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Kanokvalai Kulthanan, Saowalak Hunnangkul, Papapit Tuchinda, Leena Chularojanamontri, Puncharas Weerasubpong, Chanika Subchookul, Marcus Maurer
BACKGROUND: Several treatment options for cold urticaria (ColdU) have been studied and reported, but systematic reviews and meta-analyses are limited. OBJECTIVES: To meta-analyze and review the efficacy and safety of ColdU treatments. METHODS: We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations. Suitable reports were identified by searching PubMed, Scopus, and Web of Science. Our systematic review included 16 studies, 9 of which met the eligibility criteria for the meta-analysis...
February 15, 2019: Journal of Allergy and Clinical Immunology
John Wesson Ashford
In this issue, an article by La et al. provides evidence that trazodone delayed cognitive decline in 25 participants with Alzheimer's disease (AD), mild cognitive impairment, or normal cognition. For participants considered to have AD pathology, trazodone non-users declined at a rate 2.4 times greater than those taking trazodone for sleep over a 4-year period. In the analysis of sleep complaints, the relationship between trazodone, a widely used medication for sleep problems in the elderly, and cognition was associated with subjective improvement of sleep disruption...
2019: Journal of Alzheimer's Disease: JAD
Louisa Roudini, Negar NayebZadeh Eidgahi, Hamid Reza Rahimi, Mohammad Reza Saberi, Zeinab Amiri Tehranizadeh, Sima Beigoli, Jamshidkhan Chamani
The binding of small molecules with histone-DNA complexes can cause an interference in vital cellular processes such as cell division and the growth of cancerous cells that results in apoptosis. It is significant to study the interaction of small molecules with histone-DNA complex for the purpose of better understanding their mechanism of action, as well as designing novel and more effective drug compounds. The fluorescence quenching of ct-DNA upon interaction with Berberine has determined the binding of Berberine to ct-DNA with Ksv  = 9...
February 17, 2019: Journal of Biomolecular Structure & Dynamics
Tingting Zhou, Hongmei Wang, Jiabing Shen, Wanyan Li, Maosheng Cao, Yao Hong, Maohong Cao
The p75 neurotrophin receptor (p75NTR), a member of tumor necrosis factor receptor superfamily, involves in neuronal apoptosis after intracerebral hemorrhage (ICH). It has been previously demonstrated that phosphorylation of p35 is a crucial factor for fighting against the proapoptotic p25/CDK5 signaling in neuronal apoptosis. Then, in ICH models of rats and primary cortical neurons, we found that the expressions of p75NTR, p-histone H1 (the kinase activity of CDK5), p25, Fas-associated phosphatase-1 (FAP-1), and phosphorylated myocyte enhancer factor 2D (p-MEF2D) were enhanced after ICH, whereas the expression of p35-Thr(138) was attenuated...
February 15, 2019: Journal of Cellular Physiology
Frederick Odun-Ayo, Georgina Odaibo, David Olaleye
Background: Influenza is an acute respiratory disease that continues to cause global epidemics and pandemics in human with significant mortality and morbidity. Objectives: This study was designed to identify the circulating influenza virus in Ibadan, Nigeria during the 2006/2007 season. Methods: Throat swab samples were collected from patients presenting with acute respiratory tract infection at the Out-Patient Departments of major hospitals in Ibadan over a period of seven months from November 2006 to May 2007...
December 2018: African Health Sciences
Xiuge Wang, Chunhong Yang, Fang Guo, Yaran Zhang, Zhihua Ju, Qiang Jiang, Xueming Zhao, Yong Liu, Han Zhao, Jinpeng Wang, Yan Sun, Changfa Wang, Huabin Zhu, Jinming Huang
Sperm motility is the main index used to assess the quality of bull semen. It may also be used to evaluate the fertility potential of bulls. Protein-coding mRNA and long noncoding RNA (lncRNA) participate in the regulation of spermatogenesis. Here, we employed strand-specific RNA sequencing to profile the semen transcriptome (mRNA and lncRNA) of six paired full-sibling Holstein bulls with divergent sperm motility and to determine the functions of mRNA and lncRNA in sperm motility. Among 20,875 protein-encoding genes detected in semen, 19 were differentially expressed between the high sperm motility group (H: H1, H2, and H3) and low sperm motility group (L: L1, L2, and L3)...
February 14, 2019: Scientific Reports
Francesco De Logu, Lorenzo Landini, Malvin N Janal, Simone Li Puma, Francesco De Cesaris, Pierangelo Geppetti, Romina Nassini
BACKGROUND: Administration of endogenous mediators or exogenous chemicals in migraine patients provoke early headaches and delayed migraine-like attacks. Although migraine provoking substances are normally vasodilators, dilation of arterial vessels does not seem to be the sole contributing factor, and the underlying mechanisms of the delayed migraine pain are mostly unknown. Sustained mechanical allodynia is a common response associated with the local administration of various proalgesic substances in experimental animals and humans...
February 14, 2019: Journal of Headache and Pain
F S Santos, E C Sousa Junior, S F S Guerra, P S Lobo, E T Penha Junior, A B F Lima, C B G Vinente, E H N Chagas, M C A Justino, A C Linhares, J Matthijnssens, L S Soares, J D P Mascarenhas
Worldwide rotaviruses A (RVA) are responsible for approximately 215,000 deaths annually among children aged <5 years. RVA G1P[8] remains associated with >50% of gastroenteritis cases in this age group. The aim of this study was to assess the genetic variability of G1P[8] strains detected in children with severe diarrhea in Belém, Pará, Brazil, during the post-rotavirus vaccine introduction era. Phylogenetic analysis clustered the VP4 and VP7 genes of 40 samples selected between 2009 and 2011 into lineages found to be different from the Rotarix® vaccine strain...
February 11, 2019: Infection, Genetics and Evolution
Hanae Takatsuki, Chantal Ama Agbemabiese, Toyoko Nakagomi, Sher Bahadur Pun, Punita Gauchan, Hideki Muto, Hiroshi Masumoto, Ryuichiro Atarashi, Osamu Nakagomi, Basu Dev Pandey
Rotavirus A (RVA) causes acute diarrhoea in children and less frequently in adults. However, the knowledge about the genotype distribution of RVA strains circulating in adults is limited particularly in developing countries. This study aimed to characterise the RVA strains detected from adult patients with diarrhoea in Nepal. A total of 47 RVA positive stool samples from adult patients with diarrhoea in Kathmandu, Nepal during 2007-2008 were examined for the G and P genotypes by sequencing. Nearly half (49%) of the samples were genotyped as G9P[8] (n = 23), G1P[8], G2P[4] (n = 5 each), G12P[8] (n = 4), G12P[6] (n = 3), G1P[6] (n = 2), G3P[8] and G9P[6] (n = 1 each)...
February 11, 2019: Infection, Genetics and Evolution
Cun-En Wu, Yu-Wen Zhuang, Jin-Yong Zhou, Shen-Lin Liu, Xi Zou, Jian Wu, Rui-Ping Wang, Peng Shu
The Nm23 gene has been acknowledged to play a crucial role in lung cancer metastasis inhibitory cascades controlled by multiple factors. Low expression or allelic deletion of nm23-H1 is strongly linked to widespread metastasis and poor differentiation of non-small cell lung cancer (NSCLC). In this study, nm23-H1 was down regulated in epithelial-mesenchymal transition (EMT) and stemness enhancement under cobalt chloride (CoCl2)-induced hypoxia in NSCLC cells. Moreover, knocking down of nm23-H1 by shRNA apparently promoted hypoxia induced EMT and stemness, which was entirely suppressed via over expression of nm23-H1...
February 14, 2019: Biological Chemistry
Clévio Nobrega, José M Codesso, Liliana Mendonça, Luis Pereira de Almeida
Machado-Joseph disease (MJD) or spinocerebellar ataxia type 3 (SCA3) is an autosomal dominantly-inherited neurodegenerative disorder caused by the over-repetition of a CAG codon in the MJD1 gene. This expansion translates into a long polyglutamine tract that confers a toxic gain-of-function to the mutant protein - ataxin-3, leading to neurodegeneration in specific brain regions. No treatment able to modify the disease progression is available. However, we and others have previously shown that specific silencing mutant ataxin-3 by RNA interference with viral vectors is a promising therapeutic strategy for MJD...
February 14, 2019: Human Gene Therapy
Katja Steck, Jan H van Esch, David K Smith, Cosima Stubenrauch
Gelled lyotropic liquid crystals (LLCs) are highly tunable multi-component materials. By studying a selection of low molecular weight gelators (LMWGs), we find gelators that form self-assembled gels in LLCs without influencing their phase boundaries. We studied the system H2O/NaCl-Genapol LA070 in the presence of (a) the organogelators 12-hydroxyoctadecanoic acid (12-HOA) and 1,3:2,4-dibenzylidene-d-sorbitol (DBS) and (b) the hydrogelators N,N'-dibenzoyl-l-cystine (DBC) and a tris-amido-cyclohexane derivative (HG1)...
February 13, 2019: Soft Matter
Vu Ngo, Zhao Chen, Kai Zhang, John W Whitaker, Mengchi Wang, Wei Wang
Histones are modified by enzymes that act in a locus, cell-type, and developmental stage-specific manner. The recruitment of enzymes to chromatin is regulated at multiple levels, including interaction with sequence-specific DNA-binding factors. However, the DNA-binding specificity of the regulatory factors that orchestrate specific histone modifications has not been broadly mapped. We have analyzed 6 histone marks (H3K4me1, H3K4me3, H3K27ac, H3K27me3, K3H9me3, H3K36me3) across 121 human cell types and tissues from the NIH Roadmap Epigenomics Project as well as 8 histone marks (with addition of H3K4me2 and H3K9ac) from the mouse ENCODE Consortium...
February 12, 2019: Proceedings of the National Academy of Sciences of the United States of America
Cuihua An, Mengying Wang, Weiqin Li, Li Xu, Yijing Wang
To realize high-rate and long-term performances of an aqueous rechargeable battery, the most effective approach is to build electrode materials with more reaction active sites and stable structures. Transition metal sulfides have become up-and-coming electrodes due to their high conductivity. Herein, we demonstrated the in situ construction of core-shell Co9S8@C materials with controlled carbon content and thickness. Nanorod-like cobalt-organic chelates were used as the precursors. The cobalt in cobalt-organic chelates reacted with sublimed sulfur to generate the Co9S8 core in situ; meanwhile, the organic chelates were converted into carbon shells, which coated the Co9S8 core and connected with each other to maintain the whole rod shape...
February 12, 2019: Nanoscale
Dragana Jovanovic, Marina Roksandic Milenkovic, Jelena Kotur Stevuljevic, Jelena Markovic, Vesna Ceriman, Milica Kontic, Vesna Skodric Trifunovic
Background: Idiopathic pulmonary fibrosis (IPF) has common risk factors with cancer and significant similarities in the pathobiology process, both diseases having poor outcomes. Immune checkpoint PD-L1 has become the target of checkpoint inhibitory therapy that unleashes antitumor T cells and has revolutionized cancer treatment. This is a pilot study exploring membrane immune checkpoint PD-L1 expression in human IPF lung tissue samples and its soluble form, soluble PD-L1 (sPD-L1) plasma concentrations in IPF patients, in order to investigate potential role of PD-L1 as an IPF biomarker...
December 2018: Journal of Thoracic Disease
Huyen Tran Thi, Lan Pham Thi, Thuong Nguyen Van, Phuong Pham Thi Minh, Hao Nguyen Trong, Tro Chau Van, Sau Nguyen Huu, Trang Trinh Minh, Nghi Dinh Huu, Tam Hoang Van, Van Tran Cam, My Le Huyen, Khang Tran Hau, Thuy Nguyen Thanh, Phuong Hoang Thi, Linh Nguyen Thuy, Marco Gandolfi, Francesca Satolli, Claudio Feliciani, Michael Tirant, Aleksandra Vojvodic, Torello Lotti
BACKGROUND: Chronic urticaria, a mast cell-driven condition, is common, debilitating and hard to treat. H1-antihistamines are the first line treatment of chronic urticaria, but often patients do not get satisfactory relief with the recommended dose. European guidelines recommend increased antihistamine doses up to four-fold. AIM: We conducted this study to evaluate the efficacy of increased H1-antihistamine doses up to two-fold in Vietnamese chronic urticaria patients...
January 30, 2019: Open Access Macedonian Journal of Medical Sciences
Rujia Liao, Youchao Chen, Li Cheng, Lishi Fan, Han Chen, Yushan Wan, Yi You, Yanrong Zheng, Lei Jiang, Zhong Chen, Xiangnan Zhang, Weiwei Hu
The neurological recovery following traumatic brain injury (TBI) is limited, largely due to a deficiency in neurogenesis. The present study explores the effects of histamine H3 receptor (H3R) antagonism on TBI and mechanisms related to neurogenesis. H3R antagonism or H3R gene knockout alleviated neurological injury in the late phase of TBI, and also promoted neuroblast differentiation to enhance neurogenesis through activation of the histaminergic system. Histamine H1 receptor, but not H2 receptor, in neural stem cells is shown to be essential for this promotion by using Hrh1fl/fl ;NestinCreERT2 and Hrh2fl/fl ;NestinCreERT2 mice...
January 22, 2019: Stem Cell Reports
G G Bruer, P Hagedorn, M Kietzmann, A F Tohamy, V Filor, E Schultz, S Mielke-Kuschow, J Meissner
BACKGROUND: H1 receptor antagonists are commonly used for the treatment of allergic diseases. The aim of this study was to find out, if antihistaminic compounds like mepyramine have the ability to influence the activity of antibacterials. Therefore, the checkerboard method was chosen to detect these possible effects in vitro. Studies were performed with two different Escherichia coli (E. coli) strains as test microbes, treated with antibacterials in combination with mepyramine. RESULTS: The minimum inhibitory concentration (MIC) of E...
February 11, 2019: BMC Veterinary Research
Harry Cárdenas, Erich A Müller
We report on molecular simulations of model fluids composed of three tangentially bonded Lennard-Jones interaction sites with three distinct morphologies: a flexible "pearl-necklace" chain, a rigid "stiff" linear configuration, and an equilateral rigid triangular ring. The adsorption of these three models in cylindrical pores of diameters 1, 2, and 3 nm and with varying solid⁻fluid strength was determined by direct molecular dynamics simulations, where a sample pore was placed in contact with a bulk fluid...
February 9, 2019: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Natalia Kordulewska, Anna Cieślińska, Ewa Fiedorowicz, Beata Jarmołowska, Elżbieta Kostyra
PURPOSE: Fexofenadine (FXF) is the active metabolite of terfenadine with selective peripheral H1 receptor antagonist activity. FXF is a third-generation antihistamine, non-sedating, rapid and very long acting used in symptoms associated with allergic diseases such as allergic rhinitis, asthma and dermatitis. The pleiotropic effects of histamine are mediated by four types of receptors that belong to the G-protein-coupled receptor family: histamine H1 receptor (HRH-1), histamine H2 receptor, histamine H3 receptor, and histamine H4 receptor...
2019: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
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