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Juan Carlos Ruiz-Cabezas, Francisco Barros, Beatriz Sobrino, Gustavo García, Ramiro Burgos, Carlos Farhat, Antonella Castro, Lenin Muñoz, Ana Karina Zambrano, Mariela Martínez, Martha Montalván, César Paz-Y-Miño
The frequency distributions of cystic fibrosis variants are heterogeneous in Ecuador because of the genetic admixture of its population. The aim of this study was to identify disease-causing variants among Ecuadorian cystic fibrosis (CF) patients by next-generation sequencing (NGS) of the entire cystic fibrosis transmembrane conductance regulator (CFTR) gene. The results showed an approximation of the frequencies of pathogenic variants in the population under study and an optimal mutation panel for routine first-line CF molecular diagnosis...
February 11, 2019: Gene
Amanda N Fletcher, Richard M Schwend
STUDY DESIGN: Retrospective case series. OBJECTIVES: The purpose of this study is to (1) describe the development of our Spinal Deformity Program; (2) assess the surgical outcomes, including health-related quality of life (HRQOL), radiographic measures, and complications; and (3) explore predictors for HRQOL outcomes. SUMMARY OF BACKGROUND DATA: The Scoliosis Research Society (SRS) is very interested in international program site development to provide safe surgical care for children in low- and middle-income countries (LMICs)...
March 2019: Spine Deformity
Pool Tobar, Marcela Vega, Cathy Ordoñez, Lisette Rivera, José Landivar, Héctor Zambrano
OBJECTIVE: Atypical Squamous Cells of Undetermined Significance(ASCUS) is the most reported result on pap smears. It is most commonly related to Human Papillomavirus (HPV) infections. However, other pathogens (EBV, Chlamydia) have been reported on cervical samples with abnormal results. Zika virus(ZIKV) has been found to induce cellular abnormalities on different tissues and its presence has been identified on genital secretions. METHODS: Two real-time PCR has been made on cervical samples from the gynecological service of a third level hospital on Guayaquil-Ecuador...
December 2018: Puerto Rico Health Sciences Journal
Paola Calle, Lorena Monserrate, Francisco Medina, Madeleine Calle Delgado, Ana Tirapé, Marynes Montiel, Omar Ruiz Barzola, Omar Alvarado Cadena, Gustavo A Dominguez, Juan José Alava
Water and sediment quality, macrobenthos diversity and mercury levels were assessed in the Salado Estuary, Gulf of Guayaquil (Ecuador) during 2008, 2009 and 2014. Severe hypoxia, anoxia and large fluctuations of salinity occurred in an impacted sector within Guayaquil city relative to a mangrove area within the Salado Mangroves Faunal Production Reserve. Significant inter-site and temporal differences were observed for dissolved oxygen, salinity, total dissolved solids, percentage of silts and clays, and species diversity...
November 2018: Marine Pollution Bulletin
Shanon M Smith, Lorena Montero, Maritza Paez, Estefania Ortega, Eric Hall, Kate Bohnert, Xavier Sanchez, Edison Puebla, Pablo Endara, William Cevallos, Gabriel Trueba, Karen Levy
OBJECTIVES: Diarrhoea is a common and well-studied cause of illness afflicting international travellers. However, traveller's diarrhoea can also result from travel between high and low disease transmission regions within a country, which is the focus of this study. METHODS: We recruited participants for a case-control study of diarrhoea at four sites along an urban-rural gradient in Northern Ecuador: Quito, Esmeraldas, Borbón and rural communities outside of Borbón...
February 2019: Tropical Medicine & International Health: TM & IH
Maria Egas-Izquierdo, Xavier Wong-Achi, Geovanny Alvarado-Villa, Hans Mautong
To analyze the relationship between serum levels of uric acid and the severity of coronary disease. METHODS: This observational, descriptive and cross-sectional study included 77 patients previously selected using inclusion criteria, from September 2014 to May 2015. It was conducted in a third level regional hospital from Guayaquil, Ecuador. Patients enrolled in this study were older than 30 years with coronary disease undergoing coronary angiography, without prior diagnosis of any other condition that could influence in serum uric acid values...
October 31, 2018: Clínica e Investigación en Arteriosclerosis
Killen Harold Briones-Claudett, Antonio Esquinas Rodriguez, Mónica H Briones-Claudett, Miguel Puga-Tejada, Mariuxi Del Pilar Cabrera Baños, Christian Roberto Pazmiño Dueñas, Carlos Israel Torres Herrera, Michelle Grunauer
BACKGROUND: This study was designed to determine the results associated with the use of noninvasive mechanical ventilation (NIV) using the BiPAP S/T-AVAPS ventilation strategy in subjects with mild to moderate de novohypoxaemicrespiratory failure. METHODS: This is a prospective study that includes subjects with de novohypoxaemic respiratory failure (not produced by acute exacerbations of COPD, chronic lung disease, or congestive heart failure) with mild to moderate PaO₂/FiO₂, who were admitted to the Intensive Care Unit (ICU) of Santa Maria Clinic in Guayaquil, Ecuador...
2018: Anaesthesiology Intensive Therapy
G M Delgado Ramos, T G Cotter, L Flor Ramos, V Torres Floril, G A Ramos Martinez, J C Ruiz-Cabezas
The relationship between human papillomavirus (HPV) and oropharyngeal squamous cell carcinoma has been established. However, data from Ecuador is limited. The objective of this study was to characterize HPV infection in Ecuadorian patients with tongue cancer. Fifty-three patients with tongue cancer treated at the tertiary referral center Sociedad de Lucha Contra el Cancer (SOLCA), Guayaquil, between 2006 and 2011 were identified. Linear Array® HPV genotyping was used to identify the presence and types of HPV on formalin-fixed paraffin-embedded biopsy samples from these patients with tongue cancer...
October 8, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
Lissette Fuentes, María Flores, Adriana Iglesias, Adriana Luzuriaga, Nataly Rendón, Robert Ordoñez, Fanny Solórzano, Roberto Añez
With the objective of performing a clinical characterization of children and adolescents with acute lymphoblastic leukemia and febrile neutropenia in a hospital in Ecuador, a case series study was carried out, which involved reviewing the clinical records of patients receiving care at "Hospital de la Sociedad de Lucha Contra el Cancer" in Guayaquil between January 2014 and April 2016. Out of the 101 patients, 51.5% were female; mean age was 5.5±2.1 years old; 72.3% were at high risk for invasive bacterial infection; the most common infections were respiratory with 47...
April 2018: Revista Peruana de Medicina Experimental y Salud Pública
Juan Jose Gilbert Fernandez, Roberto Gilbert Febres-Cordero, Roger L Simpson
BACKGROUND:  In 1964, faced with the challenge of traumatic amputation, a team of surgeons at Clinica Guayaquil was convinced that the transplantation of a hand could significantly improve function and quality of life for the recipient. With a current but basic understanding of immunosuppression, the surgeons identified a recipient and waited for the correct donor. A human hand transplant had never been performed to date. METHODS:  The surgeons' criteria for the recipient included a young healthy individual who had sustained a traumatic amputation at the distal forearm level with full motion of the proximal joints...
August 31, 2018: Journal of Reconstructive Microsurgery
Karla Cruz-Moreira, Fuad Huamán-Garaicoa, Gabriela Mena
The aim of this study was to evaluate the level of knowledge on oral cancer and level of preventive care among the population. A descriptive cross-sectional study was performed to evaluate 408 individuals through a face-to-face survey at Universidad Católica de Santiago de Guayaquil during the 2016 academic year. Sixty-one percent (61%) of respondents said they knew of the existence of oral cancer, but 56.1% did not know that 'white spots' in the oral cavity could become malignant, and 50.7% did not know that 'lumps'could be oral cancer...
December 2017: Acta Odontológica Latinoamericana: AOL
Rosa de Los Ángeles Bayas-Rea, Fernando Félix, Rommel Montufar
The common bottlenose dolphin, Tursiops truncatus , is widely distributed along the western coast of South America. In Ecuador, a resident population of bottlenose dolphins inhabits the inner estuarine area of the Gulf of Guayaquil located in the southwestern part of the country and is under threat from different human activities in the area. Only one genetic study on South American common bottlenose dolphins has been carried out to date, and understanding genetic variation of wildlife populations, especially species that are identified as threatened, is crucial for defining conservation units and developing appropriate conservation strategies...
2018: PeerJ
Catherine A Lippi, Anna M Stewart-Ibarra, Ángel G Muñoz, Mercy J Borbor-Cordova, Raúl Mejía, Keytia Rivero, Katty Castillo, Washington B Cárdenas, Sadie J Ryan
Dengue fever, a mosquito-borne arbovirus, is a major public health concern in Ecuador. In this study, we aimed to describe the spatial distribution of dengue risk and identify local social-ecological factors associated with an outbreak of dengue fever in the city of Guayaquil, Ecuador. We examined georeferenced dengue cases ( n = 4248) and block-level census data variables to identify social-ecological risk factors associated with the presence/absence and burden of dengue in Guayaquil in 2012. Local Indicators of Spatial Association (LISA), specifically Anselin’s Local Moran’s I, and Moran’s I tests were used to locate hotspots of dengue transmission, and multimodel selection was used to identify covariates associated with dengue presence and burden at the census block level...
April 23, 2018: International Journal of Environmental Research and Public Health
Claudia Soria Segarra, Edison Soria Baquero, Monica Cartelle Gestal
Escherichia coli is one of the major causes of urinary tract infections in primary healthcare, and treatment is more complicated due to the increase in antibiotic resistance. Extended-spectrum β-lactamases are the most common mechanism of resistance against third-generation cephalosporin, and CTX-M-like are among the most prevalent. The aim of our work is to investigate the prevalence of blaCTX-M in isolates of E. coli obtained from samples of patients without previous known contact with the hospital. Ninety-four E...
May 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
F Aguirre P, A Coca, M F Aguirre, G Celis
OBJECTIVE: To determine the predictors and prevalence of metabolic syndrome (MS) and the presence of vascular inflammation in apparently-normal children (10-15 years) of both sexes in Guayaquil, Ecuador. STUDY DESIGN AND METHODS: We included 395 apparently-healthy students from a middle-income school in a cross-sectional survey. Informed consent was obtained from students and parents. Anthropometric measurements including blood pressure (BP), body mass index (BMI) and waist-to-height ratio (WHtR), and blood tests were recorded...
November 4, 2017: Hipertensión y Riesgo Vascular
John Barba-Pacheco, Gutenberg Navarro, Diego Gonzalez-Rivas, Fernando Polit, Pamela Wong, Fabrizio Nieto, Manuel Romero, Jaime Carrera, Jonathan Villacis, Martha J Zambrano, Karina Bravo, Renee Velastegui, Freddy Rodríguez, Manuel Reyes, Silvia Cullacay, Ramiex Cercado, Sara Salvatierra
Currently video-assisted thoracic surgery (VATS) and the evolution Uniportal VATS have a worldwide acceptance and Ecuador is not exception when we decided invited to Dr. Diego Gonzalez-Rivas pioneer surgeon in the world of single-port video-assisted thoracoscopic procedures, with the aim to provide a faster recovery of the patients compared to those who received a conventional thoracotomy. We thanks the opportunity to present a report to the first Masterclass in Uniportal VATS with live surgery, performed on February 23rd to 24th of 2017 at the Luis Vernaza Hospital in Guayaquil-Ecuador...
2017: Journal of Visualized Surgery
Patricio Ponce, Diego Morales, Adriana Argoti, Varsovia E Cevallos
Aedes (Stegomyia) albopictus (Skuse), (Diptera: Culicidae), the Asian tiger mosquito, is one of the most widespread invasive vector-borne disease insect in tropical and temperate zones. This species has invaded the Americas over the past 3 decades and has spread to six countries. We report Ae. albopictus in Guayaquil city, the first time it has been identified in Ecuador. Outdoor BG-Sentinel traps without lures collected a total of 21 Ae. albopictus.
January 10, 2018: Journal of Medical Entomology
Killen H Briones Claudett, Monica H Briones Claudett, Antonio M Esquinas, Michelle Grunauer Andrade
BACKGROUND: This study aimed to characterize which are the early determinants of immediate failure of the use of noninvasive mechanical ventilation (NIMV) outside the ICU. METHODS: This prospective study included patients who were admitted to the Military Hospital in Guayaquil, Ecuador. Each variable was analyzed independently by using a multiple logistic regression model toward establishing an association with the event. RESULTS: A total of 249 cases of NIMV over a 10 year period of its application outside the ICU was included in the study...
2017: Anaesthesiology Intensive Therapy
Sunny Sánchez, Dolores Zambrano, Maylen García, César Bedoya, Carlos Fernández, María Teresa Illnait-Zaragozí
INTRODUCTION: Neurocryptococcosis is an opportunistic fungal infection that represents a high cost in human lives and for the economy of countries. Its causative agent, the Cryptococcus neoformans/Cryptococcus gattii species complex, has a sexual and an asexual phase, four major serotypes and seven molecular varieties with phenotypic, clinical-epidemiological and antifungal susceptibility differences. OBJECTIVE: To characterize by molecular methods clinical isolates of C...
September 1, 2017: Biomédica: Revista del Instituto Nacional de Salud
M Palme, L Inostroza, G Villacreses, A Lobato, C Carrasco
This data article presents files supporting calculation for urban heat island (UHI) inclusion in building performance simulation (BPS). Methodology is used in the research article "From urban climate to energy consumption. Enhancing building performance simulation by including the urban heat island effect" (Palme et al., 2017) [1]. In this research, a Geographical Information System (GIS) study is done in order to statistically represent the most important urban scenarios of four South-American cities (Guayaquil, Lima, Antofagasta and Valparaíso)...
October 2017: Data in Brief
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