via reducing nuclear factor-kappa B (NF-κB). Therefore, we investigated whether lipopolysaccharide (LPS)-induced indirect acute lung injury (ALI) can be protected by RIPC. METHODS: RIPC was accomplished by 10 minutes of occlusion using a tourniquet on the right hind limb of mice, followed by 10 minutes of reperfusion...
January 7, 2019: Journal of International Medical Research
Chia-Fang Chen, Han-Tsung Liao
AIM: To evaluate the angiogenic effect of platelet-rich plasma (PRP)-preconditioned adipose-derived stem cells (ADSCs) both in vitro and in a mouse ischemic hindlimb model. METHODS: ADSCs were divided based on culture medium: 2.5% PRP, 5% PRP, 7.5% PRP, and 10% PRP. Cell proliferation rate was analyzed using the MTS assay. The gene expression of CD31, vascular endothelial growth factor, hypoxia-inducible factors, and endothelial cell nitric oxide synthase was analyzed using reverse transcription polymerase chain reaction...
December 26, 2018: World Journal of Stem Cells
Sebastian Bunte, Friederike Behmenburg, Franziska Eckelskemper, Felix Mohr, Martin Stroethoff, Annika Raupach, André Heinen, Markus W Hollmann, Ragnar Huhn
OBJECTIVES: Remote ischemic preconditioning (RIPC) is a practicable and noninvasive method to protect the heart against ischemia reperfusion injury. Unfortunately results from clinical studies are not convincing. Propofol is suggested to be an inhibiting factor of cardioprotection by RIPC, but the underlying mechanism is still unknown. We investigated whether after RIPC the release of humoral factors and/or the direct cardioprotective effect at the myocardium is inhibited by propofol...
January 2, 2019: Critical Care Medicine
Kentaro Ejiri, Toru Miyoshi, Kunihisa Kohno, Makoto Nakahama, Masayuki Doi, Mitsuru Munemasa, Masaaki Murakami, Atsushi Takaishi, Kazufumi Nakamura, Hiroshi Ito
Background: Remote ischemic preconditioning (RIPC) is promising for preventing periprocedural myocardial damage (pMD) in patients undergoing percutaneous coronary intervention (PCI). However, the impact of RIPC on pMD on smokers is not well elucidated. The aim of this study was to investigate an association between tobacco smoking and RIPC on pMD in patients planning to undergo PCI. Methods: This study used data from a multicenter randomized controlled trial involving patients with stable angina who planned to undergo elective PCI...
March 2019: IJC Heart & Vasculature
Gabor Varga, Souleiman Ghanem, Balazs Szabo, Kitti Nagy, Noemi Pal, Bence Tanczos, Viktoria Somogyi, Barbara Barath, Adam Deak, Katalin Peto, Norbert Nemeth
BACKGROUND: Pathomechanism and optimal renoprotective protocol for remote ischemic preconditioning (RIPC) have not been completely revealed yet. OBJECTIVE: To investigate micro-rheological effects of early and delayed RIPC in renal ischemia-reperfusion (I/R) in the rat. METHODS: In Control group the left femoral artery was cannulated and the left kidney was gently exposed. In the I/R group 45-minute renal ischemia with 120-minute reperfusion period was monitored...
December 17, 2018: Clinical Hemorheology and Microcirculation
Qiang Yuan, Hui-Xian Jia, Shu-Qin Li, Xiao-Zhang, Yong-Juan Wu, Lin Feng, Xiao-Li Liu, Xiao-Cai Sun, Wen-Bin Li
Our previous studies have demonstrated that limb ischemic preconditioning (LIP) induced brain ischemic tolerance and up-regulated the expression of p38 MAPK and ERK in the hippocampal CA1 region in rats. The present study was undertaken to investigate the role of adenosine in brain protection and up-regulation of p38 MAPK and ERK induced by LIP. It was found that adenosine A1 receptor antagonist DPCPX dose-dependently inhibited the protective effect of LIP. The up-regulation of p38 MAPK and ERK induced by LIP could be blocked by DPCPX...
November 13, 2018: Brain Research
Fernando A Fierro, Nataly Magner, Julie Beegle, Heather Dahlenburg, Jeannine Logan White, Ping Zhou, Karen Pepper, Brian Fury, Dane Philip Coleal-Bergum, Gerhard Bauer, William Gruenloh, Geralyn Annett, Christy Pifer, Jan A Nolta
Mesenchymal stem/stromal cells (MSCs) may be able to improve ischemic conditions as they can actively seek out areas of low oxygen and secrete proangiogenic factors. In more severe trauma and chronic cases, however, cells alone may not be enough. Therefore, we have combined the stem cell and angiogenic factor approaches to make a more potent therapy. We developed an engineered stem cell therapy product designed to treat critical limb ischemia that could also be used in trauma-induced scarring and fibrosis where additional collateral blood flow is needed following damage to and blockage of the primary vessels...
November 1, 2018: Transfusion
Petra Kleinbongard, Nilguen Gedik, Mücella Kirca, Leanda Stoian, Ulrich Frey, Afsaneh Zandi, Matthias Thielmann, Heinz Jakob, Jürgen Peters, Markus Kamler, Gerd Heusch
Background Remote ischemic preconditioning ( RIPC ) by repeated brief cycles of limb ischemia/reperfusion attenuates myocardial ischemia/reperfusion injury. We aimed to identify a functional parameter reflecting the RIPC -induced protection in human. Therefore, we measured mitochondrial function in right atrial tissue and contractile function of isolated right atrial trabeculae before and during hypoxia/reoxygenation from patients undergoing coronary artery bypass grafting with RIPC or placebo, respectively...
August 7, 2018: Journal of the American Heart Association
Astrid Bergmann, Christian Breitling, Göran Hedenstierna, Anders Larsson, Moritz Kretzschmar, Alf Kozian, Thomas Hachenberg, Thomas Schilling
This article contains data on experimental endpoints of a randomized controlled animal trial. Fourteen healthy piglets underwent mechanical ventilation including injurious one-lung ventilation (OLV), seven of them experienced four cycles of remote ischemic preconditioning (RIP) on one hind limb immediately before OLV, seven of them did not receive RIP and served as controls, in a randomized manner. The two major endpoints were (1) pulmonary damage assessed with the diffuse alveolar damage (DAD) score and (2) the inflammatory response assessed by cytokine concentrations in serum and in bronchoalveolar lavage fluids (BAL)...
December 2018: Data in Brief
M Reinthaler, F Jung, K Empen
BACKGROUND: Remote ischemic preconditioning (RIPC) has been demonstrated to induce potent cardioprotection in individuals experiencing coronary ischemia. A protocol combining limb ischemia and electronic muscle stimulation of the ischemic skeletal muscle (RIPC+), performed in advance of coronary artery occlusion, was superior in terms of infarct size reduction when compared to RIPC alone. METHODS: This study was performed to evaluate the benefit of RIPC + in humans compared to a standard RIPC protocol and a control group...
October 9, 2018: Clinical Hemorheology and Microcirculation
Khalid Mt Ahmed, Shannon Hernon, Sara Mohamed, Muhammed Tubassum, Michael Newell, Stewart R Walsh
OBJECTIVE: To evaluate Remote ischaemic preconditioning in management of intermittent claudication patients BACKGROUND: Animal data suggest that remote ischaemic conditioning (RIC) can improve blood flow in ischaemic limbs and, consequently, may benefit claudication patients Supervised exercise is the preferred first-line intervention for patients with intermittent claudication (IC) but is constrained by limited availability and logistical issues, particularly in rural settings METHODS: We undertook a randomised clinical trial to evaluate RIC's effect in claudication patients...
September 29, 2018: Annals of Vascular Surgery
Min Hur, Sun-Kyung Park, Jungho Shin, Jung-Yoon Choi, Seokha Yoo, Won Ho Kim, Jin-Tae Kim
BACKGROUND: Acute kidney injury (AKI) may develop during partial nephrectomy due to ischemic reperfusion injury induced by renal artery clamping or surgical insult. The effect of remote ischemic preconditioning (RIPC) on reducing the renal injury after partial nephrectomy has not been evaluated in terms of urinary biomarkers. METHODS/DESIGN: We will conduct a randomized controlled trial enrolling the patients who will undergo partial nephrectomy. In the study group, RIPC which consisted of four 5-min cycles of limb ischemia and reperfusion will be conducted after induction of anesthesia...
September 4, 2018: Trials
Astrid Bergmann, Thomas Schilling, Göran Hedenstierna, Kerstin Ahlgren, Anders Larsson, Moritz Kretzschmar, Alf Kozian, Thomas Hachenberg
BACKGROUND: One-lung ventilation (OLV) may result in lung injury due to increased mechanical stress and tidal recruitment. As a result, a pulmonary inflammatory response is induced. The present randomized, controlled, animal experiment was undertaken to assess the effects of remote ischemic preconditioning (RIP) on diffuse alveolar damage and immune response after OLV. METHODS: Fourteen piglets (26 ± 2 kg) were randomized to control (n = 7) and RIP group (n = 7)...
August 31, 2018: Respiratory Physiology & Neurobiology
Philippe Richard, François Billaut
Elite athletes in varied sports typically combine ergogenic strategies in the hope of enhancing physiological responses and competitive performance, but the scientific evidence for such practices is very scarce. The peculiar characteristics of speed skating contribute to impede blood flow and exacerbate deoxygenation in the lower limbs (especially the right leg). We investigated whether combining preconditioning strategies could modify muscular oxygenation and improve performance in that sport. Using a randomized, single-blind, placebo-controlled, crossover design, seven male elite long-track speed skaters performed on-ice 600-m time trials, preceded by either a combination of preconditioning strategies (COMBO) or a placebo condition (SHAM)...
2018: Frontiers in Physiology
Yuansheng Xu, Qinkai Yu, Jianmin Yang, Fang Yuan, Yigang Zhong, Zhanlin Zhou, Ningfu Wang
Background: The aim of this study was to assess the acute hemodynamic effects of remote ischemic preconditioning (RIPC) on coronary perfusion pressure and coronary collateral blood flow. Methods: A total of 17 patients with coronary heart disease with severe (70%-85%) stenosis in one or two vessels confirmed by angiography were enrolled into this study. They were randomly divided into the RIPC group (9 patients) and the control group (8 patients). Distal pressure of coronary artery stenosis before balloon dilation (non-occlusive pressure, Pn-occl ) and distal coronary artery occlusive pressure (Poccl ) during balloon dilation occlusion were measured in all patients...
July 2018: Acta Cardiologica Sinica
Yong-Le Xu, Min-Hong Zhang, Wei Guo, Yan Xue, Xin Du, Tao Zhang, Na Wu, Ye Wu
Ischemia-reperfusion injury (IRI) is a severe problem patients diagnosed with acute limb ischemia. Recently, microRNAs (miR) have emerged as regulators of IRI as well as ischemic preconditioning and ischemic postconditioning. Therefore, using rat models, this study aims to explore all of the possible mechanisms that miR-19 exhibits with its relation to the transforming growth factor beta (TGF-β1)/Smad signaling pathway in the lower limb IRI. An immunofluorescence staining method was used to identify the Krueppel-like factor 10 (KLF10) positive expression and the location of KLF10 expression...
November 2018: Journal of Cellular Biochemistry
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