keyword
https://read.qxmd.com/read/38535397/-mamestra-brassicae-multiple-nucleopolyhedroviruses-prevents-pupation-of-helicoverpa-armigera-by-regulating-juvenile-hormone-titer
#1
JOURNAL ARTICLE
Yanqing Yang, Jinping Dai, Guozhi Zhang, Deepali Singh, Xiaoxia Zhang, Zhenpu Liang
Baculovirus infection can prevent the pupation of insects. Juvenile hormone (JH) plays a vital role in regulating insect molting and metamorphosis. However, the molecular mechanism of baculovirus preventing the pupation of larvae by regulating the Juvenile hormone (JH) pathway is still unclear. In this study, we found that the Mamestra brassicae multiple nucleopolyhedroviruses (MbMNPV) infection prolonged the larval stage of fourth instar Helicoverpa armigera ( H. armigera ) by 0.52 d and caused an increase in JH titer...
March 18, 2024: Insects
https://read.qxmd.com/read/38533763/serum-from-pregnant-donors-induces-human-beta-cell-proliferation
#2
JOURNAL ARTICLE
Kendra R Sylvester-Armstrong, Callie F Reeder, Andrece Powell, Matthew W Becker, D Walker Hagan, Jing Chen, Clayton E Mathews, Clive H Wasserfall, Mark A Atkinson, Robert Egerman, Edward A Phelps
Pancreatic beta cells are among the slowest replicating cells in the human body and have not been observed to increase in number except during the fetal and neonatal period, in cases of obesity, during puberty, as well as during pregnancy. Pregnancy is associated with increased beta cell mass to meet heightened insulin demands. This phenomenon raises the intriguing possibility that factors present in the serum of pregnant individuals may stimulate beta cell proliferation and offer insights into expansion of the beta cell mass for treatment and prevention of diabetes...
December 31, 2024: Islets
https://read.qxmd.com/read/38533508/mrna-vaccines-encoding-computationally-optimized-hemagglutinin-elicit-protective-antibodies-against-future-antigenically-drifted-h1n1-and-h3n2-influenza-viruses-isolated-between-2018-2020
#3
JOURNAL ARTICLE
James D Allen, Ted M Ross
BACKGROUND: The implementation of mRNA vaccines against COVID-19 has successfully validated the safety and efficacy of the platform, while at the same time revealing the potential for their applications against other infectious diseases. Traditional seasonal influenza vaccines often induce strain specific antibody responses that offer limited protection against antigenically drifted viruses, leading to reduced vaccine efficacy. Modern advances in viral surveillance and sequencing have led to the development of in-silico methodologies for generating computationally optimized broadly reactive antigens (COBRAs) to improve seasonal influenza vaccines...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38531640/-initial-characterization-of-a-transgenic-mouse-with-overexpression-of-the-human-h-1-histamine-receptor-on-the-heart
#4
JOURNAL ARTICLE
Lina Maria Rayo Abella, Hannes Jacob, Max Keller, Lisa Schindler, Steffen Pockes, Sebastian Pitzl, Jan Klimas, Katarina Hadova, Sarah Schneider, Igor B Buchwalow, CongYu Jin, Pertti Panula, Uwe Kirchhefer, Joachim Neumann, Ulrich Gergs
There is controversy whether H1 -histamine receptors increase or decrease contractility in the mammalian heart. Therefore, we have generated mice that overexpress the human H1 -histamine receptor in the heart (H1 -TG). We hypothesized that histamine would either increase or decrease force of contraction and beating rate compared to littermate wild type mice (WT). In H1 -TG mice, we ascertained the presence of H1 -histamine receptors by autoradiography of atrium and ventricle using [3 H]mepyramine. The messenger RNA for human H1 -histamine-receptors was present in cardiac samples from H1 -TG and absent from WT...
March 26, 2024: Journal of Pharmacology and Experimental Therapeutics
https://read.qxmd.com/read/38531150/discovery-of-cinnamylaldehyde-derived-mono-carbonyl-curcumin-analogs-as-anti-gastric-cancer-agents-via-suppression-of-stat3-and-akt-pathway
#5
JOURNAL ARTICLE
Xi Chen, Peiqin Zhang, Huating Zhang, Xueqiang Ma, Ye Zhang, Yajie Wu, Kaiwen Jin, Jiabing Wang, Jianzhang Wu
The structural modification of curcumin has always been a hotspot in drug development. In this paper, a class of cinnamylaldehyde-derived mono-carbonyl curcumin analogs (MCAs) with 7-carbon-links were designed and synthesized and their anticancer properties were evaluated. Through screening anti-gastric cancer activity of these compounds, H1 exhibited the strongest cytotoxic activity by inhibiting cell viability and colony formation, inducing cell cycle G2/M phase arrest in vitro (SGC-7901 and AGS gastric cancer cells)...
March 24, 2024: Bioorganic Chemistry
https://read.qxmd.com/read/38530350/imaging-analysis-of-six-human-histone-h1-variants-reveals-universal-enrichment-of-h1-2-h1-3-and-h1-5-at-the-nuclear-periphery-and-nucleolar-h1x-presence
#6
JOURNAL ARTICLE
Monica Salinas-Pena, Elena Rebollo, Albert Jordan
Histone H1 participates in chromatin condensation and regulates nuclear processes. Human somatic cells may contain up to seven histone H1 variants, although their functional heterogeneity is not fully understood. Here, we have profiled the differential nuclear distribution of the somatic H1 repertoire in human cells through imaging techniques including super-resolution microscopy. H1 variants exhibit characteristic distribution patterns in both interphase and mitosis. H1.2, H1.3, and H1.5 are universally enriched at the nuclear periphery in all cell lines analyzed and co-localize with compacted DNA...
March 26, 2024: ELife
https://read.qxmd.com/read/38511218/anti-diabetic-properties-of-brewer-s-spent-yeast-peptides-in-vitro-in-silico-and-ex-vivo-study-after-simulated-gastrointestinal-digestion
#7
JOURNAL ARTICLE
Marilin E Aquino, Silvina R Drago, Fermín Sánchez de Medina, Olga Martínez-Augustin, Raúl E Cian
Brewer's spent yeast (BSY) hydrolysates are a source of antidiabetic peptides. Nevertheless, the impact of in vitro gastrointestinal digestion of BSY derived peptides on diabetes has not been assessed. In this study, two BSY hydrolysates were obtained ( H1 and H2 ) using β-glucanase and alkaline protease, with either 1 h or 2 h hydrolysis time for H1 and H2 , respectively. These hydrolysates were then subjected to simulated gastrointestinal digestion (SGID), obtaining dialysates D1 and D2 , respectively...
March 21, 2024: Food & Function
https://read.qxmd.com/read/38505441/antidotal-effects-of-the-antihistamine-diphenhydramine-against-cholinesterase-inhibitor-poisoning-a-meta-analysis-of-median-lethal-doses-in-experimental-animals
#8
REVIEW
Fouad K Mohammad, Ammar A Mohammed, Ghada A Faris, Banan Al-Baggou, Yaareb J Mousa
The H1 -antihistamine diphenhydramine antagonizes cholinesterase inhibitor poisoning in various animal species. One aspect of acute antidotal actions of diphenhydramine is increasing the median lethal doses (LD50) of toxicants. The objective of this meta-analysis was to assess the antidotal action of diphenhydramine against short-term toxicity (LD50) of cholinesterase inhibitors in experimental animals. The experimental studies selected were according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines...
February 2024: Curēus
https://read.qxmd.com/read/38504534/gehua-jiejiu-dizhi-decoction-ameliorates-alcoholic-fatty-liver-in-mice-by-regulating-lipid-and-bile-acid-metabolism-and-with-exertion-of-antioxidant-stress-based-on-4dlabel-free-quantitative-proteomic-study
#9
JOURNAL ARTICLE
Han Min, Y I Xu, You Shaowei, W U Xueli, Wang Shuoshi, H E Diancheng
OBJECTIVE: To analyze the effect and molecular mechanism of Gehua Jiejiu Dizhi decoction (, GJDD) on alcoholic fatty live disease (AFLD) by using proteomic methods. METHODS: The male C57BL/6J mouse were randomly divided into four groups: control group, model group, GJDD group and resveratrol group. After the AFLD model was successfully prepared by intragastric administration of alcohol once on the basis of the Lieber-DeCarli classical method, the GJDD group and resveratrol group were intragastrically administered with GJDD (4900 mg/kg) and resveratrol (400 mg/kg) respectively, once a day for 9 d...
April 2024: Journal of Traditional Chinese Medicine
https://read.qxmd.com/read/38503897/antiemetic-activity-of-abietic-acid-possibly-through-the-5ht-3-and-muscarinic-receptors-interaction-pathways
#10
JOURNAL ARTICLE
Rubel Hasan, Abdulrahman Alshammari, Norah A Albekairi, Md Shimul Bhuia, Meher Afroz, Raihan Chowdhury, Muhammad Ali Khan, Siddique Akber Ansari, Irfan Aamer Ansari, Mohammad S Mubarak, Muhammad Torequl Islam
The present study was designed to evaluate the antiemetic activity of abietic acid (AA) using in vivo and in silico studies. To assess the effect, doses of 50 mg/kg b.w. copper sulfate (CuSO4 ⋅5H2 O) were given orally to 2-day-old chicks. The test compound (AA) was given orally at two doses of 20 and 40 mg/kg b.w. On the other hand, aprepitant (16 mg/kg), domperidone (6 mg/kg), diphenhydramine (10 mg/kg), hyoscine (21 mg/kg), and ondansetron (5 mg/kg) were administered orally as positive controls (PCs)...
March 19, 2024: Scientific Reports
https://read.qxmd.com/read/38499411/differential-detection-of-h1n1-virus-spiker-proteins-by-two-hexaphenylbutadiene-isomers-based-on-size-matching-principle
#11
JOURNAL ARTICLE
Xiaoling Pan, Jian Wang, Kai Zhang, Peng Sun, Jianbing Shi, Junge Zhi, Zhengxu Cai, Zi Li, Dayan Wang, Bin Tong, Yuping Dong
As one of the high pathogenic influenza viruses, H1N1 virus easily induces to serious diseases, even leading to death. To date, all detection methods for H1N1 virus had shortcomings, including high equipment cost, time consumption, and etc. Therefore, a novel detection method should be established to achieve more convenient, rapid, and low-cost detection. In this work, an isomer of HPBmN-I with aggregation-induced emission characteristic was firstly synthesized on the basis of our previous reported HPBpN-I...
April 22, 2024: Analytica Chimica Acta
https://read.qxmd.com/read/38497050/-schizachyrium-scoparium-c-4-better-tolerates-drought-than-andropogon-gerardii-c-4-via-constant-co-2-supply-for-photosynthesis-during-water-stress
#12
JOURNAL ARTICLE
Alina Dekirmenjian, Diego Montano, Michelle L Budny, Nathan P Lemoine
Climate change is dramatically altering global precipitation patterns across terrestrial ecosystems, making it critically important that we understand both how and why plant species vary in their drought sensitivities. Andropogon gerardii and Schizachyrium scoparium , both C4 grasses, provide a model system for understanding the physiological mechanisms that determine how species of a single functional type can differ in drought responses, an issue remains a critical gap in our ability to model and predict the impacts of drought on grassland ecosystems...
February 2024: AoB Plants
https://read.qxmd.com/read/38496968/cellulolytic-and-ethanologenic-evaluation-of-heterotermes-indicola-s-gut-associated-bacterial-isolates
#13
JOURNAL ARTICLE
Sana Azhar, Ayesha Aihetasham, Asma Chaudhary, Zawar Hussain, Rahat Abdul Rehman, Ghulam Abbas, Sulaiman Ali Alharbi, Mohammad Javed Ansari, Samina Qamer
Cellulose is the basic component of lignocellulosic biomass (LCB) making it a suitable substrate for bioethanol fermentation. Cellulolytic and ethanologenic bacteria possess cellulases that convert cellulose to glucose, which in turn yields ethanol subsequently. Heterotermes indicola is a subterranean termite that causes destructive damage by consuming wooden structures of infrastructure, LCB products, etc. Prospectively, the study envisioned the screening of cellulolytic and ethanologenic bacteria from the termite gut...
March 12, 2024: ACS Omega
https://read.qxmd.com/read/38496948/topological-characteristics-of-the-pore-network-in-the-tight-sandstone-using-persistent-homology
#14
JOURNAL ARTICLE
Wei Wang, Zhiyong Yan, Lina Wang, Shuang Xu
Tight sandstone reservoirs have become important areas for unconventional reservoir development, and their pore network is a key feature for identifying tight sandstone, which affects fluid migration path and reservoir development efficiency. However, the connectivity characteristics of the pore network at different scales have remained unclear owing to the numerous pores and uneven pore shape. Here, using pore size distributions from many hundreds of tight sandstone samples and subsequent topological data analysis, we construct the topological structure of the pore network in the Yanchang Formation tight sandstone of the Ordos Basin in China and visualize the topological characteristics of the pore network with distances...
March 12, 2024: ACS Omega
https://read.qxmd.com/read/38491409/culture-shock-among-international-students-in-turkey-an-analysis-of-the-effects-of-self-efficacy-life-satisfaction-and-socio-cultural-adaptation-on-culture-shock
#15
JOURNAL ARTICLE
Mustafa Almukdad, Engin Karadag
In this study, we investigated whether the interaction effects of self-efficacy, life satisfaction, and sociocultural adjustment have significant negative effects on culture shock. The data were collected from 323 international students in Turkey, and the sample comprised 197 undergraduates (61%) and 126 graduates (39%). We administered the "Culture Shock Questionnaire," "General Self-Efficacy Scale", "The Satisfaction with Life Scale", and "Sociocultural Adaptation Scale" through an online survey. Of the participants, 86 were female (26...
March 15, 2024: BMC Psychology
https://read.qxmd.com/read/38490324/the-clinical-performance-of-dental-resin-composite-repeatedly-preheated-a-randomized-controlled-clinical-trial
#16
JOURNAL ARTICLE
Mahmoud Elkady, Safaa Abdelhakim, Mona Riad
OBJECTIVES: To assess the clinical performance of class II restorations performed by repeatedly preheated resin composite "RC" at 68°C up to ten times. METHODS: 105 patients were selected and randomized into three groups, each comprising 35 patients. Each patient was provided with a single class II Bulk-fill resin composite "BF-RC" posterior restoration based on the number of preheating cycles; group I (H0): The BF-RC was packed non-heated, group II (H1): BF-RC preheated once, and group III(H10): BF-RC preheated ten cycles...
March 13, 2024: Journal of Dentistry
https://read.qxmd.com/read/38490089/paraflavitalea-pollutisoli-sp-nov-pollutibacter-soli-gen-nov-sp-nov-polluticoccus-soli-gen-nov-sp-nov-and-terrimonas-pollutisoli-sp-nov-four-new-members-of-the-family-chitinophagaceae-from-polluted-soil
#17
JOURNAL ARTICLE
Ze-Shen Liu, Xiao-Kang Wang, Ke-Huan Wang, Mei-Ling Yang, De-Feng Li, Shuang-Jiang Liu
A taxonomic investigation was conducted on four bacterial strains isolated from soil contaminated with polycyclic aromatic hydrocarbons and heavy metals. Phylogenetic analysis revealed that these strains belonged to the family Chitinophagaceae. Examination of the 16S rRNA genes indicated that their sequence identities were below 97.6 % compared to any known and validly nominated bacterial species. The genomes of the four strains ranged from 4.12 to 8.76 Mb, with overall G + C molar contents varying from 41...
March 12, 2024: Systematic and Applied Microbiology
https://read.qxmd.com/read/38489059/sustained-delivery-of-olopatadine-from-vitamin-e-loaded-contact-lenses
#18
JOURNAL ARTICLE
Inês M Reis, Philip J Dixon, Poorvajan Sekar, Anuj Chauhan
Purpose: Topical antihistamines, such as olopatadine hydrochloride, an H1 receptor antagonist, are commonly prescribed for treating allergic conjunctivitis. Drug delivery via eye drops has many deficiencies including a short residence time due to tear drainage via the nasolacrimal duct, which results in a low bioavailability and potential for side effects. These deficiencies could be mitigated by a drug-eluting contact lens such as the recently approved ACUVUE® THERAVISION™ WITH KETOTIFEN which is a daily disposable etafilcon, a drug-eluting contact lens with ketotifen (19 μg per lens)...
March 2024: Journal of Ocular Pharmacology and Therapeutics
https://read.qxmd.com/read/38488661/wrnip1-prevents-transcription-associated-genomic-instability
#19
JOURNAL ARTICLE
Pasquale Valenzisi, Veronica Marabitti, Pietro Pichierri, Annapaola Franchitto
R-loops are non-canonical DNA structures that form during transcription and play diverse roles in various physiological processes. Disruption of R-loop homeostasis can lead to genomic instability and replication impairment, contributing to several human diseases, including cancer. Although the molecular mechanisms that protect cells against such events are not fully understood, recent research has identified fork protection factors and DNA damage response proteins as regulators of R-loop dynamics. In this study, we identify the Werner helicase-interacting protein 1 (WRNIP1) as a novel factor that counteracts transcription-associated DNA damage upon replication perturbation...
March 15, 2024: ELife
https://read.qxmd.com/read/38488104/validation-of-air-storage-system-for-hypoxia-exposure-during-exercise
#20
JOURNAL ARTICLE
Matheus S Norberto, João Victor G Torini, Matheus S Firmino, Marcelo Papoti
Norberto, Matheus S., João Victor G. Torini, Matheus S. Firmino, and Marcelo Papoti. Validation of air storage system for hypoxia exposure during exercise. High Alt Med Biol . 00:000-000, 2024.-Considering the importance of optimizing normobaric hypoxia exposure (i.e., higher delivery capacity), the current study aims to validate a hypoxic air storage system. The study has a cross-over, one-blind randomized design. The air storage is composed of a piping system that directs hypoxic air from a hypoxia generator into nylon bags...
March 15, 2024: High Altitude Medicine & Biology
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