keyword
https://read.qxmd.com/read/38506378/association-of-the-esr1-rs9340799-olr1-rs3736234-lipc-rs2070895-vdr-rs2228570-and-cetp-rs708272-polymorphisms-with-risk-of-coronary-artery-disease-in-iranian-patients
#1
JOURNAL ARTICLE
Zahra Miri Karam, Abolfazl Yari, Atefeh Najmadini, Nima Norouzi Khorasani, Rezvan Attari, Saeideh Jafarinejad-Farsangi, Mohammad Ali Miri Karam, Hamid Najafipour, Kolsoum Saeidi
BACKGROUND: Coronary artery disease (CAD) is a devastating illness and a leading cause of death worldwide, primarily caused by atherosclerosis resulting from a genetic-environmental interaction. This study aimed to investigate the relationship between the ESR1 (rs9340799), OLR1 (rs3736234), LIPC (rs2070895), VDR (rs2228570), and CETP (rs708272) polymorphisms, lipid profile parameters, and CAD risk in a southeast Iranian population. METHODS: A total of 400 subjects (200 CAD patients with hyperlipidemia and 200 healthy controls) were enrolled in this case-control study...
March 20, 2024: Journal of Clinical Laboratory Analysis
https://read.qxmd.com/read/38485220/effects-of-prednisolone-on-1-2-o-dilauryl-rac-glycero-glutaric-acid-60-methylresorufin-ester-lipase-activity-and-pancreatic-lipase-immunoreactivity-in-healthy-cats
#2
JOURNAL ARTICLE
Militsa Pacheva, Daniel Brugger, Barbara Riond, Matthias Dennler, Peter Hendrik Kook
BACKGROUND: Corticosteroids are among the most commonly used drugs in cats and are increasingly discussed as a treatment for feline pancreatitis. However, its effects on serum lipase in healthy cats remain unknown. OBJECTIVES: To evaluate the effects of prednisolone on serum lipase activity and pancreatic lipase immunoreactivity (PLI) in cats. ANIMALS: Seven clinically healthy colony cats, aged 4 to 7 years, with unremarkable CBC/biochemistry panel were studied...
March 14, 2024: Journal of Veterinary Internal Medicine
https://read.qxmd.com/read/38336686/rare-and-common-coding-variants-in-lipid-metabolism-related-genes-and-their-association-with-coronary-artery-disease
#3
JOURNAL ARTICLE
Wei Li, Yongyi Wang, Ritai Huang, Feng Lian, Genxing Xu, Weijun Wang, Song Xue
BACKGROUND: Coronary artery disease (CAD) is a complex disease that is influenced by environmental and genetic factors. In this study, we aimed to investigate the relationship between coding variants in lipid metabolism-related genes and CAD in a Chinese Han population. METHODS: A total of 252 individuals were recruited for this study, including 120 CAD patients and 132 healthy control individuals. Rare and common coding variants in 12 lipid metabolism-related genes (ANGPTL3, ANGPTL4, APOA1, APOA5, APOC1, APOC3, CETP, LDLR, LIPC, LPL, PCSK9 and SCARB1) were detected via next-generation sequencing (NGS)-based targeted sequencing...
February 9, 2024: BMC Cardiovascular Disorders
https://read.qxmd.com/read/38218552/sensitive-simultaneous-measurements-of-oxygenation-and-extracellular-ph-by-epr-using-a-stable-monophosphonated-trityl-radical-and-lithium-phthalocyanine
#4
JOURNAL ARTICLE
Chloe Buyse, Lionel Mignion, Nicolas Joudiou, Samia Melloul, Benoit Driesschaert, Bernard Gallez
The monitoring of acidosis and hypoxia is crucial because both factors promote cancer progression and impact the efficacy of anti-cancer treatments. A phosphonated tetrathiatriarylmethyl (pTAM) has been previously described to monitor both parameters simultaneously, but the sensitivity to tackle subtle changes in oxygenation was limited. Here, we describe an innovative approach combining the pTAM radical and lithium phthalocyanine (LiPc) crystals to provide sensitive simultaneous measurements of extracellular pH (pHe ) and pO2 ...
January 11, 2024: Free Radical Biology & Medicine
https://read.qxmd.com/read/38195542/the-translational-potential-of-mir-26-in-atherosclerosis-and-development-of-agents-for-its-target-genes-acc1-2-col1a1-cpt1a-fbp1-dgat2-and-smad7
#5
REVIEW
Wujun Chen, Xiaolin Wu, Jianxia Hu, Xiaolei Liu, Zhu Guo, Jianfeng Wu, Yingchun Shao, Minglu Hao, Shuangshuang Zhang, Weichao Hu, Yanhong Wang, Miao Zhang, Meng Zhu, Chao Wang, Yudong Wu, Jie Wang, Dongming Xing
Atherosclerosis is one of the leading causes of death worldwide. miR-26 is a potential biomarker of atherosclerosis. Standardized diagnostic tests for miR-26 (MIR26-DX) have been developed, but the fastest progress has been in predicting the efficacy of IFN-α therapy for hepatocellular carcinoma (HCC, phase 3). MiR-26 slows atherosclerosis development by suppressing ACC1/2, ACLY, ACSL3/4, ALDH3A2, ALPL, BMP2, CD36, COL1A1, CPT1A, CTGF, DGAT2, EHHADH, FAS, FBP1, GATA4, GSK3β, G6PC, Gys2, HMGA1, HMGB1, LDLR, LIPC, IL-1β, IL-6, JAG2, KCNJ2, MALT1, β-MHC, NF-κB, PCK1, PLCβ1, PYGL, RUNX2, SCD1, SMAD1/4/5/7, SREBF1, TAB3, TAK1, TCF7L2, and TNF-α expression...
January 9, 2024: Cardiovascular Diabetology
https://read.qxmd.com/read/38192945/increased-expression-of-lipc-is-associated-with-the-clinicopathological-features-and-development-of-head-and-neck-squamous-cell-carcinoma
#6
JOURNAL ARTICLE
Sahith Putluru, Chandra Pandi, Balachander Kannan, Vijayashree J Priyadharsini, Paramasivam Arumugam
Introduction Lipase C hepatic type (LIPC) is a member of the lipase family and plays a role in tumor development. However, its specific role in head and neck squamous cell carcinoma (HNSCC) is not well understood. Objective This study aims to investigate LIPC gene expression in HNSCC and elucidate its potential role in the context of the disease. Methods LIPC expression was analyzed using the Cancer Genome Atlas-HNSCC (TCGA-HNSCC) dataset. Real-time polymerase chain reaction (qPCR) was used to validate LIPC expression in oral squamous cell carcinoma (OSCC) tissue samples, which is the most common type of HNSCC...
December 2023: Curēus
https://read.qxmd.com/read/38115108/identifying-the-natural-products-in-the-treatment-of-atherosclerosis-by-increasing-hdl-c-level-based-on-bioinformatics-analysis-molecular-docking-and-in-vitro-experiment
#7
JOURNAL ARTICLE
Yilin Chen, Fengwei Zhang, Jijia Sun, Lei Zhang
BACKGROUND: Previous studies have demonstrated that high-density lipoprotein cholesterol (HDL-C) plays an anti-atherosclerosis role through reverse cholesterol transport. Several studies have validated the efficacy and safety of natural products in treating atherosclerosis (AS). However, the study of raising HDL-C levels through natural products to treat AS still needs to be explored. METHODS: The gene sets associated with AS were collected and identified by differential gene analysis and database query...
December 19, 2023: Journal of Translational Medicine
https://read.qxmd.com/read/38069394/a-novel-lipase-from-streptomyces-exfoliatus-dsmz-41693-for-biotechnological-applications
#8
JOURNAL ARTICLE
Guillermo Rodríguez-Alonso, Juan Toledo-Marcos, Lara Serrano-Aguirre, Carlos Rumayor, Beatriz Pasero, Aida Flores, Ana Saborido, Pilar Hoyos, María J Hernáiz, Isabel de la Mata, Miguel Arroyo
Genome mining of Streptomyces exfoliatus DSMZ 41693 has allowed us to identify four different lipase-encoding sequences, and one of them ( Se LipC) has been successfully cloned and extracellularly expressed using Rhodococcus sp. T104 as a host. Se LipC was purified by one-step hydrophobic interaction chromatography. The enzyme is a monomeric protein of 27.6 kDa, which belongs to subfamily I.7 of lipolytic enzymes according to its phylogenetic analysis and biochemical characterization. The purified enzyme shows the highest activity at 60 °C and an optimum pH of 8...
December 2, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/38047534/improvement-of-restless-leg-syndrome-in-maintenance-hemodialysis-patients-with-limb-ischemic-preconditioning-a-single-center-randomized-controlled-clinical-trial
#9
RANDOMIZED CONTROLLED TRIAL
Juntian Xu, Yuan Qi, Yushang Tang, Wanfen Zhang, Qiaoyang Zhang, Linfang Xu, Zhongqin Ding, Tongqiang Liu
OBJECTIVE: This study evaluated the efficacy and safety of limb ischemic preconditioning (LIPC) in treating restless leg syndrome (RLS) in maintenance hemodialysis (MHD) patients. METHODS: A total number of 45 patients participated in the study. They were randomly divided into LIPC group and control group. The LIPC was performed by inflating the limb ischemic preconditioning training device in the patient's thigh to 200 mmHg to create transient ischemia, whereas control group inflated the device to 20 mmHg...
2023: Renal Failure
https://read.qxmd.com/read/38025159/relationship-between-retinal-layer-thickness-and-genetic-susceptibility-to-age-related-macular-degeneration-in-asian-populations
#10
JOURNAL ARTICLE
Kai Xiong Cheong, Hengtong Li, Yih Chung Tham, Kelvin Yi Chong Teo, Anna Cheng Sim Tan, Leopold Schmetterer, Tien Yin Wong, Chui Ming Gemmy Cheung, Ching-Yu Cheng, Qiao Fan
PURPOSE: For OCT retinal thickness measurements to be used as a prodromal age-related macular degeneration (AMD) risk marker, the 3-dimensional (3D) topographic variation of the relationship between genetic susceptibility to AMD and retinal thickness needs to be assessed. We aimed to evaluate individual retinal layer thickness changes and topography at the macula that are associated with AMD genetic susceptibility. DESIGN: Genetic association study. PARTICIPANTS: A total of 1579 healthy participants (782 Chinese, 353 Malays, and 444 Indians) from the multiethnic Singapore Epidemiology of Eye Diseases study were included...
December 2023: Ophthalmol Sci
https://read.qxmd.com/read/37980758/genome-wide-association-study-for-body-weight-and-feed-consumption-traits-in-japanese-quail-using-bayesian-approaches
#11
JOURNAL ARTICLE
Hassan Alboali, Mohammad Hossein Moradi, Amir Hossein Khaltabadi Farahani, Hossein Mohammadi
The aim of this study was to perform a genome-wide association study (GWAS) based on Bayes A and Bayes B statistical methods to identify genomic loci and candidate genes associated with body weight gain, feed intake, and feed conversion ratio in Japanese quail. For this purpose, genomic data obtained from Illumina iSelect 4K quail SNP chip were utilized. After implementing various quality control steps, genotype data from a total of 875 birds for 2,015 SNP markers were used for subsequent analyses. The Bayesian analyses were performed using hibayes package in R (version 4...
October 17, 2023: Poultry Science
https://read.qxmd.com/read/37625559/olive-oil-increases-the-lipc-expression-when-associated-with-an-eastern-pattern-diet-an-experimental-study-with-wistar-rats
#12
JOURNAL ARTICLE
Priscila Bitencourt Brito, Mayza Dalcin Teixeira, Ricardo Lehtonen Rodrigues de Souza, Lupe Furtado-Alle, Luciane Viater Tureck
Some nutrigenomic effects of extra virgin olive oil (EVOO) are described in the literature; however, it is unknown whether its interaction with lipid-related genes is independent of the combined diet. In this sense, our objective was to investigate whether EVOO consumption associated with Western or Eastern human-based chow modulates the expression of APOE, APOB, and LIPC genes in rats. In view of this, the hypothesis is that the consumption of olive oil may not have the same nutrigenomic effects, depending on the diet consumed...
August 23, 2023: Gene
https://read.qxmd.com/read/37546620/synthesis-and-characterization-of-octacyano-fe-phthalocyanine
#13
JOURNAL ARTICLE
Momoka Isobe, Shota Nakayama, Shunsuke Takagi, Kakeru Araki, Kaname Kanai
Octacyano-metal-phthalocyanine MPc(CN)8 is a promising n-type stable organic semiconductor material with eight cyano groups, including a strong electron-withdrawing group at its molecular terminals. However, a thorough investigation of MPc(CN)8 has not yet been conducted. Therefore, we synthesized FePc(CN)8 and investigated its crystal structure, chemical and electronic states, electrical properties, photocatalytic activity, and magnetic properties. In this paper, we discuss the various properties of MPc(CN)8 in comparison with those of FePc...
August 1, 2023: ACS Omega
https://read.qxmd.com/read/37497943/application-value-of-limb-ischemic-preconditioning-in-preventing-intradialytic-hypotension-during-maintenance-hemodialysis
#14
JOURNAL ARTICLE
Yaqin Mao, Linfang Xu, Juntian Xu, Yushang Tang, Tongqiang Liu
OBJECTIVE: To investigate the efficacy and safety of limb ischemia preconditioning (LIPC) in the treatment of intradialytic hypotension (IDH) in patients with maintenance hemodialysis (MHD). METHODS: This was a single-center, prospective and randomized controlled case study. A total of 38 patients with MHD who met the inclusion criteria from September 2021 to August 2022 were selected from the Blood Purification Center of our hospital. They were randomly divided into the LIPC group (n = 19) and the control group (n = 19)...
July 27, 2023: Kidney & Blood Pressure Research
https://read.qxmd.com/read/37461045/ancestry-driven-metabolite-variation-provides-insights-into-disease-states-in-admixed-populations
#15
JOURNAL ARTICLE
Kaylia M Reynolds, Andrea R V R Horimoto, Bridget M Lin, Ying Zhang, Nuzulul Kurniansyah, Bing Yu, Eric Boerwinkle, Qibin Qi, Robert Kaplan, Martha Daviglus, Lifang Hou, Laura Y Zhou, Jianwen Cai, Saame Raza Shaikh, Tamar Sofer, Sharon R Browning, Nora Franceschini
BACKGROUND: Metabolic pathways are related to physiological functions and disease states and are influenced by genetic variation and environmental factors. Hispanics/Latino individuals have ancestry-derived genomic regions (local ancestry) from their recent admixture that have been less characterized for associations with metabolite abundance and disease risk. METHODS: We performed admixture mapping of 640 circulating metabolites in 3887 Hispanic/Latino individuals from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)...
July 17, 2023: Genome Medicine
https://read.qxmd.com/read/37460425/-identification-and-3d-architecture-analysis-of-the-lipc-gene-mutation-in-a-pedigree-with-familial-hypercholesterolemia-like-phenotype
#16
JOURNAL ARTICLE
H Zhang, F Y Li, Y Hao, X M Wang, J Zhang, Y L Ma, H Zeng, J Lin
Objective: To identify and analyze 3D architecture of the mutational sites of susceptible genes in a pedigree with familial hypercholesterolemia-like phenotype (FHLP). Methods: This is a case series study. A pedigree with suspected familial hypercholesterolemia was surveyed. The proband admitted in Beijing Anzhen Hospital in April 2019. Whole-exome sequencing was performed to determine the mutational sites of susceptible genes in the proband. Polymerase chain reaction (PCR) sequencing was used to verify the pathogenic variant on proband's relatives...
July 24, 2023: Zhonghua Xin Xue Guan Bing za Zhi
https://read.qxmd.com/read/37372394/genetic-determinants-of-atherogenic-indexes
#17
JOURNAL ARTICLE
Tomas Texis, Susana Rivera-Mancía, Eloisa Colín-Ramírez, Raul Cartas-Rosado, David Koepsell, Kenneth Rubio-Carrasco, Mauricio Rodríguez-Dorantes, Vanessa Gonzalez-Covarrubias
Atherogenesis and dyslipidemia increase the risk of cardiovascular disease, which is the leading cause of death in developed countries. While blood lipid levels have been studied as disease predictors, their accuracy in predicting cardiovascular risk is limited due to their high interindividual and interpopulation variability. The lipid ratios, atherogenic index of plasma (AIP = log TG/HDL-C) and the Castelli risk index 2 (CI2 = LDL-C/HDL-C), have been proposed as better predictors of cardiovascular risk, but the genetic variability associated with these ratios has not been investigated...
June 1, 2023: Genes
https://read.qxmd.com/read/37273686/association-of-lipc-polymorphisms-with-stroke-risk-in-the-chinese-population
#18
JOURNAL ARTICLE
Jiaxing Pan, Qingqing Zhuo, Xu Chen, Xuehong Huang, Shiqiang Shen, Qiu Yang, Jiawen Luo, Suiyan Wang, Tianbo Jin
BACKGROUND: Stroke is a common cerebrovascular disease. The purpose of this study was to explore the association between LIPC single nucleotide polymorphisms (SNPs) and the risk of stroke in the Chinese population. METHODS: This study recruited 710 stroke patients and 701 healthy controls. The four SNPs (rs690, rs6083, rs3829461, and rs6074) in LIPC were genotyped by the Agena MassARRAY. The correlation between LIPC polymorphisms and stroke risk was measured by odds ratio (OR) and 95% confidence interval (CI)...
2023: Frontiers in Neurology
https://read.qxmd.com/read/37186438/lipid-related-genetic-variants-for-personalized-dietary-interventions-a-systematic-review
#19
REVIEW
Rivera-Íñiguez Ingrid, González-Becerra Karina, Ramos-Lopez Omar, Peréz-Beltrán Yolanda E, Chagüén-Hernández Marian S, Martínez-López Erika, Mendivil Edgar J
SCOPE: Dyslipidemias are known risk factors for chronic diseases. Precision nutrition interventions are designed according to characteristics, such as diet, phenotype, and genotype. This systematic review aimed to define a panel of genetic variants associated with lipid abnormalities that could be later used in nutrigenetic intervention studies. METHODS AND RESULTS: A systematic review was conducted following the PRISMA-P. Studies published from January 2010 to December 2020 in English language and humans were included from PubMed and ScienceDirect databases...
April 27, 2023: Molecular Nutrition & Food Research
https://read.qxmd.com/read/36876364/apoc3-and-abca1-variants-in-unusual-combined-hypolipidaemia-showing-premature-peripheral-vascular-disease
#20
JOURNAL ARTICLE
Zuzana Pos, Milad Khedr, Jan Radvanszky, Adela Penesova, Rastislav Hekel, Tomas Szemes, Lakshminarayan Rao Ranganath, Andrea Zatkova
BACKGROUND: Familial combined hypolipidaemia is a condition characterised by very low concentrations of circulating very-low-density lipoprotein (VLDL), low-density lipoprotein cholesterol (LDL), and high-density lipoprotein cholesterol (HDL). It is thought that low LDL/combined hypolipidaemia can protect from cardiovascular disease (CVD), but this is not what we found in a case we present. OBJECTIVE: We report on a 57-years-old male patient with combined hypolipidaemia who presented with premature peripheral vascular disease...
February 28, 2023: Bratislavské Lekárske Listy
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