Chunyong Yang, Mei Sun, Yihui Yang, Yan Han, Xiulin Wu, Xianfeng Wu, Huilin Cao, Lin Chen, Yuhao Lei, Xiaoyan Hu, Yang Chen, Ziyang Zeng, Junhong Li, Xin Shu, Zhiyong Yang, Kaizhi Lu, Yujie Li, Xiaobo Wang, Bin Yi
BACKGROUND: Bone morphogenetic protein 9 (BMP9) is a hepatokine that plays a pivotal role in the progression of liver diseases. Moreover, an increasing number of studies have shown that BMP9 is associated with hepatopulmonary syndrome (HPS), but its role in HPS is unclear. Here, we evaluated the influence of CBDL on BMP9 expression and investigated potential mechanisms of BMP9 signalling in HPS. METHODS: We profiled the circulating BMP9 levels in common bile duct ligation-induced HPS rat model, and then investigated the effects and mechanisms of HPS rat serum on pulmonary vascular endothelial dysfunction in rat model, as well as in primarily cultured rat pulmonary microvascular endothelial cells...
April 9, 2024: European Journal of Clinical Investigation