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Wai Gin Lee, Cameron I Wells, John L McCall, Rinki Murphy, Lindsay D Plank
An association between diabetes mellitus (DM) and liver cirrhosis is well known but estimates of the prevalence of DM in patients with liver cirrhosis vary widely. A systematic review was undertaken to determine the prevalence of DM in adult patients with liver cirrhosis. The Medline, EMBASE and Cochrane Library databases were searched for peer-reviewed studies published in English (1979-2017) that investigated the prevalence of diabetes in adult patients with cirrhosis. Pooled estimates of prevalence of DM were determined for all eligible patients and according to etiology and severity of liver disease...
March 22, 2019: Diabetes/metabolism Research and Reviews
Tony Rosen, Alyssa Elman, Sarah Dion, Diana Delgado, Michelle Demetres, Risa Breckman, Kristin Lees, Kim Dash, Debi Lang, Alice Bonner, Jason Burnett, Carmel B Dyer, Rani Snyder, Amy Berman, Terry Fulmer, Mark S Lachs
BACKGROUND: Elder mistreatment is common and has serious social and medical consequences for victims. Though programs to combat this mistreatment have been developed and implemented for more than three decades, previous systematic literature reviews have found few successful ones. OBJECTIVE: To conduct a more comprehensive examination of programs to improve elder mistreatment identification, intervention, or prevention, including those that had not undergone evaluation...
March 22, 2019: Journal of the American Geriatrics Society
Ismaeel Yunusa, Adnan Alsumali, Asabe E Garba, Quentin R Regestein, Tewodros Eguale
Importance: Atypical antipsychotics offer modest effectiveness compared with placebo but with serious safety risks, including a boxed warning for the risk of death in the treatment of behavioral and psychological symptoms of dementia (BPSD). Their comparative effectiveness and safety are not fully known. Objective: To assess the relative benefits and safety of atypical antipsychotics in the treatment of BPSD shown in randomized clinical trials using network meta-analysis...
March 1, 2019: JAMA Network Open
Martin C Gulliford, Dorota Juszczyk, A Toby Prevost, Jamie Soames, Lisa McDermott, Kirin Sultana, Mark Wright, Robin Fox, Alastair D Hay, Paul Little, Michael Moore, Lucy Yardley, Mark Ashworth, Judith Charlton
BACKGROUND: Unnecessary prescribing of antibiotics in primary care is contributing to the emergence of antimicrobial drug resistance. OBJECTIVES: To develop and evaluate a multicomponent intervention for antimicrobial stewardship in primary care, and to evaluate the safety of reducing antibiotic prescribing for self-limiting respiratory infections (RTIs). INTERVENTIONS: A multicomponent intervention, developed as part of this study, including a webinar, monthly reports of general practice-specific data for antibiotic prescribing and decision support tools to inform appropriate antibiotic prescribing...
March 2019: Health Technology Assessment: HTA
Ya Gao, Jipin Li, Xueni Ma, Jiancheng Wang, Bo Wang, Jinhui Tian, Gen Chen
Several systematic reviews have investigated the accuracy of imaging modalities for lymph node involvement of rectal cancer, but there are considerable differences in conclusions. This overview aimed to assess the methodological and reporting quality of systematic reviews that evaluated the diagnostic value of imaging modalities for lymph node involvement in patients with rectal cancer and to compare the diagnostic value of different modalities for lymph node involvement. The PubMed, EMBASE, Cochrane Library and Chinese Biomedicine Literature were searched to identify relevant systematic reviews...
March 21, 2019: Clinical and Experimental Medicine
Chi Ren, Weiming Liu, Jianqing Li, Yihong Cao, Jiayi Xu, Peirong Lu
AIMS: Diabetic retinopathy (DR) is an important microvascular complication of diabetes mellitus (DM) and a leading cause of visual impairment and blindness among people of working age. Physical activity (PA) or exercise is critical and beneficial for DM patients, whereas studies evaluating the relationship between PA and DR have yielded inconsistent and inconclusive results. The American Diabetes Association's "Standards of Medical Care in Diabetes" has also pointed out the indeterminate roles of PA in DR prevention...
March 21, 2019: Acta Diabetologica
Darby A Houck, Matthew J Kraeutler, Loree B Thornton, Eric C McCarty, Jonathan T Bravman
Background: Previous meta-analyses have been conducted to compare outcomes of various treatment injections for lateral epicondylitis (LE), including corticosteroid injection (CSI) and autologous blood products such as autologous blood (AB) and platelet-rich plasma (PRP). Purpose: To conduct a systematic review of overlapping meta-analyses comparing different injection treatments (CSI, AB, PRP) for LE to determine which meta-analyses provide the best available evidence...
March 2019: Orthopaedic Journal of Sports Medicine
Rana Hassan, Ayub Akbari, Pierre A Brown, Swapnil Hiremath, K Scott Brimble, Amber O Molnar
Background: Unplanned dialysis initiation is common in patients with chronic kidney disease (CKD). Objective: To determine common definitions and patient risk factors for unplanned dialysis. Design: Systematic review. Setting: MEDLINE, EMBASE, and the Cochrane Library were searched from inception to February 2018. Patients: Studies that included incident chronic dialysis patients or patients with CKD that cited a definition or examined risk factors for unplanned dialysis were included...
2019: Canadian Journal of Kidney Health and Disease
Ji-Qing Hao, Qian-Kun Zhang, Yi-Xin Zhou, Li-Hao Chen, Peng-Fei Wu
Introduction: The aim of this meta-analysis was to summarize the evidence on the serum/plasma leptin concentrations in breast cancer (BC) patients, as well as the associations between leptin G-2548A gene polymorphisms and susceptibility to BC. Material and methods: Potentially relevant studies about serum/plasma leptin levels and leptin G-2548A gene polymorphism were selected using the electronic databases PubMed, EMBASE and The Cochrane Library (from January 1 1995 to Jun 30 2017, no language restrictions)...
March 2019: Archives of Medical Science: AMS
Maya V Epifanova, Badri R Gvasalia, Maksim A Durashov, Sergey A Artemenko
INTRODUCTION: Platelet-rich plasma (PRP) found its use in treating different conditions and diseases, because concentrated plasma PRP consists of many growth factors. Their interaction with surrounding cells, intracellular matrix, and mediators at the site of injection leads to tissue regeneration. Angiogenic, vasculogenic, and regenerative effects of PRP may be used for erectile dysfunction (ED) and Peyronie's disease (PD) treatment. AIM: To present a current data review of preclinical and clinical trials on PRP use for treating ED and PD...
March 19, 2019: Sexual Medicine Reviews
Zhiyan Liu, Qian Xiang, Guangyan Mu, Qiufen Xie, Shuang Zhou, Zining Wang, Shuqing Chen, Kun Hu, Yanjun Gong, Jie Jiang, Yimin Cui
Background As reports on the influence of cigarette smoking, an important cardiovascular risk factor, on platelet ADP -P2Y12 receptor inhibitors lack consistency, we aimed to assess the effectiveness and safety of platelet ADP -P2Y12 receptor inhibitors influenced by smoking status. Methods and Results PubMed, Web of Science, EMBASE , Clinical Trials, and the Cochrane Library were searched from inception until June 2018. Among the 5076 citations retrieved, 22 studies, including 163 011 patients with or without percutaneous coronary intervention, were included for meta-analysis...
April 2, 2019: Journal of the American Heart Association
Chia L Saw, Abhijeet Rakshasbhuvankar, Shripada Rao, Bulsara Mk, Sanjay Patole
CONTEXT: Therapeutic hypothermia is the recommended treatment for neonates with moderate or severe hypoxic ischemic encephalopathy (HIE). There is an increasing trend to use therapeutic hypothermia even in infants with mild hypoxic ischemic encephalopathy, even though there is little evidence to support/refute this. OBJECTIVE: To estimate the incidences of mild hypoxic ischemic encephalopathy among infants who received therapeutic hypothermia, and its short- and long-term outcomes...
March 22, 2019: Journal of Child Neurology
Fenny Sf Chia, Suzanne Kuys, Nancy Low Choy
OBJECTIVE: This systematic review aimed to investigate the effects of interventions intended for retraining leg somatosensory function on somatosensory impairment, and secondary outcomes of balance and gait, after stroke. DATA SOURCES: Databases searched from inception to 16 January 2019 included Cochrane Library, PubMed, MEDLINE, CINAHL, EMBASE, PEDro, PsycINFO, and Scopus. Reference lists of relevant publications were also manually searched. REVIEW METHODS: All types of quantitative studies incorporating interventions that intended to improve somatosensory function in the leg post stroke were retrieved...
March 22, 2019: Clinical Rehabilitation
Yun Ye, Su-Liang Li, Jian-Jun Wang, Bing Liu
BACKGROUND: Circulating tumor cells (CTCs) have become a potential diagnostic tumor marker and have the potential for wide clinical applications. However, the diagnostic parameters vary among previous studies. A systematic review of the literature and meta-analysis were conducted to assess the diagnostic value of CTCs for lung cancer. METHODS: Eligible studies were searched in PubMed, Medline, Cochrane Library, and Embase databases. The included studies assessed the diagnostic value of CTCs in patients with lung cancer up to September 30, 2018...
March 2019: Medicine (Baltimore)
Si-Cong Huang, Yu-Fang Chen, Xue-Dong Liu, Yan-Hong Han, Yi-Qun Li
BACKGROUND: High tibial osteotomy (HTO) is an effective surgical technique that can stop or inhibit the progression of unicompartmental knee osteoarthritis (KOA) to avoid or postpone the need for knee arthroplasty in patients. Whether opening-wedge high tibial osteotomy (OWHTO) is superior to closing-wedge high tibial osteotomy (CWHTO) in treating unicompartmental KOA remains controversial. METHODS: Databases (Cochrane Library, EMBASE, and PubMed) were searched from their establishment to July 1, 2018 for randomized controlled trials comparing the application of OWHTO to CWHTO in patients with unicompartmental KOA...
March 2019: Medicine (Baltimore)
Xiao Chen, Yang Liu
BACKGROUND: This study aims to assess the efficacy and safety of nasal endoscopic dacryocystorhinostomy (NED) for patients with chronic dacryocystitis (CD). METHODS: The following 7 electronic databases will be searched from inception to the present: Cochrane Library, EMBASE, MEDLINE, Cumulative Index to Nursing and Allied Health Literature, Web of Science, Allied and Complementary Medicine Database, and Chinese Biomedical Literature Database. In addition, the clinical trials registry and reference lists of included studies will also be searched...
March 2019: Medicine (Baltimore)
Federico Ravaioli, Antonio Colecchia, Luigina Vanessa Alemanni, Amanda Vestito, Elton Dajti, Giovanni Marasco, Mariarosaria Sessa, Andrea Pession, Francesca Bonifazi, Davide Festi
Veno-occlusive-disease (VOD), known also as sinusoidal-obstruction-syndrome (SOS), is one of the main complications of haematopoietic stem cell transplantation and is related to the treatment with pyrrolizidine alkaloids or other toxic agents (chemotherapy for liver-metastasis). Clinical diagnosis using the recent criteria from the European Society for Blood and Marrow Transplantation, is the reference for VOD/SOS diagnosis. However, increasing evidence suggests the emerging role of several imaging methods that could help the clinician in VOD/SOS assessment...
March 21, 2019: Expert Review of Gastroenterology & Hepatology
Amanda Vestito, Giovanni Marasco, Giovanni Maconi, Davide Festi, Franco Bazzoli, Rocco Maurizio Zagari
PURPOSE:  To perform a systematic review with meta-analysis to assess whether ultrasound elastography can have a diagnostic role in detecting fibrotic bowel strictures in patients with Crohn's disease. MATERIALS AND METHODS:  MEDLINE via the PubMed, Ovid Embase, Scopus and Cochrane Library databases, and abstracts of international conference proceedings were searched up to March 31, 2018. Studies were included if they assessed the performance of abdominal ultrasound elastography in detecting fibrotic bowel strictures in patients with Crohn's disease using histology or the need for surgery after medical treatment as a reference standard...
March 20, 2019: Ultraschall in der Medizin
N E van Hoogenhuijze, J C Kasius, F J M Broekmans, J Bosteels, H L Torrance
STUDY QUESTION: What is the effect of endometrial scratching in patients with or without prior failed ART cycles on live birth (LBR) and clinical pregnancy rates (CPR)? SUMMARY ANSWER: It remains unclear if endometrial scratching improves the chance of pregnancy and, if so, for whom. WHAT IS KNOWN ALREADY: Endometrial scratching is hypothesized to improve embryo implantation in ART. Multiple studies have been published, but it remains unclear if endometrial scratching actually improves pregnancy rates and, if so, for which patients...
2019: Human Reproduction Open
Jia-Qi Wu, Lin-Bo Mao, Jian Wu
BACKGROUND: To investigate whether the clinical effects of balance training were improved in hip fracture patients. METHODS: Electronic databases which included PubMed, Embase, Web of Science, and the Cochrane Library up to December 2018 were searched. High-quality randomized controlled trials (RCTs) and prospective clinical controlled studies were selected based on inclusion criteria. Stata 12.0 was used for the meta-analysis. Standard mean difference (SMD) with 95% confidence interval (CI) was used to assess the effects...
March 20, 2019: Journal of Orthopaedic Surgery and Research
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