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Glaucylara Reis Geovanini, Geraldo Lorenzi-Filho, Lilian K de Paula, Camila Maciel Oliveira, Rafael de Oliveira Alvim, Felipe Beijamini, André Brooking Negrão, Malcolm von Schantz, Kristen L Knutson, José Eduardo Krieger, Alexandre Costa Pereira
AIM: To test the association between cardiometabolic risk factors and subjective sleep quality assessed by the Pittsburgh sleep quality index (PSQI), independent of obstructive sleep apnea (OSA) and sleep duration. METHODS: A total of 573 participants from the Baependi Heart Study, a rural cohort from Brazil, completed sleep questionnaires and underwent polygraphy for OSA evaluation. Multivariable linear regression analysis tested the association between cardiovascular risk factors (outcome variables) and sleep quality measured by PSQI, adjusting for OSA and other potential confounders (age, sex, race, salary/wage, education, marital status, alcohol intake, obesity, smoking, hypertension, and sleep duration)...
January 30, 2019: Sleep Medicine
Aditya Saxena, Pradeep Tiwari, Nitin Wahi, Arpana Soni, Ram Chandra Bansiwal, Anshul Kumar, Balram Sharma, Poonam Punjabi, Nidhi Gupta, Babita Malik, Krishna Mohan Medicherla, Prashanth Suravajhala, Sandeep Kumar Mathur
Type 2 Diabetes (T2D) is a complex disease with an elusive link between its molecular etiology and clinical presentation. Although, the role of visceral adipose tissue in the pathogenesis of insulin resistance and T2D is well known, only a limited information is available on the role of peripheral subcutaneous adipose tissue especiallyin Asian Indians. In this microarray based study of diabetic and normal glucose tolerant (NGT) Asian Indians, we generated the transcription profile of their thigh subcutaneous adipose tissue and further analyzed the diffrentially expressed genes (DEGs) using weighted gene co-expression network analysis (WGCNA) approach...
March 20, 2019: Adipocyte
Syed Abbas Raza, Mariam Hassan, Farhana Badar, Farah Rasheed, Fouzia Meerza, Sumeyya Azam, Ali Jawa, Imtiaz Hassan, Faisal Masood Qureshi, Zakir Alvi, Saeed Ahmed Mahar, Azizul Hasan Aamir, Rauf Niazi, Najmul Islam
OBJECTIVE: To explore cardiovascular risk factors in people with newly-diagnosed type 2 diabetes mellitus. METHODS: The cross-sectional, prospective, multicentre, study was conducted from June 2014 till July 2015 at family practice clinics in 27 cities across Pakistan, and comprised individuals aged 30-50 years diagnosed with type 2 diabetes mellitus within the preceding six months. Laboratory investigations were conducted at Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, and Aga Khan University Hospital, Karachi...
March 2019: JPMA. the Journal of the Pakistan Medical Association
Megumi Yano, Akira Matsunaga, Sadako Harada, Bo Zhang, Emi Kawachi, Mikiko Tadera, Keijiro Saku
AIM: The purpose of this study was to compare two homogeneous assays of low-density lipoprotein-cholesterol (LDL-C) with a modified beta quantification reference measurement for LDL-C (BQ-LDL), fractions of chylomicron (CM), very low-density lipoprotein (VLDL) and intermediate-density lipoprotein (IDL) by quantitative ultracentrifugation in patients with hypertriglyceridemia. METHODS: Two homogeneous LDL-C assays (LDL-C(K), Kyowa Medex and LDL-C(S), Sekisui Medical) were used to measure 198 samples of fresh anonymized leftover sera with hypertriglyceridemia (≥ 150 mg/dL)...
March 19, 2019: Journal of Atherosclerosis and Thrombosis
Preeti Pathak, John Y L Chiang
Sterol 12α-hydroxylase (CYP8B1) is required for synthesis of cholic acid in the classic bile acid synthesis pathway and plays a role in dyslipidemia and insulin resistance. However, the mechanism of the involvement of Cyp8b1 in dyslipidemia and insulin resistance is not known. CYP8B1 mRNA and protein expression are elevated in diabetic and obese ( db/db ) mouse liver. In this study adenovirus-mediated transduction of CYP8B1 was used to study the effect of Cyp8b1 on lipid metabolism in mice. Results show that Ad-Cyp8b1 increased 12α-hydroxylated bile acids and induced sterol regulatory element binding protein 1c (Srebp1c)-mediated lipogenic gene expression...
March 19, 2019: Gene Expression
L Renee Ruhaak, Arnoud van der Laarse, Christa M Cobbaert
An elevated low-density lipoprotein cholesterol concentration is a classical risk factor for cardiovascular disease. This has led to pharmacotherapy in patients with atherosclerotic heart disease or high heart disease risk with statins to reduce serum low-density lipoprotein cholesterol. Even in patients in whom the target levels of low-density lipoprotein cholesterol are reached, there remains a significant residual cardiovascular risk; this is due, in part, to a focus on low-density lipoprotein cholesterol alone and neglect of other important aspects of lipoprotein metabolism...
March 19, 2019: Annals of Clinical Biochemistry
Paula Dlugosz, Roland Tresky, Johannes Nimpf
The canonical Reelin signaling cascade regulates correct neuronal layering during embryonic brain development. Details of this pathway are still not fully understood since the participating components are highly variable and create a complex mixture of interacting molecules. Reelin is proteolytically processed resulting in five different fragments some of which carrying the binding site for two different but highly homologous receptors, apolipoprotein E receptor 2 (ApoER2) and very low density lipoprotein receptor (VLDLR)...
2019: Frontiers in Molecular Neuroscience
Jiajun Yang, Minhong Zhang, Ying Zhou
BACKGROUND: Both selenium (Se) and probiotic Bacillus regulate the metabolism to help defense clod stress and improve the meat quality in breeding chicks. The purpose of this study was to evaluate the effect of supplemental Se and Bacillus in the form of Se-enriched Bacillus (SECB) on the growth performance, lipid parameters, breast Se and antibiotic levels, and breast meat quality of chicken in winter cold stress. METHODS: Five hundred 1-d-old chickens were divided into five groups randomly: Control, inorganic Se, compound Bacillus, SECB, and antibiotic...
March 14, 2019: Lipids in Health and Disease
Shujing Ji, Yufan Xu, Dating Han, Xiuming Peng, Xiangyun Lu, Norbert H Brockmeyer, Nanping Wu
We assess long-term changes in lipid levels in human immunodeficiency disease- (HIV-) infected patients undergoing highly active antiretroviral treatment (HAART) and their association with diabetes mellitus (DM) and thyroid dysfunction. We observed changes in the levels of total cholesterol (TC) and total triglyceride (TG) of 63 HIV-infected patients in the 6 years from starting HAART and analyzed correlations between relevant parameters. TC levels of patients with normal baseline TC levels as well as those diagnosed with DM or impaired fasting glucose (IFG) increased significantly ( P   < 0...
2019: BioMed Research International
Yuna Horiuchi, Ryunosuke Ohkawa, Shao-Jui Lai, Shitsuko Shimano, Michio Hagihara, Shuji Tohda, Takahiro Kameda, Minoru Tozuka
Cholesterol efflux capacity (CEC) in atherosclerotic lesions is the main anti-atherosclerotic function of high-density lipoprotein (HDL). In recent studies, apolipoprotein (apo) B-depleted serum (BDS) obtained with the polyethylene glycol precipitation method is used as a cholesterol acceptor (CA) substitution for HDL isolated by ultracentrifugation. However, the suitability of BDS as a CA is controversial. In the present study, CEC obtained from BDS was evaluated based on a parameter, defined as whole-CEC, which was calculated by multiplying CEC obtained using fixed amounts of HDL by cholesterol concentration to HDL-cholesterol (HDL-C) levels in the serum...
March 13, 2019: Bioscience Reports
Duc Du, Raimondo Bruno, Leigh Blizzard, Alison Venn, Terence Dwyer, Kylie J Smith, Costan G Magnussen, Seana Gall
BACKGROUND: Metabolomic analysis may help us to understand the association between alcohol consumption and cardio-metabolic health. We aimed to: (i) replicate a previous study of alcohol consumption and metabolic profiles, (ii) examine associations between types of alcoholic beverages and metabolites and (iii) include potential confounders not examined in previous studies. METHODS: Cross-sectional data of 1785 participants (age 26-36 years, 52% women) from the 2004-2006 Childhood Determinants of Adult Health study were used...
March 11, 2019: European Journal of Preventive Cardiology
Hidekatsu Yanai, Hiroshi Yoshida
Circulating adiponectin concentrations are reduced in obese individuals, and this reduction has been proposed to have a crucial role in the pathogenesis of atherosclerosis and cardiovascular diseases associated with obesity and the metabolic syndrome. We focus on the effects of adiponectin on glucose and lipid metabolism and on the molecular anti-atherosclerotic properties of adiponectin and also discuss the factors that increase the circulating levels of adiponectin. Adiponectin reduces inflammatory cytokines and oxidative stress, which leads to an improvement of insulin resistance...
March 8, 2019: International Journal of Molecular Sciences
Hengzhi Z Zhang, Daiwen W Chen, Jun He, Ping Zheng, Jie Yu, Xiangbing B Mao, Zhiqing Q Huang, Yuheng H Luo, Junqiu Q Luo, Bing Yu
This study was conducted to evaluate the effects of dietary resveratrol supplementation on growth performance, meat quality, serum lipid profiles, intramuscular fat (IMF) deposition, and the expression levels of several lipid metabolism-related miRNAs and genes in growing-finishing pigs. A total of 36 healthy crossbred pigs (Duroc × Landrace × Yorkshire) with an average initial BW of 24.67 ± 3.49 kg were randomly divided into two groups and fed either with a basal diet (CON) or basal diet containing 600 mg/kg resveratrol (RES)...
February 14, 2019: Journal of Animal Science
Monika Czaplińska, Agnieszka Ćwiklińska, Monika Sakowicz-Burkiewicz, Ewa Wieczorek, Agnieszka Kuchta, Robert Kowalski, Barbara Kortas-Stempak, Alicja Dębska-Ślizień, Maciej Jankowski, Ewa Król
BACKGROUND: Chronic kidney disease (CKD) associates with complex lipoprotein disturbances resulting in high cardiovascular risk. Apolipoprotein E (APOE) is a polymorphic protein with three common isoforms (E2; E3; E4) that plays a crucial role in lipoprotein metabolism, including hepatic clearance of chylomicrons and very low-density lipoprotein (VLDL) remnants, and reverse cholesterol transport. It demonstrates anti-atherogenic properties but data concerning the link between polymorphism and level of APOE in CKD patients are inconclusive...
March 9, 2019: Lipids in Health and Disease
Yundai Chen, Zuyi Yuan, Juming Lu, Freddy G Eliaschewitz, Alberto J Lorenzatti, Maria Laura Monsalvo, Nan Wang, Andrew W Hamer, Junbo Ge
AIM: To evaluate the efficacy and safety of evolocumab with background atorvastatin in Chinese patients with type 2 diabetes mellitus (T2DM) and hyperlipidaemia or mixed dyslipidaemia. MATERIALS AND METHODS: This is a pre-specified analysis of patients in the BERSON study (, NCT02662569) in China. Patients were started on background atorvastatin 20 mg/day and then were randomised 2:2:1:1 to evolocumab 140 mg every 2 weeks (Q2W) or 420 monthly (QM) or placebo Q2W or QM...
March 9, 2019: Diabetes, Obesity & Metabolism
Mrinal Samtiya, Mohd Iqbal Bhat, Taruna Gupta, Suman Kapila, Rajeev Kapila
Safety assessment of probiotic Lactobacillus fermentum MTCC-5898 (LF) with three doses (107 , 109 , and 1011  cfu/day/animal) was carried on Swiss albino mouse weanlings for 28 days using oral route. Health status of animals was monitored by physical assessment of body weight, organ indices, and histological appearances of liver and intestine along with measurement of hematological parameters (Hb, WBC, RBC count, MCHC, MCV, MCH), biochemical analytes in blood involving glucose, serum enzymes (ALT, AST and LDH), urea, creatinine, and lipid profile (total cholesterol, triglycerides, HDL, VLDL, LDL, and atherogenic index)...
March 8, 2019: Probiotics and Antimicrobial Proteins
Shobini Jayaraman, Clive Baveghems, Olivia R Chavez, Andrea Rivas-Urbina, Jose Luis Sánchez-Quesada, Olga Gursky
Very low-density lipoprotein (VLDL) is the main plasma carrier of triacylglycerol that is elevated in pathological conditions such as diabetes, metabolic syndrome, obesity and dyslipidemia. How variations in triacylglycerol levels influence structural stability and remodeling of VLDL and its metabolic product, low-density lipoproteins (LDL), is unknown. We applied a biochemical and biophysical approach using lipoprotein remodeling by lipoprotein lipase and cholesterol ester transfer protein, along with thermal denaturation that mimics key aspects of lipoprotein remodeling in vivo...
March 4, 2019: Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids
Stefan Ljunggren, Torbjörn Bengtsson, Helen Karlsson, Carin Johansson Starkhammar, Eleonor Palm, Fariba Nayeri, Bijar Ghafouri, Julia Davies, Gunnel Svensäter, Johanna Lönn
There is a strong association between periodontal disease and atherosclerotic cardiovascular disorders. A key event in the development of atherosclerosis is accumulation of modified lipoproteins within the arterial wall. We hypothesize that patients with periodontitis have an altered lipoprotein profile towards an atherogenic form. Therefore, this study aims at identifying modifications of plasma lipoproteins in periodontitis. Lipoproteins from ten female patients with periodontitis and gender- and age-matched healthy controls were isolated by density-gradient-ultracentrifugation...
March 6, 2019: Bioscience Reports
O O Erejuwa, J L Akpan, N J I Uwaezuoke, N N Nwobodo, B C Ezeokpo, E Erhiano, E J Araromi, U N Ude, M AbdulWahab, S A Sulaiman
Postprandial hyperlipidemia is associated with oxidative stress and is an important risk factor for atherosclerosisand cardiovascular disease. The aims of this study were to investigate the antihyperlipidemic effect of honey administered 5or 60 minutes before a high-fat diet (HFD), to explore the role of 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA)reductase in antihyperlipidemic effect of honey and to investigate the effect of honey on postprandial oxidative stress. Ratswere fasted and randomized into 5 groups...
December 30, 2018: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
Magdalena Franczyk-Żarów, Edyta Kuś, Renata B. Kostogrys
Background: Nutritional recommendations emphasize the need to limit consumption of saturated fatty acids and to increase the intake of polyunsaturated fatty acids in the prevention of non-communicable chronic diseases, particularly cardiovascular diseases. Among the fatty acids with health-related effects on the body, conjugated fatty acids are mentioned (i.e. CLA). Objective: The current study was designed to determine the effects of conjugated linoleic acid (CLA) on serum lipid profile, glucose, liver enzymes activity (AST and ALT), malonic dialdehyde (MDA) as well as lipid hydroperoxide (LPO) concentrations in rats fed diet differing in type of dietary fat...
2019: Roczniki Państwowego Zakładu Higieny
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