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Holistic cancer treatment

Carina Feuz, Karen Tse, Maisie Kwan, Christine Hill, Peter Rakaric, Kieng Tan, Tara Rosewall
OBJECTIVES: Although it is widely acknowledged that radiotherapy treatments can have a negative impact on a patient's sexual health, this aspect of side effect management is not commonly addressed by radiation therapists or by other cancer specialists. It is important for radiation therapists to recognize and address possible sexual health issues to provide a holistic approach to care. This quality-improvement project was designed to help radiation therapists discuss the sexual health needs of patients undergoing radiotherapy by improving their clinical knowledge, skills, and comfort level about the topic...
March 2019: Journal of Medical Imaging and Radiation Sciences
Amy L Clarke, Julia Roscoe, Rebecca Appleton, Jeremy Dale, Veronica Nanton
BACKGROUND: Men surviving prostate cancer report a wide range of unmet needs. Holistic needs assessments (HNA) are designed to capture these, but are traditionally paper-based, generic, and only carried out in secondary care despite national initiatives advocating a "shared care" approach. We developed an online prostate cancer-specific HNA (sHNA) built into existing IT healthcare infrastructure to provide a platform for service integration. Barriers and facilitators to implementation and use of the sHNA were explored from both the patients and healthcare professionals (HCPs) perspectives...
February 12, 2019: BMC Health Services Research
Trisha L Raque-Bogdan, Amanda Kracen, Nicole E Taylor, Ellen Joseph, Heather Engblom, Kaitlin Ross, Taylor Michl, Afton Nelson, Hannah Rowold
Cancer centers have adopted a holistic approach to cancer treatment to better meet the psychosocial needs of cancer survivors. However, the current number of psychosocial providers in oncology is inadequate to meet the growing demand and psychosocial providers may face barriers in accessing oncology-specific training. The current study aims to explore the career development of psychologists working in oncology to inform training and workplace supports, as well as to inform training for health psychologists interested in other sub-specialties...
February 8, 2019: Journal of Clinical Psychology in Medical Settings
June James
Death is an inevitable part of living. There are undoubtedly clinical and psychological challenges when any individual is passing from life to death. For a person with a long-term condition such as diabetes, these challenges can be compounded and impact on the care and experience of both the individual and their families and carers. It is estimated that about 500,000 people die each year in the United Kingdom; of these approximately 75,000 will have diabetes. The vast majority of people with diabetes who die do not do so as a result of a metabolic diabetes emergency such as diabetic ketoacidosis or hyperosmolar hyperglycaemic state...
January 17, 2019: Annals of Palliative Medicine
Yanan Zhang, Abdur Rauf Khan, Manfei Fu, Yujia Zhai, Jianbo Ji, Larisa Bobrovskaya, Guangxi Zhai
Curcumin (CUR), one of the major extracts of Turmeric, has gained extensive attention owing to its extraordinary benefits as anti-cancer, anti-bacterial, anti-ulcerative, anti-depressant, anti-inflammatory and wound healing agent. However, a major barrier in its application lies in its inherent nature of low water solubility, instability, and short half-life. Different strategies have been adopted to overcome these barriers like preparing nano-sized formulations and exploiting stable and hydrophilic derivatives, and collaborative drug delivery...
January 23, 2019: Journal of Drug Targeting
Anna M Catania, Clarissa Sammut Scerri, Gottfried J Catania
AIMS AND OBJECTIVES: The purpose of this study was to investigate the experiences of male partners of female breast cancer patients who had undergone surgery and oncological treatment and who were still raising children. BACKGROUND: Research on the psychological effects of breast cancer has focused primarily on the patients undergoing treatment, neglecting the effect of such a condition on their closest family members. This study addresses this gap by focusing on understanding the effects of this disease on male partners of these patients...
January 22, 2019: Journal of Clinical Nursing
Shelly Latte-Naor, Jun J Mao
Unmet symptom needs and a desire for holistic health approaches or even cure are among the motivations patients have for seeking out complementary and alternative medicine. Using complementary and alternative medicine instead of conventional cancer treatment can have a negative impact on clinical outcomes and survival. Integrative oncology is a patient-centered, evidence-informed field of comprehensive cancer care that uses mind-body practices, natural products, and lifestyle modifications from different traditions alongside conventional cancer treatments...
January 2019: Journal of Oncology Practice
Esra Atakul, İmatullah Akyar
Objective: This study investigated the prevalence of frailty in older patients with hematologic cancer and assessed the association between older patients' characteristics and frailty. Methods: This descriptive study enrolled 90 older patients undergoing treatment for hematological malignancies at an oncology hospital. Frailty was assessed with the Edmonton Frailty Scale as not frail (0-4), apparently vulnerable (5-6), mildly frail (7-8), moderately frail (9-10), and severely frail (11-17)...
January 2019: Asia-Pacific Journal of Oncology Nursing
Olgun Elicin, Martina A Broglie, Niklaus Fankhauser, Sandro J Stoeckli, Philippe Pasche, Antoine Reinhard, Massimo Bongiovanni, Gerhard F Huber, Grégoire B Morand, Alex Soltermann, Andreas Arnold, Matthias S Dettmer, André Arnoux, Edouard Stauffer, Vittoria Espeli, Francesco Martucci, Daniel M Aebersold, Roland Giger
BACKGROUND: Between the publication of the Union of International Cancer Control staging system (UICC) 7th and 8th editions, other staging algorithms for oropharyngeal squamous cell carcinoma (OPSCC) were proposed from Radiation Therapy Oncology Group (RTOG), MD Anderson Cancer Center (MDACC), and Yale University. METHODS: With C-statistics, the above-mentioned five staging algorithms were compared for overall and relapse-free survival endpoints in a multi-institutional cohort of OPSCC cases (n = 338) treated with primary surgery...
December 28, 2018: Head & Neck
Wonsun Sunny Kim, Dara James, Denise M Millstine
PURPOSE: To understand patient preferences for integrative therapeutics and/or modalities during cancer care. METHODS: Cancer patients currently going through treatment were recruited from the Mayo Clinic in Arizona. Participants were asked to engage in 1 of 4 focus groups to understand preferences regarding integrative therapeutic modalities in cancer treatment. Focus group data were transcribed and analyzed using thematic analysis. Eighty-five percent of inter-coder reliability was achieved with four team investigators...
December 19, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Vanessa Oschwald, Aram Prokop, Jonas Boehme, Nadja Gressler, Felicitas Harscheidt, Volker Maas, Wilhelm Bloch, Freerk T Baumann, Julia Daeggelmann
BACKGROUND: With improved survival rates in pediatric oncology, the detection of adverse side- and late-effects is gaining increased interest. This cross-sectional study investigated walking abilities and ankle dorsiflexion function in children with cancer. PATIENTS: Study participants included 16 children with various cancers (4-20 years, patient group) after completion of the intense treatment and 16 age- and gender-matched healthy peers (comparison group). METHOD: Walking speed (10-meter-walking-test, treadmill test assessing preferred transition speed), walking capacity (2-minute-walk-test), walking balance (Timed-Up-And-Go-Test), active/passive ankle dorsiflexion range of motion (ROM) (goniometer) and ankle dorsiflexion strength (hand-held dynamometer) were comprehensively assessed...
December 13, 2018: Klinische Pädiatrie
Kasper Bendix Johnsen, Johann Mar Gudbergsson, Thomas Lars Andresen, Jens Bæk Simonsen
Circulating biomarkers have a great potential in diagnosing cancer diseases at early stages, where curative treatment is a realistic possibility. In the recent years, using extracellular vesicles (EVs) derived from blood as biomarkers has gained widespread popularity, mainly because they are thought to be easy to isolate and carry a vast variety of biological cargos that can be analyzed for biomarker purposes. However, our current knowledge on the plasma EV concentration in normophysiological states is sparse...
December 6, 2018: Biochimica et biophysica acta. Reviews on cancer
Ning Li, Yong-Wei Tian, Yue Xu, Dan-Dan Meng, Ling Gao, Wen-Jie Shen, Zong-Lan Liu, Zhi-Qiao Xu
To investigate the clinical efficacy of autologous cytokine induced killer (CIK) cells transfusion combined with radiochemotherapy in the treatment of advanced cervical cancer. A total of 89 hospitalized patients with advanced cervical cancer were admitted and divided into the treatment group (44 cases, autologous CIK cells transfusion combined with radiochemotherapy) and the control group (45 cases, radiochemotherapy) by a randomized non-blind method. Comparisons of therapeutic efficacies, immune functions, life qualities and survival rates were analyzed between the two groups...
December 3, 2018: Pathology Oncology Research: POR
Sarah Lea, Rachel M Taylor, Ana Martins, Lorna A Fern, Jeremy S Whelan, Faith Gibson
Purpose: Teenage and young adult cancer care in England is centralized around 13 principal treatment centers, alongside linked "designated" hospitals, following recommendations that this population should have access to age-appropriate care. The term age-appropriate care has not yet been defined; it is however the explicit term used when communicating the nature of specialist care. The aim of this study was to develop an evidence-based, contextually relevant and operational model defining age-appropriate care for teenagers and young adults with cancer...
2018: Adolescent Health, Medicine and Therapeutics
Jiahui Zheng, Min Wu, Haiyan Wang, Shasha Li, Xin Wang, Yan Li, Dong Wang, Shao Li
Health-strengthening ( Fu-Zheng ) herbs is a representative type of traditional Chinese medicine (TCM) widely used for cancer treatment in China, which is in contrast to pathogen eliminating ( Qu-Xie ) herbs. However, the commonness in the biological basis of health-strengthening herbs remains to be holistically elucidated. In this study, an innovative high-throughput research strategy integrating computational and experimental methods of network pharmacology was proposed, and 22 health-strengthening herbs were selected for the investigation...
November 21, 2018: Cancers
Ragnhild J Tveit Sekse, Gail Dunberger, Mette Linnet Olesen, Maria Østerbye, Lene Seibaek
AIM AND OBJECTIVES: To review the literature on Nordic women's lived experiences and quality of life (QoL) after gynaecological cancer treatment. BACKGROUND: While incidence and survival are increasing in all groups of gynaecological cancers in the Nordic countries, inpatient hospitalization has become shorter in relation to treatment. This has increased the need for follow-up and rehabilitation. DESIGN: Integrative literature review using the Equator PRISMA guidelines...
November 21, 2018: Journal of Clinical Nursing
Christiane Hildebrandt, Hanna Mayer, Antje Koller
OBJECTIVE: The purpose of this meta-synthesis was to explore the experience of living with symptoms caused by colorectal cancer (CRC) and its treatment from the perspectives of those affected. METHODS: In a systematic search of qualitative studies published up to September 2017, seventeen relevant papers were identified. The meta-ethnography followed the approach developed by Noblit and Hare. To relate key themes from one paper to similar themes of different papers, a 'reciprocal translation' was carried out...
November 17, 2018: Psycho-oncology
Gary Mitchell, Sam Porter, Elizabeth Manias
BACKGROUND: Healthcare professionals are encouraged to promote concordance, a shared agreement about prescription and administration of medications, in their communication with patients. However, there is a paucity of research regarding the impact of communication about self-administered oral chemotherapy. The aim of this study was to examine the changing dynamics of communication through the patient journey from diagnosis of colorectal cancer to posttreatment of chemotherapy. METHODS: Over 60 hours of observational data were digitally recorded from interactions between 15 healthcare professionals, eight patients with colorectal cancer prescribed capecitabine, and 11 family members over a 6-month period in outpatient departments within one hospital in the United Kingdom...
November 16, 2018: Psycho-oncology
R Srinivas, Ajit Pratap Singh, Ayush Aman Gupta, Piyush Kumar
Global scarcity of freshwater has been gearing towards an unsustainable river basin management and corresponding services to the humans. It needs a holistic approach, which exclusively focuses on effective river water quality monitoring and quantification and identification of pollutant sources, in order to address the issue of sustainability. These days, rivers are heavily contaminated due to the presence of organic and metallic pollutants released from several anthropogenic sources, such as industrial effluents, domestic sewage, and agricultural runoff...
November 14, 2018: Environmental Monitoring and Assessment
Ming Yang, Jialei Chen, Liwen Xu, Xiufeng Shi, Xin Zhou, Rui An, Xinhong Wang
Ban-Xia-Xie-Xin-Tang (BXXXT) is a classical formula from Shang-Han-Lun which is one of the earliest books of TCM clinical practice. In this work, we investigated the therapeutic mechanisms of BXXXT for the treatment of multiple diseases using a network pharmacology approach. Here three BXXXT representative diseases (colitis, diabetes mellitus, and gastric cancer) were discussed, and we focus on in silico methods that integrate drug-likeness screening, target prioritizing, and multilayer network extending. A total of 140 core targets and 72 representative compounds were finally identified to elucidate the pharmacology of BXXXT formula...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
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