P Shrestha, M Graff, Y Gu, Y Wang, C L Avery, J Ginnis, M A Simancas-Pallares, A G Ferreira Zandoná, H S Ahn, K N Nguyen, D Y Lin, J S Preisser, G D Slade, M L Marazita, K E North, K Divaris
Early childhood caries (ECC) is the most common non-communicable childhood disease. It is an important health problem with known environmental and social/behavioral influences that lacks evidence for specific associated genetic risk loci. To address this knowledge gap, we conducted a genome-wide association study of ECC in a multi-ancestry population of U.S. preschool-age children (n=6,103) participating in a community-based epidemiologic study of early childhood oral health. Calibrated examiners used ICDAS criteria to measure ECC with the primary trait using the dmfs index with decay classified as macroscopic enamel loss (ICDAS ≥3)...
March 18, 2024: medRxiv